RU2641198C3 - Композиции glp-1 пептидов и их получение - Google Patents
Композиции glp-1 пептидов и их получениеInfo
- Publication number
- RU2641198C3 RU2641198C3 RU2014141700A RU2014141700A RU2641198C3 RU 2641198 C3 RU2641198 C3 RU 2641198C3 RU 2014141700 A RU2014141700 A RU 2014141700A RU 2014141700 A RU2014141700 A RU 2014141700A RU 2641198 C3 RU2641198 C3 RU 2641198C3
- Authority
- RU
- Russia
- Prior art keywords
- type
- pharmaceutical composition
- composition according
- glp
- granules
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Claims (9)
1. Фармацевтическая композиция для лечения диабета 2 типа, содержащая первый тип гранул и второй тип гранул, где указанный первый тип гранул содержит соль N-(8-(2-гидроксибензоил)амино)каприловой кислоты и не содержит пептид GLP-1, и где указанный второй тип гранул содержит пептид GLP-1 и не содержит соль N-(8-(2-гидроксибензоил)амино)каприловой кислоты, где указанная соль N-(8-(2-гидроксибензоил)амино)каприловой кислоты представляет собой SNAC, и указанный пептид GLP-1 представляет собой N-эпсилон26-[2-(2-{2-[2-(2-{2-[(S)-4-карбокси-4-(17-карбоксигептадеканоиламино)бутириламино]этокси}этокси)ацетиламино]этокси}этокси)ацетил][Аib8,Аrg34]GLР-1(7-37).
2. Фармацевтическая композициия по п. 1, где указанная композиция, кроме того, содержит более чем один фармацевтически приемлемый эксципиент.
3. Фармацевтическая композиция по п. 1, где указанный первый тип гранул, кроме того, содержит смазку, которая представляет собой стеарат магния.
4. Фармацевтическая композиция по п. 1, в которой указанный первый тип гранул, кроме того, содержит наполнитель, который представляет собой микрокристаллическую целлюлозу.
5. Фармацевтическая композиция по п. 1, в которой указанный второй тип гранул, кроме того, содержит наполнитель, который представляет собой микрокристаллическую целлюлозу.
6. Фармацевтическая композиция по п. 1, в которой указанный второй тип гранул, кроме того, содержит связующее вещество, которое представляет собой повидон.
7. Композиция по п. 1 в виде таблетки, где масса указанной таблетки составляет 400,7, 404,7 или 411,7 мг.
8. Фармацевтическая композиция по любому из пп. 1-7 для применения в медицине, где указанная композиция вводится перорально.
9. Фармацевтическая композиция по любому из пп. 1-7 для применения в лечении диабета 2 типа, где указанная композиция вводится перорально.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12160743.6 | 2012-03-22 | ||
EP12160743 | 2012-03-22 | ||
US201361748840P | 2013-01-04 | 2013-01-04 | |
US61/748,840 | 2013-01-04 | ||
EP13153459.6 | 2013-01-31 | ||
EP13153459 | 2013-01-31 | ||
PCT/EP2013/055362 WO2013139694A1 (en) | 2012-03-22 | 2013-03-15 | Compositions of glp-1 peptides and preparation thereof |
Publications (3)
Publication Number | Publication Date |
---|---|
RU2014141700A RU2014141700A (ru) | 2016-05-20 |
RU2641198C2 RU2641198C2 (ru) | 2018-01-16 |
RU2641198C3 true RU2641198C3 (ru) | 2021-12-10 |
Family
ID=49221868
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2014141700A RU2641198C3 (ru) | 2012-03-22 | 2013-03-15 | Композиции glp-1 пептидов и их получение |
Country Status (21)
Country | Link |
---|---|
US (5) | US10933120B2 (ru) |
EP (3) | EP2827885B1 (ru) |
JP (1) | JP6001158B2 (ru) |
KR (1) | KR102072202B1 (ru) |
CN (2) | CN104203266B (ru) |
AU (2) | AU2013234496B2 (ru) |
BR (1) | BR112014023374B1 (ru) |
CA (1) | CA2868188A1 (ru) |
DK (1) | DK2827885T3 (ru) |
ES (2) | ES2690553T3 (ru) |
HR (2) | HRP20231060T1 (ru) |
HU (2) | HUE062740T2 (ru) |
LT (1) | LT2827885T (ru) |
MX (1) | MX353067B (ru) |
MY (1) | MY171146A (ru) |
PL (2) | PL3488857T3 (ru) |
RS (2) | RS57727B1 (ru) |
RU (1) | RU2641198C3 (ru) |
SI (1) | SI2827885T1 (ru) |
WO (1) | WO2013139694A1 (ru) |
ZA (1) | ZA201406250B (ru) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK3326620T3 (da) | 2010-12-16 | 2020-05-25 | Novo Nordisk As | Faste sammensætninger omfattende en glp-1-agonist og et salt af n-(8-(2- hydroxybenzoyl)amino)caprylsyre |
KR101972836B1 (ko) | 2011-04-12 | 2019-04-29 | 노보 노르디스크 에이/에스 | 이중 아실화된 glp-1 유도체 |
PT2827885T (pt) * | 2012-03-22 | 2018-11-05 | Novo Nordisk As | Composições de péptidos glp-1 e sua preparação |
US10335369B2 (en) | 2012-03-22 | 2019-07-02 | Novo Nordisk A/S | Compositions comprising a delivery agent and preparation thereof |
DK2827845T3 (en) * | 2012-03-22 | 2019-04-01 | Novo Nordisk As | COMPOSITIONS INCLUDING A PROCEDURE AND PREPARING THEREOF |
HUE062740T2 (hu) | 2012-03-22 | 2023-12-28 | Novo Nordisk As | GLP-1 peptidek készítményei és elõállításuk |
ES2871328T3 (es) | 2012-06-20 | 2021-10-28 | Novo Nordisk As | Formulación de comprimido que comprende un péptido y un agente de suministro |
EP2991671B1 (en) * | 2013-05-02 | 2018-08-15 | Novo Nordisk A/S | Oral dosing of glp-1 compounds |
DK3006045T3 (en) | 2014-10-07 | 2017-07-17 | Cyprumed Gmbh | Pharmaceutical formulations for oral administration of peptide or protein drugs |
WO2017060500A1 (en) | 2015-10-07 | 2017-04-13 | Cyprumed Gmbh | Pharmaceutical formulations for the oral delivery of peptide drugs |
US10946074B2 (en) | 2016-03-03 | 2021-03-16 | Novo Nordisk A/S | GLP-1 derivatives and uses thereof |
CN108606957A (zh) * | 2016-12-13 | 2018-10-02 | 南京星银药业集团有限公司 | 一种含索马鲁肽的口服缓释制剂及其制备方法 |
AR112015A1 (es) | 2017-06-09 | 2019-09-11 | Novo Nordisk As | Composiciones sólidas para administración oral |
CN111683676B (zh) | 2018-02-02 | 2024-06-18 | 诺和诺德股份有限公司 | 包含glp-1激动剂、n-(8-(2-羟基苯甲酰基)氨基)辛酸的盐和润滑剂的固体组合物 |
WO2019173571A1 (en) * | 2018-03-09 | 2019-09-12 | Northwestern University | Insulin-loaded metal-organic frameworks |
EP3773475A1 (en) | 2018-04-06 | 2021-02-17 | Cyprumed GmbH | Pharmaceutical compositions for the transmucosal delivery of therapeutic peptides and proteins |
TWI829687B (zh) * | 2018-05-07 | 2024-01-21 | 丹麥商諾佛 儂迪克股份有限公司 | 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物 |
JP7422754B2 (ja) | 2018-10-26 | 2024-01-26 | ノヴォ ノルディスク アー/エス | 安定性セマグルチド組成物およびその使用 |
CN111265654B (zh) * | 2018-12-05 | 2023-05-16 | 江苏恒瑞医药股份有限公司 | Glp-1类似物的药物组合物及其制备方法 |
US11617965B2 (en) | 2018-12-21 | 2023-04-04 | Novo Nordisk A/S | Process of spray drying of GLP-1 peptide |
EP3914383A1 (en) | 2019-01-24 | 2021-12-01 | Novo Nordisk A/S | Roller compactor and method of dry granulation using a roller compactor |
EP3938094A1 (en) * | 2019-03-15 | 2022-01-19 | Novo Nordisk A/S | Process for spray drying a glp-1 peptide |
MX2022000889A (es) | 2019-08-07 | 2022-02-14 | Novo Nordisk As | Composiciones solidas que comprenden un derivado de egf(a) y una sal de acido n-(8-(2-hidroxibenzoil)amino)caprilico. |
ES2969534T3 (es) * | 2019-08-07 | 2024-05-21 | Novo Nordisk As | Composición sólida que comprende un compuesto del PYY y una sal de ácido N-(8-(2-hidroxibenzoil)amino)caprílico |
JP2023502004A (ja) | 2019-11-07 | 2023-01-20 | ノヴォ ノルディスク アー/エス | Glp-1作動薬、sglt2阻害剤、およびn-(8-(2-ヒドロキシベンゾイル)アミノ)カプリル酸の塩を含む固形組成物 |
MX2022004718A (es) | 2019-11-07 | 2022-06-08 | Novo Nordisk As | Omposiciones sólidas que comprenden un inhibidor de proproteína convertasa subtilisina/kexina tipo 9 (pcsk9) y una sal de ácido n-(8-(2-hidroxibenzoil)amino)caprílico. |
WO2021219710A1 (en) * | 2020-04-29 | 2021-11-04 | Novo Nordisk A/S | Solid compositions comprising a glp-1 agonist and histidine |
TW202227474A (zh) | 2020-12-18 | 2022-07-16 | 丹麥商諾佛 儂迪克股份有限公司 | Glp-1及澱粉素受體之共促效劑 |
WO2022235991A1 (en) * | 2021-05-07 | 2022-11-10 | Eli Lilly And Company | Erodible tablet |
US20230000764A1 (en) * | 2021-06-11 | 2023-01-05 | Boa Nutrition, Inc. | Pressurized nutritional supplement delivery |
EP4360645A1 (en) | 2021-06-25 | 2024-05-01 | Gan & Lee Pharmaceuticals Co., Ltd. | Pharmaceutical composition containing glp-1 compound |
KR20240036563A (ko) | 2021-07-15 | 2024-03-20 | 노보 노르디스크 에이/에스 | N-(8-(2-하이드록시벤조일)아미노)카프릴산의 염을 포함하는 정제 |
WO2023012263A1 (en) | 2021-08-04 | 2023-02-09 | Novo Nordisk A/S | Solid oral peptide formulations |
WO2023065231A1 (en) * | 2021-10-21 | 2023-04-27 | Guangzhou Dazhou Biomedicine Ltd. | Oral delivery of therapeutic agents |
WO2023098777A1 (zh) * | 2021-12-01 | 2023-06-08 | 江苏恒瑞医药股份有限公司 | Glp-1和gip受体双重激动剂的药物组合物及其用途 |
WO2023174433A1 (en) * | 2022-03-18 | 2023-09-21 | Smart Pharmaceutical (Suzhou) Co., Ltd. | Solid, semisolid, or liquid compositions for augmenting the stability, permeability and bioavailability of active pharmaceutical substances |
CN114984191B (zh) * | 2022-07-04 | 2022-10-25 | 北京惠之衡生物科技有限公司 | 一种多肽类药物口服递送组合物 |
WO2024110614A1 (en) | 2022-11-25 | 2024-05-30 | Novo Nordisk A/S | Oral administration of peptide therapeutics, such as glp-1 |
Family Cites Families (192)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0238259B1 (en) | 1986-03-12 | 1993-09-29 | American Cyanamid Company | Macrolide compounds |
EP0512042B1 (en) | 1990-01-24 | 1998-04-08 | BUCKLEY, Douglas I. | Glp-1 analogs useful for diabetes treatment |
US5545618A (en) | 1990-01-24 | 1996-08-13 | Buckley; Douglas I. | GLP-1 analogs useful for diabetes treatment |
DK39892D0 (da) | 1992-03-25 | 1992-03-25 | Bernard Thorens | Peptid |
AU685803B2 (en) | 1993-03-29 | 1998-01-29 | University Of Cincinnati, The | Analogs of peptide YY and uses thereof |
US5705483A (en) | 1993-12-09 | 1998-01-06 | Eli Lilly And Company | Glucagon-like insulinotropic peptides, compositions and methods |
EP0803255A4 (en) | 1994-06-03 | 1999-06-30 | Tsumura & Co | DRUG |
US5512549A (en) | 1994-10-18 | 1996-04-30 | Eli Lilly And Company | Glucagon-like insulinotropic peptide analogs, compositions, and methods of use |
US5574010A (en) | 1994-11-14 | 1996-11-12 | The Regents Of The University Of California | Treatment of pancreatic tumors with peptide YY and analogs thereof |
US5869602A (en) | 1995-03-17 | 1999-02-09 | Novo Nordisk A/S | Peptide derivatives |
US5650386A (en) | 1995-03-31 | 1997-07-22 | Emisphere Technologies, Inc. | Compositions for oral delivery of active agents |
US5866536A (en) | 1995-03-31 | 1999-02-02 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
CN1151836C (zh) | 1995-03-31 | 2004-06-02 | 艾米斯菲尔技术有限公司 | 用作传送活性剂的化合物和组合物 |
SE9600070D0 (sv) | 1996-01-08 | 1996-01-08 | Astra Ab | New oral pharmaceutical dosage forms |
US6458924B2 (en) | 1996-08-30 | 2002-10-01 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
US7235627B2 (en) | 1996-08-30 | 2007-06-26 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
BRPI9711437B8 (pt) | 1996-08-30 | 2021-05-25 | Novo Nordisk As | derivados de glp-1 |
US6268343B1 (en) | 1996-08-30 | 2001-07-31 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
ATE366584T1 (de) | 1996-11-12 | 2007-08-15 | Novo Nordisk As | Verwendung von glp-1 peptiden |
WO1998020885A1 (en) | 1996-11-13 | 1998-05-22 | University Of Cincinnati | Analogs of peptide yy and uses thereof |
US5773647A (en) | 1997-02-07 | 1998-06-30 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
EP0908515A3 (en) | 1997-09-16 | 2000-04-26 | Smithkline Beecham Plc | Pancreatic polypeptide |
WO1999043705A1 (en) | 1998-02-27 | 1999-09-02 | Novo Nordisk A/S | N-terminally truncated glp-1 derivatives |
JP2002512175A (ja) | 1998-02-27 | 2002-04-23 | ノボ ノルディスク アクティーゼルスカブ | Glp−1類似体の誘導体類 |
WO1999043708A1 (en) | 1998-02-27 | 1999-09-02 | Novo Nordisk A/S | Glp-1 derivatives of glp-1 and exendin with protracted profile of action |
AU2610899A (en) | 1998-02-27 | 1999-09-15 | Novo Nordisk A/S | N-terminally modified glp-1 derivatives |
AU2610799A (en) | 1998-02-27 | 1999-09-15 | Novo Nordisk A/S | Glp-1 derivatives with helix-content exceeding 25 per cent, forming partially structured micellar-like aggregates |
US6046167A (en) | 1998-03-25 | 2000-04-04 | University Of Cincinnati | Peptide YY analogs |
CA2334298C (en) | 1998-06-08 | 2008-01-08 | Schering Corporation | Neuropeptide y5 receptor antagonists |
SE9802080D0 (sv) * | 1998-06-11 | 1998-06-11 | Hellstroem | Pharmaceutical composition for the treatment of functional dyspepsia and/or irritable bowel syndrome and new use of substances therein |
DE69911975T2 (de) | 1998-07-31 | 2004-09-09 | Novo Nordisk A/S | In-vitro stimulation von beta zellen vermehrung |
MY155270A (en) | 1998-09-24 | 2015-09-30 | Lilly Co Eli | Use of glp-1 or analogs in treatment of stroke |
NZ527241A (en) | 1998-12-07 | 2004-12-24 | Sod Conseils Rech Applic | Analogues of GLP-1 |
EP1149066B1 (en) | 1999-02-05 | 2005-11-09 | Emisphere Technologies, Inc. | Method of preparing alkylated salicylamides |
US7658938B2 (en) | 1999-02-22 | 2010-02-09 | Merrion Reasearch III Limited | Solid oral dosage form containing an enhancer |
JP2002537321A (ja) | 1999-02-22 | 2002-11-05 | エラン コーポレイション ピーエルスィー | 促進剤を含む固体経口剤形 |
WO2000048589A1 (en) | 1999-02-22 | 2000-08-24 | Emisphere Holdings, Inc. | Solid oral dosage form containing heparin or a heparinoid in combination with a carrier |
EP1175443A1 (en) | 1999-04-30 | 2002-01-30 | Amylin Pharmaceuticals, Inc. | Modified exendins and exendin agonists |
US7601691B2 (en) | 1999-05-17 | 2009-10-13 | Conjuchem Biotechnologies Inc. | Anti-obesity agents |
ATE252601T1 (de) | 1999-05-17 | 2003-11-15 | Conjuchem Inc | Lang wirkende insulinotrope peptide |
EP1076066A1 (en) | 1999-07-12 | 2001-02-14 | Zealand Pharmaceuticals A/S | Peptides for lowering blood glucose levels |
GB9923436D0 (en) | 1999-10-04 | 1999-12-08 | American Home Prod | Pharmaceutical compositions |
US6793934B1 (en) | 1999-12-08 | 2004-09-21 | Shire Laboratories, Inc. | Solid oral dosage form |
US7262325B2 (en) | 2000-06-02 | 2007-08-28 | Emisphere Technologies, Inc. | Method of preparing salicylamides |
US7049283B2 (en) | 2000-12-06 | 2006-05-23 | Novartis Ag | Pharmaceutical compositions for the oral delivery of pharmacologically active agents |
PL393178A1 (pl) | 2000-12-07 | 2011-02-14 | Eli Lilly And Company | Heterogenne białko fuzyjne, kompozycja farmaceutyczna do leczenia pacjentów z cukrzycą insulino-niezależną i kompozycja farmaceutyczna do leczenia pacjentów z otyłością |
US7199217B2 (en) | 2000-12-13 | 2007-04-03 | Eli Lilly And Company | Amidated glucagon-like peptide-1 |
MXPA03005388A (es) | 2000-12-14 | 2003-09-25 | Amylin Pharmaceuticals Inc | Peptido yy y agonistas de peptido yy para el tratamiento de desordenes metabolicos. |
GB0102075D0 (en) * | 2001-01-26 | 2001-03-14 | Astrazeneca Ab | Process |
US6589938B2 (en) | 2001-06-29 | 2003-07-08 | National University Of Singapore | Use of angiotensin I derivatives as an agent for the treatment and prevention of infarction-related cardiac injuries and disorders |
US20030068356A1 (en) | 2001-07-10 | 2003-04-10 | Pather S. Indiran | Sequential drug delivery systems |
DE60228972D1 (de) | 2001-07-31 | 2008-10-30 | Us Gov Health & Human Serv | Glp 1 exendin 4 peptidanaloga und deren verwendungen |
US7459432B2 (en) | 2001-09-24 | 2008-12-02 | Imperial College Innovations Ltd. | Modification of feeding behavior |
EP1461031B1 (en) | 2001-11-29 | 2016-06-29 | Emisphere Technologies, Inc. | Formulations for oral administration of cromolyn sodium |
US8058233B2 (en) | 2002-01-10 | 2011-11-15 | Oregon Health And Science University | Modification of feeding behavior using PYY and GLP-1 |
MXPA04007427A (es) | 2002-02-01 | 2004-10-11 | Pfizer Prod Inc | Formulaciones de azitromicina granuladas por via seca. |
EP1478233B1 (en) | 2002-02-20 | 2016-11-09 | Emisphere Technologies, Inc. | Method for administering glp-1 molecules |
DK1525219T3 (da) | 2002-07-04 | 2009-09-07 | Zealand Pharma As | GLP-1 og fremgangsm der til behandling af diabetes |
JP2004131398A (ja) | 2002-10-08 | 2004-04-30 | Taihei Chemical Industrial Co Ltd | 錠剤用滑沢剤 |
US7811989B2 (en) | 2003-01-17 | 2010-10-12 | Ipsen Pharma S.A.S. | Peptide YY analogs |
US20050059605A1 (en) | 2003-01-31 | 2005-03-17 | Krishna Peri | Chemically modified metabolites of regulatory peptides and methods of producing and using same |
CN1832959A (zh) | 2003-03-19 | 2006-09-13 | 伊莱利利公司 | 聚乙二醇连接的glp-1化合物 |
NZ543274A (en) | 2003-05-14 | 2007-12-21 | Emisphere Tech Inc | Compositions for delivering peptide YY and PYY agonists |
US7572581B2 (en) | 2003-06-30 | 2009-08-11 | Roche Molecular Systems, Inc. | 2′-terminator nucleotide-related methods and systems |
BRPI0412458A (pt) | 2003-07-11 | 2006-10-17 | Novartis Ag | composições farmacêuticas oralmente dosadas compreendendo um agente de liberação na forma micronizada |
WO2005014049A2 (en) | 2003-08-08 | 2005-02-17 | Novo Nordisk A/S | Synthesis and application of new structural well defined branched polymers as conjugating agents for peptides |
CN101380476A (zh) | 2003-09-19 | 2009-03-11 | 诺沃挪第克公司 | 治疗肽的清蛋白结合型衍生物 |
CA2539253A1 (en) | 2003-09-19 | 2005-03-31 | Novo Nordisk A/S | Albumin-binding derivatives of therapeutic peptides |
WO2005028516A2 (en) | 2003-09-19 | 2005-03-31 | Novo Nordisk A/S | Albumin-binding derivatives of therapeutic peptides |
KR101243648B1 (ko) | 2003-11-20 | 2013-03-14 | 노보 노르디스크 에이/에스 | 제조 및 주사 장치용에 최적인 프로필렌 글리콜 함유펩티드 제제 |
BRPI0417717A (pt) | 2003-12-18 | 2007-04-03 | Novo Nordisk As | composto, composição farmacêutica, e, uso de um composto |
EP1696962A2 (en) | 2003-12-18 | 2006-09-06 | Novo Nordisk A/S | Novel glp-1 analogues linked to albumin-like agents |
US20060286129A1 (en) | 2003-12-19 | 2006-12-21 | Emisphere Technologies, Inc. | Oral GLP-1 formulations |
EP2335715A3 (en) | 2004-02-11 | 2013-12-18 | Amylin Pharmaceuticals, LLC | Pancreatic polypeptide family motifs and polypeptides comprising the same |
WO2005077072A2 (en) | 2004-02-11 | 2005-08-25 | Amylin Pharmaceuticals, Inc. | Hybrid polypeptides with selectable properties |
JP2007529463A (ja) | 2004-03-17 | 2007-10-25 | 7ティーエム ファーマ エイ/エス | 治療的介入のためのy4選択性レセプターアゴニスト |
WO2005089790A2 (en) | 2004-03-17 | 2005-09-29 | 7Tm Pharma A/S | Y2/y4 selective receptor agonists for therapeutic interventions |
US20090186811A1 (en) | 2004-03-17 | 2009-07-23 | Thue Schwartz | Y2 Selective Receptor Agonists for Therapeutic Interventions |
AU2005224026A1 (en) | 2004-03-17 | 2005-09-29 | 7Tm Pharma A/S | Y2 selective receptor agonists for therapeutic interventions |
WO2005099672A1 (en) | 2004-04-13 | 2005-10-27 | Ranbaxy Laboratories Limited | A modified release pharmaceutical formulation comprising amoxicillin and clavulanate |
NZ550894A (en) | 2004-05-06 | 2011-02-25 | Emisphere Tech Inc | Solid dosage form of wetted heparin |
CA2897225C (en) | 2004-05-06 | 2017-12-05 | Emisphere Technologies, Inc. | Crystalline polymorphic forms of monosodium n-[8-(2-hydroxybenzoyl)amino]caprylate |
WO2005112633A2 (en) * | 2004-05-14 | 2005-12-01 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
GB0412181D0 (en) | 2004-06-01 | 2004-06-30 | Celltech R&D Ltd | Biological products |
WO2005121090A1 (en) | 2004-06-02 | 2005-12-22 | Abbott Laboratories | Substituted piperidines that have antiangiogenic activity |
CN101010339B (zh) * | 2004-07-02 | 2011-11-09 | 布里斯托尔-迈尔斯斯奎布公司 | 人类胰高血糖素样肽-1调节剂及它们在治疗糖尿病及相关病况中的用途 |
TW200611704A (en) | 2004-07-02 | 2006-04-16 | Bristol Myers Squibb Co | Human glucagon-like-peptide-1 modulators and their use in the treatment of diabetes and related conditions |
JP2008507477A (ja) | 2004-07-08 | 2008-03-13 | ノボ ノルディスク アクティーゼルスカブ | ポリペプチド延長タグ |
CA2573512C (en) | 2004-07-12 | 2014-09-23 | Emisphere Technologies, Inc. | Compositions for delivering peptide yy and pyy agonists |
US7994119B2 (en) | 2004-07-19 | 2011-08-09 | University Of Cincinnati | Compounds for control of appetite |
US20060078622A1 (en) | 2004-08-13 | 2006-04-13 | Emisphere Technologies, Inc. | Pharmaceutical formulations containing microparticles or nanoparticles of a delivery agent |
WO2006049681A2 (en) | 2004-08-30 | 2006-05-11 | Bayer Pharmaceuticals Corporation | Selective neuropeptide y2 receptor agonists |
JP2008515856A (ja) | 2004-10-07 | 2008-05-15 | ノボ ノルディスク アクティーゼルスカブ | 遅延性glp−1化合物 |
JP5107713B2 (ja) | 2004-10-07 | 2012-12-26 | ノヴォ ノルディスク アー/エス | 遅延性のエキセンディン−4化合物 |
US7410949B2 (en) | 2005-01-18 | 2008-08-12 | Hoffmann-La Roche Inc. | Neuropeptide-2 receptor (Y-2R) agonists and uses thereof |
ES2540929T3 (es) | 2005-02-01 | 2015-07-14 | Emisphere Technologies, Inc. | Sistema de administración de retención gástrica y liberación controlada |
ES2438145T3 (es) | 2005-02-02 | 2014-01-16 | Novo Nordisk A/S | Nuevos derivados de insulina |
WO2006096515A2 (en) | 2005-03-04 | 2006-09-14 | Biorexis Pharmaceutical Corporation | Modified transferrin fusion proteins |
GB0504857D0 (en) | 2005-03-09 | 2005-04-13 | Imp College Innovations Ltd | Novel compounds and their effects on feeding behaviour |
TWI362392B (en) | 2005-03-18 | 2012-04-21 | Novo Nordisk As | Acylated glp-1 compounds |
JP2008533104A (ja) | 2005-03-18 | 2008-08-21 | ノボ ノルディスク アクティーゼルスカブ | Glp−1受容体の二量体ペプチドアゴニスト |
WO2006097535A2 (en) | 2005-03-18 | 2006-09-21 | Novo Nordisk A/S | Peptide agonists of the glucagon family with secretin like activity |
ES2484796T3 (es) | 2005-03-18 | 2014-08-12 | Novo Nordisk A/S | Compuestos de GLP-1 extendidos |
EP1863449A2 (en) | 2005-03-28 | 2007-12-12 | Dexcel Pharma Technologies Ltd. | Controlled absorption of statins in the intestine |
PE20061448A1 (es) | 2005-05-26 | 2006-12-17 | Bristol Myers Squibb Co | Compuestos polipeptidos como moduladores del peptido 1 similar al glucagon humano |
WO2007008778A2 (en) | 2005-07-11 | 2007-01-18 | Nastech Pharmaceutical Company Inc. | Formulations for enhanced mucosal delivery of pyy |
US8975227B2 (en) | 2005-07-15 | 2015-03-10 | Emisphere Technologies, Inc. | Intraoral dosage forms of glucagon |
US20090203581A1 (en) | 2005-07-18 | 2009-08-13 | Novo Nordisk A/S | Novel Peptides for Use in the Treatment of Obesity |
JP5693817B2 (ja) | 2005-08-19 | 2015-04-01 | アミリン・ファーマシューティカルズ, リミテッド・ライアビリティ・カンパニーAmylin Pharmaceuticals, Llc | 糖尿病の治療法および体重の減少法 |
US20070049557A1 (en) | 2005-08-24 | 2007-03-01 | Hashim Ahmed | Solid pharmaceutical dosage forms comprising bisphosphonates and modified amino acid carriers |
US8022035B2 (en) | 2005-09-21 | 2011-09-20 | 7Tm Pharma A/S | Y4 selective receptor agonists for therapeutic interventions |
EA200800875A1 (ru) | 2005-09-21 | 2008-08-29 | 7ТиЭм ФАРМА А/С | Рецепторные агонисты, селективные к y2 рецептору, для терапевтического воздействия |
WO2007061434A2 (en) | 2005-11-10 | 2007-05-31 | Nastech Pharmaceutical Company Inc. | A pharmaceutical formulation of glp-1 and its use for treating a metabolic syndrome |
CN101309674A (zh) | 2005-11-17 | 2008-11-19 | 诺瓦提斯公司 | 药物组合物 |
KR101059602B1 (ko) | 2005-12-07 | 2011-08-25 | 에프. 호프만-라 로슈 아게 | 신경펩타이드 2 수용체 작용물질 |
BRPI0620571A2 (pt) | 2005-12-08 | 2011-11-22 | Nastech Pharm Co | formulação farmacêutica aquosa, forma de dosagem de exendina, solução aquosa, uso de uma formulação farmacêutica, e uso de uma formulação farmacêutica aquosa |
EP1963343A1 (en) | 2005-12-14 | 2008-09-03 | Novo Nordisk A/S | Polypeptide protracting tags |
US20070197445A1 (en) | 2006-01-18 | 2007-08-23 | University Of Cincinnati | Compounds for control of appetite |
JP5412273B2 (ja) | 2006-03-21 | 2014-02-12 | アミリン・ファーマシューティカルズ,リミテッド・ライアビリティ・カンパニー | ペプチド−ぺプチダーゼ阻害剤及びその使用 |
BRPI0710503A2 (pt) | 2006-04-07 | 2011-08-16 | Merrion Res Iii Ltd | uso de uma composição farmacêutica, composição farmacêutica, e, forma de dosagem oral |
US8927015B2 (en) | 2006-04-12 | 2015-01-06 | Emisphere Technologies, Inc. | Formulations for delivering insulin |
MX2008014061A (es) | 2006-05-09 | 2008-11-14 | Novo Nordisk As | Derivado de insulina. |
US20070292512A1 (en) | 2006-06-09 | 2007-12-20 | Merrion Research Ii Limited | Solid Oral Dosage Form Containing an Enhancer |
JP5475443B2 (ja) | 2006-06-28 | 2014-04-16 | エミスフェアー・テクノロジーズ・インク | 硝酸ガリウム製剤 |
GB0613196D0 (en) | 2006-07-03 | 2006-08-09 | Imp Innovations Ltd | Novel compounds and their effects on feeding behaviour |
ES2296529B1 (es) | 2006-08-07 | 2009-04-01 | Laboratorios Farmaceuticos Rovi, S.A. | Composicion farmaceutica con promotores de absorcion. |
US20090318353A1 (en) | 2006-08-25 | 2009-12-24 | Novo Nordisk A/S | Acylated Exendin-4 Compounds |
CN101506147B (zh) | 2006-09-07 | 2012-03-21 | 霍夫曼-拉罗奇有限公司 | 用于制备snac(n-(8-[2-羟基苯甲酰基]-氨基)辛酸钠)的方法 |
TWI430806B (zh) | 2006-09-13 | 2014-03-21 | Smithkline Beecham Corp | 用於投與長效降血糖藥劑之方法 |
PE20080845A1 (es) | 2006-09-22 | 2008-08-13 | Novartis Ag | Metodo para fabricar tabletas que contienen agentes farmacologicamente activos |
GB0621973D0 (en) | 2006-11-03 | 2006-12-13 | Philogen Spa | Binding molecules and uses thereof |
US20100069410A1 (en) | 2006-12-01 | 2010-03-18 | Emisphere Technologies Inc. | acyclovir formulations |
US20090099074A1 (en) | 2007-01-10 | 2009-04-16 | Conjuchem Biotechnologies Inc. | Modulating food intake |
JP2010516652A (ja) | 2007-01-18 | 2010-05-20 | ノボ・ノルデイスク・エー/エス | 肥満の治療に使用される新規ペプチド |
US20100022446A1 (en) | 2007-01-18 | 2010-01-28 | Novo Nordisk A/S | Use of Peptides in Combination with Surgical Intervention for the Treatment of Obesity |
CA2679782C (en) | 2007-03-02 | 2015-02-17 | Novartis Ag | Oral administration of a calcitonin |
GB0708226D0 (en) | 2007-04-27 | 2007-06-06 | 7Tm Pharma As | Y-receptor agonists |
EP2171080A4 (en) | 2007-06-12 | 2010-10-27 | Glaxosmithkline Llc | METHODS OF PROTEIN DETECTION IN PLASMA |
US8093689B2 (en) * | 2007-07-02 | 2012-01-10 | Infineon Technologies Ag | Attachment member for semiconductor sensor device |
EP2167535A2 (en) | 2007-07-09 | 2010-03-31 | Imperial Innovations Limited | Human pancreatic polypeptide (hpp) analogues and their effects on feeding behaviour |
EP2182956A2 (en) | 2007-08-29 | 2010-05-12 | The Regents of the University of California | Salicylanilide modified peptides for use as oral therapeutics |
ES2550363T3 (es) | 2007-09-05 | 2015-11-06 | Novo Nordisk A/S | Derivados truncados de GLP-1 y su uso terapéutico |
ES2532116T3 (es) | 2007-09-05 | 2015-03-24 | Novo Nordisk A/S | Péptidos derivados con A-B-C-D y sus usos terapéuticos |
WO2009030738A1 (en) | 2007-09-05 | 2009-03-12 | Novo Nordisk A/S | Glucagon-like peptide-1 derivatives and their pharmaceutical use |
AU2008303922A1 (en) | 2007-09-11 | 2009-04-02 | Mondobiotech Laboratories Ag | Use of the peptide His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe alone or in combination with the peptide Gly-Ard-Gly-Asp-Asn-Pro-OH as a therapeutic agent |
WO2009042922A2 (en) | 2007-09-27 | 2009-04-02 | Amylin Pharmaceuticals, Inc. | Peptide-peptidase inhibitor conjugates and methods of making and using same |
JP5868594B2 (ja) | 2007-10-16 | 2016-02-24 | バイオコン・リミテッドBiocon Limited | 経口投与可能な固形医薬組成物及びそのプロセス |
PL2215047T3 (pl) | 2007-11-02 | 2014-05-30 | Emisphere Tech Inc | Sposób leczenia niedoborów witaminy b12 |
US20090124639A1 (en) * | 2007-11-06 | 2009-05-14 | Emisphere Technologies Inc. | valacyclovir formulations |
US20100317057A1 (en) | 2007-12-28 | 2010-12-16 | Novo Nordisk A/S | Semi-recombinant preparation of glp-1 analogues |
BRPI0912615A2 (pt) | 2008-05-16 | 2016-01-26 | Novo Nordisk As | agonistas de receptor y2 e/ou y4 de longa ação |
ES2823233T3 (es) | 2008-08-18 | 2021-05-06 | Entera Bio Ltd | Métodos y composiciones para la administración oral de proteínas |
EP2340049B1 (en) | 2008-09-12 | 2015-11-11 | Novo Nordisk A/S | Method of acylating a peptide or protein |
US8299023B2 (en) | 2008-09-17 | 2012-10-30 | Hoffmann-La Roche Inc. | Neuropeptide-2 receptor (Y-2R) agonists |
GB0817067D0 (en) | 2008-09-18 | 2008-10-22 | 7Tm Pharma As | Intestinal treatment |
ES2445540T3 (es) | 2008-10-15 | 2014-03-03 | Bayer Cropscience Ag | Uso de ditiina-tetracarboximidas para combatir hongos fitopatógenos |
KR20110097807A (ko) | 2008-11-05 | 2011-08-31 | 에프. 호프만-라 로슈 아게 | 뉴로펩티드-2-수용체(y-2r) 작용제 및 이의 용도 |
CN101463081B (zh) | 2009-01-12 | 2012-07-04 | 华东师范大学 | 一种glp-1衍生物 |
JP2012517977A (ja) | 2009-02-13 | 2012-08-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Dpp−4阻害剤(リナグリプチン)を任意で他の抗糖尿病薬と組み合わせて含む抗糖尿病薬 |
JP5584236B2 (ja) | 2009-02-20 | 2014-09-03 | イプセン ファルマ ソシエテ パール アクシオン サンプリフィエ | 神経ペプチドy受容体結合化合物を有する細胞毒性コンジュゲート |
AR077956A1 (es) | 2009-09-14 | 2011-10-05 | Bayer Cropscience Ag | Combinaciones de compuestos activos |
JP2013505221A (ja) | 2009-09-18 | 2013-02-14 | ノヴォ ノルディスク アー/エス | 長時間作用性y2受容体アゴニスト |
CA2776302A1 (en) | 2009-10-13 | 2011-04-21 | F. Hoffmann-La Roche Ag | Neuropeptide-2 receptor (y-2r) agonists |
JP2013510829A (ja) | 2009-11-13 | 2013-03-28 | ノヴォ ノルディスク アー/エス | 長時間作用型y2受容体アゴニスト |
WO2011084618A2 (en) | 2009-12-16 | 2011-07-14 | Nod Pharmaceuticals, Inc. | Compositions and methods for oral drug delivery |
EP2513141B1 (en) | 2009-12-16 | 2017-03-01 | Novo Nordisk A/S | Glp-1 analogues and derivatives |
US20110182985A1 (en) | 2010-01-28 | 2011-07-28 | Coughlan David C | Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof |
WO2011109787A1 (en) | 2010-03-05 | 2011-09-09 | Conjuchem, Llc | Methods of administering insulinotropic peptides |
WO2011116139A2 (en) | 2010-03-16 | 2011-09-22 | Chiasma Inc. | Improved pharmaceutical compositions and methods of delivery |
US9040660B2 (en) | 2010-04-20 | 2015-05-26 | Novo Nordisk A/S | Long-acting gastrin derivatives |
MX2012012383A (es) | 2010-04-30 | 2012-11-30 | Sanwa Kagaku Kenkyusho Co | Peptido para mejorar la bioestabilidad de una sustancia bioactica y sustancia bioactiva que tiene bioestabilidad mejorada. |
CN102946875A (zh) | 2010-05-05 | 2013-02-27 | 贝林格尔.英格海姆国际有限公司 | 组合疗法 |
DE202010015867U1 (de) | 2010-11-25 | 2011-05-05 | Buchhalter, Thomas | Elektromechanische Halterung zur Aufnahme von Navigations- und Kommunikationsgeräte im KFZ |
DK3326620T3 (da) | 2010-12-16 | 2020-05-25 | Novo Nordisk As | Faste sammensætninger omfattende en glp-1-agonist og et salt af n-(8-(2- hydroxybenzoyl)amino)caprylsyre |
GB201101459D0 (en) | 2011-01-27 | 2011-03-16 | Imp Innovations Ltd | Novel compounds and thier effects on fedding behaviour |
KR101972836B1 (ko) | 2011-04-12 | 2019-04-29 | 노보 노르디스크 에이/에스 | 이중 아실화된 glp-1 유도체 |
WO2013009545A1 (en) | 2011-07-08 | 2013-01-17 | Amylin Pharmaceuticals, Inc. | Engineered polypeptides having enhanced duration of action with reduced immunogenicity |
US10335369B2 (en) | 2012-03-22 | 2019-07-02 | Novo Nordisk A/S | Compositions comprising a delivery agent and preparation thereof |
HUE062740T2 (hu) | 2012-03-22 | 2023-12-28 | Novo Nordisk As | GLP-1 peptidek készítményei és elõállításuk |
DK2827845T3 (en) | 2012-03-22 | 2019-04-01 | Novo Nordisk As | COMPOSITIONS INCLUDING A PROCEDURE AND PREPARING THEREOF |
US20150141336A1 (en) | 2012-05-29 | 2015-05-21 | Novo Nordisk A/S | Pancreatic Peptide Compounds and Use |
ES2871328T3 (es) | 2012-06-20 | 2021-10-28 | Novo Nordisk As | Formulación de comprimido que comprende un péptido y un agente de suministro |
SI2866825T1 (sl) | 2012-07-01 | 2020-07-31 | Novo Nordisk A/S | Uporaba dolgo delujočih peptidov GLP-1 |
CN105263957A (zh) | 2013-05-02 | 2016-01-20 | 葛兰素史克知识产权开发有限公司 | 治疗肽 |
EP2991671B1 (en) | 2013-05-02 | 2018-08-15 | Novo Nordisk A/S | Oral dosing of glp-1 compounds |
JP6629198B2 (ja) | 2013-11-15 | 2020-01-15 | ノヴォ ノルディスク アー/エス | 35位にβ−ホモアルギニン置換を有するHPYY(1−36) |
TWI661835B (zh) | 2013-11-15 | 2019-06-11 | 丹麥商諾佛 儂迪克股份有限公司 | 選擇性pyy化合物及其用途 |
US20180050096A1 (en) | 2015-02-09 | 2018-02-22 | Entera Bio Ltd. | Treatment of hypoparathyroidism |
AU2016275735B2 (en) | 2015-06-12 | 2020-02-06 | Novo Nordisk A/S | Selective PYY compounds and uses thereof |
WO2017060500A1 (en) | 2015-10-07 | 2017-04-13 | Cyprumed Gmbh | Pharmaceutical formulations for the oral delivery of peptide drugs |
AR112015A1 (es) | 2017-06-09 | 2019-09-11 | Novo Nordisk As | Composiciones sólidas para administración oral |
CN111683676B (zh) | 2018-02-02 | 2024-06-18 | 诺和诺德股份有限公司 | 包含glp-1激动剂、n-(8-(2-羟基苯甲酰基)氨基)辛酸的盐和润滑剂的固体组合物 |
-
2013
- 2013-03-15 HU HUE18188815A patent/HUE062740T2/hu unknown
- 2013-03-15 RS RS20181144A patent/RS57727B1/sr unknown
- 2013-03-15 SI SI201331172T patent/SI2827885T1/sl unknown
- 2013-03-15 CN CN201380015554.2A patent/CN104203266B/zh active Active
- 2013-03-15 EP EP13709231.8A patent/EP2827885B1/en active Active
- 2013-03-15 EP EP18188815.7A patent/EP3488857B9/en active Active
- 2013-03-15 PL PL18188815.7T patent/PL3488857T3/pl unknown
- 2013-03-15 KR KR1020147028164A patent/KR102072202B1/ko active IP Right Grant
- 2013-03-15 MX MX2014010685A patent/MX353067B/es active IP Right Grant
- 2013-03-15 US US14/386,589 patent/US10933120B2/en active Active
- 2013-03-15 RS RS20230691A patent/RS64460B1/sr unknown
- 2013-03-15 CA CA2868188A patent/CA2868188A1/en not_active Withdrawn
- 2013-03-15 AU AU2013234496A patent/AU2013234496B2/en active Active
- 2013-03-15 CN CN201711156842.6A patent/CN107812181B/zh active Active
- 2013-03-15 BR BR112014023374-8A patent/BR112014023374B1/pt active IP Right Grant
- 2013-03-15 RU RU2014141700A patent/RU2641198C3/ru active Protection Beyond IP Right Term
- 2013-03-15 HR HRP20231060TT patent/HRP20231060T1/hr unknown
- 2013-03-15 LT LTEP13709231.8T patent/LT2827885T/lt unknown
- 2013-03-15 DK DK13709231.8T patent/DK2827885T3/en active
- 2013-03-15 EP EP23177173.4A patent/EP4324475A1/en active Pending
- 2013-03-15 HU HUE13709231A patent/HUE039406T2/hu unknown
- 2013-03-15 PL PL13709231T patent/PL2827885T3/pl unknown
- 2013-03-15 WO PCT/EP2013/055362 patent/WO2013139694A1/en active Application Filing
- 2013-03-15 JP JP2015500853A patent/JP6001158B2/ja active Active
- 2013-03-15 MY MYPI2014002632A patent/MY171146A/en unknown
- 2013-03-15 ES ES13709231.8T patent/ES2690553T3/es active Active
- 2013-03-15 ES ES18188815T patent/ES2952874T3/es active Active
-
2014
- 2014-08-25 ZA ZA2014/06250A patent/ZA201406250B/en unknown
-
2017
- 2017-10-27 AU AU2017251814A patent/AU2017251814B2/en active Active
-
2018
- 2018-09-11 HR HRP20181447TT patent/HRP20181447T1/hr unknown
-
2021
- 2021-01-25 US US17/157,363 patent/US11759501B2/en active Active
-
2022
- 2022-04-13 US US17/719,610 patent/US11759502B2/en active Active
- 2022-04-13 US US17/719,629 patent/US11759503B2/en active Active
-
2023
- 2023-08-01 US US18/228,706 patent/US20240016897A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU2641198C3 (ru) | Композиции glp-1 пептидов и их получение | |
HRP20231613T1 (hr) | Pripravci koji sadrže sredstvo za unošenje i njihova priprava | |
JP2015515459A5 (ru) | ||
RU2015147876A (ru) | Пероральная дозированная форма соединений глюкагоноподобного пептида-1 | |
RU2470016C2 (ru) | Производное бипиразола | |
HRP20231205T1 (hr) | Čvrsti pripravci koji sadrže agonist glp-1, sol n-(8-(2- hidroksibenzoil)amino)kaprilne kiseline i mazivo | |
JP2015512374A5 (ru) | ||
HRP20180425T1 (hr) | Čvrste kompozicije koje sadrže agonist glp-1 i sol n-(8-(2-hidroksibenzoil)amino)kaprilne kiseline | |
JP2016519128A5 (ru) | ||
NO20091501L (no) | Farmasoytiske sammensetninger | |
JP2013199505A5 (ru) | ||
RU2016122609A (ru) | Составы соединений азаиндола | |
JP2015522630A5 (ru) | ||
EA201490014A1 (ru) | Модифицированное высвобождение 4-метил-3-[[4-(3-пиридинил)-2-пиримидинил]амино]-n-[5-(4-метил-1h-имидазол-1-ил)-3-(трифторметил)фенил]бензамида, солюбилизированного с использованием органических кислот | |
HRP20201736T1 (hr) | Postupak liječenja diskinezije | |
RU2017107760A (ru) | Соединение | |
EA200901146A1 (ru) | Твердые лекарственные формы, содержащие алискирен и его фармацевтически приемлемые соли | |
RU2007132971A (ru) | Способы и материалы с транс-кломифеном для лечения мужского бесплодия | |
RU2012131959A (ru) | Способ лечения остеоартрита | |
JP2014527506A5 (ru) | ||
RU2006115784A (ru) | Применение l-бутилфталида для изготовления лекарственного средства для профилактики и лечения церебрального инфаркта | |
RU2016103764A (ru) | Стабилизированные фармацевтические лекарственные формы, содержащие атрасентан | |
JP2011516544A5 (ru) | ||
RU2015113031A (ru) | Использование 3-n-бутил изоиндолин кетонов при приготовлении лекарственных средств для профилактики и лечения церебрального инфаркта | |
JP2012046484A5 (ru) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
ND4A | Extension of patent duration |
Effective date: 20211210 |