PL3578560T3 - Związek chinazolinowy - Google Patents

Związek chinazolinowy

Info

Publication number
PL3578560T3
PL3578560T3 PL18747957T PL18747957T PL3578560T3 PL 3578560 T3 PL3578560 T3 PL 3578560T3 PL 18747957 T PL18747957 T PL 18747957T PL 18747957 T PL18747957 T PL 18747957T PL 3578560 T3 PL3578560 T3 PL 3578560T3
Authority
PL
Poland
Prior art keywords
quinazoline compound
quinazoline
compound
Prior art date
Application number
PL18747957T
Other languages
English (en)
Inventor
Kazuyuki Kuramoto
Michinori AKAIWA
Tomoaki Abe
Takanobu Araki
Susumu Yamaki
Shigeki Kunikawa
Tomoyoshi IMAIZUMI
Takahiro Nigawara
Keisuke Arakawa
Itsuro Shimada
Masashi Shimazaki
Yoshiki SATAKE
Kazushi Watanabe
Takanori Koike
Original Assignee
Astellas Pharma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc. filed Critical Astellas Pharma Inc.
Publication of PL3578560T3 publication Critical patent/PL3578560T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10Spiro-condensed systems
PL18747957T 2017-02-02 2018-02-01 Związek chinazolinowy PL3578560T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2017017266 2017-02-02
JP2017143607 2017-07-25
PCT/JP2018/003323 WO2018143315A1 (ja) 2017-02-02 2018-02-01 キナゾリン化合物
EP18747957.1A EP3578560B1 (en) 2017-02-02 2018-02-01 Quinazoline compound

Publications (1)

Publication Number Publication Date
PL3578560T3 true PL3578560T3 (pl) 2022-01-17

Family

ID=63040813

Family Applications (1)

Application Number Title Priority Date Filing Date
PL18747957T PL3578560T3 (pl) 2017-02-02 2018-02-01 Związek chinazolinowy

Country Status (21)

Country Link
US (2) US10556906B2 (pl)
EP (1) EP3578560B1 (pl)
JP (1) JP6587116B2 (pl)
KR (1) KR20190113799A (pl)
CN (1) CN110267957B (pl)
AU (1) AU2018216411A1 (pl)
BR (1) BR112019015364A2 (pl)
CA (1) CA3052125A1 (pl)
CO (1) CO2019008487A2 (pl)
ES (1) ES2899871T3 (pl)
IL (1) IL268190A (pl)
JO (1) JOP20190186A1 (pl)
MA (1) MA47433A (pl)
MX (1) MX2019009187A (pl)
PH (1) PH12019501685A1 (pl)
PL (1) PL3578560T3 (pl)
PT (1) PT3578560T (pl)
RU (1) RU2019123529A (pl)
SG (1) SG11201907038WA (pl)
TW (1) TW201838996A (pl)
WO (1) WO2018143315A1 (pl)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9227978B2 (en) 2013-03-15 2016-01-05 Araxes Pharma Llc Covalent inhibitors of Kras G12C
TWI659021B (zh) 2013-10-10 2019-05-11 亞瑞克西斯製藥公司 Kras g12c之抑制劑
TW201702232A (zh) 2015-04-10 2017-01-16 亞瑞克西斯製藥公司 經取代之喹唑啉化合物及其使用方法
US10858343B2 (en) 2015-09-28 2020-12-08 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
US10882847B2 (en) 2015-09-28 2021-01-05 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
WO2017058807A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
WO2017058915A1 (en) 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
JP7015059B2 (ja) 2015-11-16 2022-02-15 アラクセス ファーマ エルエルシー 置換複素環式基を含む2-置換キナゾリン化合物およびその使用方法
ES2863873T3 (es) 2016-05-18 2021-10-11 Mirati Therapeutics Inc Inhibidores de KRAS G12C
WO2018140514A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc 1-(6-(3-hydroxynaphthalen-1-yl)quinazolin-2-yl)azetidin-1-yl)prop-2-en-1-one derivatives and similar compounds as kras g12c inhibitors for the treatment of cancer
WO2018140513A1 (en) 2017-01-26 2018-08-02 Araxes Pharma Llc 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer
EP3573964A1 (en) 2017-01-26 2019-12-04 Araxes Pharma LLC Benzothiophene and benzothiazole compounds and methods of use thereof
US11274093B2 (en) 2017-01-26 2022-03-15 Araxes Pharma Llc Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
US11059819B2 (en) 2017-01-26 2021-07-13 Janssen Biotech, Inc. Fused hetero-hetero bicyclic compounds and methods of use thereof
US11639346B2 (en) 2017-05-25 2023-05-02 Araxes Pharma Llc Quinazoline derivatives as modulators of mutant KRAS, HRAS or NRAS
CA3063440A1 (en) 2017-05-25 2018-11-29 Araxes Pharma Llc Covalent inhibitors of kras
WO2018218071A1 (en) 2017-05-25 2018-11-29 Araxes Pharma Llc Compounds and methods of use thereof for treatment of cancer
EP3710439B1 (en) 2017-11-15 2023-02-15 Mirati Therapeutics, Inc. Kras g12c inhibitors
US10647715B2 (en) 2017-11-15 2020-05-12 Mirati Therapeutics, Inc. KRas G12C inhibitors
WO2019217307A1 (en) 2018-05-07 2019-11-14 Mirati Therapeutics, Inc. Kras g12c inhibitors
TW202012415A (zh) 2018-05-08 2020-04-01 瑞典商阿斯特捷利康公司 化學化合物
JP2021176820A (ja) * 2018-07-31 2021-11-11 アステラス製薬株式会社 キナゾリン化合物を有効成分とする医薬組成物
JP2021176819A (ja) * 2018-07-31 2021-11-11 アステラス製薬株式会社 キナゾリン化合物を有効成分とする医薬組成物
JP2022505835A (ja) * 2018-10-24 2022-01-14 アラクセス ファーマ エルエルシー 腫瘍転移を阻害するためのg12c変異体krasタンパク質の阻害剤としての2-(2-アクリロイル-2,6-ジアザスピロ[3.4]オクタン-6-イル)-6-(1h-インダゾール-4-イル)-ベンゾニトリル誘導体および関連化合物
US20210395234A1 (en) * 2018-10-26 2021-12-23 Taiho Pharmaceutical Co., Ltd. Novel indazole compound or salt thereof
MX2021005924A (es) * 2018-11-29 2021-06-30 Araxes Pharma Llc Compuestos y metodos de uso de los mismos para el tratamiento del cancer.
EP3908283A4 (en) 2019-01-10 2022-10-12 Mirati Therapeutics, Inc. KRAS G12C INHIBITORS
CN111499634B (zh) * 2019-01-31 2023-05-12 贝达药业股份有限公司 一种喹唑啉化合物及其在医药上的应用
EP3924053A1 (en) 2019-02-12 2021-12-22 Novartis AG Pharmaceutical combination comprising tno155 and a krasg12c inhibitor
WO2020177629A1 (zh) * 2019-03-01 2020-09-10 劲方医药科技(上海)有限公司 螺环取代的嘧啶并环类化合物,其制法与医药上的用途
US20220194959A1 (en) * 2019-04-10 2022-06-23 Medshine Discovery Inc. Crystal form of egfr inhibitor and preparation method thereof
EP3967695B1 (en) * 2019-04-22 2024-01-17 Betta Pharmaceuticals Co., Ltd 1-(7-(quinazolin-4-yl)-2,7-diazaspiro[3.5]nonan-2-yl)prop-2-en-1-one derivatives as kras inhibitors for the treatment of cancer
CA3141604A1 (en) * 2019-05-20 2020-11-26 1200 Pharma Llc Kras g12c inhibitors and uses thereof
CN112110918B (zh) * 2019-06-21 2023-08-22 劲方医药科技(上海)有限公司 螺环取代的嘧啶并环类化合物,其制法与医药上的用途
CN113993860B (zh) * 2019-06-25 2023-08-01 正大天晴药业集团股份有限公司 作为kras g12c突变蛋白抑制剂的七元杂环类衍生物
WO2021031952A1 (zh) * 2019-08-16 2021-02-25 劲方医药科技(上海)有限公司 氧代六元环并嘧啶类化合物,其制法与医药上的用途
JP2022546043A (ja) 2019-08-29 2022-11-02 ミラティ セラピューティクス, インコーポレイテッド Kras g12d阻害剤
KR20220091480A (ko) 2019-09-24 2022-06-30 미라티 테라퓨틱스, 인크. 병용 요법
IL292438A (en) 2019-10-28 2022-06-01 Merck Sharp & Dohme Small molecules that inhibit the g12c mutant of kras
TW202132314A (zh) 2019-11-04 2021-09-01 美商銳新醫藥公司 Ras抑制劑
EP4054719A1 (en) 2019-11-04 2022-09-14 Revolution Medicines, Inc. Ras inhibitors
CA3159559A1 (en) 2019-11-04 2021-05-14 Revolution Medicines, Inc. Ras inhibitors
CN112851663B (zh) * 2019-11-12 2023-07-18 博瑞生物医药(苏州)股份有限公司 一种并杂环化合物及其用途
CN114630832A (zh) * 2019-11-15 2022-06-14 四川海思科制药有限公司 一种嘧啶并环衍生物及其在医药上的应用
JP2023505100A (ja) 2019-11-27 2023-02-08 レボリューション メディシンズ インコーポレイテッド 共有ras阻害剤及びその使用
WO2021106231A1 (en) * 2019-11-29 2021-06-03 Taiho Pharmaceutical Co., Ltd. A compound having inhibitory activity against kras g12d mutation
WO2021120890A1 (en) 2019-12-20 2021-06-24 Novartis Ag Pyrazolyl derivatives useful as anti-cancer agents
IL294048A (en) 2019-12-20 2022-08-01 Mirati Therapeutics Inc sos1 inhibitors
EP4083042A1 (en) 2019-12-27 2022-11-02 Wigen Biomedicine Technology (Shanghai) Co., Ltd. Spiro ring-containing quinazoline compound
GB202001344D0 (en) 2020-01-31 2020-03-18 Redx Pharma Plc Ras Inhibitors
WO2021169963A1 (zh) * 2020-02-24 2021-09-02 上海喆邺生物科技有限公司 芳香类化合物及其在制备抗肿瘤药物中的应用
TW202140450A (zh) * 2020-02-24 2021-11-01 大陸商泰勵生物科技(上海)有限公司 用於癌症治療的kras抑制劑
WO2021190467A1 (zh) 2020-03-25 2021-09-30 微境生物医药科技(上海)有限公司 含螺环的喹唑啉化合物
CN115697994A (zh) * 2020-06-10 2023-02-03 江苏恒瑞医药股份有限公司 稠合喹唑啉类衍生物、其制备方法及其在医药上的应用
CN115916194A (zh) 2020-06-18 2023-04-04 锐新医药公司 用于延迟、预防和治疗针对ras抑制剂的获得性抗性的方法
AU2021344830A1 (en) 2020-09-03 2023-04-06 Revolution Medicines, Inc. Use of SOS1 inhibitors to treat malignancies with SHP2 mutations
KR20230067635A (ko) 2020-09-15 2023-05-16 레볼루션 메디슨즈, 인크. 암의 치료에서 ras 억제제로서 인돌 유도체
CN116390728B (zh) * 2020-09-27 2024-03-29 微境生物医药科技(上海)有限公司 喹唑啉衍生物及其制备方法和用途
CN116323624A (zh) * 2020-09-30 2023-06-23 上海医药集团股份有限公司 一种喹唑啉类化合物及其应用
WO2022083616A1 (zh) * 2020-10-21 2022-04-28 贝达药业股份有限公司 一种喹唑啉化合物及其药物组合物
CN112341351B (zh) * 2020-10-27 2022-03-11 无锡双启科技有限公司 一种2-氨基-4-溴-3-氟-5-碘苯甲酰胺的制备方法
WO2022105855A1 (en) * 2020-11-20 2022-05-27 Jacobio Pharmaceuticals Co., Ltd. Kras g12d inhibitors
CN115803328A (zh) * 2020-11-24 2023-03-14 成都百裕制药股份有限公司 哌嗪-2,3-二酮衍生物及其在医药上的应用
WO2022140246A1 (en) 2020-12-21 2022-06-30 Hangzhou Jijing Pharmaceutical Technology Limited Methods and compounds for targeted autophagy
CN116648452A (zh) * 2020-12-22 2023-08-25 上海科州药物研发有限公司 作为kras抑制剂的杂环化合物的制备及其应用方法
WO2022152313A1 (zh) * 2021-01-18 2022-07-21 成都百裕制药股份有限公司 嘧啶衍生物及其在医药上的应用
CN116783194A (zh) * 2021-02-09 2023-09-19 微境生物医药科技(上海)有限公司 含螺环的喹唑啉衍生物
KR20230136636A (ko) * 2021-02-09 2023-09-26 메드샤인 디스커버리 아이엔씨. 피리미딘 방향족 환 화합물
WO2022173032A1 (ja) * 2021-02-15 2022-08-18 アステラス製薬株式会社 G12d変異krasタンパクの分解を誘導するためのキナゾリン化合物
WO2022173033A1 (ja) * 2021-02-15 2022-08-18 アステラス製薬株式会社 4-アミノキナゾリン化合物
CN115124524A (zh) * 2021-03-26 2022-09-30 浙江海正药业股份有限公司 三环类衍生物及其制备方法和用途
EP4329749A1 (en) * 2021-04-27 2024-03-06 Merck Sharp & Dohme LLC Small molecule inhibitors of kras g12c mutant
WO2022235870A1 (en) 2021-05-05 2022-11-10 Revolution Medicines, Inc. Ras inhibitors for the treatment of cancer
CR20230570A (es) 2021-05-05 2024-01-22 Revolution Medicines Inc Inhibidores de ras
WO2022247760A1 (zh) * 2021-05-22 2022-12-01 上海科州药物研发有限公司 作为kras抑制剂的杂环化合物,及其制备和治疗用途
WO2022247770A1 (zh) * 2021-05-24 2022-12-01 上海璎黎药业有限公司 一种含氮杂环化合物、其制备方法及应用
WO2022266206A1 (en) 2021-06-16 2022-12-22 Erasca, Inc. Kras inhibitor conjugates
TW202317100A (zh) 2021-06-23 2023-05-01 瑞士商諾華公司 包含kras g12c抑制劑的藥物組合及其用於治療癌症之用途
CN117677398A (zh) 2021-07-27 2024-03-08 东丽株式会社 用于癌的治疗和/或预防的药品
CA3224341A1 (en) 2021-09-01 2023-03-09 Novartis Ag Pharmaceutical combinations comprising a tead inhibitor and uses thereof for the treatment of cancers
WO2023040989A1 (en) * 2021-09-16 2023-03-23 Suzhou Zanrong Pharma Limited Kras g12c inhibitors and uses thereof
AR127308A1 (es) 2021-10-08 2024-01-10 Revolution Medicines Inc Inhibidores ras
TW202340214A (zh) 2021-12-17 2023-10-16 美商健臻公司 做為shp2抑制劑之吡唑并吡𠯤化合物
WO2023122723A1 (en) 2021-12-23 2023-06-29 The Broad Institute, Inc. Panels and methods for diagnosing and treating lung cancer
WO2023119677A1 (en) * 2021-12-24 2023-06-29 Astellas Pharma Inc. Pharmaceutical composition comprising a quinazoline compound
EP4227307A1 (en) 2022-02-11 2023-08-16 Genzyme Corporation Pyrazolopyrazine compounds as shp2 inhibitors
WO2023172940A1 (en) 2022-03-08 2023-09-14 Revolution Medicines, Inc. Methods for treating immune refractory lung cancer
TW202346270A (zh) * 2022-03-11 2023-12-01 日商安斯泰來製藥股份有限公司 用於誘發g12d突變kras蛋白分解之雜環化合物
WO2023199180A1 (en) 2022-04-11 2023-10-19 Novartis Ag Therapeutic uses of a krasg12c inhibitor
WO2023205701A1 (en) 2022-04-20 2023-10-26 Kumquat Biosciences Inc. Macrocyclic heterocycles and uses thereof
WO2023240263A1 (en) 2022-06-10 2023-12-14 Revolution Medicines, Inc. Macrocyclic ras inhibitors
WO2024029613A1 (ja) * 2022-08-05 2024-02-08 アステラス製薬株式会社 変異krasタンパクの分解を誘導するための複素環化合物
WO2024034593A1 (ja) * 2022-08-09 2024-02-15 アステラス製薬株式会社 G12v変異krasタンパクの分解を誘導するための複素環化合物
WO2024034123A1 (ja) * 2022-08-12 2024-02-15 アステラス製薬株式会社 複素環化合物を含む医薬組成物
GB202212641D0 (en) 2022-08-31 2022-10-12 Jazz Pharmaceuticals Ireland Ltd Novel compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2836482B1 (en) * 2012-04-10 2019-12-25 The Regents of The University of California Compositions and methods for treating cancer
KR20160076519A (ko) 2013-10-10 2016-06-30 아락세스 파마 엘엘씨 Kras g12c 억제제
TW201702232A (zh) 2015-04-10 2017-01-16 亞瑞克西斯製藥公司 經取代之喹唑啉化合物及其使用方法
JP7015059B2 (ja) 2015-11-16 2022-02-15 アラクセス ファーマ エルエルシー 置換複素環式基を含む2-置換キナゾリン化合物およびその使用方法

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Publication number Publication date
SG11201907038WA (en) 2019-08-27
JOP20190186A1 (ar) 2019-08-01
EP3578560A1 (en) 2019-12-11
EP3578560A4 (en) 2020-10-21
JPWO2018143315A1 (ja) 2019-08-08
MX2019009187A (es) 2019-09-26
CN110267957B (zh) 2022-04-26
BR112019015364A2 (pt) 2020-03-10
CO2019008487A2 (es) 2019-08-20
US20190292182A1 (en) 2019-09-26
KR20190113799A (ko) 2019-10-08
CN110267957A (zh) 2019-09-20
US10556906B2 (en) 2020-02-11
ES2899871T3 (es) 2022-03-15
EP3578560B1 (en) 2021-11-10
PT3578560T (pt) 2021-12-13
MA47433A (fr) 2019-12-11
AU2018216411A1 (en) 2019-08-15
US10774082B2 (en) 2020-09-15
TW201838996A (zh) 2018-11-01
IL268190A (en) 2019-10-31
US20200140437A1 (en) 2020-05-07
JP6587116B2 (ja) 2019-10-09
RU2019123529A (ru) 2021-03-02
CA3052125A1 (en) 2018-08-09
WO2018143315A1 (ja) 2018-08-09
PH12019501685A1 (en) 2020-06-01

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