PL208283B1 - Pochodna indolinonu, sposób jej wytwarzania, jej zastosowanie, kompozycja farmaceutyczna ją zawierająca i zastosowanie tej kompozycji - Google Patents

Pochodna indolinonu, sposób jej wytwarzania, jej zastosowanie, kompozycja farmaceutyczna ją zawierająca i zastosowanie tej kompozycji

Info

Publication number: PL208283B1
Authority: PL; Poland
Prior art keywords: compound; formula; dimethyl; pyrrol; dihydroindol
Prior art date: 2001-12-27

Application number

PL369602A

Other languages

English (en)

Polish (pl)

Other versions

PL369602A1 (en

Inventor

John H. Griffin

Roger Briesewitz

Jonathan W. Wray

Original Assignee

Theravance

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-27

Filing date

2002-12-20

Publication date

2011-04-29

2002-12-20 Application filed by Theravance filed Critical Theravance

2005-05-02 Publication of PL369602A1 publication Critical patent/PL369602A1/xx

2011-04-29 Publication of PL208283B1 publication Critical patent/PL208283B1/pl

Links

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229910052739 hydrogen Inorganic materials 0.000 claims description 13
239000001257 hydrogen Substances 0.000 claims description 12
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KVIAIJLTPHXNEB-UHFFFAOYSA-N 3-[[3,5-dimethyl-4-(3-oxo-3-piperazin-1-ylpropyl)-1h-pyrrol-2-yl]methylidene]-1h-indol-2-one Chemical compound CC=1NC(C=C2C3=CC=CC=C3NC2=O)=C(C)C=1CCC(=O)N1CCNCC1 KVIAIJLTPHXNEB-UHFFFAOYSA-N 0.000 claims description 8
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125000004433 nitrogen atom Chemical group N* 0.000 claims description 3
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Cardiology (AREA)
Oncology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)
Peptides Or Proteins (AREA)
Investigating Or Analysing Biological Materials (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

PL369602A 2001-12-27 2002-12-20 Pochodna indolinonu, sposób jej wytwarzania, jej zastosowanie, kompozycja farmaceutyczna ją zawierająca i zastosowanie tej kompozycji PL208283B1 (pl)

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US34374601P	2001-12-27	2001-12-27
US34381301P	2001-12-27	2001-12-27

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US (3)	US6686362B2 (ko)
EP (1)	EP1458713B1 (ko)
JP (1)	JP4363985B2 (ko)
KR (1)	KR100965519B1 (ko)
CN (1)	CN1290844C (ko)
AT (1)	ATE302771T1 (ko)
AU (1)	AU2002360753B2 (ko)
BR (1)	BR0215360A (ko)
CA (1)	CA2470480C (ko)
CO (1)	CO5611126A2 (ko)
DE (1)	DE60205776T2 (ko)
DK (1)	DK1458713T3 (ko)
ES (1)	ES2247411T3 (ko)
HK (1)	HK1068886A1 (ko)
HU (1)	HUP0500111A3 (ko)
IL (1)	IL162203A0 (ko)
MX (1)	MXPA04006271A (ko)
NO (1)	NO327550B1 (ko)
NZ (1)	NZ533219A (ko)
PL (1)	PL208283B1 (ko)
RU (1)	RU2316554C2 (ko)
WO (1)	WO2003057690A1 (ko)

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US7195876B2 (en) *	2002-08-09	2007-03-27	Theravance, Inc.	Oncokinase fusion polypeptides associated with hyperproliferative and related disorders, nucleic acids encoding the same and methods for detecting and identifying the same
US7105563B2 (en) *	2003-10-24	2006-09-12	Schering Aktiengesellschaft	Indolinone derivatives and their use in treating disease-states such as cancer
US20050171182A1 (en) *	2003-12-11	2005-08-04	Roger Briesewitz	Methods and compositions for use in the treatment of mutant receptor tyrosine kinase driven cellular proliferative diseases
SE0401790D0 (sv) *	2004-07-07	2004-07-07	Forskarpatent I Syd Ab	Tamoxifen response in pre- and postmenopausal breast cancer patients
US20060281788A1 (en)	2005-06-10	2006-12-14	Baumann Christian A	Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor
US8071768B2 (en)	2005-06-10	2011-12-06	Janssen Pharmaceutica, N.V.	Alkylquinoline and alkylquinazoline kinase modulators
US7825244B2 (en)	2005-06-10	2010-11-02	Janssen Pharmaceutica Nv	Intermediates useful in the synthesis of alkylquinoline and alkylquinazoline kinase modulators, and related methods of synthesis
JP2009511628A (ja)	2005-10-18	2009-03-19	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	Ｆｌｔ３キナーゼの阻害方法
US7414050B2 (en)	2006-04-20	2008-08-19	Janssen Pharmaceutica, N.V.	Inhibitors of c-fms kinase
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US6686362B2 (en)	2004-02-03
CO5611126A2 (es)	2006-02-28
DE60205776D1 (en)	2005-09-29
ATE302771T1 (de)	2005-09-15
US20040198804A1 (en)	2004-10-07
DK1458713T3 (da)	2005-10-31
US7223783B2 (en)	2007-05-29
JP2005514420A (ja)	2005-05-19
ES2247411T3 (es)	2006-03-01
US20030171378A1 (en)	2003-09-11
NO20042926L (no)	2004-07-08
CN1608063A (zh)	2005-04-20
WO2003057690A1 (en)	2003-07-17
JP4363985B2 (ja)	2009-11-11
NZ533219A (en)	2005-10-28
RU2316554C2 (ru)	2008-02-10
DE60205776T2 (de)	2006-06-14
EP1458713B1 (en)	2005-08-24
PL369602A1 (en)	2005-05-02
KR100965519B1 (ko)	2010-06-23
IL162203A0 (en)	2005-11-20
HUP0500111A2 (hu)	2005-07-28
KR20040070283A (ko)	2004-08-06
HK1068886A1 (en)	2005-05-06
AU2002360753B2 (en)	2008-08-21
BR0215360A (pt)	2004-12-14
US7060703B2 (en)	2006-06-13
CA2470480A1 (en)	2003-07-17
HUP0500111A3 (en)	2009-10-28
RU2004122918A (ru)	2005-03-27
EP1458713A1 (en)	2004-09-22
AU2002360753A1 (en)	2003-07-24
CN1290844C (zh)	2006-12-20
MXPA04006271A (es)	2004-10-04
CA2470480C (en)	2010-12-14
NO327550B1 (no)	2009-08-10
US20060142281A1 (en)	2006-06-29

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