CY1117221T1 - Παραγωγα αζα σπειρο αλκανιου ως αναστολεις μεταλλοπρωτεασων - Google Patents
Παραγωγα αζα σπειρο αλκανιου ως αναστολεις μεταλλοπρωτεασωνInfo
- Publication number
- CY1117221T1 CY1117221T1 CY20161100165T CY161100165T CY1117221T1 CY 1117221 T1 CY1117221 T1 CY 1117221T1 CY 20161100165 T CY20161100165 T CY 20161100165T CY 161100165 T CY161100165 T CY 161100165T CY 1117221 T1 CY1117221 T1 CY 1117221T1
- Authority
- CY
- Cyprus
- Prior art keywords
- aza
- producer
- suspensions
- spiral
- metal protection
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/10—Spiro-condensed systems
Abstract
Η παρούσα εφεύρεση παρέχει ένωση του Τύπου I ή του Τύπου II: εναντιομερές, διαστερεομερές, προφάρμακο, διαλύτωμα, μεταβολίτη ή φαρμακευτικώς αποδεκτό άλας αυτής, όπου οι συστατικές μεταβλητές παρέχονται στο παρόν. Οι ενώσεις του Τύπου (I) και (II) είναι ρυθμιστές μεταλλοπρωτεασών και είναι χρήσιμες στη θεραπεία ασθενειών που συνδυάζονται με δραστικότητα μεταλλοπρωτεάσης όπως αρθρίτιδας, καρκίνου, καρδιαγγειακών διαταραχών, δερματικών διαταραχών, φλεγμονής και αλλεργικών καταστάσεων.
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EP04760368.3A EP1622569B1 (en) | 2003-04-24 | 2004-04-23 | Aza spiro alkane derivatives as inhibitors of metallproteases |
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FR2854899B1 (fr) | 2003-05-16 | 2006-07-07 | Atofina | Compositions de polymeres thermoplastiques olefiniques et de charges de taille nanometrique sous forme de melanges-maitres |
JP4956191B2 (ja) | 2003-10-17 | 2012-06-20 | インサイト コーポレーション | マトリックスメタロプロテイナーゼの阻害剤としての置換環状ヒドロキサメート |
WO2005117882A2 (en) | 2004-04-20 | 2005-12-15 | Incyte Corporation | Hydroxamic acid derivatives as metalloprotease inhibitors |
US8324194B2 (en) | 2005-11-22 | 2012-12-04 | Incyte Corporation | Combination therapy for the treatment of cancer |
WO2007143600A2 (en) | 2006-06-05 | 2007-12-13 | Incyte Corporation | Sheddase inhibitors combined with cd30-binding immunotherapeutics for the treatment of cd30 positive diseases |
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2004
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2007
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