SK281990B6 - Spôsob výroby metoprololu - Google Patents

Spôsob výroby metoprololu Download PDF

Info

Publication number
SK281990B6
SK281990B6 SK564-99A SK56499A SK281990B6 SK 281990 B6 SK281990 B6 SK 281990B6 SK 56499 A SK56499 A SK 56499A SK 281990 B6 SK281990 B6 SK 281990B6
Authority
SK
Slovakia
Prior art keywords
metoprolol
methoxyethyl
epoxypropoxy
epichlorohydrin
base
Prior art date
Application number
SK564-99A
Other languages
English (en)
Slovak (sk)
Other versions
SK56499A3 (en
Inventor
Sven Palm�R
Michael Sidenqvist
Original Assignee
Astra Aktiebolag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Aktiebolag filed Critical Astra Aktiebolag
Publication of SK56499A3 publication Critical patent/SK56499A3/sk
Publication of SK281990B6 publication Critical patent/SK281990B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/04—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reaction of ammonia or amines with olefin oxides or halohydrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
SK564-99A 1996-11-20 1997-11-18 Spôsob výroby metoprololu SK281990B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9604253A SE9604253D0 (sv) 1996-11-20 1996-11-20 New manufacturing process metoprolol
PCT/SE1997/001926 WO1998022426A1 (en) 1996-11-20 1997-11-18 New manufacturing process of metoprolol

Publications (2)

Publication Number Publication Date
SK56499A3 SK56499A3 (en) 2000-03-13
SK281990B6 true SK281990B6 (sk) 2001-09-11

Family

ID=20404680

Family Applications (1)

Application Number Title Priority Date Filing Date
SK564-99A SK281990B6 (sk) 1996-11-20 1997-11-18 Spôsob výroby metoprololu

Country Status (36)

Country Link
US (1) US6252113B1 (ja)
EP (1) EP0942899B1 (ja)
JP (1) JP4039640B2 (ja)
KR (1) KR100544560B1 (ja)
CN (1) CN1128786C (ja)
AR (1) AR010069A1 (ja)
AT (1) ATE234273T1 (ja)
AU (1) AU728270B2 (ja)
BR (1) BR9713370A (ja)
CA (1) CA2269941A1 (ja)
CZ (1) CZ174499A3 (ja)
DE (1) DE69719788T2 (ja)
DK (1) DK0942899T3 (ja)
EE (1) EE03761B1 (ja)
EG (1) EG21158A (ja)
ES (1) ES2193365T3 (ja)
HK (1) HK1022684A1 (ja)
HU (1) HUP0002445A3 (ja)
ID (1) ID21505A (ja)
IL (1) IL129747A (ja)
IN (1) IN187175B (ja)
IS (1) IS1964B (ja)
MY (1) MY119303A (ja)
NO (1) NO311352B1 (ja)
NZ (1) NZ335213A (ja)
PL (1) PL191392B1 (ja)
PT (1) PT942899E (ja)
RU (1) RU2210565C2 (ja)
SA (1) SA97180599B1 (ja)
SE (1) SE9604253D0 (ja)
SK (1) SK281990B6 (ja)
TR (1) TR199901115T2 (ja)
TW (1) TW412513B (ja)
UA (1) UA66769C2 (ja)
WO (1) WO1998022426A1 (ja)
ZA (1) ZA9710005B (ja)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050107635A1 (en) * 2003-11-14 2005-05-19 Mehra Janakraj K. Metoprolol manufacturing process
WO2007141593A2 (en) * 2005-12-23 2007-12-13 Medichem, S.A. Process for the preparation of metoprolol and its salts
US20080107726A1 (en) * 2006-11-01 2008-05-08 Pramod Kharwade Compositions comprising beta-adrenergic receptor antagonists and diuretics
CN101607918B (zh) * 2008-06-16 2014-02-19 北京德众万全药物技术开发有限公司 一种美托洛尔的制备方法
WO2011056929A1 (en) * 2009-11-04 2011-05-12 Massachusetts Institute Of Technology Continuous flow synthesis of amino alcohols using microreactors
US8680303B2 (en) 2010-03-01 2014-03-25 Massachusetts Institute Of Technology Epoxidation catalysts
CN102381995B (zh) * 2010-08-31 2015-04-15 扬子江药业集团北京海燕药业有限公司 美托洛尔的制备方法
CN102432476A (zh) * 2010-09-29 2012-05-02 湖南康普医药研究院 一种规模化制备琥珀酸美托洛尔的方法
CN102503843B (zh) * 2011-10-28 2013-10-23 山东阿如拉药物研究开发有限公司 一种美托洛尔盐的制备方法
KR101379383B1 (ko) * 2012-03-23 2014-04-02 주식회사 알에스텍 고순도 ⒮―메토프롤롤의 제조방법
CN103980134B (zh) * 2014-05-30 2015-09-30 安徽省新星药物开发有限责任公司 一种琥珀酸s-美托洛尔的制备方法
CN105820057B (zh) * 2016-04-22 2017-09-29 上海应用技术学院 一种制备美多心安的方法
CN106543015A (zh) * 2016-11-07 2017-03-29 上海应用技术大学 一种美多心安的制备方法
CN108299279B (zh) * 2018-02-09 2021-03-23 北京梅尔森医药技术开发有限公司 取代芳基胺醇化合物及其制备方法和用途
EP3768378A4 (en) 2018-03-22 2021-11-17 InCarda Therapeutics, Inc. INNOVATIVE METHOD OF SLOWING THE VENTRICULAR RATE
CN111018724B (zh) * 2019-12-27 2022-11-08 江西美晶科技有限公司 一种美托洛尔及其制备方法
CN112645827A (zh) * 2020-12-25 2021-04-13 浙江普洛家园药业有限公司 一种连续合成美多心安及其盐的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2011584A6 (es) * 1989-05-26 1990-01-16 Esteve Quimica Sa Procedimiento industrial para la obtencion de una ariloxipropanolamina.
WO1992016197A1 (en) 1991-03-18 1992-10-01 Sepracor Inc. Composition and method containing optically pure (s) metoprolol

Also Published As

Publication number Publication date
DK0942899T3 (da) 2003-06-02
IL129747A (en) 2003-01-12
ES2193365T3 (es) 2003-11-01
JP4039640B2 (ja) 2008-01-30
AR010069A1 (es) 2000-05-15
ZA9710005B (en) 1998-05-20
PL191392B1 (pl) 2006-05-31
PT942899E (pt) 2003-06-30
IS1964B (is) 2004-12-15
ATE234273T1 (de) 2003-03-15
NO311352B1 (no) 2001-11-19
IL129747A0 (en) 2000-02-29
EG21158A (en) 2000-12-31
NZ335213A (en) 2001-02-23
TW412513B (en) 2000-11-21
NO992401D0 (no) 1999-05-19
IS5034A (is) 1999-04-26
KR20000057134A (ko) 2000-09-15
CN1237958A (zh) 1999-12-08
EE9900202A (et) 1999-12-15
DE69719788D1 (de) 2003-04-17
SA97180599B1 (ar) 2006-03-25
EP0942899B1 (en) 2003-03-12
CN1128786C (zh) 2003-11-26
HUP0002445A3 (en) 2001-09-28
SE9604253D0 (sv) 1996-11-20
JP2001503388A (ja) 2001-03-13
NO992401L (no) 1999-07-13
DE69719788T2 (de) 2004-02-12
AU728270B2 (en) 2001-01-04
EE03761B1 (et) 2002-06-17
BR9713370A (pt) 2000-03-21
HUP0002445A2 (hu) 2001-08-28
KR100544560B1 (ko) 2006-01-24
RU2210565C2 (ru) 2003-08-20
IN187175B (ja) 2002-02-23
CA2269941A1 (en) 1998-05-28
WO1998022426A1 (en) 1998-05-28
AU5077698A (en) 1998-06-10
SK56499A3 (en) 2000-03-13
HK1022684A1 (en) 2000-08-18
EP0942899A1 (en) 1999-09-22
MY119303A (en) 2005-04-30
CZ174499A3 (cs) 1999-11-17
TR199901115T2 (xx) 1999-07-21
US6252113B1 (en) 2001-06-26
UA66769C2 (uk) 2004-06-15
ID21505A (id) 1999-06-17

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