PL1838718T3 - Pirolopirazole, silne inhibitory kinazy - Google Patents

Pirolopirazole, silne inhibitory kinazy

Info

Publication number: PL1838718T3
Authority: PL; Poland
Prior art keywords: pyrrolopyrazoles; kinase inhibitors; potent kinase; potent; inhibitors
Prior art date: 2005-01-10

Application number

PL05850734T

Other languages

English (en)

Inventor

Djamal Bouzida

Liming Dong

Chuangxing Guo

Yufeng Hong

Haitao Li

Joseph T Marakovits

Anle Yang

Junhu Zhang

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-01-10

Filing date

2005-12-28

Publication date

2011-10-31

2005-12-28 Application filed by Pfizer filed Critical Pfizer

2011-10-31 Publication of PL1838718T3 publication Critical patent/PL1838718T3/pl

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

PL05850734T 2005-01-10 2005-12-28 Pirolopirazole, silne inhibitory kinazy PL1838718T3 (pl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US64290005P	2005-01-10	2005-01-10
US73377005P	2005-11-04	2005-11-04
EP05850734A EP1838718B1 (en)	2005-01-10	2005-12-28	Pyrrolopyrazoles, potent kinase inhibitors
PCT/IB2005/003975 WO2006072831A1 (en)	2005-01-10	2005-12-28	Pyrrolopyrazoles, potent kinase inhibitors

Publications (1)

Publication Number	Publication Date
PL1838718T3 true PL1838718T3 (pl)	2011-10-31

Family

ID=36463340

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL05850734T PL1838718T3 (pl)	2005-01-10	2005-12-28	Pirolopirazole, silne inhibitory kinazy

Country Status (30)

Country	Link
US (2)	US8067591B2 (pl)
EP (1)	EP1838718B1 (pl)
JP (1)	JP4250195B2 (pl)
KR (1)	KR100919343B1 (pl)
CN (1)	CN101115760B (pl)
AP (1)	AP2007004061A0 (pl)
AT (1)	ATE512972T1 (pl)
AU (1)	AU2005323797B2 (pl)
BR (1)	BRPI0518509A2 (pl)
CA (1)	CA2593428C (pl)
CU (1)	CU23778B7 (pl)
CY (1)	CY1111752T1 (pl)
DK (1)	DK1838718T3 (pl)
EA (1)	EA011815B1 (pl)
ES (1)	ES2365245T3 (pl)
GE (1)	GEP20094785B (pl)
HK (1)	HK1114380A1 (pl)
HR (1)	HRP20110485T1 (pl)
IL (1)	IL184275A0 (pl)
MA (1)	MA29141B1 (pl)
MX (1)	MX2007008385A (pl)
NO (1)	NO20073859L (pl)
NZ (1)	NZ556273A (pl)
PL (1)	PL1838718T3 (pl)
PT (1)	PT1838718E (pl)
RS (1)	RS51891B (pl)
SI (1)	SI1838718T1 (pl)
TN (1)	TNSN07254A1 (pl)
WO (1)	WO2006072831A1 (pl)
ZA (1)	ZA200705628B (pl)

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AP2369A (en)	2005-12-21	2012-02-29	Pfizer Prod Inc	Carbonylamino pyrrolopyrazoles, potent kinase inhibitors.
CN101646673B (zh) *	2007-02-07	2014-06-25	辉瑞大药厂	作为pkc抑制剂的3-氨基-吡咯并[3,4-c]吡唑-5(1h,4h,6h)甲醛衍生物
MX2009008546A (es)	2007-02-07	2009-10-08	Pfizer	Derivados de 3-amino-pirrolo[3,4-c]pirazol-5(1h,4h,6h)carbaldehido como inhibidores de la proteina quinasa c.
JP5404601B2 (ja)	2007-04-12	2014-02-05	ファイザー・インク	新規な３−アミド−ピロロ［３，４−ｃ］ピラゾール−５（１Ｈ，４Ｈ，６Ｈ）カルバルデヒド誘導体
EP2175933B1 (en) *	2007-07-25	2012-08-22	Bristol-Myers Squibb Company	Triazine kinase inhibitors
FR2928150A1 (fr)	2008-02-29	2009-09-04	Vetoquinol Sa Sa	Nouveaux derives 7-substitues de 3-carboxy-oxadiazino-quinolones, leur preparation et leur application comme anti-bacteriens
JPWO2009130900A1 (ja) *	2008-04-24	2011-08-11	日本曹達株式会社	オキシム誘導体、中間体化合物および植物病害防除剤
EP2145891A1 (en)	2008-07-09	2010-01-20	Vetoquinol S.A.	9-substituted-5-carboxy-oxadiazino-quinolone derivatives, their preparation and their application as anti-bacterials
EP2485727A4 (en) *	2009-10-06	2013-05-01	Afraxis Inc	PYRROLOPYRAZOLE FOR THE TREATMENT OF CNS DISEASES
KR101483215B1 (ko) *	2010-01-29	2015-01-16	한미약품 주식회사	단백질 키나아제 저해활성을 갖는 비시클릭 헤테로아릴 유도체
RU2013126036A (ru)	2010-11-17	2014-12-27	Ф. Хоффманн-Ля Рош Аг	Способ лечения опухолей
CA2842190A1 (en)	2011-07-19	2013-01-24	Infinity Pharmaceuticals Inc.	Heterocyclic compounds and uses thereof
EP2809659A1 (en)	2012-02-03	2014-12-10	Basf Se	Fungicidal pyrimidine compounds
WO2013113778A1 (en)	2012-02-03	2013-08-08	Basf Se	Fungicidal pyrimidine compounds
WO2013113773A1 (en)	2012-02-03	2013-08-08	Basf Se	Fungicidal pyrimidine compounds
WO2013113776A1 (en)	2012-02-03	2013-08-08	Basf Se	Fungicidal pyrimidine compounds
JP2015511940A (ja)	2012-02-03	2015-04-23	ビーエーエスエフソシエタス・ヨーロピアＢａｓｆＳｅ	殺菌性ピリミジン化合物
WO2013113782A1 (en)	2012-02-03	2013-08-08	Basf Se	Fungicidal pyrimidine compounds
WO2013113781A1 (en)	2012-02-03	2013-08-08	Basf Se	Fungicidal pyrimidine compounds i
WO2013113716A1 (en)	2012-02-03	2013-08-08	Basf Se	Fungicidal pyrimidine compounds
WO2013113788A1 (en)	2012-02-03	2013-08-08	Basf Se	Fungicidal pyrimidine compounds
WO2013113720A1 (en)	2012-02-03	2013-08-08	Basf Se	Fungicidal pyrimidine compounds
WO2013113719A1 (en)	2012-02-03	2013-08-08	Basf Se	Fungicidal pyrimidine compounds ii
US9462809B2 (en)	2012-03-13	2016-10-11	Basf Se	Fungicidal pyrimidine compounds
WO2013135672A1 (en)	2012-03-13	2013-09-19	Basf Se	Fungicidal pyrimidine compounds
WO2013135745A1 (en)	2012-03-16	2013-09-19	F. Hoffmann-La Roche Ag	Methods of treating melanoma with pak1 inhibitors
CN104640865B (zh)	2012-09-19	2018-05-11	诺华股份有限公司	作为激酶抑制剂的二氢吡咯烷子基-嘧啶
ES2615743T3 (es) *	2012-10-15	2017-06-08	Pfizer Ireland Pharmaceuticals	Procedimiento de preparación de voriconazol y análogos de los mismos
WO2015036059A1 (en)	2013-09-16	2015-03-19	Basf Se	Fungicidal pyrimidine compounds
CN105722833A (zh)	2013-09-16	2016-06-29	巴斯夫欧洲公司	杀真菌的嘧啶化合物
RU2765718C1 (ru) *	2015-06-15	2022-02-02	Убе Индастриз, Лтд.	Замещенное производное дигидропирролопиразола
CN104926735A (zh) *	2015-06-16	2015-09-23	上海合全药物研发有限公司	4-氯-5-氟-2-甲基嘧啶的工业化制备方法
CA3008171A1 (en)	2015-12-22	2017-06-29	SHY Therapeutics LLC	Compounds for the treatment of cancer and inflammatory disease
WO2017144546A1 (en)	2016-02-23	2017-08-31	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and pharmaceutical compositions for the treatment of nasopharyngeal carcinoma
CA3041563C (en)	2016-11-22	2023-10-31	Dana-Farber Cancer Institute, Inc.	Pyrimidin-2-amine derivatives and pharmaceutical compositions thereof useful as inhibitors of cyclin-dependent kinase 12 (cdk12)
IL310023A (en)	2017-06-21	2024-03-01	SHY Therapeutics LLC	Compounds interacting with the RAS superfamily for the treatment of cancer, inflammation, RAS pathology and fibrotic diseases
US20210161943A1 (en) *	2018-04-16	2021-06-03	The Regents Of The University Of California	Pak4 inhibitors and methods of use
EP3956446A1 (en)	2019-04-17	2022-02-23	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and compositions for treatment of nlrp3 inflammasome mediated il-1beta dependent disorders
WO2021198511A1 (en)	2020-04-03	2021-10-07	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and compositions for treatment of sars-cov-2 infection
CN111454278B (zh) *	2020-05-15	2021-03-19	四川大学	Pak1抑制剂及其合成和在制备抗肿瘤药物中的应用
WO2022008597A1 (en)	2020-07-08	2022-01-13	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and pharmaceutical composition for the treatment of infectious diseases
JP2024507433A (ja) *	2020-12-31	2024-02-20	シノハブファーマシューティカルズカンパニーリミテッド	プラスミン阻害剤、そのための調製方法及びその応用

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US3526633A (en)	1968-03-06	1970-09-01	American Cyanamid Co	Substituted 2,4,5,6-tetrahydropyrrolo(3,4-c)pyrazoles
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JPS5163193A (ja)	1974-11-26	1976-06-01	Yoshitomi Pharmaceutical	Tetorahidoropirazoropirijinkagobutsuno seizoho
US6013500A (en)	1998-05-21	2000-01-11	The Trustees Of Columbia University In The City Of New York	PAK4, a novel gene encoding a serine/threonine kinase
EA006381B1 (ru)	2000-08-10	2005-12-29	Фармация Италия С.П.А.	Бициклопиразолы, активные в качестве ингибиторов киназы, способ их получения и включающие их фармацевтические композиции
JP2005537290A (ja) *	2002-07-25	2005-12-08	ファルマシア・イタリア・エス・ピー・エー	キナーゼ阻害剤として活性なビシクロピラゾール類、その製造方法、およびそれを含有する薬学的組成物
UA81790C2 (uk)	2002-12-19	2008-02-11	Фармация Италия С.П.А.	Заміщені піролопіразольні похідні як інгібітори кінази
US7141568B2 (en)	2003-07-09	2006-11-28	Pfizer Italia S.R.L.	Pyrrolo[3,4-c]pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them

2005
- 2005-12-28 CA CA2593428A patent/CA2593428C/en not_active Expired - Fee Related
- 2005-12-28 DK DK05850734.4T patent/DK1838718T3/da active
- 2005-12-28 SI SI200531320T patent/SI1838718T1/sl unknown
- 2005-12-28 GE GEAP200510173A patent/GEP20094785B/en unknown
- 2005-12-28 PL PL05850734T patent/PL1838718T3/pl unknown
- 2005-12-28 KR KR1020077018110A patent/KR100919343B1/ko not_active IP Right Cessation
- 2005-12-28 PT PT05850734T patent/PT1838718E/pt unknown
- 2005-12-28 EA EA200701257A patent/EA011815B1/ru not_active IP Right Cessation
- 2005-12-28 ES ES05850734T patent/ES2365245T3/es active Active
- 2005-12-28 US US11/813,658 patent/US8067591B2/en not_active Expired - Fee Related
- 2005-12-28 AP AP2007004061A patent/AP2007004061A0/xx unknown
- 2005-12-28 NZ NZ556273A patent/NZ556273A/en not_active IP Right Cessation
- 2005-12-28 BR BRPI0518509-2A patent/BRPI0518509A2/pt not_active Application Discontinuation
- 2005-12-28 EP EP05850734A patent/EP1838718B1/en active Active
- 2005-12-28 RS RS20110352A patent/RS51891B/en unknown
- 2005-12-28 MX MX2007008385A patent/MX2007008385A/es active IP Right Grant
- 2005-12-28 CN CN2005800480012A patent/CN101115760B/zh not_active Expired - Fee Related
- 2005-12-28 AT AT05850734T patent/ATE512972T1/de active
- 2005-12-28 AU AU2005323797A patent/AU2005323797B2/en not_active Ceased
- 2005-12-28 JP JP2007549962A patent/JP4250195B2/ja not_active Expired - Fee Related
- 2005-12-28 WO PCT/IB2005/003975 patent/WO2006072831A1/en active Application Filing
2007
- 2007-06-28 IL IL184275A patent/IL184275A0/en unknown
- 2007-07-04 TN TNP2007000254A patent/TNSN07254A1/en unknown
- 2007-07-09 CU CU20070160A patent/CU23778B7/es not_active IP Right Cessation
- 2007-07-09 ZA ZA200705628A patent/ZA200705628B/xx unknown
- 2007-07-10 MA MA30059A patent/MA29141B1/fr unknown
- 2007-07-23 NO NO20073859A patent/NO20073859L/no not_active Application Discontinuation
2008
- 2008-03-19 HK HK08103173.5A patent/HK1114380A1/xx not_active IP Right Cessation
2011
- 2011-06-30 HR HR20110485T patent/HRP20110485T1/hr unknown
- 2011-07-20 CY CY20111100716T patent/CY1111752T1/el unknown
- 2011-10-06 US US13/267,302 patent/US8530652B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU2005323797A1 (en)	2006-07-13
US20120264751A1 (en)	2012-10-18
AU2005323797B2 (en)	2009-07-09
HRP20110485T1 (hr)	2011-07-31
NZ556273A (en)	2010-01-29
AP2007004061A0 (en)	2007-08-31
EA200701257A1 (ru)	2007-12-28
US8530652B2 (en)	2013-09-10
US8067591B2 (en)	2011-11-29
TNSN07254A1 (en)	2008-12-31
KR100919343B1 (ko)	2009-09-25
NO20073859L (no)	2007-10-03
EP1838718A1 (en)	2007-10-03
BRPI0518509A2 (pt)	2008-11-25
CA2593428A1 (en)	2006-07-13
CN101115760A (zh)	2008-01-30
CU23778B7 (es)	2012-02-15
KR20070096007A (ko)	2007-10-01
MA29141B1 (fr)	2008-01-02
HK1114380A1 (en)	2008-10-31
EA011815B1 (ru)	2009-06-30
ATE512972T1 (de)	2011-07-15
CU20070160A7 (es)	2009-03-16
EP1838718B1 (en)	2011-06-15
IL184275A0 (en)	2007-10-31
US20100222342A1 (en)	2010-09-02
ES2365245T3 (es)	2011-09-27
SI1838718T1 (sl)	2011-08-31
MX2007008385A (es)	2007-08-21
JP4250195B2 (ja)	2009-04-08
DK1838718T3 (da)	2011-07-25
CN101115760B (zh)	2010-11-03
RS51891B (en)	2012-02-29
ZA200705628B (en)	2008-11-26
GEP20094785B (en)	2009-09-25
CY1111752T1 (el)	2015-10-07
CA2593428C (en)	2012-04-17
JP2008526826A (ja)	2008-07-24
PT1838718E (pt)	2011-08-17
WO2006072831A1 (en)	2006-07-13

Publication	Publication Date	Title
AP2007004061A0 (en)	2007-08-31	Pyrrolopyrazoles, potent kinase inhibitors
AP2369A (en)	2012-02-29	Carbonylamino pyrrolopyrazoles, potent kinase inhibitors.
IL190078A0 (en)	2008-08-07	Kinase inhibitors
TWI370127B (en)	2012-08-11	Pyrazolylaminopyridine derivatives useful as kinase inhibitors
GB2424882B (en)	2008-08-06	Selective kinase inhibitors
SI2270008T1 (sl)	2013-01-31	8-heteroaril-3-alkil-1,3-dihidro-imidazo(4,5-c)kinolin-2-oni kot inhibitorji PI-3 kinaz
ZA200606683B (en)	2008-01-30	Pyrazolotriazines as kinase inhibitors
HK1117523A1 (en)	2009-01-16	Substituted benzimidazoles as kinase inhibitors
PL1943243T3 (pl)	2011-05-31	Inhibitory kinazy
IL183276A0 (en)	2007-10-31	Kinase inhibitors
EP1968581A4 (en)	2009-05-27	TETRACYCLIC KINASE INHIBITORS
HK1100141A1 (en)	2007-09-07	Kinase inhibitors
ZA200805028B (en)	2009-12-30	Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor Xla inhibitors
ZA200804667B (en)	2010-05-26	Carbonylamino pyrrolopyrazoles, potent kinase inhibitors
ZA200803287B (en)	2009-10-28	Kinase inhibitors
IL189985A0 (en)	2008-08-07	Kinase inhibitors
ZA200706212B (en)	2008-06-25	Pyrazolylaminopyridine derivatives useful as kinase inhibitors
EP1940411A4 (en)	2008-10-29	MACROHETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS