CL2013001221A1 - Compuesto clorhidrato de (4a-r, 9a-s)-1-(1h-benzoimidazol-5-carbonil-2,3,4,4a,9,9a-hexahidro-1 h-inden[2,1-b] piridin-6-carbonitrilo y sus formas cristalinas i y ii, inhibidores de hsd 1; composicion farmaceutica; metodo para producir la forma cristalina i del compuesto; metodo para producir la forma cristalina ii del compuesto. - Google Patents

Compuesto clorhidrato de (4a-r, 9a-s)-1-(1h-benzoimidazol-5-carbonil-2,3,4,4a,9,9a-hexahidro-1 h-inden[2,1-b] piridin-6-carbonitrilo y sus formas cristalinas i y ii, inhibidores de hsd 1; composicion farmaceutica; metodo para producir la forma cristalina i del compuesto; metodo para producir la forma cristalina ii del compuesto.

Info

Publication number
CL2013001221A1
CL2013001221A1 CL2013001221A CL2013001221A CL2013001221A1 CL 2013001221 A1 CL2013001221 A1 CL 2013001221A1 CL 2013001221 A CL2013001221 A CL 2013001221A CL 2013001221 A CL2013001221 A CL 2013001221A CL 2013001221 A1 CL2013001221 A1 CL 2013001221A1
Authority
CL
Chile
Prior art keywords
compound
producing
crystalline form
benzoimidazol
hsd
Prior art date
Application number
CL2013001221A
Other languages
English (en)
Inventor
Matthias Eckhardt
Hans-Juergen Martin
Martin Schuehle
Sandra Sick
Bing-Shiou Yang
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44999935&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2013001221(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/US2010/055586 external-priority patent/WO2011057054A1/en
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of CL2013001221A1 publication Critical patent/CL2013001221A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
CL2013001221A 2010-11-05 2013-05-03 Compuesto clorhidrato de (4a-r, 9a-s)-1-(1h-benzoimidazol-5-carbonil-2,3,4,4a,9,9a-hexahidro-1 h-inden[2,1-b] piridin-6-carbonitrilo y sus formas cristalinas i y ii, inhibidores de hsd 1; composicion farmaceutica; metodo para producir la forma cristalina i del compuesto; metodo para producir la forma cristalina ii del compuesto. CL2013001221A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US2010/055586 WO2011057054A1 (en) 2009-11-06 2010-11-05 Aryl- and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline
US201161484995P 2011-05-11 2011-05-11

Publications (1)

Publication Number Publication Date
CL2013001221A1 true CL2013001221A1 (es) 2013-11-08

Family

ID=44999935

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2013001221A CL2013001221A1 (es) 2010-11-05 2013-05-03 Compuesto clorhidrato de (4a-r, 9a-s)-1-(1h-benzoimidazol-5-carbonil-2,3,4,4a,9,9a-hexahidro-1 h-inden[2,1-b] piridin-6-carbonitrilo y sus formas cristalinas i y ii, inhibidores de hsd 1; composicion farmaceutica; metodo para producir la forma cristalina i del compuesto; metodo para producir la forma cristalina ii del compuesto.

Country Status (36)

Country Link
US (2) US8686149B2 (es)
EP (1) EP2635563B1 (es)
JP (1) JP2013541592A (es)
KR (1) KR20130119939A (es)
CN (1) CN103228642B (es)
AP (1) AP3521A (es)
AR (1) AR083678A1 (es)
AU (1) AU2011323164B2 (es)
BR (1) BR112013011095A2 (es)
CA (1) CA2816136A1 (es)
CL (1) CL2013001221A1 (es)
CO (1) CO6781480A2 (es)
CY (1) CY1116043T1 (es)
DK (1) DK2635563T3 (es)
EA (1) EA022406B1 (es)
EC (2) ECSP12011788A (es)
ES (1) ES2533833T3 (es)
GE (1) GEP20166481B (es)
HK (1) HK1184144A1 (es)
HR (1) HRP20150327T1 (es)
IL (1) IL225647A0 (es)
ME (1) ME02066B (es)
MX (1) MX2013005069A (es)
NZ (1) NZ609281A (es)
PE (1) PE20140123A1 (es)
PL (1) PL2635563T3 (es)
PT (1) PT2635563E (es)
RS (1) RS53900B1 (es)
SG (1) SG189859A1 (es)
SI (1) SI2635563T1 (es)
SM (1) SMT201500095B (es)
TN (1) TN2012000117A1 (es)
TW (1) TWI537258B (es)
UA (1) UA110807C2 (es)
UY (1) UY33701A (es)
WO (1) WO2012061708A1 (es)

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US8703765B2 (en) 2009-06-02 2014-04-22 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
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US8933072B2 (en) 2010-06-16 2015-01-13 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
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US8735585B2 (en) 2011-08-17 2014-05-27 Boehringer Ingelheim International Gmbh Indenopyridine derivatives
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EP3935050A4 (en) 2019-03-06 2023-01-04 C4 Therapeutics, Inc. HETEROCYCLIC COMPOUNDS FOR MEDICAL TREATMENT

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Also Published As

Publication number Publication date
TN2012000117A1 (en) 2013-09-19
ES2533833T3 (es) 2015-04-15
JP2013541592A (ja) 2013-11-14
RS53900B1 (en) 2015-08-31
EA201390643A1 (ru) 2013-11-29
KR20130119939A (ko) 2013-11-01
US8686149B2 (en) 2014-04-01
UA110807C2 (uk) 2016-02-25
PT2635563E (pt) 2015-04-13
AP3521A (en) 2016-01-11
CN103228642A (zh) 2013-07-31
EA022406B1 (ru) 2015-12-30
SG189859A1 (en) 2013-06-28
ECSP12011788A (es) 2012-10-30
AP2013006902A0 (en) 2013-06-30
HRP20150327T1 (hr) 2015-04-24
CN103228642B (zh) 2015-02-18
PE20140123A1 (es) 2014-03-02
EP2635563B1 (en) 2015-01-14
IL225647A0 (en) 2013-06-27
UY33701A (es) 2012-05-31
CO6781480A2 (es) 2013-10-31
MX2013005069A (es) 2013-08-29
AR083678A1 (es) 2013-03-13
BR112013011095A2 (pt) 2016-08-02
HK1184144A1 (en) 2014-01-17
CY1116043T1 (el) 2017-01-25
ECSP13012664A (es) 2013-08-30
PL2635563T3 (pl) 2015-06-30
NZ609281A (en) 2015-02-27
US9120769B2 (en) 2015-09-01
TWI537258B (zh) 2016-06-11
WO2012061708A1 (en) 2012-05-10
TW201242960A (en) 2012-11-01
DK2635563T3 (en) 2015-02-02
AU2011323164A1 (en) 2013-05-02
EP2635563A1 (en) 2013-09-11
ME02066B (me) 2015-05-20
GEP20166481B (en) 2016-05-25
AU2011323164B2 (en) 2015-07-23
CA2816136A1 (en) 2012-05-10
SI2635563T1 (sl) 2015-04-30
US20140249174A1 (en) 2014-09-04
SMT201500095B (it) 2015-07-09
US20120157488A1 (en) 2012-06-21

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