SI0948509T1 - 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives - Google Patents
2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivativesInfo
- Publication number
- SI0948509T1 SI0948509T1 SI9730455T SI9730455T SI0948509T1 SI 0948509 T1 SI0948509 T1 SI 0948509T1 SI 9730455 T SI9730455 T SI 9730455T SI 9730455 T SI9730455 T SI 9730455T SI 0948509 T1 SI0948509 T1 SI 0948509T1
- Authority
- SI
- Slovenia
- Prior art keywords
- purin
- tetrahydrofuran
- diol derivatives
- diol
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9626852.9A GB9626852D0 (en) | 1996-12-24 | 1996-12-24 | Chemical compounds |
GBGB9626845.3A GB9626845D0 (en) | 1996-12-24 | 1996-12-24 | Chemical compounds |
GBGB9626846.1A GB9626846D0 (en) | 1996-12-24 | 1996-12-24 | Chemical compounds |
GBGB9720536.3A GB9720536D0 (en) | 1997-09-27 | 1997-09-27 | Chemical compounds |
GBGB9722730.0A GB9722730D0 (en) | 1997-10-29 | 1997-10-29 | Chemical compounds |
PCT/EP1997/007197 WO1998028319A1 (fr) | 1996-12-24 | 1997-12-22 | Derives de 2-(purine-9-yl)-tetrahydrofuran-3,4-diol |
EP97953888A EP0948509B1 (fr) | 1996-12-24 | 1997-12-22 | Derives de 2-(purine-9-yl)-tetrahydrofuran-3,4-diol |
Publications (1)
Publication Number | Publication Date |
---|---|
SI0948509T1 true SI0948509T1 (en) | 2003-06-30 |
Family
ID=27517393
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI9730455T SI0948509T1 (en) | 1996-12-24 | 1997-12-22 | 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives |
Country Status (36)
Country | Link |
---|---|
US (2) | US6426337B1 (fr) |
EP (1) | EP0948509B1 (fr) |
JP (1) | JP4156035B2 (fr) |
KR (1) | KR20000069682A (fr) |
CN (1) | CN1246124A (fr) |
AP (1) | AP1105A (fr) |
AR (1) | AR011044A1 (fr) |
AT (1) | ATE226212T1 (fr) |
AU (1) | AU733684B2 (fr) |
BG (1) | BG63310B1 (fr) |
BR (1) | BR9714082A (fr) |
CA (1) | CA2275271A1 (fr) |
CO (1) | CO4940488A1 (fr) |
CZ (1) | CZ230999A3 (fr) |
DE (1) | DE69716468T2 (fr) |
DK (1) | DK0948509T3 (fr) |
EA (1) | EA001714B1 (fr) |
EE (1) | EE04019B1 (fr) |
ES (1) | ES2186015T3 (fr) |
GE (1) | GEP20022656B (fr) |
HU (1) | HUP0000673A3 (fr) |
ID (1) | ID22271A (fr) |
IL (1) | IL130547A0 (fr) |
IS (1) | IS5089A (fr) |
NO (1) | NO312840B1 (fr) |
NZ (1) | NZ336332A (fr) |
OA (1) | OA11071A (fr) |
PE (1) | PE27499A1 (fr) |
PL (1) | PL334218A1 (fr) |
PT (1) | PT948509E (fr) |
SI (1) | SI0948509T1 (fr) |
SK (1) | SK86599A3 (fr) |
TR (1) | TR199901905T2 (fr) |
TW (1) | TW528755B (fr) |
WO (1) | WO1998028319A1 (fr) |
YU (1) | YU29099A (fr) |
Families Citing this family (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
YU44900A (sh) | 1998-01-31 | 2003-01-31 | Glaxo Group Limited | Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola |
PE20000270A1 (es) | 1998-02-14 | 2000-05-20 | Glaxo Group Ltd | Derivados de 2-(purin-9-il)-tetrahidrofuran-3,4-diol |
GB9813554D0 (en) * | 1998-06-23 | 1998-08-19 | Glaxo Group Ltd | Chemical compounds |
GB9813540D0 (en) * | 1998-06-23 | 1998-08-19 | Glaxo Group Ltd | Chemical compounds |
ATE246701T1 (de) * | 1998-06-23 | 2003-08-15 | Glaxo Group Ltd | 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivate |
GB9813565D0 (en) * | 1998-06-23 | 1998-08-19 | Glaxo Group Ltd | Chemical compounds |
GB9930082D0 (en) * | 1999-12-20 | 2000-02-09 | Glaxo Group Ltd | Medicaments |
US6667300B2 (en) | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
GB0022695D0 (en) | 2000-09-15 | 2000-11-01 | Pfizer Ltd | Purine Derivatives |
GB0104555D0 (en) * | 2001-02-23 | 2001-04-11 | Glaxo Group Ltd | New Therapeutic method |
WO2002072067A2 (fr) * | 2001-03-12 | 2002-09-19 | Glaxo Group Limited | Formulation aerosol pharmaceutique |
JP2002338593A (ja) * | 2001-05-22 | 2002-11-27 | Ajinomoto Co Inc | β−D−リボフラノース誘導体又はその光学異性体の製造方法 |
PE20030008A1 (es) * | 2001-06-19 | 2003-01-22 | Bristol Myers Squibb Co | Inhibidores duales de pde 7 y pde 4 |
TW200519106A (en) | 2003-05-02 | 2005-06-16 | Novartis Ag | Organic compounds |
GB0401334D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
TWI346109B (en) * | 2004-04-30 | 2011-08-01 | Otsuka Pharma Co Ltd | 4-amino-5-cyanopyrimidine derivatives |
CN101031569B (zh) | 2004-05-13 | 2011-06-22 | 艾科斯有限公司 | 作为人磷脂酰肌醇3-激酶δ抑制剂的喹唑啉酮 |
GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
AR049384A1 (es) | 2004-05-24 | 2006-07-26 | Glaxo Group Ltd | Derivados de purina |
PT1758596E (pt) | 2004-05-26 | 2010-06-23 | Inotek Pharmaceuticals Corp | Derivados de purina como agonistas do receptor de adenosina a1 e processos para a sua utilização |
JP5011112B2 (ja) * | 2004-09-20 | 2012-08-29 | イノテック ファーマシューティカルズ コーポレイション | プリン誘導体を含有する炎症性疾患の治療用医薬 |
GB0424284D0 (en) | 2004-11-02 | 2004-12-01 | Novartis Ag | Organic compounds |
GB0426164D0 (en) | 2004-11-29 | 2004-12-29 | Novartis Ag | Organic compounds |
GB0500785D0 (en) * | 2005-01-14 | 2005-02-23 | Novartis Ag | Organic compounds |
GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
GB0514809D0 (en) * | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
EP1957530A2 (fr) | 2005-10-21 | 2008-08-20 | Novartis AG | Anticorps humains contre l'il-13 et ses utilisations therapeutiques |
GB0523845D0 (en) * | 2005-11-23 | 2006-01-04 | Glaxo Group Ltd | Novel salts |
CA2627319A1 (fr) * | 2005-11-30 | 2007-06-07 | Prakash Jagtap | Derives de purine et leurs procedes d'utilisation |
GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
EP1889846A1 (fr) * | 2006-07-13 | 2008-02-20 | Novartis AG | Dérivés de purine comme agonistes du recepteur A2a |
DE602007013441D1 (de) | 2006-09-29 | 2011-05-05 | Novartis Ag | Pyrazolopyrimidine als pi3k-lipidkinasehemmer |
CN101522682A (zh) | 2006-10-30 | 2009-09-02 | 诺瓦提斯公司 | 作为抗炎剂的杂环化合物 |
PL2231642T3 (pl) | 2008-01-11 | 2014-04-30 | Novartis Ag | Pirymidyny jako inhibitory kinazy |
ES2674719T3 (es) | 2008-11-13 | 2018-07-03 | Gilead Calistoga Llc | Terapias para neoplasias hematológicas |
US9492449B2 (en) | 2008-11-13 | 2016-11-15 | Gilead Calistoga Llc | Therapies for hematologic malignancies |
WO2010088335A1 (fr) | 2009-01-29 | 2010-08-05 | Novartis Ag | Benzimidazoles substitués destinés au traitement d'astrocytomes |
AU2010239312A1 (en) * | 2009-04-20 | 2011-11-10 | Gilead Calistoga Llc | Methods of treatment for solid tumors |
MX2012000817A (es) | 2009-07-21 | 2012-05-08 | Gilead Calistoga Llc | Tratamiento para desordenes del higado con inhibidores pi3k. |
US8389526B2 (en) | 2009-08-07 | 2013-03-05 | Novartis Ag | 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives |
EP2464649A1 (fr) | 2009-08-12 | 2012-06-20 | Novartis AG | Composés hydrazone hétérocycliques et leurs utilisations pour traiter le cancer et l'inflammation |
NZ598220A (en) | 2009-08-17 | 2014-02-28 | Intellikine Llc | Heterocyclic compounds and uses thereof |
MX2012002179A (es) | 2009-08-20 | 2012-03-16 | Novartis Ag | Compuestos heterociclicos de oxima. |
EP2509606A1 (fr) | 2009-12-09 | 2012-10-17 | Glaxo Group Limited | Nouvelle utilisation médicale |
PT2523669T (pt) | 2010-01-11 | 2017-01-31 | Inotek Pharmaceuticals Corp | Associação, conjunto ( kit ) e método de redução da pressão intraocular |
US8476247B2 (en) | 2010-03-26 | 2013-07-02 | Inotek Pharmaceuticals Corporation | Method of reducing intraocular pressure in humans |
WO2012034095A1 (fr) | 2010-09-09 | 2012-03-15 | Irm Llc | Composés et compositions comme inhibiteurs de trk |
US8637516B2 (en) | 2010-09-09 | 2014-01-28 | Irm Llc | Compounds and compositions as TRK inhibitors |
EP3513787A1 (fr) * | 2011-01-10 | 2019-07-24 | Invion, Inc | Utilisation d'agonistes inverses béta-adrénergiques pour désaccoutumance du tabac |
JP2014505088A (ja) | 2011-02-10 | 2014-02-27 | ノバルティス アーゲー | C−METチロシンキナーゼ阻害剤としての[1,2,4]トリアゾロ[4,3−b]ピリダジン化合物 |
US9127000B2 (en) | 2011-02-23 | 2015-09-08 | Intellikine, LLC. | Heterocyclic compounds and uses thereof |
MA34969B1 (fr) | 2011-02-25 | 2014-03-01 | Irm Llc | Composes et compositions en tant qu inibiteurs de trk |
BR112014006223A8 (pt) | 2011-09-15 | 2018-01-09 | Novartis Ag | 3-(quinolin-6-iltio)-[1,2,4-triazol[4,3-a] piradinas 6-substituídas, seus usos, composições farmacêuticas, e combinação |
JP6130391B2 (ja) | 2011-11-23 | 2017-05-17 | インテリカイン, エルエルシー | Mtor阻害剤を使用する強化された治療レジメン |
AU2013211957B2 (en) | 2012-01-26 | 2017-08-10 | Inotek Pharmaceuticals Corporation | Anhydrous polymorphs of (2R,3S,4R,5R)-5-(6-(cyclopentylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl) } methyl nitrate and processes of preparation thereof |
UY34656A (es) | 2012-03-05 | 2013-10-31 | Gilead Calistoga Llc | Polimorfos de (s)?2?(1?(9h?purin?6?ilamino)propil)?5?fluor?3?fenilquinazolin?4(3h)?ona, composición y método de preparación |
MX371119B (es) | 2012-04-03 | 2020-01-17 | Novartis Ag | Productos de combinacion con los inhibidores de cinasa de tirosina y su uso. |
US9771356B2 (en) * | 2012-09-21 | 2017-09-26 | Rhode Island Hospital | Inhibitors of beta-hydroxylase for treatment of cancer |
JP2016512835A (ja) | 2013-03-15 | 2016-05-09 | インテリカイン, エルエルシー | キナーゼ阻害剤の組み合わせ及びそれらの使用 |
MX2015013234A (es) | 2013-03-15 | 2016-04-15 | Inotek Pharmaceuticals Corp | Formulaciones oftalmicas. |
TW201605450A (zh) | 2013-12-03 | 2016-02-16 | 諾華公司 | Mdm2抑制劑與BRAF抑制劑之組合及其用途 |
EA201690990A1 (ru) | 2013-12-20 | 2016-11-30 | Джилид Калистога Ллс | Способы получения ингибиторов фосфатидилинозитол-3-киназы |
EP3083623A1 (fr) | 2013-12-20 | 2016-10-26 | Gilead Calistoga LLC | Formes polymorphes d'un sel chlorhydrate de la (s)-2-(9h-purine-6-ylamino)propyl)-5-fluoro-3-phénylquinazolin-4(3h)-one |
BR112016028642A2 (pt) | 2014-06-13 | 2017-08-22 | Gilead Sciences Inc | composto, composição farmacêutica, método de tratamento de uma doença ou condição, método de inibição da atividade de um polipeptídeo de fosfatidilinositol 3-quinase, método de inibição de reações imunes ou crescimento excessivo ou destrutivo ou de proliferação de células cancerosas, kit, e, uso de um composto, de um sal, de um isômero ou de uma mistura farmaceuticamente aceitável do mesmo. |
WO2016011658A1 (fr) | 2014-07-25 | 2016-01-28 | Novartis Ag | Polythérapie |
JP6526789B2 (ja) | 2014-07-31 | 2019-06-05 | ノバルティス アーゲー | 組み合わせ療法 |
JP7125144B2 (ja) | 2016-09-09 | 2022-08-24 | キャリセラ バイオサイエンシーズ, インコーポレイテッド | エクトヌクレオチダーゼ阻害剤およびその使用方法 |
JP2021529172A (ja) | 2018-06-21 | 2021-10-28 | キャリセラ バイオサイエンシーズ, インコーポレイテッド | エクトヌクレオチダーゼ阻害剤及びその使用方法 |
CA3143496A1 (fr) * | 2019-06-20 | 2020-12-24 | Calithera Biosciences, Inc. | Inhibiteurs d'ectonucleotidases et leurs procedes d'utilisation |
TW202140550A (zh) | 2020-01-29 | 2021-11-01 | 瑞士商諾華公司 | 使用抗tslp抗體治療炎性或阻塞性氣道疾病之方法 |
Family Cites Families (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3796700A (en) | 1970-06-30 | 1974-03-12 | Takedo Chem Ind Ltd | Adenosine derivatives and the production thereof |
DE2034785A1 (de) | 1970-07-14 | 1972-01-20 | Boehnnger Mannheim GmbH, 6800 Mann heim Waldhof | Adenosin 5 carbonsäurederivate |
CA1019727A (en) | 1971-03-18 | 1977-10-25 | Abbott Laboratories | Adenosine-5'-carboxylic acid amides |
BE789773A (fr) | 1971-10-08 | 1973-04-06 | Schering Ag | Adenosines n6 -substituees et leur procede de |
US3864483A (en) | 1972-03-22 | 1975-02-04 | Abbott Lab | Adenosine-5{40 -carboxylic acid amides |
CA1082695A (fr) | 1972-04-10 | 1980-07-29 | Francis E. Fischer | Preparation d'adenosine-5'-carboxamides |
US3966917A (en) | 1974-07-30 | 1976-06-29 | Abbott Laboratories | Platelet aggregation inhibitors |
DE2621470A1 (de) * | 1976-05-14 | 1977-12-01 | Pharma Waldhof Gmbh & Co | Nucleosidcarbonsaeurenitrile und ihre derivate, und verfahren zu ihrer herstellung |
US4167565A (en) | 1976-11-08 | 1979-09-11 | Abbott Laboratories | Adenosine-5'-carboxamides and method of use |
AU8379182A (en) | 1981-06-04 | 1982-12-09 | Procter & Gamble Company, The | Composition of salicylates and purine derivatives |
CA1239397A (fr) | 1983-08-01 | 1988-07-19 | James A. Bristol | Adenosines substituee en position n.sup.6 |
DE3406533A1 (de) | 1984-02-23 | 1985-08-29 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verwendung von adenosin-derivaten als antiallergica und arzneimittel, die diese enthalten |
US4496643A (en) | 1984-03-23 | 1985-01-29 | Eastman Kodak Company | Two-component dry electrostatic developer composition containing onium charge control agent |
DE3576344D1 (de) | 1984-04-18 | 1990-04-12 | Whitby Research Inc | Cardio-vasodilatatore n-6-substituierte adenosine. |
US5310731A (en) | 1984-06-28 | 1994-05-10 | Whitby Research, Inc. | N-6 substituted-5'-(N-substitutedcarboxamido)adenosines as cardiac vasodilators and antihypertensive agents |
US4663313A (en) | 1984-10-26 | 1987-05-05 | Warner-Lambert Company | N6 -tricyclic adenosines for treating hypertension |
AU575438B2 (en) | 1984-10-26 | 1988-07-28 | Warner-Lambert Company | N6 - substituted deoxyribose analogues of adenosines |
US4738954A (en) | 1985-11-06 | 1988-04-19 | Warner-Lambert Company | Novel N6 -substituted-5'-oxidized adenosine analogs |
US4755594A (en) | 1986-01-31 | 1988-07-05 | Warner-Lambert Company | N6 -substituted adenosines |
US5106837A (en) | 1988-03-16 | 1992-04-21 | The Scripps Research Institute | Adenosine derivatives with therapeutic activity |
US4767747A (en) | 1986-08-28 | 1988-08-30 | Warner-Lambert Company | Method for treating congestive heart failure with N6 -acenaphthyl adenosine |
AU8276187A (en) | 1986-10-31 | 1988-05-25 | Warner-Lambert Company | Selected n6-substituted adenosines having selective a2 binding activity |
AU8274187A (en) | 1986-10-31 | 1988-05-25 | Warner-Lambert Company | Heteroaromatic derivatives of adenosine |
NL8702926A (nl) | 1986-12-15 | 1988-07-01 | Sandoz Ag | Nieuwe furanuronzuurderivaten en werkwijzen voor het bereiden en toepassen van deze derivaten. |
US4968697A (en) | 1987-02-04 | 1990-11-06 | Ciba-Geigy Corporation | 2-substituted adenosine 5'-carboxamides as antihypertensive agents |
FI880405A (fi) | 1987-02-04 | 1988-08-05 | Ciba Geigy Ag | Adenosin-5'-karboxamidderivat. |
US4962194A (en) | 1987-04-02 | 1990-10-09 | Warner-Lambert Company | Method of preparing 51,N6-disubstituted adenosines from inosines |
US5219840A (en) | 1987-04-06 | 1993-06-15 | Sandoz Ltd. | Antihypertensive 9-(2,N6 -disubstituted adenyl) ribofuranuronic acid derivatives |
LU87181A1 (fr) | 1987-04-06 | 1988-11-17 | Sandoz Sa | Nouveaux derives de l'acide furannuronique,leur preparation et leur utilisation comme medicaments |
JPH0725785B2 (ja) | 1989-01-11 | 1995-03-22 | 日本臓器製薬株式会社 | アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物 |
IE903747A1 (en) | 1989-10-19 | 1991-04-24 | Searle & Co | Method of treating gastrointestinal motility disorders |
US5055569A (en) | 1989-10-19 | 1991-10-08 | G. D. Searle & Co. | N-(6)-substituted adenosine compounds |
US5140015A (en) | 1990-02-20 | 1992-08-18 | Whitby Research, Inc. | 2-aralkoxy and 2-alkoxy adenosine derivatives as coronary vasodilators and antihypertensive agents |
US5280015A (en) | 1990-09-05 | 1994-01-18 | The United States Of America As Represented By The Department Of Health And Human Services | 2-substituted adenosines and 2-substituted adenosine 5'-carboxamides |
AU654507B2 (en) | 1990-09-25 | 1994-11-10 | Rhone-Poulenc Rorer International (Holdings) Inc. | Compounds having antihypertensive and anti-ischemic properties |
FR2685918B1 (fr) | 1992-01-08 | 1995-06-23 | Union Pharma Scient Appl | Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant. |
FR2687678B1 (fr) | 1992-01-31 | 1995-03-31 | Union Pharma Scient Appl | Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant. |
US5424297A (en) | 1992-04-27 | 1995-06-13 | University Of Virginia Alumni Patents Foundation | Adenosine dextran conjugates |
WO1994002497A1 (fr) | 1992-07-15 | 1994-02-03 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Derives sulfo d'adenosine |
GB9301000D0 (en) * | 1993-01-20 | 1993-03-10 | Glaxo Group Ltd | Chemical compounds |
JPH08506343A (ja) | 1993-02-03 | 1996-07-09 | ジェンシア・インコーポレイテッド | リキソフラノシル誘導体を含むアデノシンキナーゼ阻害物質 |
US5773423A (en) | 1993-07-13 | 1998-06-30 | The United States Of America As Represented By The Department Of Health And Human Services | A3 adenosine receptor agonists |
US5446046A (en) | 1993-10-28 | 1995-08-29 | University Of Florida Research Foundation | A1 adenosine receptor agonists and antagonists as diuretics |
WO1995018817A1 (fr) | 1994-01-07 | 1995-07-13 | Laboratoires Upsa | Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant |
GB9414193D0 (en) * | 1994-07-14 | 1994-08-31 | Glaxo Group Ltd | Compounds |
GB9414208D0 (en) | 1994-07-14 | 1994-08-31 | Glaxo Group Ltd | Compounds |
-
1997
- 1997-12-16 TW TW086118941A patent/TW528755B/zh active
- 1997-12-22 SI SI9730455T patent/SI0948509T1/xx unknown
- 1997-12-22 AP APAP/P/1999/001572A patent/AP1105A/en active
- 1997-12-22 EA EA199900494A patent/EA001714B1/ru not_active IP Right Cessation
- 1997-12-22 AU AU57622/98A patent/AU733684B2/en not_active Ceased
- 1997-12-22 PT PT97953888T patent/PT948509E/pt unknown
- 1997-12-22 HU HU0000673A patent/HUP0000673A3/hu unknown
- 1997-12-22 AR ARP970106111A patent/AR011044A1/es not_active Application Discontinuation
- 1997-12-22 TR TR1999/01905T patent/TR199901905T2/xx unknown
- 1997-12-22 SK SK865-99A patent/SK86599A3/sk unknown
- 1997-12-22 CA CA002275271A patent/CA2275271A1/fr not_active Abandoned
- 1997-12-22 CZ CZ992309A patent/CZ230999A3/cs unknown
- 1997-12-22 DE DE69716468T patent/DE69716468T2/de not_active Expired - Lifetime
- 1997-12-22 PL PL97334218A patent/PL334218A1/xx unknown
- 1997-12-22 CN CN97181854A patent/CN1246124A/zh active Pending
- 1997-12-22 DK DK97953888T patent/DK0948509T3/da active
- 1997-12-22 NZ NZ336332A patent/NZ336332A/xx unknown
- 1997-12-22 KR KR1019997005729A patent/KR20000069682A/ko not_active Application Discontinuation
- 1997-12-22 YU YU29099A patent/YU29099A/sh unknown
- 1997-12-22 AT AT97953888T patent/ATE226212T1/de not_active IP Right Cessation
- 1997-12-22 ES ES97953888T patent/ES2186015T3/es not_active Expired - Lifetime
- 1997-12-22 GE GEAP19974870A patent/GEP20022656B/en unknown
- 1997-12-22 WO PCT/EP1997/007197 patent/WO1998028319A1/fr not_active Application Discontinuation
- 1997-12-22 EP EP97953888A patent/EP0948509B1/fr not_active Expired - Lifetime
- 1997-12-22 IL IL13054797A patent/IL130547A0/xx unknown
- 1997-12-22 EE EEP199900312A patent/EE04019B1/xx not_active IP Right Cessation
- 1997-12-22 BR BR9714082-1A patent/BR9714082A/pt not_active IP Right Cessation
- 1997-12-22 ID IDW990575A patent/ID22271A/id unknown
- 1997-12-22 US US09/331,526 patent/US6426337B1/en not_active Expired - Lifetime
- 1997-12-22 JP JP52838098A patent/JP4156035B2/ja not_active Expired - Fee Related
- 1997-12-23 CO CO97074732A patent/CO4940488A1/es unknown
- 1997-12-23 PE PE1997001160A patent/PE27499A1/es not_active Application Discontinuation
-
1999
- 1999-06-22 IS IS5089A patent/IS5089A/is unknown
- 1999-06-22 BG BG103518A patent/BG63310B1/bg unknown
- 1999-06-22 OA OA9900139A patent/OA11071A/en unknown
- 1999-06-23 NO NO19993114A patent/NO312840B1/no unknown
-
2001
- 2001-12-19 US US10/025,678 patent/US6528494B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL130547A0 (en) | 2-(purin-9-YL)-tetrahydrofuran-3,4-diol derivatives | |
HK1030611A1 (en) | 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives | |
IL140396A0 (en) | 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives | |
HK1032062A1 (en) | 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives | |
PL345097A1 (en) | 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives | |
SG46779A1 (en) | Carbohydrate derivatives | |
ZA9711535B (en) | 2-(Purin-9-yl)-tetrahydrofuran-3,4-diol derivatives | |
SI1056759T1 (en) | 2-(purin-9-yl) -tetrahydrofuran-3, 4-diol derivatives | |
ZA991154B (en) | 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives. | |
ZA99689B (en) | 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives. | |
IL137391A0 (en) | Purine l-nucleosides, analogs and uses thereof | |
HU0002452D0 (en) | Purine l-nucleosides, analogs and uses thereof | |
GB9909482D0 (en) | 2-(Purin-9-yl)-tetahydrofuran-3,4-diol derivatives | |
IL137393A0 (en) | Purine l-nucleosides, analogs and uses thereof | |
ZA956924B (en) | Adenosine derivatives. |