RU2474580C2 - Гетероциклические амидные соединения как ингибиторы протеинкиназ - Google Patents
Гетероциклические амидные соединения как ингибиторы протеинкиназ Download PDFInfo
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- RU2474580C2 RU2474580C2 RU2010105678/04A RU2010105678A RU2474580C2 RU 2474580 C2 RU2474580 C2 RU 2474580C2 RU 2010105678/04 A RU2010105678/04 A RU 2010105678/04A RU 2010105678 A RU2010105678 A RU 2010105678A RU 2474580 C2 RU2474580 C2 RU 2474580C2
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- Prior art keywords
- disease
- protein kinase
- heterocyclic amide
- kinase inhibitors
- amide compounds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
Настоящее изобретение касается нового гетероциклического амидного соединения формулы I:
или его фармацевтически приемлемой соли. Также описана фармацевтическая композиция, содержащая указанное соединение, обладающая свойствами ингибитора, регулятора или модулятора протеинкиназ, что приемлемо для лечения или профилактики пролиферативного заболевания, антипролиферативного нарушения, воспаления, артрита, неврологического или нейродегенеративного заболевания, сердечно-сосудистого заболевания, облысения, нейронного заболевания, ишемического нарушения, вирусного заболевания или грибкового заболевания. 2 н.п. ф-лы, 20 табл.
Description
Claims (2)
2. Фармацевтическая композиция, обладающая свойствами ингибитора, регулятора или модулятора протеинкиназ, содержащая терапевтически эффективное количество соединения по п.1 или его фармацевтически приемлемую соль в комбинации с, по меньшей мере, одним фармацевтически приемлемым носителем.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95070907P | 2007-07-19 | 2007-07-19 | |
US60/950,709 | 2007-07-19 | ||
PCT/US2008/008749 WO2009014637A2 (en) | 2007-07-19 | 2008-07-17 | Heterocyclic amide compounds as protein kinase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2010105678A RU2010105678A (ru) | 2011-08-27 |
RU2474580C2 true RU2474580C2 (ru) | 2013-02-10 |
Family
ID=40070807
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2010105678/04A RU2474580C2 (ru) | 2007-07-19 | 2008-07-17 | Гетероциклические амидные соединения как ингибиторы протеинкиназ |
Country Status (20)
Country | Link |
---|---|
US (1) | US8293747B2 (ru) |
EP (1) | EP2178861B1 (ru) |
JP (1) | JP5241834B2 (ru) |
KR (1) | KR101552742B1 (ru) |
CN (1) | CN101801958B (ru) |
AR (1) | AR067585A1 (ru) |
AU (1) | AU2008279776B2 (ru) |
BR (1) | BRPI0814441A2 (ru) |
CA (1) | CA2693967A1 (ru) |
CL (1) | CL2008002131A1 (ru) |
CO (1) | CO6290765A2 (ru) |
EC (1) | ECSP109886A (ru) |
IL (1) | IL203354A (ru) |
MY (1) | MY150032A (ru) |
NZ (1) | NZ582708A (ru) |
PE (1) | PE20090905A1 (ru) |
RU (1) | RU2474580C2 (ru) |
TW (1) | TWI371275B (ru) |
WO (1) | WO2009014637A2 (ru) |
ZA (1) | ZA201000366B (ru) |
Cited By (1)
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RU2712092C2 (ru) * | 2013-11-05 | 2020-01-24 | Байер Кропсайенс Акциенгезельшафт | Замещенные бензамиды для борьбы с членистоногими |
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CN101801958B (zh) | 2014-01-29 |
CO6290765A2 (es) | 2011-06-20 |
BRPI0814441A2 (pt) | 2015-07-14 |
WO2009014637A3 (en) | 2009-03-19 |
AR067585A1 (es) | 2009-10-14 |
TW200920370A (en) | 2009-05-16 |
MY150032A (en) | 2013-11-29 |
US8293747B2 (en) | 2012-10-23 |
EP2178861B1 (en) | 2014-08-20 |
KR20100045481A (ko) | 2010-05-03 |
JP2010533716A (ja) | 2010-10-28 |
WO2009014637A2 (en) | 2009-01-29 |
AU2008279776A1 (en) | 2009-01-29 |
CA2693967A1 (en) | 2009-01-29 |
KR101552742B1 (ko) | 2015-09-11 |
US20100286135A1 (en) | 2010-11-11 |
JP5241834B2 (ja) | 2013-07-17 |
IL203354A (en) | 2013-12-31 |
TWI371275B (en) | 2012-09-01 |
AU2008279776A2 (en) | 2010-02-18 |
CN101801958A (zh) | 2010-08-11 |
RU2010105678A (ru) | 2011-08-27 |
ZA201000366B (en) | 2010-10-27 |
PE20090905A1 (es) | 2009-07-13 |
ECSP109886A (es) | 2010-02-26 |
NZ582708A (en) | 2012-04-27 |
EP2178861A2 (en) | 2010-04-28 |
CL2008002131A1 (es) | 2009-01-23 |
AU2008279776B2 (en) | 2013-05-23 |
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