PE20191546A1 - Moleculas de union antigeno biespecificas que comprenden el clon 20h4.9 anti-41bb - Google Patents
Moleculas de union antigeno biespecificas que comprenden el clon 20h4.9 anti-41bbInfo
- Publication number
- PE20191546A1 PE20191546A1 PE2019001290A PE2019001290A PE20191546A1 PE 20191546 A1 PE20191546 A1 PE 20191546A1 PE 2019001290 A PE2019001290 A PE 2019001290A PE 2019001290 A PE2019001290 A PE 2019001290A PE 20191546 A1 PE20191546 A1 PE 20191546A1
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- Prior art keywords
- cdr
- seq
- binding
- antigen
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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- G—PHYSICS
- G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
- G09G—ARRANGEMENTS OR CIRCUITS FOR CONTROL OF INDICATING DEVICES USING STATIC MEANS TO PRESENT VARIABLE INFORMATION
- G09G5/00—Control arrangements or circuits for visual indicators common to cathode-ray tube indicators and other visual indicators
- G09G5/36—Control arrangements or circuits for visual indicators common to cathode-ray tube indicators and other visual indicators characterised by the display of a graphic pattern, e.g. using an all-points-addressable [APA] memory
- G09G5/37—Details of the operation on graphic patterns
- G09G5/377—Details of the operation on graphic patterns for mixing or overlaying two or more graphic patterns
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- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
- H04N9/00—Details of colour television systems
- H04N9/12—Picture reproducers
- H04N9/31—Projection devices for colour picture display, e.g. using electronic spatial light modulators [ESLM]
- H04N9/3102—Projection devices for colour picture display, e.g. using electronic spatial light modulators [ESLM] using two-dimensional electronic spatial light modulators
- H04N9/312—Driving therefor
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- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
- H04N9/00—Details of colour television systems
- H04N9/12—Picture reproducers
- H04N9/31—Projection devices for colour picture display, e.g. using electronic spatial light modulators [ESLM]
- H04N9/3179—Video signal processing therefor
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- G—PHYSICS
- G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
- G09G—ARRANGEMENTS OR CIRCUITS FOR CONTROL OF INDICATING DEVICES USING STATIC MEANS TO PRESENT VARIABLE INFORMATION
- G09G2320/00—Control of display operating conditions
- G09G2320/02—Improving the quality of display appearance
- G09G2320/0257—Reduction of after-image effects
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- G—PHYSICS
- G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
- G09G—ARRANGEMENTS OR CIRCUITS FOR CONTROL OF INDICATING DEVICES USING STATIC MEANS TO PRESENT VARIABLE INFORMATION
- G09G2320/00—Control of display operating conditions
- G09G2320/04—Maintaining the quality of display appearance
- G09G2320/043—Preventing or counteracting the effects of ageing
- G09G2320/046—Dealing with screen burn-in prevention or compensation of the effects thereof
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- G—PHYSICS
- G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
- G09G—ARRANGEMENTS OR CIRCUITS FOR CONTROL OF INDICATING DEVICES USING STATIC MEANS TO PRESENT VARIABLE INFORMATION
- G09G2320/00—Control of display operating conditions
- G09G2320/04—Maintaining the quality of display appearance
- G09G2320/043—Preventing or counteracting the effects of ageing
- G09G2320/048—Preventing or counteracting the effects of ageing using evaluation of the usage time
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- G—PHYSICS
- G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
- G09G—ARRANGEMENTS OR CIRCUITS FOR CONTROL OF INDICATING DEVICES USING STATIC MEANS TO PRESENT VARIABLE INFORMATION
- G09G2320/00—Control of display operating conditions
- G09G2320/06—Adjustment of display parameters
- G09G2320/0606—Manual adjustment
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- G—PHYSICS
- G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
- G09G—ARRANGEMENTS OR CIRCUITS FOR CONTROL OF INDICATING DEVICES USING STATIC MEANS TO PRESENT VARIABLE INFORMATION
- G09G2354/00—Aspects of interface with display user
Abstract
Referido a una molecula de union a antigeno biespecifica, que comprende al menos un dominio de union al antigeno capaz de unirse de manera especifica a 4-1BB, al menos un dominio de union al antigeno capaz de unirse a un antigeno de celula diana y un dominio Fc. Dicho dominio de union a 4-1BB, comprende una region variable de la cadena pesada, que comprende (i) CDR-H1 de SEQ ID NO: 1, (ii) CDR-H2 de SEQ ID NO: 2 y (iii) CDR-H3 de SEQ ID NO: 3; y una region variable de cadena ligera, que comprende (iv) CDR-L1 de SEQ ID NO: 4, (v) CDR -L2 de SEQ ID NO: 5, y (vi) CDR-L3 de SEQ ID NO: 6. El antigeno de celula diana se selecciona entre la proteina de activacion de fibroblastos (FAP), proteoglucano de sulfato de condroitina asociado a melanoma (MCSP), receptor de factor de crecimiento epidermico (EGFR), antigeno carcinoembrionario (CEA), CD19, CD20 o CD33. El dominio Fc de IgG formado por una primera y segunda subunidad capaces de asociarse de manera estable. Dicha molecula es util para el tratamiento de infecciones y cancer. Tambien se refiere a un polinucleotido, una celula huesped que codifica dicho anticuerpo y una composicion farmaceutica que comprende dicho anticuerpo.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17150150 | 2017-01-03 | ||
EP17164224 | 2017-03-31 | ||
PCT/EP2018/050024 WO2018127473A1 (en) | 2017-01-03 | 2018-01-02 | Bispecific antigen binding molecules comprising anti-4-1bb clone 20h4.9 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20191546A1 true PE20191546A1 (es) | 2019-10-24 |
Family
ID=61024728
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2019001290A PE20191546A1 (es) | 2017-01-03 | 2018-01-02 | Moleculas de union antigeno biespecificas que comprenden el clon 20h4.9 anti-41bb |
Country Status (19)
Country | Link |
---|---|
US (2) | US11447558B2 (es) |
EP (1) | EP3565843A1 (es) |
JP (1) | JP7122311B2 (es) |
KR (1) | KR20190099527A (es) |
CN (1) | CN110461873B (es) |
AU (1) | AU2018206138A1 (es) |
BR (1) | BR112019013189A2 (es) |
CA (1) | CA3047070A1 (es) |
CL (1) | CL2019001828A1 (es) |
CO (1) | CO2019007046A2 (es) |
CR (1) | CR20190309A (es) |
IL (1) | IL267607A (es) |
MA (1) | MA47200A (es) |
MX (1) | MX2019007795A (es) |
PE (1) | PE20191546A1 (es) |
PH (1) | PH12019501440A1 (es) |
RU (1) | RU2019123613A (es) |
TW (1) | TW201829469A (es) |
WO (1) | WO2018127473A1 (es) |
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EP3559034B1 (en) | 2016-12-20 | 2020-12-02 | H. Hoffnabb-La Roche Ag | Combination therapy of anti-cd20/anti-cd3 bispecific antibodies and 4-1bb (cd137) agonists |
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AR121706A1 (es) | 2020-04-01 | 2022-06-29 | Hoffmann La Roche | Moléculas de unión a antígeno biespecíficas dirigidas a ox40 y fap |
BR112022021447A2 (pt) * | 2020-05-19 | 2022-12-13 | Boehringer Ingelheim Int | Moléculas de ligação para o tratamento de câncer |
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-
2018
- 2018-01-02 BR BR112019013189A patent/BR112019013189A2/pt not_active Application Discontinuation
- 2018-01-02 KR KR1020197022782A patent/KR20190099527A/ko unknown
- 2018-01-02 WO PCT/EP2018/050024 patent/WO2018127473A1/en unknown
- 2018-01-02 MX MX2019007795A patent/MX2019007795A/es unknown
- 2018-01-02 MA MA047200A patent/MA47200A/fr unknown
- 2018-01-02 RU RU2019123613A patent/RU2019123613A/ru not_active Application Discontinuation
- 2018-01-02 EP EP18701244.8A patent/EP3565843A1/en active Pending
- 2018-01-02 PE PE2019001290A patent/PE20191546A1/es unknown
- 2018-01-02 AU AU2018206138A patent/AU2018206138A1/en not_active Abandoned
- 2018-01-02 CR CR20190309A patent/CR20190309A/es unknown
- 2018-01-02 JP JP2019536046A patent/JP7122311B2/ja active Active
- 2018-01-02 CA CA3047070A patent/CA3047070A1/en not_active Abandoned
- 2018-01-02 TW TW107100076A patent/TW201829469A/zh unknown
- 2018-01-02 CN CN201880011647.0A patent/CN110461873B/zh active Active
-
2019
- 2019-06-19 US US16/446,486 patent/US11447558B2/en active Active
- 2019-06-21 PH PH12019501440A patent/PH12019501440A1/en unknown
- 2019-06-24 IL IL267607A patent/IL267607A/en unknown
- 2019-06-28 CO CONC2019/0007046A patent/CO2019007046A2/es unknown
- 2019-07-01 CL CL2019001828A patent/CL2019001828A1/es unknown
-
2022
- 2022-08-15 US US17/819,867 patent/US20230045262A1/en active Pending
Also Published As
Publication number | Publication date |
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KR20190099527A (ko) | 2019-08-27 |
CL2019001828A1 (es) | 2019-10-18 |
RU2019123613A (ru) | 2021-02-05 |
TW201829469A (zh) | 2018-08-16 |
CR20190309A (es) | 2019-08-21 |
US20230045262A1 (en) | 2023-02-09 |
CA3047070A1 (en) | 2018-07-12 |
MA47200A (fr) | 2019-11-13 |
WO2018127473A1 (en) | 2018-07-12 |
BR112019013189A2 (pt) | 2019-12-10 |
MX2019007795A (es) | 2019-08-16 |
CN110461873A (zh) | 2019-11-15 |
CO2019007046A2 (es) | 2019-07-10 |
PH12019501440A1 (en) | 2020-02-10 |
EP3565843A1 (en) | 2019-11-13 |
CN110461873B (zh) | 2023-05-12 |
AU2018206138A1 (en) | 2019-07-11 |
JP2020504622A (ja) | 2020-02-13 |
IL267607A (en) | 2019-08-29 |
JP7122311B2 (ja) | 2022-08-19 |
US20200190206A1 (en) | 2020-06-18 |
US11447558B2 (en) | 2022-09-20 |
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