AP2013006902A0 - e and their use as HSD 1 inhibitors A-S)-1-(1H-benzoimidazole-5-carbonyl)-2,3,4,4A,9,9Crystalline forms of hydrochloride salt of (4A-R,9A-hexahydro-1H-indeno[2,1-B]pyridine-6-carbonitril - Google Patents

e and their use as HSD 1 inhibitors A-S)-1-(1H-benzoimidazole-5-carbonyl)-2,3,4,4A,9,9Crystalline forms of hydrochloride salt of (4A-R,9A-hexahydro-1H-indeno[2,1-B]pyridine-6-carbonitril

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Publication number
AP2013006902A0
AP2013006902A0 AP2013006902A AP2013006902A AP2013006902A0 AP 2013006902 A0 AP2013006902 A0 AP 2013006902A0 AP 2013006902 A AP2013006902 A AP 2013006902A AP 2013006902 A AP2013006902 A AP 2013006902A AP 2013006902 A0 AP2013006902 A0 AP 2013006902A0
Authority
AP
ARIPO
Prior art keywords
carbonitril
benzoimidazole
indeno
hsd
hexahydro
Prior art date
Application number
AP2013006902A
Other versions
AP3521A (en
Inventor
Hans-Juergen Martin
Matthias Eckhardt
Martin Schuehle
Original Assignee
Boehringer Ingelheim Int
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Priority claimed from PCT/US2010/055586 external-priority patent/WO2011057054A1/en
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of AP2013006902A0 publication Critical patent/AP2013006902A0/en
Application granted granted Critical
Publication of AP3521A publication Critical patent/AP3521A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
AP2013006902A 2010-11-05 2011-11-04 Crystalline forms of hydrochloride salt of (4a-r,9a-s)-1-(1h-benzoimidazole-5-carbonyl)-2,3,4,4a,9,9a-hexahydro-1h-indeno [2,1-b]pyridine-6-carbonitrile and their use as hsd 1 inhibitors AP3521A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US2010/055586 WO2011057054A1 (en) 2009-11-06 2010-11-05 Aryl- and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline
US201161484995P 2011-05-11 2011-05-11
PCT/US2011/059331 WO2012061708A1 (en) 2010-11-05 2011-11-04 Crystalline forms of hydrochloride salt of (4a-r,9a-s) -1- (1h - benzoimidazole- 5 -carbonyl) -2, 3, 4, 4a, 9, 9a - hexahydro -1h- indeno [2, 1 -b] pyridine- 6 -carbonitrile and their use as hsd 1 inhibitors

Publications (2)

Publication Number Publication Date
AP2013006902A0 true AP2013006902A0 (en) 2013-06-30
AP3521A AP3521A (en) 2016-01-11

Family

ID=44999935

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2013006902A AP3521A (en) 2010-11-05 2011-11-04 Crystalline forms of hydrochloride salt of (4a-r,9a-s)-1-(1h-benzoimidazole-5-carbonyl)-2,3,4,4a,9,9a-hexahydro-1h-indeno [2,1-b]pyridine-6-carbonitrile and their use as hsd 1 inhibitors

Country Status (36)

Country Link
US (2) US8686149B2 (en)
EP (1) EP2635563B1 (en)
JP (1) JP2013541592A (en)
KR (1) KR20130119939A (en)
CN (1) CN103228642B (en)
AP (1) AP3521A (en)
AR (1) AR083678A1 (en)
AU (1) AU2011323164B2 (en)
BR (1) BR112013011095A2 (en)
CA (1) CA2816136A1 (en)
CL (1) CL2013001221A1 (en)
CO (1) CO6781480A2 (en)
CY (1) CY1116043T1 (en)
DK (1) DK2635563T3 (en)
EA (1) EA022406B1 (en)
EC (2) ECSP12011788A (en)
ES (1) ES2533833T3 (en)
GE (1) GEP20166481B (en)
HK (1) HK1184144A1 (en)
HR (1) HRP20150327T1 (en)
IL (1) IL225647A0 (en)
ME (1) ME02066B (en)
MX (1) MX2013005069A (en)
NZ (1) NZ609281A (en)
PE (1) PE20140123A1 (en)
PL (1) PL2635563T3 (en)
PT (1) PT2635563E (en)
RS (1) RS53900B1 (en)
SG (1) SG189859A1 (en)
SI (1) SI2635563T1 (en)
SM (1) SMT201500095B (en)
TN (1) TN2012000117A1 (en)
TW (1) TWI537258B (en)
UA (1) UA110807C2 (en)
UY (1) UY33701A (en)
WO (1) WO2012061708A1 (en)

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CN103228642A (en) 2013-07-31
DK2635563T3 (en) 2015-02-02
TN2012000117A1 (en) 2013-09-19
MX2013005069A (en) 2013-08-29
SMT201500095B (en) 2015-07-09
SG189859A1 (en) 2013-06-28
KR20130119939A (en) 2013-11-01
EP2635563B1 (en) 2015-01-14
TWI537258B (en) 2016-06-11
ME02066B (en) 2015-05-20
AU2011323164A1 (en) 2013-05-02
CA2816136A1 (en) 2012-05-10
ECSP13012664A (en) 2013-08-30
PE20140123A1 (en) 2014-03-02
EP2635563A1 (en) 2013-09-11
AP3521A (en) 2016-01-11
AU2011323164B2 (en) 2015-07-23
WO2012061708A1 (en) 2012-05-10
CN103228642B (en) 2015-02-18
CL2013001221A1 (en) 2013-11-08
US20140249174A1 (en) 2014-09-04
CO6781480A2 (en) 2013-10-31
EA022406B1 (en) 2015-12-30
BR112013011095A2 (en) 2016-08-02
PL2635563T3 (en) 2015-06-30
ES2533833T3 (en) 2015-04-15
US20120157488A1 (en) 2012-06-21
JP2013541592A (en) 2013-11-14
AR083678A1 (en) 2013-03-13
RS53900B1 (en) 2015-08-31
HRP20150327T1 (en) 2015-04-24
SI2635563T1 (en) 2015-04-30
GEP20166481B (en) 2016-05-25
US8686149B2 (en) 2014-04-01
UA110807C2 (en) 2016-02-25
TW201242960A (en) 2012-11-01
UY33701A (en) 2012-05-31
NZ609281A (en) 2015-02-27
PT2635563E (en) 2015-04-13
ECSP12011788A (en) 2012-10-30
HK1184144A1 (en) 2014-01-17
IL225647A0 (en) 2013-06-27
EA201390643A1 (en) 2013-11-29
CY1116043T1 (en) 2017-01-25
US9120769B2 (en) 2015-09-01

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