SK15022002A3 - Bicyklické soli N-acylovaných imidazo-3-amínov a imidazo-5-amínov, adičné produkty s kyselinami, spôsob ich výroby a liečivá s ich obsahom - Google Patents

Bicyklické soli N-acylovaných imidazo-3-amínov a imidazo-5-amínov, adičné produkty s kyselinami, spôsob ich výroby a liečivá s ich obsahom Download PDF

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Publication number
SK15022002A3
SK15022002A3 SK1502-2002A SK15022002A SK15022002A3 SK 15022002 A3 SK15022002 A3 SK 15022002A3 SK 15022002 A SK15022002 A SK 15022002A SK 15022002 A3 SK15022002 A3 SK 15022002A3
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SK
Slovakia
Prior art keywords
imidazo
acetyl
acid
cyclohexylamino
pyridin
Prior art date
Application number
SK1502-2002A
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English (en)
Slovak (sk)
Inventor
Matthias Gerlach
Corinna Maul
Original Assignee
Grnenthal Gmbh
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Filing date
Publication date
Application filed by Grnenthal Gmbh filed Critical Grnenthal Gmbh
Publication of SK15022002A3 publication Critical patent/SK15022002A3/sk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
SK1502-2002A 2000-04-20 2001-04-03 Bicyklické soli N-acylovaných imidazo-3-amínov a imidazo-5-amínov, adičné produkty s kyselinami, spôsob ich výroby a liečivá s ich obsahom SK15022002A3 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10019714A DE10019714A1 (de) 2000-04-20 2000-04-20 Salze von bicyclischen, N-acylierten Imidazo-3-aminen und Imidazo-5-aminen
PCT/EP2001/003772 WO2001081344A1 (de) 2000-04-20 2001-04-03 Salze von bicyclischen, n-acylierten imidazo-3-aminen und imidazo-5-aminen

Publications (1)

Publication Number Publication Date
SK15022002A3 true SK15022002A3 (sk) 2003-04-01

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
SK1502-2002A SK15022002A3 (sk) 2000-04-20 2001-04-03 Bicyklické soli N-acylovaných imidazo-3-amínov a imidazo-5-amínov, adičné produkty s kyselinami, spôsob ich výroby a liečivá s ich obsahom

Country Status (30)

Country Link
US (2) US7087607B2 (da)
EP (1) EP1274709B1 (da)
JP (1) JP2003531208A (da)
KR (1) KR100756594B1 (da)
CN (1) CN1232520C (da)
AR (1) AR030559A1 (da)
AT (1) ATE277045T1 (da)
AU (2) AU2001258305B2 (da)
BR (1) BR0110357A (da)
CA (1) CA2402808A1 (da)
CZ (1) CZ20023476A3 (da)
DE (2) DE10019714A1 (da)
DK (1) DK1274709T3 (da)
ES (1) ES2227186T3 (da)
HK (1) HK1052703B (da)
HU (1) HUP0300532A3 (da)
IL (2) IL152352A0 (da)
MX (1) MXPA02009602A (da)
NO (1) NO323542B1 (da)
NZ (1) NZ521069A (da)
PE (1) PE20011213A1 (da)
PL (1) PL365676A1 (da)
PT (1) PT1274709E (da)
RU (1) RU2268888C2 (da)
SI (1) SI1274709T1 (da)
SK (1) SK15022002A3 (da)
TR (1) TR200402755T4 (da)
UY (1) UY26675A1 (da)
WO (1) WO2001081344A1 (da)
ZA (1) ZA200209408B (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10019714A1 (de) 2000-04-20 2002-01-10 Gruenenthal Gmbh Salze von bicyclischen, N-acylierten Imidazo-3-aminen und Imidazo-5-aminen
DE10050663A1 (de) † 2000-10-13 2002-04-18 Gruenenthal Gmbh Verwendung von substituierten Imidazo[1,2-a]pyridin-, -pyrimidin- und pyrazin-3-yl-amin-Derivaten zur Herstellung von Medikamenten zur NOS-Inhibierung
US7566716B2 (en) 2005-05-20 2009-07-28 Array Biopharma Inc. Imidazopyrazines as Raf inhibitor compounds
US7709468B2 (en) 2005-09-02 2010-05-04 Abbott Laboratories Imidazo based heterocycles
KR101436303B1 (ko) 2005-12-23 2014-09-02 어리어드 파마슈티칼스, 인코포레이티드 비시클릭 헤테로아릴 화합물
BRPI0708823B1 (pt) * 2006-03-17 2022-01-18 Ambit Biosciences Corporation Composto, e, composição
EA200870592A1 (ru) * 2006-05-31 2009-08-28 Галапагос Н.В. Триазолопиразиновые соединения, пригодные для лечения дегенеративных и воспалительных заболеваний
CA2665214A1 (en) * 2006-10-06 2008-05-29 Abbott Laboratories Novel imidazothiazoles and imidazoxazoles
US8703492B2 (en) 2007-04-06 2014-04-22 Qiagen Gaithersburg, Inc. Open platform hybrid manual-automated sample processing system
US7985375B2 (en) * 2007-04-06 2011-07-26 Qiagen Gaithersburg, Inc. Sample preparation system and method for processing clinical specimens
DK2201018T3 (da) * 2007-09-19 2016-05-17 Ambit Biosciences Corp Faste former omfattende n-(5-tert-butyl-isoxazol-3-yl)-n'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]-benzothiazol-2-yl]phenyl}urea, sammensætninger deraf og anvendelser dermed
US9953141B2 (en) 2009-11-18 2018-04-24 Becton, Dickinson And Company Laboratory central control unit method and system
KR200453430Y1 (ko) * 2011-01-10 2011-05-03 백현숙 싱크대용 선반
ES2640916T3 (es) 2012-04-26 2017-11-07 Bristol-Myers Squibb Company Derivados de imidazotiadiazol e imidazopirazina como inhibidores del receptor 4 activados por proteasa (PAR4) para tratar agregación plaquetaria
ES2617879T3 (es) 2012-04-26 2017-06-20 Bristol-Myers Squibb Company Derivados de imidazotiadiazol e imidazopiridazina como inhibidores del receptor activado por proteasa 4 (PAR4) para el tratamiento de la agregación plaquetaria
EA201491967A1 (ru) 2012-04-26 2015-03-31 Бристол-Майерс Сквибб Компани Производные имидазотиадиазола в качестве ингибиторов активируемых протеазой рецепторов 4 (par4) для лечения агрегации тромбоцитов
US9617279B1 (en) 2014-06-24 2017-04-11 Bristol-Myers Squibb Company Imidazooxadiazole compounds
US9598419B1 (en) 2014-06-24 2017-03-21 Universite De Montreal Imidazotriazine and imidazodiazine compounds

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2857776A (en) 1955-01-13 1958-10-28 American Metal Prod Lead screw selectively operable and releasable under load
US3489755A (en) 1966-08-03 1970-01-13 Pfizer & Co C Imidazo (1,2-b) pyridazines
US3792166A (en) * 1970-11-16 1974-02-12 American Cyanamid Co Method of using substituted imidazo (2,1-b)thiazoles as anthelmintic agents
US3894022A (en) * 1973-06-25 1975-07-08 Sandoz Ag Tetracyclic quinazolinones and quinazolinium salts
JPS5398997A (en) * 1977-02-09 1978-08-29 Sumitomo Chem Co Ltd Fused pyridine derivertives and process for their preparation
GB2039882A (en) * 1979-01-05 1980-08-20 Ciba Geigy Ag Bicyclic thiadiaza compounds and their use as medicaments
DE3269604D1 (en) * 1981-06-26 1986-04-10 Schering Corp Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
FR2568880B1 (fr) * 1984-08-07 1986-12-12 Synthelabo Derives d'acylaminomethyl-3 imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique
FR2627491B1 (fr) 1988-02-18 1992-01-24 Roussel Uclaf Nouveaux derives du benzocyclohexane et du benzocycloheptane ainsi que leurs sels, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions les renfermant
JPH0753730B2 (ja) * 1988-07-26 1995-06-07 三共株式会社 イミダゾピラゾール誘導体
US5536853A (en) 1994-04-11 1996-07-16 Chiron Corporation Opiate receptor ligands
DE10019714A1 (de) 2000-04-20 2002-01-10 Gruenenthal Gmbh Salze von bicyclischen, N-acylierten Imidazo-3-aminen und Imidazo-5-aminen

Also Published As

Publication number Publication date
HK1052703B (zh) 2005-04-22
HK1052703A1 (en) 2003-09-26
KR20020087497A (ko) 2002-11-22
NO20024838L (no) 2002-10-07
DK1274709T3 (da) 2004-07-12
WO2001081344A1 (de) 2001-11-01
NO323542B1 (no) 2007-06-11
TR200402755T4 (tr) 2004-12-21
PL365676A1 (en) 2005-01-10
RU2002130245A (ru) 2004-03-27
CN1232520C (zh) 2005-12-21
KR100756594B1 (ko) 2007-09-10
HUP0300532A2 (hu) 2003-07-28
ZA200209408B (en) 2004-02-19
AR030559A1 (es) 2003-08-27
NO20024838D0 (no) 2002-10-07
JP2003531208A (ja) 2003-10-21
CZ20023476A3 (cs) 2003-01-15
BR0110357A (pt) 2004-04-20
MXPA02009602A (es) 2003-03-10
EP1274709A1 (de) 2003-01-15
CA2402808A1 (en) 2001-11-01
SI1274709T1 (en) 2005-02-28
US7153873B2 (en) 2006-12-26
AU5830501A (en) 2001-11-07
IL152352A0 (en) 2003-05-29
UY26675A1 (es) 2001-05-31
US7087607B2 (en) 2006-08-08
NZ521069A (en) 2004-07-30
EP1274709B1 (de) 2004-09-22
HUP0300532A3 (en) 2009-01-28
US20060217378A1 (en) 2006-09-28
US20030119842A1 (en) 2003-06-26
IL152352A (en) 2009-09-22
PT1274709E (pt) 2005-01-31
ES2227186T3 (es) 2005-04-01
ATE277045T1 (de) 2004-10-15
CN1422270A (zh) 2003-06-04
PE20011213A1 (es) 2001-12-29
DE50103764D1 (de) 2004-10-28
RU2268888C2 (ru) 2006-01-27
AU2001258305B2 (en) 2005-08-18
DE10019714A1 (de) 2002-01-10

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