YU29099A - Derivati 2-(purin-9-il)-tetrahidrofuran-3,4-diola - Google Patents
Derivati 2-(purin-9-il)-tetrahidrofuran-3,4-diolaInfo
- Publication number
- YU29099A YU29099A YU29099A YU29099A YU29099A YU 29099 A YU29099 A YU 29099A YU 29099 A YU29099 A YU 29099A YU 29099 A YU29099 A YU 29099A YU 29099 A YU29099 A YU 29099A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- purin
- tetrahydrofuran
- diol derivatives
- diol
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Abstract
U ovom pronalasku daju se nova jedinjenja formule (I) u kojoj su R1, R2 i R3 opisani u specifikaciji, postupci njihovog dobijanja, formulacije koje ih sadrže i njihova upotreba u lečenju zapaljivih bolesti.[There are provided according to the invention novel compounds of formula (I) wherein R1, R2 and R3 are as described in the specification, processes for preparing them, formulations containing them and their use in therapy for the treatment of inflammatory diseases.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9626846.1A GB9626846D0 (en) | 1996-12-24 | 1996-12-24 | Chemical compounds |
GBGB9626852.9A GB9626852D0 (en) | 1996-12-24 | 1996-12-24 | Chemical compounds |
GBGB9626845.3A GB9626845D0 (en) | 1996-12-24 | 1996-12-24 | Chemical compounds |
GBGB9720536.3A GB9720536D0 (en) | 1997-09-27 | 1997-09-27 | Chemical compounds |
GBGB9722730.0A GB9722730D0 (en) | 1997-10-29 | 1997-10-29 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
YU29099A true YU29099A (sh) | 2002-06-19 |
Family
ID=27517393
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU29099A YU29099A (sh) | 1996-12-24 | 1997-12-22 | Derivati 2-(purin-9-il)-tetrahidrofuran-3,4-diola |
Country Status (36)
Country | Link |
---|---|
US (2) | US6426337B1 (sh) |
EP (1) | EP0948509B1 (sh) |
JP (1) | JP4156035B2 (sh) |
KR (1) | KR20000069682A (sh) |
CN (1) | CN1246124A (sh) |
AP (1) | AP1105A (sh) |
AR (1) | AR011044A1 (sh) |
AT (1) | ATE226212T1 (sh) |
AU (1) | AU733684B2 (sh) |
BG (1) | BG63310B1 (sh) |
BR (1) | BR9714082A (sh) |
CA (1) | CA2275271A1 (sh) |
CO (1) | CO4940488A1 (sh) |
CZ (1) | CZ230999A3 (sh) |
DE (1) | DE69716468T2 (sh) |
DK (1) | DK0948509T3 (sh) |
EA (1) | EA001714B1 (sh) |
EE (1) | EE04019B1 (sh) |
ES (1) | ES2186015T3 (sh) |
GE (1) | GEP20022656B (sh) |
HU (1) | HUP0000673A3 (sh) |
ID (1) | ID22271A (sh) |
IL (1) | IL130547A0 (sh) |
IS (1) | IS5089A (sh) |
NO (1) | NO312840B1 (sh) |
NZ (1) | NZ336332A (sh) |
OA (1) | OA11071A (sh) |
PE (1) | PE27499A1 (sh) |
PL (1) | PL334218A1 (sh) |
PT (1) | PT948509E (sh) |
SI (1) | SI0948509T1 (sh) |
SK (1) | SK86599A3 (sh) |
TR (1) | TR199901905T2 (sh) |
TW (1) | TW528755B (sh) |
WO (1) | WO1998028319A1 (sh) |
YU (1) | YU29099A (sh) |
Families Citing this family (70)
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YU44900A (sh) | 1998-01-31 | 2003-01-31 | Glaxo Group Limited | Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola |
PE20000270A1 (es) | 1998-02-14 | 2000-05-20 | Glaxo Group Ltd | Derivados de 2-(purin-9-il)-tetrahidrofuran-3,4-diol |
GB9813554D0 (en) * | 1998-06-23 | 1998-08-19 | Glaxo Group Ltd | Chemical compounds |
GB9813565D0 (en) * | 1998-06-23 | 1998-08-19 | Glaxo Group Ltd | Chemical compounds |
GB9813540D0 (en) * | 1998-06-23 | 1998-08-19 | Glaxo Group Ltd | Chemical compounds |
US6495528B1 (en) * | 1998-06-23 | 2002-12-17 | Smithkline Beecham Corporation | 2-(Purin -9-yl)-tetrahydrofuran-3,4-diol derivatives |
GB9930082D0 (en) * | 1999-12-20 | 2000-02-09 | Glaxo Group Ltd | Medicaments |
US6667300B2 (en) | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
GB0022695D0 (en) | 2000-09-15 | 2000-11-01 | Pfizer Ltd | Purine Derivatives |
GB0104555D0 (en) * | 2001-02-23 | 2001-04-11 | Glaxo Group Ltd | New Therapeutic method |
AU2002238748A1 (en) * | 2001-03-12 | 2002-09-24 | Glaxo Group Limited | Pharmaceutical aerosol formulation |
JP2002338593A (ja) * | 2001-05-22 | 2002-11-27 | Ajinomoto Co Inc | β−D−リボフラノース誘導体又はその光学異性体の製造方法 |
PE20030008A1 (es) * | 2001-06-19 | 2003-01-22 | Bristol Myers Squibb Co | Inhibidores duales de pde 7 y pde 4 |
TW200519106A (en) | 2003-05-02 | 2005-06-16 | Novartis Ag | Organic compounds |
GB0401334D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
TWI346109B (en) | 2004-04-30 | 2011-08-01 | Otsuka Pharma Co Ltd | 4-amino-5-cyanopyrimidine derivatives |
US7932260B2 (en) | 2004-05-13 | 2011-04-26 | Icos Corporation | Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta |
GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
AR049384A1 (es) | 2004-05-24 | 2006-07-26 | Glaxo Group Ltd | Derivados de purina |
DE602005020286D1 (de) * | 2004-05-26 | 2010-05-12 | Inotek Pharmaceuticals Corp | Purinderivate als adenosin a 1 rezeptoragonisten und anwendungsverfahren dafür |
AU2005286946B2 (en) * | 2004-09-20 | 2012-03-15 | Inotek Pharmaceuticals Corporation | Purine derivatives and methods of use thereof |
GB0424284D0 (en) | 2004-11-02 | 2004-12-01 | Novartis Ag | Organic compounds |
GB0426164D0 (en) | 2004-11-29 | 2004-12-29 | Novartis Ag | Organic compounds |
GB0500785D0 (en) * | 2005-01-14 | 2005-02-23 | Novartis Ag | Organic compounds |
GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
GB0514809D0 (en) * | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
EP2532678A1 (en) | 2005-10-21 | 2012-12-12 | Novartis AG | Human antibodies against il13 and therapeutic uses |
GB0523845D0 (en) * | 2005-11-23 | 2006-01-04 | Glaxo Group Ltd | Novel salts |
WO2007064795A2 (en) * | 2005-11-30 | 2007-06-07 | Inotek Pharmaceuticals Corporation | Purine derivatives and methods of use thereof |
GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
EP1889846A1 (en) * | 2006-07-13 | 2008-02-20 | Novartis AG | Purine derivatives as A2a agonists |
ATE502943T1 (de) | 2006-09-29 | 2011-04-15 | Novartis Ag | Pyrazolopyrimidine als pi3k-lipidkinasehemmer |
CN101522682A (zh) | 2006-10-30 | 2009-09-02 | 诺瓦提斯公司 | 作为抗炎剂的杂环化合物 |
PL2231642T3 (pl) | 2008-01-11 | 2014-04-30 | Novartis Ag | Pirymidyny jako inhibitory kinazy |
US9492449B2 (en) | 2008-11-13 | 2016-11-15 | Gilead Calistoga Llc | Therapies for hematologic malignancies |
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US20110281917A1 (en) | 2009-01-29 | 2011-11-17 | Darrin Stuart | Substituted Benzimidazoles for the Treatment of Astrocytomas |
ES2548253T3 (es) * | 2009-04-20 | 2015-10-15 | Gilead Calistoga Llc | Métodos para el tratamiento de tumores sólidos |
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JP2013513562A (ja) * | 2009-12-09 | 2013-04-22 | グラクソ グループ リミテッド | 新規の医療用使用 |
JP2013516495A (ja) | 2010-01-11 | 2013-05-13 | イノテック ファーマシューティカルズ コーポレイション | 眼圧を低下させる組合せ、キット、および方法 |
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US8637516B2 (en) | 2010-09-09 | 2014-01-28 | Irm Llc | Compounds and compositions as TRK inhibitors |
WO2012034095A1 (en) | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
CN103732611B (zh) | 2011-01-10 | 2016-06-01 | 伊沃恩有限公司 | β-肾上腺素能反向激动剂用于戒烟的用途 |
WO2012107500A1 (en) | 2011-02-10 | 2012-08-16 | Novartis Ag | [1, 2, 4] triazolo [4, 3 -b] pyridazine compounds as inhibitors of the c-met tyrosine kinase |
US9127000B2 (en) | 2011-02-23 | 2015-09-08 | Intellikine, LLC. | Heterocyclic compounds and uses thereof |
CA2828219A1 (en) | 2011-02-25 | 2012-08-30 | Irm Llc | Pyrazolo [1,5-a] pyridines as trk inhibitors |
MX339302B (es) | 2011-09-15 | 2016-05-19 | Novartis Ag | 3-(quinolin-6-il-tio)-[1,2,4]-triazolo-[4,3-a]-piridinas 6-sustituidas como cinasas de tirosina. |
WO2013078440A2 (en) | 2011-11-23 | 2013-05-30 | Intellikine, Llc | Enhanced treatment regimens using mtor inhibitors |
BR112014018413A8 (pt) | 2012-01-26 | 2017-07-11 | Inotek Pharmaceuticals Corp | Polimorfos anidros de nitrato de metila [(2r,3s,4r,5r)-5-(6-(ciclopentilamino)-9h-purin-9-il)-3,4-diidroxitetraidrofuran-2-il)] e processos de preparação do mesmo |
WO2013134288A1 (en) | 2012-03-05 | 2013-09-12 | Gilead Calistoga Llc | Polymorphic forms of (s)-2-(1-(9h-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3h)-one |
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RU2695230C2 (ru) | 2014-07-31 | 2019-07-22 | Новартис Аг | Сочетанная терапия |
JP7125144B2 (ja) | 2016-09-09 | 2022-08-24 | キャリセラ バイオサイエンシーズ, インコーポレイテッド | エクトヌクレオチダーゼ阻害剤およびその使用方法 |
CN112888696B (zh) | 2018-06-21 | 2024-04-16 | 德琪医疗有限公司 | 外核苷酸酶抑制剂及其使用方法 |
KR20220024629A (ko) * | 2019-06-20 | 2022-03-03 | 칼리테라 바이오사이언시즈, 인코포레이티드 | 엑토뉴클레오티다제 억제제 및 이의 사용 방법 |
TW202140550A (zh) | 2020-01-29 | 2021-11-01 | 瑞士商諾華公司 | 使用抗tslp抗體治療炎性或阻塞性氣道疾病之方法 |
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-
1997
- 1997-12-16 TW TW086118941A patent/TW528755B/zh active
- 1997-12-22 ID IDW990575A patent/ID22271A/id unknown
- 1997-12-22 EE EEP199900312A patent/EE04019B1/xx not_active IP Right Cessation
- 1997-12-22 AP APAP/P/1999/001572A patent/AP1105A/en active
- 1997-12-22 JP JP52838098A patent/JP4156035B2/ja not_active Expired - Fee Related
- 1997-12-22 CN CN97181854A patent/CN1246124A/zh active Pending
- 1997-12-22 CA CA002275271A patent/CA2275271A1/en not_active Abandoned
- 1997-12-22 BR BR9714082-1A patent/BR9714082A/pt not_active IP Right Cessation
- 1997-12-22 TR TR1999/01905T patent/TR199901905T2/xx unknown
- 1997-12-22 PL PL97334218A patent/PL334218A1/xx unknown
- 1997-12-22 HU HU0000673A patent/HUP0000673A3/hu unknown
- 1997-12-22 YU YU29099A patent/YU29099A/sh unknown
- 1997-12-22 DK DK97953888T patent/DK0948509T3/da active
- 1997-12-22 EP EP97953888A patent/EP0948509B1/en not_active Expired - Lifetime
- 1997-12-22 US US09/331,526 patent/US6426337B1/en not_active Expired - Lifetime
- 1997-12-22 SI SI9730455T patent/SI0948509T1/xx unknown
- 1997-12-22 GE GEAP19974870A patent/GEP20022656B/en unknown
- 1997-12-22 KR KR1019997005729A patent/KR20000069682A/ko not_active Application Discontinuation
- 1997-12-22 AU AU57622/98A patent/AU733684B2/en not_active Ceased
- 1997-12-22 PT PT97953888T patent/PT948509E/pt unknown
- 1997-12-22 DE DE69716468T patent/DE69716468T2/de not_active Expired - Lifetime
- 1997-12-22 CZ CZ992309A patent/CZ230999A3/cs unknown
- 1997-12-22 NZ NZ336332A patent/NZ336332A/xx unknown
- 1997-12-22 SK SK865-99A patent/SK86599A3/sk unknown
- 1997-12-22 IL IL13054797A patent/IL130547A0/xx unknown
- 1997-12-22 EA EA199900494A patent/EA001714B1/ru not_active IP Right Cessation
- 1997-12-22 AR ARP970106111A patent/AR011044A1/es not_active Application Discontinuation
- 1997-12-22 ES ES97953888T patent/ES2186015T3/es not_active Expired - Lifetime
- 1997-12-22 WO PCT/EP1997/007197 patent/WO1998028319A1/en not_active Application Discontinuation
- 1997-12-22 AT AT97953888T patent/ATE226212T1/de not_active IP Right Cessation
- 1997-12-23 CO CO97074732A patent/CO4940488A1/es unknown
- 1997-12-23 PE PE1997001160A patent/PE27499A1/es not_active Application Discontinuation
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1999
- 1999-06-22 IS IS5089A patent/IS5089A/is unknown
- 1999-06-22 BG BG103518A patent/BG63310B1/bg unknown
- 1999-06-22 OA OA9900139A patent/OA11071A/en unknown
- 1999-06-23 NO NO19993114A patent/NO312840B1/no unknown
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2001
- 2001-12-19 US US10/025,678 patent/US6528494B2/en not_active Expired - Fee Related
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