HRP20231205T1 - Čvrsti pripravci koji sadrže agonist glp-1, sol n-(8-(2- hidroksibenzoil)amino)kaprilne kiseline i mazivo - Google Patents
Čvrsti pripravci koji sadrže agonist glp-1, sol n-(8-(2- hidroksibenzoil)amino)kaprilne kiseline i mazivo Download PDFInfo
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- HRP20231205T1 HRP20231205T1 HRP20231205TT HRP20231205T HRP20231205T1 HR P20231205 T1 HRP20231205 T1 HR P20231205T1 HR P20231205T T HRP20231205T T HR P20231205TT HR P20231205 T HRP20231205 T HR P20231205T HR P20231205 T1 HRP20231205 T1 HR P20231205T1
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- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 title claims 14
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 title claims 13
- 239000003877 glucagon like peptide 1 receptor agonist Substances 0.000 title claims 10
- 239000000314 lubricant Substances 0.000 title claims 10
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 title claims 6
- 229960002446 octanoic acid Drugs 0.000 title claims 6
- 150000003839 salts Chemical class 0.000 title claims 6
- 239000008247 solid mixture Substances 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 24
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical group [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 12
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 10
- 238000002360 preparation method Methods 0.000 claims 8
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 6
- 235000019359 magnesium stearate Nutrition 0.000 claims 6
- 102100025101 GATA-type zinc finger protein 1 Human genes 0.000 claims 4
- 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 claims 4
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical group C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims 4
- 239000008187 granular material Substances 0.000 claims 4
- DLSWIYLPEUIQAV-UHFFFAOYSA-N Semaglutide Chemical group CCC(C)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CCC(O)=O)NC(=O)C(CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CCC(NC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CCC(N)=O)NC(=O)CNC(=O)C(CCC(O)=O)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(NC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)CNC(=O)C(CCC(O)=O)NC(=O)C(C)(C)NC(=O)C(N)Cc1cnc[nH]1)C(C)O)C(C)O)C(C)C)C(=O)NC(C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CCCNC(N)=N)C(=O)NCC(O)=O DLSWIYLPEUIQAV-UHFFFAOYSA-N 0.000 claims 3
- 239000000556 agonist Substances 0.000 claims 3
- 229950011186 semaglutide Drugs 0.000 claims 3
- 108010060325 semaglutide Proteins 0.000 claims 3
- VCUFZILGIRCDQQ-KRWDZBQOSA-N N-[[(5S)-2-oxo-3-(2-oxo-3H-1,3-benzoxazol-6-yl)-1,3-oxazolidin-5-yl]methyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C1O[C@H](CN1C1=CC2=C(NC(O2)=O)C=C1)CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F VCUFZILGIRCDQQ-KRWDZBQOSA-N 0.000 claims 2
- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- DEXFNLNNUZKHNO-UHFFFAOYSA-N 6-[3-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperidin-1-yl]-3-oxopropyl]-3H-1,3-benzoxazol-2-one Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C1CCN(CC1)C(CCC1=CC2=C(NC(O2)=O)C=C1)=O DEXFNLNNUZKHNO-UHFFFAOYSA-N 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 238000007906 compression Methods 0.000 claims 1
- 230000006835 compression Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- BYNVYIUJKRRNNC-UHFFFAOYSA-N docosanoic acid;propane-1,2,3-triol Chemical compound OCC(O)CO.CCCCCCCCCCCCCCCCCCCCCC(O)=O BYNVYIUJKRRNNC-UHFFFAOYSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000007908 dry granulation Methods 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-M octanoate Chemical compound CCCCCCCC([O-])=O WWZKQHOCKIZLMA-UHFFFAOYSA-M 0.000 claims 1
- GCYXWQUSHADNBF-AAEALURTSA-N preproglucagon 78-108 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 GCYXWQUSHADNBF-AAEALURTSA-N 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Claims (24)
1. Farmaceutski pripravak, koji sadrži:
a) 0,5-50 mg agonista GLP-1; i
b) 20-800 mg, primjerice 50-500 mg, soli N-(8-(2-hidroksibenzoil)amino)kaprilne kiseline; i
c) 0,6-20 mg, primjerice 1-10 mg, maziva,
naznačen time što navedena sol N-(8-(2-hidroksibenzoil)amino)kaprilne kiseline čini najmanje 95% tež./tež. pomoćnih sredstava u pripravku.
2. Farmaceutski pripravak u skladu s patentnim zahtjevom 1, naznačen time što je mazivo magnezijev stearat ili gliceril-dibehenat.
3. Farmaceutski pripravak u skladu s patentnim zahtjevom 1, naznačen time što je mazivo magnezijev stearat.
4. Farmaceutski pripravak u skladu s patentnim zahtjevom 1, patentnim zahtjevom 2 ili patentnim zahtjevom 3, naznačen time što se sastoji od:
a) 0,5-50 mg agonista GLP-1;
b) 20-800 mg, primjerice 50-500 mg, soli N-(8-(2-hidroksibenzoil)amino)kaprilne kiseline; i
c) 0,6-20 mg, primjerice 1-10 mg, maziva.
5. Farmaceutski pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što navedena sol N-(8-(2-hidroksibenzoil)amino)kaprilne kiseline čini najmanje 90% tež./tež. pripravka.
6. Farmaceutski pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što pripravci sadrže 1-8 mg, primjerice 2-5 mg ili primjerice 2-3 mg magnezijevog stearata na 100 mg navedene soli N-(8-(2-hidroksibenzoil)amino)kaprilne kiseline.
7. Farmaceutski pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što je agonist GLP-1 peptid GLP-1 supstituiran masnom kiselinom ili masnom dikiselinom.
8. Farmaceutski pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što je agonist GLP-1 semaglutid.
9. Farmaceutski pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva 1-6, naznačen time što je agonist GLP-1 Nε26-{2-[2-(2-{2-[2-(2-{(S)-4-karboksi-4-[10-(4-karboksifenoksi)dekanoilamino]butirilamino}etoksi)etoksi]acetilamino}etoksi)etoksi]acetil}, Nε37-{2-[2-(2-{2-[2-(2-{(S)-4-karboksi-4-[10-(4-karboksifenoksi)dekanoilamino]butirilamino}etoksi)etoksi]acetilamino}etoksi)etoksi]acetil}-[Aib8,Arg34,Lys37]GLP-1(7-37)-peptid (agonist GLP-1 B).
10. Farmaceutski pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva 1-6, naznačen time što je agonist GLP-1 Nε27-[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-[10-(4-karboksifenoksi)dekanoilamino]butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil], Nε36-[2-[2-[2-[[2-[2-[2-[[(4S)-4-karboksi-4-[10-(4-karboksifenoksi)dekanoilamino]butanoil]amino]etoksi]etoksi]acetil]amino]etoksi]etoksi]acetil]-[Aib8,Glu22,Arg26,Lys27, Glu30,Arg34,Lys36]-GLP-1-(7-37)-peptidil-Glu-Gly (agonist C GLP-1).
11. Farmaceutski pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što je sol N-(8-(2-hidroksibenzoil)amino)kaprilne kiseline natrijev N-(8-(2-hidroksibenzoil)amino)kaprilat (SNAC).
12. Farmaceutski pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što pripravak sadrži najmanje jedan granulat, koji sadrži navedenu sol N-(8-(2-hidroksibenzoil)amino)kaprilne kiseline.
13. Farmaceutski pripravak u skladu s patentnim zahtjevom 12, naznačen time što najmanje jedan granulat dodatno sadrži navedeno mazivo.
14. Farmaceutski pripravak u skladu s patentnim zahtjevom 12 ili 13, naznačen time što najmanje jedan granulat dodatno sadrži agonist GLP-1.
15. Farmaceutski pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva 12-14, naznačen time što se najmanje jedan granulat pripravlja suhim granuliranjem, primjerice komprimiranjem valjcima.
16. Farmaceutski pripravak u skladu s bilo kojim od patentnih zahtjeva 12-15, naznačen time što pripravak sadrži izvangranularni dio.
17. Farmaceutski pripravak u skladu s patentnim zahtjevom 16, naznačen time što izvangranularni dio pripravka sadrži mazivo ili sredstvo za klizanje, poput magnezijevog stearata, i/ili agonist GLP-1.
18. Farmaceutski pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva 1-7 i 11-17, naznačen time što jedinična doza sadrži:
a) 0,5-20 mg semaglutida;
b) 50-400 mg SNAC; i
c) 1-10 mg maziva.
19. Farmaceutski pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva 1-7 i 11-17, naznačen time što jedinična doza sadrži:
a) 1-10 mg semaglutida;
b) 50-300 mg SNAC; i
c) 1-10 mg magnezijevog stearata.
20. Farmaceutski pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva 1-7 i 11-17, naznačen time što jedinična doza sadrži:
a) 0,5-20 mg agonista C GLP-1;
b) 50-400 mg SNAC; i
c) 1-10 mg maziva.
21. Farmaceutski pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva 1-7 i 11-17, naznačen time što jedinična doza sadrži:
a) 1-10 mg agonista C GLP-1;
b) 50-300 mg SNAC; i
c) 1-10 mg magnezijevog stearata.
22. Farmaceutski pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što je pripravak čvrsti pripravak, poput tablete namijenjene oralnoj primjeni.
23. Farmaceutski pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što je namijenjen upotrebi u medicini.
24. Farmaceutski pripravak u skladu s bilo kojim od prethodnih patentnih zahtjeva, naznačen time što je namijenjen upotrebi u postupku liječenja dijabetesa i/ili pretilosti.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP18154913 | 2018-02-02 | ||
PCT/EP2019/052487 WO2019149880A1 (en) | 2018-02-02 | 2019-02-01 | Solid compositions comprising a glp-1 agonist, a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid and a lubricant |
EP19702275.9A EP3746111B1 (en) | 2018-02-02 | 2019-02-01 | Solid compositions comprising a glp-1 agonist, a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid and a lubricant |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20231205T1 true HRP20231205T1 (hr) | 2024-01-19 |
Family
ID=61157101
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20231205TT HRP20231205T1 (hr) | 2018-02-02 | 2019-02-01 | Čvrsti pripravci koji sadrže agonist glp-1, sol n-(8-(2- hidroksibenzoil)amino)kaprilne kiseline i mazivo |
Country Status (24)
Country | Link |
---|---|
US (2) | US11833248B2 (hr) |
EP (2) | EP4299118A3 (hr) |
JP (2) | JP6898518B2 (hr) |
KR (1) | KR102647171B1 (hr) |
CN (1) | CN111683676B (hr) |
AR (1) | AR114353A1 (hr) |
AU (1) | AU2019216442A1 (hr) |
BR (1) | BR112020014624A2 (hr) |
CA (1) | CA3087928A1 (hr) |
CL (1) | CL2020001899A1 (hr) |
CO (1) | CO2020009997A2 (hr) |
ES (1) | ES2960687T3 (hr) |
HR (1) | HRP20231205T1 (hr) |
HU (1) | HUE063787T2 (hr) |
IL (1) | IL275778B2 (hr) |
MA (1) | MA53076B1 (hr) |
MX (1) | MX2020007598A (hr) |
PE (1) | PE20210453A1 (hr) |
PH (1) | PH12020551066A1 (hr) |
PL (1) | PL3746111T3 (hr) |
RS (1) | RS64643B1 (hr) |
SG (1) | SG11202006595RA (hr) |
TW (1) | TWI804571B (hr) |
WO (1) | WO2019149880A1 (hr) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RS56998B1 (sr) | 2010-12-16 | 2018-05-31 | Novo Nordisk As | Čvrste kompozicije koje sadrže agonist glp-1 i so n-(8-(2-hidroksibenzoil)amino)kaprilne kiseline |
WO2012140117A1 (en) | 2011-04-12 | 2012-10-18 | Novo Nordisk A/S | Double-acylated glp-1 derivatives |
WO2013139694A1 (en) | 2012-03-22 | 2013-09-26 | Novo Nordisk A/S | Compositions of glp-1 peptides and preparation thereof |
KR102647171B1 (ko) | 2018-02-02 | 2024-03-15 | 노보 노르디스크 에이/에스 | Glp-1 작용제 및 n-(8-(2-하이드록시벤조일)아미노)카프릴산의 염을 포함하는 고형 조성물 |
TWI829687B (zh) | 2018-05-07 | 2024-01-21 | 丹麥商諾佛 儂迪克股份有限公司 | 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物 |
WO2021043803A1 (en) | 2019-09-02 | 2021-03-11 | Novo Nordisk A/S | Process for producing a tablet comprising glp-1 peptides |
WO2021219710A1 (en) | 2020-04-29 | 2021-11-04 | Novo Nordisk A/S | Solid compositions comprising a glp-1 agonist and histidine |
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