PT1622569E - Derivados de aza espiro alcanos como inibidores de metaloproteases - Google Patents

Derivados de aza espiro alcanos como inibidores de metaloproteases Download PDF

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Publication number
PT1622569E
PT1622569E PT47603683T PT04760368T PT1622569E PT 1622569 E PT1622569 E PT 1622569E PT 47603683 T PT47603683 T PT 47603683T PT 04760368 T PT04760368 T PT 04760368T PT 1622569 E PT1622569 E PT 1622569E
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Prior art keywords
metallproteases
inhibitors
alkane derivatives
aza spiro
spiro alkane
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PT47603683T
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English (en)
Inventor
Yao Wenqing
Zhou Jincong
Xu Meizhong
Zhang Fenglei
Metcalf Brian
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Incyte Corp
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Publication of PT1622569E publication Critical patent/PT1622569E/pt

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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/10—Spiro-condensed systems
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AU2004233863B2 (en) 2010-06-17
NZ543102A (en) 2008-12-24
CN101880277A (zh) 2010-11-10
US9801877B2 (en) 2017-10-31
SE531352C8 (sv) 2009-05-19
PL380275A1 (pl) 2007-01-22
SI1622569T1 (sl) 2016-02-29
ES2563304T3 (es) 2016-03-14
RU2379303C2 (ru) 2010-01-20
HUE026904T2 (en) 2016-08-29
EA200701782A3 (ru) 2008-04-28
BRPI0409686A (pt) 2006-07-04
US20110288068A1 (en) 2011-11-24
CO5700719A2 (es) 2006-11-30
IL171480A (en) 2012-03-29
IS2974B (is) 2017-07-15
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US20140187530A1 (en) 2014-07-03
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US7723349B2 (en) 2010-05-25
IS8140A (is) 2005-11-22
AU2004233863A1 (en) 2004-11-11
US8039471B2 (en) 2011-10-18
HK1086494A1 (zh) 2006-09-22
EA200501658A2 (ru) 2006-06-30
ECSP056118A (es) 2006-08-30
EP2617419A1 (en) 2013-07-24
SE0701538L (sv) 2007-06-26
US9403775B2 (en) 2016-08-02
DK1622569T3 (en) 2015-12-14
NO332758B1 (no) 2013-01-07
WO2004096139A2 (en) 2004-11-11
PL1622569T3 (pl) 2016-06-30
EP3020402A1 (en) 2016-05-18
KR101120414B1 (ko) 2012-04-12
CY1117221T1 (el) 2017-04-05
KR20060008918A (ko) 2006-01-27
PL217630B1 (pl) 2014-08-29
US20170035751A1 (en) 2017-02-09
SE529469C2 (sv) 2007-08-14
US8637497B2 (en) 2014-01-28
HRP20160180T1 (hr) 2016-03-25
CA2523426C (en) 2013-02-26
SE0502338L (sv) 2005-12-23
AU2010214762A1 (en) 2010-09-23
US10226459B2 (en) 2019-03-12

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