MX2013005069A - Formas cristalinas de sal de clorhidrato de (4a-r, 9a-s)-1-(1h-benzoimidazol-5-carbonil)-2,3,4,4a,9,9a,-hexahidro-1h -indeno[2,1-b]piridin-6-carbonitrilo y su uso como inhibidores de 11 beta-hidroxiesteroide deshidrogenasa 1. - Google Patents

Formas cristalinas de sal de clorhidrato de (4a-r, 9a-s)-1-(1h-benzoimidazol-5-carbonil)-2,3,4,4a,9,9a,-hexahidro-1h -indeno[2,1-b]piridin-6-carbonitrilo y su uso como inhibidores de 11 beta-hidroxiesteroide deshidrogenasa 1.

Info

Publication number
MX2013005069A
MX2013005069A MX2013005069A MX2013005069A MX2013005069A MX 2013005069 A MX2013005069 A MX 2013005069A MX 2013005069 A MX2013005069 A MX 2013005069A MX 2013005069 A MX2013005069 A MX 2013005069A MX 2013005069 A MX2013005069 A MX 2013005069A
Authority
MX
Mexico
Prior art keywords
hsd
inhibitors
benzoimidazole
indeno
carbonitrile
Prior art date
Application number
MX2013005069A
Other languages
English (en)
Inventor
Matthias Eckhardt
Hans-Juergen Martin
Martin Schuehle
Sandra Sick
Bing-Shiou Yang
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44999935&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2013005069(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/US2010/055586 external-priority patent/WO2011057054A1/en
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MX2013005069A publication Critical patent/MX2013005069A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a compuestos cristalinos de la siguiente fórmula estructural (II) que tienen actividad farmacológica importante; en particular, los compuestos son inhibidores de 11ß- hidroxiesteroide deshidrogenasa (HSD) 1 y, por lo tanto, son adecuados para el tratamiento y prevención de enfermedades que pueden verse influidas por la inhibición de esta enzima, tal como enfermedades metabólicas, en particular diabetes tipo 2, obesidad y dislipidemia.
MX2013005069A 2010-11-05 2011-11-04 Formas cristalinas de sal de clorhidrato de (4a-r, 9a-s)-1-(1h-benzoimidazol-5-carbonil)-2,3,4,4a,9,9a,-hexahidro-1h -indeno[2,1-b]piridin-6-carbonitrilo y su uso como inhibidores de 11 beta-hidroxiesteroide deshidrogenasa 1. MX2013005069A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US2010/055586 WO2011057054A1 (en) 2009-11-06 2010-11-05 Aryl- and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline
US201161484995P 2011-05-11 2011-05-11
PCT/US2011/059331 WO2012061708A1 (en) 2010-11-05 2011-11-04 Crystalline forms of hydrochloride salt of (4a-r,9a-s) -1- (1h - benzoimidazole- 5 -carbonyl) -2, 3, 4, 4a, 9, 9a - hexahydro -1h- indeno [2, 1 -b] pyridine- 6 -carbonitrile and their use as hsd 1 inhibitors

Publications (1)

Publication Number Publication Date
MX2013005069A true MX2013005069A (es) 2013-08-29

Family

ID=44999935

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013005069A MX2013005069A (es) 2010-11-05 2011-11-04 Formas cristalinas de sal de clorhidrato de (4a-r, 9a-s)-1-(1h-benzoimidazol-5-carbonil)-2,3,4,4a,9,9a,-hexahidro-1h -indeno[2,1-b]piridin-6-carbonitrilo y su uso como inhibidores de 11 beta-hidroxiesteroide deshidrogenasa 1.

Country Status (36)

Country Link
US (2) US8686149B2 (es)
EP (1) EP2635563B1 (es)
JP (1) JP2013541592A (es)
KR (1) KR20130119939A (es)
CN (1) CN103228642B (es)
AP (1) AP3521A (es)
AR (1) AR083678A1 (es)
AU (1) AU2011323164B2 (es)
BR (1) BR112013011095A2 (es)
CA (1) CA2816136A1 (es)
CL (1) CL2013001221A1 (es)
CO (1) CO6781480A2 (es)
CY (1) CY1116043T1 (es)
DK (1) DK2635563T3 (es)
EA (1) EA022406B1 (es)
EC (2) ECSP12011788A (es)
ES (1) ES2533833T3 (es)
GE (1) GEP20166481B (es)
HK (1) HK1184144A1 (es)
HR (1) HRP20150327T1 (es)
IL (1) IL225647A0 (es)
ME (1) ME02066B (es)
MX (1) MX2013005069A (es)
NZ (1) NZ609281A (es)
PE (1) PE20140123A1 (es)
PL (1) PL2635563T3 (es)
PT (1) PT2635563E (es)
RS (1) RS53900B1 (es)
SG (1) SG189859A1 (es)
SI (1) SI2635563T1 (es)
SM (1) SMT201500095B (es)
TN (1) TN2012000117A1 (es)
TW (1) TWI537258B (es)
UA (1) UA110807C2 (es)
UY (1) UY33701A (es)
WO (1) WO2012061708A1 (es)

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US8735585B2 (en) 2011-08-17 2014-05-27 Boehringer Ingelheim International Gmbh Indenopyridine derivatives
US20130303446A1 (en) * 2012-05-09 2013-11-14 Boehringer Ingelheim International Gmbh Pharmaceutical combinations for the treatment of metabolic disorders
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Also Published As

Publication number Publication date
CN103228642A (zh) 2013-07-31
SI2635563T1 (sl) 2015-04-30
HRP20150327T1 (hr) 2015-04-24
ME02066B (me) 2015-05-20
SG189859A1 (en) 2013-06-28
PE20140123A1 (es) 2014-03-02
DK2635563T3 (en) 2015-02-02
SMT201500095B (it) 2015-07-09
WO2012061708A1 (en) 2012-05-10
US20120157488A1 (en) 2012-06-21
IL225647A0 (en) 2013-06-27
KR20130119939A (ko) 2013-11-01
RS53900B1 (en) 2015-08-31
US20140249174A1 (en) 2014-09-04
US8686149B2 (en) 2014-04-01
UA110807C2 (uk) 2016-02-25
PL2635563T3 (pl) 2015-06-30
UY33701A (es) 2012-05-31
CY1116043T1 (el) 2017-01-25
CL2013001221A1 (es) 2013-11-08
EP2635563B1 (en) 2015-01-14
AU2011323164A1 (en) 2013-05-02
AU2011323164B2 (en) 2015-07-23
TW201242960A (en) 2012-11-01
GEP20166481B (en) 2016-05-25
CN103228642B (zh) 2015-02-18
CA2816136A1 (en) 2012-05-10
NZ609281A (en) 2015-02-27
BR112013011095A2 (pt) 2016-08-02
CO6781480A2 (es) 2013-10-31
ES2533833T3 (es) 2015-04-15
TWI537258B (zh) 2016-06-11
HK1184144A1 (en) 2014-01-17
EA022406B1 (ru) 2015-12-30
ECSP12011788A (es) 2012-10-30
EA201390643A1 (ru) 2013-11-29
ECSP13012664A (es) 2013-08-30
AP3521A (en) 2016-01-11
US9120769B2 (en) 2015-09-01
TN2012000117A1 (en) 2013-09-19
EP2635563A1 (en) 2013-09-11
PT2635563E (pt) 2015-04-13
AR083678A1 (es) 2013-03-13
JP2013541592A (ja) 2013-11-14
AP2013006902A0 (en) 2013-06-30

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