ES2011584A6 - Procedimiento industrial para la obtencion de una ariloxipropanolamina. - Google Patents
Procedimiento industrial para la obtencion de una ariloxipropanolamina.Info
- Publication number
- ES2011584A6 ES2011584A6 ES8901774A ES8901774A ES2011584A6 ES 2011584 A6 ES2011584 A6 ES 2011584A6 ES 8901774 A ES8901774 A ES 8901774A ES 8901774 A ES8901774 A ES 8901774A ES 2011584 A6 ES2011584 A6 ES 2011584A6
- Authority
- ES
- Spain
- Prior art keywords
- methoxyethyl
- aryloxypropanolamine
- phenoxy
- obtaining
- industrial process
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/04—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reaction of ammonia or amines with olefin oxides or halohydrins
Abstract
PROCEDIMIENTO INDUSTRIAL PARA LA OBTENCION DE UNA ARILOXIPROPANOLAMINA, DE NOMBRE QUIMICO 1-[4-(2-METOXIETIL)FENOXI]-3-[(1-METILETIL)AMINOL-2-PROPANO], CARACTERIZADO POR COMPRENDER LAS SIGUIENTES FASES OPERATIVAS. POR REACCION DEL 4-(2-METOXIETIL)FENOL CON EPICLORHIDRINA EN MEDIO ACUOSO ALCALINO A TEMPERATURAS ENTRE 0 Y 25GC SE OBTIENE DESPUES DE LAS OPORTUNAS EXTRACCIONES Y LAVADOS UN CRUDO DE REACCION, COMPUESTO POR UN 75-80% DE 3-[4-(2-METOXIETIL)FENOXI]-1,2-EPOXIPROPANO Y UN 15-20% DE 1-[4-(2-METOXIETIL)FENOXI]-3-CLORO-2-PROPANOL, SIENDO AMBOS COMPUESTOS ADECUADOS PARA REACCIONAR CON ISOPROPILAMINA EN MEDIO ACUOSO Y A TEMPERATURAS COMPRENDIDAS ENTRE LOS 0 Y LOS 30GC PARA OBTENER LA ARILOXIPROPANOLAMINA DESEADA DE FORMULA (I).
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES8901774A ES2011584A6 (es) | 1989-05-26 | 1989-05-26 | Procedimiento industrial para la obtencion de una ariloxipropanolamina. |
US07/525,410 US5082969A (en) | 1989-05-26 | 1990-05-16 | Industrial process for obtaining an aryloxypropanolamine |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES8901774A ES2011584A6 (es) | 1989-05-26 | 1989-05-26 | Procedimiento industrial para la obtencion de una ariloxipropanolamina. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2011584A6 true ES2011584A6 (es) | 1990-01-16 |
Family
ID=8262115
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8901774A Expired - Lifetime ES2011584A6 (es) | 1989-05-26 | 1989-05-26 | Procedimiento industrial para la obtencion de una ariloxipropanolamina. |
Country Status (2)
Country | Link |
---|---|
US (1) | US5082969A (es) |
ES (1) | ES2011584A6 (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998022426A1 (en) * | 1996-11-20 | 1998-05-28 | Astra Aktiebolag | New manufacturing process of metoprolol |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050107635A1 (en) * | 2003-11-14 | 2005-05-19 | Mehra Janakraj K. | Metoprolol manufacturing process |
US20090247642A1 (en) * | 2005-12-23 | 2009-10-01 | Carmen Arnalot Aguilar | Synthesis and preparations of metoprolol and its salts |
CN102633660A (zh) * | 2011-11-03 | 2012-08-15 | 北京华禧联合科技发展有限公司 | 一种琥珀酸美托洛尔的新晶型 |
CN105820057B (zh) * | 2016-04-22 | 2017-09-29 | 上海应用技术学院 | 一种制备美多心安的方法 |
GB202102575D0 (en) | 2021-02-23 | 2021-04-07 | Teva Pharmaceutical Industries Ltd | Fixed-dose pharmaceutical compositions |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE354851B (es) * | 1970-02-18 | 1973-03-26 | Haessle Ab | |
GB1387630A (en) * | 1971-05-07 | 1975-03-19 | Ici Ltd | Phenoxyalkanolamine derivatives |
DE2645710C2 (de) * | 1976-10-09 | 1985-06-27 | Merck Patent Gmbh, 6100 Darmstadt | Phenoxy-amino-propanole, Verfahren zu ihrer Herstellung und pharmazeutische Zubereitung |
US4396629A (en) * | 1980-12-29 | 1983-08-02 | Sterling Drug Inc. | Compositions, processes and method |
FR2512443A1 (fr) * | 1981-09-10 | 1983-03-11 | Synthelabo | Derives de phenoxy-3 propanol-2, leur preparation et leur application en therapeutique |
ES8609190A1 (es) * | 1985-02-07 | 1986-07-16 | Pharma Investi S A | Un procedimiento para preparar eteres fenolicos |
-
1989
- 1989-05-26 ES ES8901774A patent/ES2011584A6/es not_active Expired - Lifetime
-
1990
- 1990-05-16 US US07/525,410 patent/US5082969A/en not_active Expired - Fee Related
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998022426A1 (en) * | 1996-11-20 | 1998-05-28 | Astra Aktiebolag | New manufacturing process of metoprolol |
Also Published As
Publication number | Publication date |
---|---|
US5082969A (en) | 1992-01-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20060527 |