PT942899E - Novo processo de fabrico de metoprolol - Google Patents

Novo processo de fabrico de metoprolol

Info

Publication number
PT942899E
PT942899E PT97913641T PT97913641T PT942899E PT 942899 E PT942899 E PT 942899E PT 97913641 T PT97913641 T PT 97913641T PT 97913641 T PT97913641 T PT 97913641T PT 942899 E PT942899 E PT 942899E
Authority
PT
Portugal
Prior art keywords
methodrolol
new
manufacturing process
manufacturing
new methodrolol
Prior art date
Application number
PT97913641T
Other languages
English (en)
Inventor
Sven Palmer
Michael Sidenqvist
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PT942899E publication Critical patent/PT942899E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/04—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reaction of ammonia or amines with olefin oxides or halohydrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
PT97913641T 1996-11-20 1997-11-18 Novo processo de fabrico de metoprolol PT942899E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9604253A SE9604253D0 (sv) 1996-11-20 1996-11-20 New manufacturing process metoprolol

Publications (1)

Publication Number Publication Date
PT942899E true PT942899E (pt) 2003-06-30

Family

ID=20404680

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97913641T PT942899E (pt) 1996-11-20 1997-11-18 Novo processo de fabrico de metoprolol

Country Status (36)

Country Link
US (1) US6252113B1 (pt)
EP (1) EP0942899B1 (pt)
JP (1) JP4039640B2 (pt)
KR (1) KR100544560B1 (pt)
CN (1) CN1128786C (pt)
AR (1) AR010069A1 (pt)
AT (1) ATE234273T1 (pt)
AU (1) AU728270B2 (pt)
BR (1) BR9713370A (pt)
CA (1) CA2269941A1 (pt)
CZ (1) CZ174499A3 (pt)
DE (1) DE69719788T2 (pt)
DK (1) DK0942899T3 (pt)
EE (1) EE03761B1 (pt)
EG (1) EG21158A (pt)
ES (1) ES2193365T3 (pt)
HK (1) HK1022684A1 (pt)
HU (1) HUP0002445A3 (pt)
ID (1) ID21505A (pt)
IL (1) IL129747A (pt)
IN (1) IN187175B (pt)
IS (1) IS1964B (pt)
MY (1) MY119303A (pt)
NO (1) NO311352B1 (pt)
NZ (1) NZ335213A (pt)
PL (1) PL191392B1 (pt)
PT (1) PT942899E (pt)
RU (1) RU2210565C2 (pt)
SA (1) SA97180599B1 (pt)
SE (1) SE9604253D0 (pt)
SK (1) SK281990B6 (pt)
TR (1) TR199901115T2 (pt)
TW (1) TW412513B (pt)
UA (1) UA66769C2 (pt)
WO (1) WO1998022426A1 (pt)
ZA (1) ZA9710005B (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050107635A1 (en) * 2003-11-14 2005-05-19 Mehra Janakraj K. Metoprolol manufacturing process
US20090247642A1 (en) * 2005-12-23 2009-10-01 Carmen Arnalot Aguilar Synthesis and preparations of metoprolol and its salts
US20080107726A1 (en) * 2006-11-01 2008-05-08 Pramod Kharwade Compositions comprising beta-adrenergic receptor antagonists and diuretics
CN101607918B (zh) * 2008-06-16 2014-02-19 北京德众万全药物技术开发有限公司 一种美托洛尔的制备方法
US8877930B2 (en) * 2009-11-04 2014-11-04 Massachusetts Institute Of Technology Continuous flow synthesis of amino alcohols using microreactors
WO2011109276A1 (en) 2010-03-01 2011-09-09 Massachussets Institute Of Technology Epoxidation catalysts
CN102381995B (zh) * 2010-08-31 2015-04-15 扬子江药业集团北京海燕药业有限公司 美托洛尔的制备方法
CN102432476A (zh) * 2010-09-29 2012-05-02 湖南康普医药研究院 一种规模化制备琥珀酸美托洛尔的方法
CN102503843B (zh) * 2011-10-28 2013-10-23 山东阿如拉药物研究开发有限公司 一种美托洛尔盐的制备方法
KR101379383B1 (ko) * 2012-03-23 2014-04-02 주식회사 알에스텍 고순도 ⒮―메토프롤롤의 제조방법
CN103980134B (zh) * 2014-05-30 2015-09-30 安徽省新星药物开发有限责任公司 一种琥珀酸s-美托洛尔的制备方法
CN105820057B (zh) * 2016-04-22 2017-09-29 上海应用技术学院 一种制备美多心安的方法
CN106543015A (zh) * 2016-11-07 2017-03-29 上海应用技术大学 一种美多心安的制备方法
CN108299279B (zh) * 2018-02-09 2021-03-23 北京梅尔森医药技术开发有限公司 取代芳基胺醇化合物及其制备方法和用途
US10744087B2 (en) 2018-03-22 2020-08-18 Incarda Therapeutics, Inc. Method to slow ventricular rate
CN111018724B (zh) * 2019-12-27 2022-11-08 江西美晶科技有限公司 一种美托洛尔及其制备方法
CN112645827A (zh) * 2020-12-25 2021-04-13 浙江普洛家园药业有限公司 一种连续合成美多心安及其盐的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2011584A6 (es) * 1989-05-26 1990-01-16 Esteve Quimica Sa Procedimiento industrial para la obtencion de una ariloxipropanolamina.
DK0576617T3 (da) 1991-03-18 1996-12-30 Sepracor Inc Præparat og fremgangsmåde indeholdende optisk rent (S) metoprolol

Also Published As

Publication number Publication date
HK1022684A1 (en) 2000-08-18
SK281990B6 (sk) 2001-09-11
JP4039640B2 (ja) 2008-01-30
NO311352B1 (no) 2001-11-19
ATE234273T1 (de) 2003-03-15
CZ174499A3 (cs) 1999-11-17
ZA9710005B (en) 1998-05-20
AR010069A1 (es) 2000-05-15
RU2210565C2 (ru) 2003-08-20
HUP0002445A2 (hu) 2001-08-28
IS5034A (is) 1999-04-26
EE9900202A (et) 1999-12-15
IL129747A0 (en) 2000-02-29
JP2001503388A (ja) 2001-03-13
IS1964B (is) 2004-12-15
EP0942899A1 (en) 1999-09-22
WO1998022426A1 (en) 1998-05-28
US6252113B1 (en) 2001-06-26
EE03761B1 (et) 2002-06-17
CN1237958A (zh) 1999-12-08
DE69719788D1 (de) 2003-04-17
EP0942899B1 (en) 2003-03-12
BR9713370A (pt) 2000-03-21
UA66769C2 (uk) 2004-06-15
TR199901115T2 (xx) 1999-07-21
NO992401D0 (no) 1999-05-19
SA97180599B1 (ar) 2006-03-25
CA2269941A1 (en) 1998-05-28
ID21505A (id) 1999-06-17
KR20000057134A (ko) 2000-09-15
MY119303A (en) 2005-04-30
DK0942899T3 (da) 2003-06-02
SK56499A3 (en) 2000-03-13
IL129747A (en) 2003-01-12
KR100544560B1 (ko) 2006-01-24
PL191392B1 (pl) 2006-05-31
NZ335213A (en) 2001-02-23
AU5077698A (en) 1998-06-10
DE69719788T2 (de) 2004-02-12
SE9604253D0 (sv) 1996-11-20
IN187175B (pt) 2002-02-23
NO992401L (no) 1999-07-13
TW412513B (en) 2000-11-21
EG21158A (en) 2000-12-31
HUP0002445A3 (en) 2001-09-28
CN1128786C (zh) 2003-11-26
AU728270B2 (en) 2001-01-04
ES2193365T3 (es) 2003-11-01

Similar Documents

Publication Publication Date Title
BR9703577A (pt) Processo de esterificação
PT942899E (pt) Novo processo de fabrico de metoprolol
BR9815223B1 (pt) processo de aminação.
IT1283646B1 (it) Processo di preparazione di perfluoropolieteri
PT874822E (pt) Novo processo de producao
BR9709525A (pt) Processo de filtração
NO20003079D0 (no) Polymerisasjon-oppstartningsprosess
BR9700007A (pt) Processo
BR9602032A (pt) Processo de fabricação de 1,1-difluoroetano
PT844999E (pt) Processo de purificacao
NO20003080D0 (no) Polymerisasjon-oppstartningsprosess
ID18491A (id) Proses produksi polikarbonat
PT1141077E (pt) Processo de fabrico de poliester
BR9705163A (pt) Eletrodo e processo de produção de um eletrodo
BR9800610A (pt) Processo de isomerização
BR9704368A (pt) Processo
BR9603738A (pt) Processo de produção
NO982200L (no) Produksjonsprosess
PT912536E (pt) Processo de monoacilacao de hidroxi-taxanos
PT101862A (pt) Processo electrquimico
PT897427E (pt) Processo de precipitacao de polissacarideos
FI974067A0 (fi) Process foer cellulasbehandling
BR9704194A (pt) Processo transblock
BR7400360U (pt) Processo de fabricação de cúpula de abajur
BR9601939A (pt) Processo de produção de energia elétrica