RS20050042A - Novel inhibitors of kinases - Google Patents
Novel inhibitors of kinasesInfo
- Publication number
- RS20050042A RS20050042A YUP-2005/0042A YUP4205A RS20050042A RS 20050042 A RS20050042 A RS 20050042A YU P4205 A YUP4205 A YU P4205A RS 20050042 A RS20050042 A RS 20050042A
- Authority
- RS
- Serbia
- Prior art keywords
- formula
- kinases
- compounds
- useful
- growth factor
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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Abstract
Sadašnji pronalazak se odnosi na jedinjenja Formule (I) i njegove farmaceutski prihvatljive soli. Jedinjenja Formule (I) inhibiraju aktivnost tirozin kinaze na receptore faktora rasta kao što su VEGFR-2 i FGFR-1, što ih čini korisnim u lečenju karcinoma. Jedinjenja Formule (I) su takodje korisna za lečenje drugih oboljenja povezanih sa putevima prenosa signala koji deluju preko receptora faktora rasta.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US39725602P | 2002-07-19 | 2002-07-19 | |
US44721303P | 2003-02-13 | 2003-02-13 | |
PCT/US2003/022826 WO2004009784A2 (en) | 2002-07-19 | 2003-07-18 | Novel inhibitors of kinases |
Publications (2)
Publication Number | Publication Date |
---|---|
RS20050042A true RS20050042A (en) | 2007-06-04 |
RS52325B RS52325B (sr) | 2012-12-31 |
Family
ID=30773005
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YUP-2005/0041A RS20050041A (en) | 2002-07-19 | 2003-07-18 | Azaindole kinase inhibitors |
YU20050042A RS52325B (sr) | 2002-07-19 | 2003-07-18 | Novi inhibitori kinaza |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YUP-2005/0041A RS20050041A (en) | 2002-07-19 | 2003-07-18 | Azaindole kinase inhibitors |
Country Status (33)
Country | Link |
---|---|
US (6) | US6969717B2 (sr) |
EP (3) | EP2280012A3 (sr) |
JP (2) | JP4361485B2 (sr) |
KR (1) | KR100901939B1 (sr) |
CN (3) | CN1681508B (sr) |
AR (1) | AR040500A1 (sr) |
AT (2) | ATE505471T1 (sr) |
AU (2) | AU2003254088B2 (sr) |
BR (2) | BR0312801A (sr) |
CA (2) | CA2492804C (sr) |
CO (1) | CO5680407A2 (sr) |
CY (1) | CY1112628T1 (sr) |
DE (1) | DE60336732D1 (sr) |
DK (1) | DK1534290T3 (sr) |
ES (1) | ES2377963T3 (sr) |
GE (2) | GEP20074124B (sr) |
HK (1) | HK1072545A1 (sr) |
HR (2) | HRP20050059B8 (sr) |
IL (3) | IL166129A0 (sr) |
IS (2) | IS2880B (sr) |
MX (2) | MXPA05000715A (sr) |
MY (1) | MY134848A (sr) |
NO (2) | NO330132B1 (sr) |
NZ (1) | NZ537523A (sr) |
PE (1) | PE20040680A1 (sr) |
PL (2) | PL375352A1 (sr) |
PT (1) | PT1534290E (sr) |
RS (2) | RS20050041A (sr) |
RU (2) | RU2331642C2 (sr) |
SI (1) | SI1534290T1 (sr) |
TW (1) | TWI329112B (sr) |
UA (1) | UA82846C2 (sr) |
WO (2) | WO2004009784A2 (sr) |
Families Citing this family (192)
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AU756699B2 (en) * | 1996-12-03 | 2003-01-23 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
EP0881669B1 (en) * | 1997-05-30 | 2005-12-14 | STMicroelectronics S.r.l. | Manufacturing process of a germanium implanted heterojunction bipolar transistor |
US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
US6982265B1 (en) * | 1999-05-21 | 2006-01-03 | Bristol Myers Squibb Company | Pyrrolotriazine inhibitors of kinases |
US6867300B2 (en) * | 2000-11-17 | 2005-03-15 | Bristol-Myers Squibb Company | Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors |
US6670357B2 (en) * | 2000-11-17 | 2003-12-30 | Bristol-Myers Squibb Company | Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors |
TW200300350A (en) * | 2001-11-14 | 2003-06-01 | Bristol Myers Squibb Co | C-5 modified indazolylpyrrolotriazines |
WO2003091229A1 (en) | 2002-04-23 | 2003-11-06 | Bristol-Myers Squibb Company | Aryl ketone pyrrolo-triazine compounds useful as kinase inhibitors |
EP2289894A3 (en) * | 2002-04-23 | 2011-07-20 | Bristol-Myers Squibb Company | Pyrrolo-triazine compounds useful as kinase inhibitors |
TW200401638A (en) * | 2002-06-20 | 2004-02-01 | Bristol Myers Squibb Co | Heterocyclic inhibitors of kinases |
TWI329112B (en) * | 2002-07-19 | 2010-08-21 | Bristol Myers Squibb Co | Novel inhibitors of kinases |
US7649006B2 (en) * | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
JP4791183B2 (ja) * | 2002-08-23 | 2011-10-12 | スローン−ケッタリング インスティトュート フォア キャンサー リサーチ | エポチロン、その中間体、類似体の合成およびその使用 |
TW200420565A (en) | 2002-12-13 | 2004-10-16 | Bristol Myers Squibb Co | C-6 modified indazolylpyrrolotriazines |
MXPA05008183A (es) | 2003-02-05 | 2005-10-05 | Bristol Myers Squibb Co | Proceso para preparar pirrolotriazina como inhibidores de cinasa. |
RS53476B (sr) | 2003-07-18 | 2014-12-31 | Amgen Fremont Inc. | Sredstva za specifično vezivanje faktora rasta hepatocita |
US20060014741A1 (en) * | 2003-12-12 | 2006-01-19 | Dimarco John D | Synthetic process, and crystalline forms of a pyrrolotriazine compound |
US7102001B2 (en) | 2003-12-12 | 2006-09-05 | Bristol-Myers Squibb Company | Process for preparing pyrrolotriazine |
US7064203B2 (en) | 2003-12-29 | 2006-06-20 | Bristol Myers Squibb Company | Di-substituted pyrrolotriazine compounds |
MY145634A (en) | 2003-12-29 | 2012-03-15 | Bristol Myers Squibb Co | Pyrrolotriazine compounds as kinase inhibitors |
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US7498342B2 (en) | 2004-06-17 | 2009-03-03 | Plexxikon, Inc. | Compounds modulating c-kit activity |
US7432373B2 (en) * | 2004-06-28 | 2008-10-07 | Bristol-Meyers Squibb Company | Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors |
US7439246B2 (en) * | 2004-06-28 | 2008-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic kinase inhibitors |
US7173031B2 (en) * | 2004-06-28 | 2007-02-06 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
CN101005843A (zh) * | 2004-06-28 | 2007-07-25 | 布里斯托尔-迈尔斯·斯奎布公司 | 吡咯并三嗪激酶抑制剂 |
TW200600513A (en) | 2004-06-30 | 2006-01-01 | Bristol Myers Squibb Co | A method for preparing pyrrolotriazine compounds |
US7253167B2 (en) * | 2004-06-30 | 2007-08-07 | Bristol-Myers Squibb Company | Tricyclic-heteroaryl compounds useful as kinase inhibitors |
US7102003B2 (en) | 2004-07-01 | 2006-09-05 | Bristol-Myers Squibb Company | Pyrrolotriazine compounds |
SE0401790D0 (sv) * | 2004-07-07 | 2004-07-07 | Forskarpatent I Syd Ab | Tamoxifen response in pre- and postmenopausal breast cancer patients |
US7504521B2 (en) * | 2004-08-05 | 2009-03-17 | Bristol-Myers Squibb Co. | Methods for the preparation of pyrrolotriazine compounds |
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EP1827434B1 (en) | 2004-11-30 | 2014-01-15 | Amgen Inc. | Quinolines and quinazoline analogs and their use as medicaments for treating cancer |
DE102004060659A1 (de) | 2004-12-15 | 2006-07-06 | Lanxess Deutschland Gmbh | Neue substituierte 1H-Pyrrolo[2,3-b]pyridine und deren Herstellung |
US7534882B2 (en) | 2005-04-06 | 2009-05-19 | Bristol-Myers Squibb Company | Method for preparing pyrrolotriazine compounds via in situ amination of pyrroles |
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MXPA03000874A (es) * | 2000-08-09 | 2003-06-06 | Astrazeneca Ab | Compuestos quimicos. |
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CA2429628A1 (en) * | 2000-11-17 | 2002-05-23 | Bristol-Myers Squibb Company | Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors |
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TWI329112B (en) * | 2002-07-19 | 2010-08-21 | Bristol Myers Squibb Co | Novel inhibitors of kinases |
US6951859B2 (en) | 2002-08-02 | 2005-10-04 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
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