BR9713370A - Processos para fabricação de metoprolol e de uma preparação farmacêutica, e, metoprolol - Google Patents

Processos para fabricação de metoprolol e de uma preparação farmacêutica, e, metoprolol

Info

Publication number
BR9713370A
BR9713370A BR9713370A BR9713370A BR9713370A BR 9713370 A BR9713370 A BR 9713370A BR 9713370 A BR9713370 A BR 9713370A BR 9713370 A BR9713370 A BR 9713370A BR 9713370 A BR9713370 A BR 9713370A
Authority
BR
Brazil
Prior art keywords
metoprolol
manufacture
processes
pharmaceutical preparation
solvent
Prior art date
Application number
BR9713370A
Other languages
English (en)
Inventor
Sven Palmer Sueco
Michael Sidengvist
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of BR9713370A publication Critical patent/BR9713370A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/04—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reaction of ammonia or amines with olefin oxides or halohydrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

Abstract

para a fabricação de metoprolol que é realizado em água como solvente.
BR9713370A 1996-11-20 1997-11-18 Processos para fabricação de metoprolol e de uma preparação farmacêutica, e, metoprolol BR9713370A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9604253A SE9604253D0 (sv) 1996-11-20 1996-11-20 New manufacturing process metoprolol
PCT/SE1997/001926 WO1998022426A1 (en) 1996-11-20 1997-11-18 New manufacturing process of metoprolol

Publications (1)

Publication Number Publication Date
BR9713370A true BR9713370A (pt) 2000-03-21

Family

ID=20404680

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9713370A BR9713370A (pt) 1996-11-20 1997-11-18 Processos para fabricação de metoprolol e de uma preparação farmacêutica, e, metoprolol

Country Status (36)

Country Link
US (1) US6252113B1 (pt)
EP (1) EP0942899B1 (pt)
JP (1) JP4039640B2 (pt)
KR (1) KR100544560B1 (pt)
CN (1) CN1128786C (pt)
AR (1) AR010069A1 (pt)
AT (1) ATE234273T1 (pt)
AU (1) AU728270B2 (pt)
BR (1) BR9713370A (pt)
CA (1) CA2269941A1 (pt)
CZ (1) CZ174499A3 (pt)
DE (1) DE69719788T2 (pt)
DK (1) DK0942899T3 (pt)
EE (1) EE03761B1 (pt)
EG (1) EG21158A (pt)
ES (1) ES2193365T3 (pt)
HK (1) HK1022684A1 (pt)
HU (1) HUP0002445A3 (pt)
ID (1) ID21505A (pt)
IL (1) IL129747A (pt)
IN (1) IN187175B (pt)
IS (1) IS1964B (pt)
MY (1) MY119303A (pt)
NO (1) NO311352B1 (pt)
NZ (1) NZ335213A (pt)
PL (1) PL191392B1 (pt)
PT (1) PT942899E (pt)
RU (1) RU2210565C2 (pt)
SA (1) SA97180599B1 (pt)
SE (1) SE9604253D0 (pt)
SK (1) SK281990B6 (pt)
TR (1) TR199901115T2 (pt)
TW (1) TW412513B (pt)
UA (1) UA66769C2 (pt)
WO (1) WO1998022426A1 (pt)
ZA (1) ZA9710005B (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050107635A1 (en) * 2003-11-14 2005-05-19 Mehra Janakraj K. Metoprolol manufacturing process
WO2007141593A2 (en) * 2005-12-23 2007-12-13 Medichem, S.A. Process for the preparation of metoprolol and its salts
US20080107726A1 (en) * 2006-11-01 2008-05-08 Pramod Kharwade Compositions comprising beta-adrenergic receptor antagonists and diuretics
CN101607918B (zh) * 2008-06-16 2014-02-19 北京德众万全药物技术开发有限公司 一种美托洛尔的制备方法
WO2011056929A1 (en) * 2009-11-04 2011-05-12 Massachusetts Institute Of Technology Continuous flow synthesis of amino alcohols using microreactors
WO2011109276A1 (en) 2010-03-01 2011-09-09 Massachussets Institute Of Technology Epoxidation catalysts
CN102381995B (zh) * 2010-08-31 2015-04-15 扬子江药业集团北京海燕药业有限公司 美托洛尔的制备方法
CN102432476A (zh) * 2010-09-29 2012-05-02 湖南康普医药研究院 一种规模化制备琥珀酸美托洛尔的方法
CN102503843B (zh) * 2011-10-28 2013-10-23 山东阿如拉药物研究开发有限公司 一种美托洛尔盐的制备方法
KR101379383B1 (ko) * 2012-03-23 2014-04-02 주식회사 알에스텍 고순도 ⒮―메토프롤롤의 제조방법
CN103980134B (zh) * 2014-05-30 2015-09-30 安徽省新星药物开发有限责任公司 一种琥珀酸s-美托洛尔的制备方法
CN105820057B (zh) * 2016-04-22 2017-09-29 上海应用技术学院 一种制备美多心安的方法
CN106543015A (zh) * 2016-11-07 2017-03-29 上海应用技术大学 一种美多心安的制备方法
CN108299279B (zh) * 2018-02-09 2021-03-23 北京梅尔森医药技术开发有限公司 取代芳基胺醇化合物及其制备方法和用途
WO2019183470A2 (en) 2018-03-22 2019-09-26 Incarda Therapeutics, Inc. A novel method to slow ventricular rate
CN111018724B (zh) * 2019-12-27 2022-11-08 江西美晶科技有限公司 一种美托洛尔及其制备方法
CN112645827A (zh) * 2020-12-25 2021-04-13 浙江普洛家园药业有限公司 一种连续合成美多心安及其盐的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2011584A6 (es) * 1989-05-26 1990-01-16 Esteve Quimica Sa Procedimiento industrial para la obtencion de una ariloxipropanolamina.
DE69212646T2 (de) 1991-03-18 1997-03-13 Sepracor Inc Zubereitung und verfahren enthaltend optisch reines s-metoprolol

Also Published As

Publication number Publication date
WO1998022426A1 (en) 1998-05-28
ID21505A (id) 1999-06-17
IN187175B (pt) 2002-02-23
JP2001503388A (ja) 2001-03-13
CN1237958A (zh) 1999-12-08
PL191392B1 (pl) 2006-05-31
EG21158A (en) 2000-12-31
US6252113B1 (en) 2001-06-26
KR100544560B1 (ko) 2006-01-24
TR199901115T2 (xx) 1999-07-21
RU2210565C2 (ru) 2003-08-20
DE69719788T2 (de) 2004-02-12
HUP0002445A2 (hu) 2001-08-28
AU5077698A (en) 1998-06-10
DK0942899T3 (da) 2003-06-02
AU728270B2 (en) 2001-01-04
TW412513B (en) 2000-11-21
NO311352B1 (no) 2001-11-19
IL129747A0 (en) 2000-02-29
PT942899E (pt) 2003-06-30
KR20000057134A (ko) 2000-09-15
IL129747A (en) 2003-01-12
CN1128786C (zh) 2003-11-26
HUP0002445A3 (en) 2001-09-28
NZ335213A (en) 2001-02-23
ES2193365T3 (es) 2003-11-01
ATE234273T1 (de) 2003-03-15
IS5034A (is) 1999-04-26
ZA9710005B (en) 1998-05-20
HK1022684A1 (en) 2000-08-18
UA66769C2 (uk) 2004-06-15
NO992401D0 (no) 1999-05-19
SK281990B6 (sk) 2001-09-11
NO992401L (no) 1999-07-13
SA97180599B1 (ar) 2006-03-25
JP4039640B2 (ja) 2008-01-30
CA2269941A1 (en) 1998-05-28
DE69719788D1 (de) 2003-04-17
IS1964B (is) 2004-12-15
AR010069A1 (es) 2000-05-15
EE03761B1 (et) 2002-06-17
EE9900202A (et) 1999-12-15
MY119303A (en) 2005-04-30
SE9604253D0 (sv) 1996-11-20
EP0942899B1 (en) 2003-03-12
CZ174499A3 (cs) 1999-11-17
EP0942899A1 (en) 1999-09-22
SK56499A3 (en) 2000-03-13

Similar Documents

Publication Publication Date Title
BR9713370A (pt) Processos para fabricação de metoprolol e de uma preparação farmacêutica, e, metoprolol
ES2175460T3 (es) Compuesto de lipoxinas y su utilizacion en el tratamiento de patologias con proliferacion celular.
AR010346A1 (es) COMPUESTOS DERIVADOS DE BENZOFURANO; SUS USOS, Y COMPOSICIoN FARMACÉUTICA QUE LOS CONTIENE.
ES2135966T3 (es) Polimerizacion de olefinas.
GB9818916D0 (en) Use
BR8902066A (pt) Composicao para tratamento de tecidos,liquida,nao aquosa
ES2160897T3 (es) Pirazoles como inhibidores de la secretora fosfolipasa a2 humana no pancreatica.
ES2172937T3 (es) 21-hidroxi-6,19-oxidoprogesterona(21oh-6op) como medicamento para tratar el exceso de glucocorticoides.
UY26370A1 (es) "imidazo-5-il-aminas bicíclicas, medicamentos que las contienen, su uso para la preparación de medicamentos y procedimiento para su preparación".
AR016981A2 (es) Polipeptidos sinteticos
ECSP003590A (es) Compuestos calcioliticos
AR005704A1 (es) Heteroariloxazolidinonas
BR0110881A (pt) Processo para a preparação de corpos sólidos inorg nicos porosos a partir de uma dispersão aquosa de partìculas, corpos sólidos inorg nicos porosos, e, uso de corpos sólidos inorg nicos porosos
MX9301747A (es) Microorganismos capaces de producir selectivamente los compuestos a y b de las estreptograminas, procedimiento para su preparacion y las estreptograminas producidas a partir del mismo.
AR021616A1 (es) Cicloheptenos sustituidos, procedimiento para su preparacion y uso de los mismos.
MX9206365A (es) Tetrahidrobenzotienopiridinas,proceso para su preparacion y composicion farmaceutica que las contiene
BR9711960A (pt) Verapamil como um medicamento para o tratamento de angina
AR005958A1 (es) Acidos 8-cian-1-ciclopropil-7-(2,8-diazabiciclo[4.3.0]-nonan-8-il)-6-fluor-1,4-dihidro-4-oxo-3-quinolincarboxilicos, opcionalmente substituidos, y sus derivados, procedimiento para su obtencion, medicamentos que los contienen y su empleo para la fabricacion de medicamentos y como agentes antibacterianos
ES2023395B3 (es) Procedimiento para el condicionamiento de desechos secos, bionocivos.
ES1031636Y (es) Aparato para el aprovechamiento de aguas domesticas utilizadas.
ECSP972189A (es) Nuevas triazolopurinas, procedimientos para su preparacion y su empleo como medicamentos
ECSP972003A (es) Ciclopentanopiridil- oxazolidinonas que contienen heteroatomos
ECSP961816A (es) Compuestos de -6 -dimetilaminometil-1 - fenil ciclohexano y procedimiento para el uso de dichos compuestos
BR9812489A (pt) Uso de 6,7-substituìdas-2-aminotetralinas adequadas para a preparação de uma composição farmacêutica para o tratamento terapêutico de patologias inflamatórias e/ou autoimunes
ECSP961978A (es) 1- fenil- 2- dimetil-amino - metil ciclohexan ol, a procedimientos para su preparacion y la aplicación de estos compuestos en medicamentos

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE DE ACORDO COM ART. 36 DA LPI .