CL2019001828A1 - Moléculas de unión a antígeno biespecíficas que comprenden el clon 20h4.9 anti-4-1bb. - Google Patents
Moléculas de unión a antígeno biespecíficas que comprenden el clon 20h4.9 anti-4-1bb.Info
- Publication number
- CL2019001828A1 CL2019001828A1 CL2019001828A CL2019001828A CL2019001828A1 CL 2019001828 A1 CL2019001828 A1 CL 2019001828A1 CL 2019001828 A CL2019001828 A CL 2019001828A CL 2019001828 A CL2019001828 A CL 2019001828A CL 2019001828 A1 CL2019001828 A1 CL 2019001828A1
- Authority
- CL
- Chile
- Prior art keywords
- clone
- binding molecules
- bispecific antigen
- antigen
- binding
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
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- G—PHYSICS
- G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
- G09G—ARRANGEMENTS OR CIRCUITS FOR CONTROL OF INDICATING DEVICES USING STATIC MEANS TO PRESENT VARIABLE INFORMATION
- G09G5/00—Control arrangements or circuits for visual indicators common to cathode-ray tube indicators and other visual indicators
- G09G5/36—Control arrangements or circuits for visual indicators common to cathode-ray tube indicators and other visual indicators characterised by the display of a graphic pattern, e.g. using an all-points-addressable [APA] memory
- G09G5/37—Details of the operation on graphic patterns
- G09G5/377—Details of the operation on graphic patterns for mixing or overlaying two or more graphic patterns
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- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
- H04N9/00—Details of colour television systems
- H04N9/12—Picture reproducers
- H04N9/31—Projection devices for colour picture display, e.g. using electronic spatial light modulators [ESLM]
- H04N9/3102—Projection devices for colour picture display, e.g. using electronic spatial light modulators [ESLM] using two-dimensional electronic spatial light modulators
- H04N9/312—Driving therefor
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- H—ELECTRICITY
- H04—ELECTRIC COMMUNICATION TECHNIQUE
- H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
- H04N9/00—Details of colour television systems
- H04N9/12—Picture reproducers
- H04N9/31—Projection devices for colour picture display, e.g. using electronic spatial light modulators [ESLM]
- H04N9/3179—Video signal processing therefor
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- G—PHYSICS
- G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
- G09G—ARRANGEMENTS OR CIRCUITS FOR CONTROL OF INDICATING DEVICES USING STATIC MEANS TO PRESENT VARIABLE INFORMATION
- G09G2320/00—Control of display operating conditions
- G09G2320/02—Improving the quality of display appearance
- G09G2320/0257—Reduction of after-image effects
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- G—PHYSICS
- G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
- G09G—ARRANGEMENTS OR CIRCUITS FOR CONTROL OF INDICATING DEVICES USING STATIC MEANS TO PRESENT VARIABLE INFORMATION
- G09G2320/00—Control of display operating conditions
- G09G2320/04—Maintaining the quality of display appearance
- G09G2320/043—Preventing or counteracting the effects of ageing
- G09G2320/046—Dealing with screen burn-in prevention or compensation of the effects thereof
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- G—PHYSICS
- G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
- G09G—ARRANGEMENTS OR CIRCUITS FOR CONTROL OF INDICATING DEVICES USING STATIC MEANS TO PRESENT VARIABLE INFORMATION
- G09G2320/00—Control of display operating conditions
- G09G2320/04—Maintaining the quality of display appearance
- G09G2320/043—Preventing or counteracting the effects of ageing
- G09G2320/048—Preventing or counteracting the effects of ageing using evaluation of the usage time
-
- G—PHYSICS
- G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
- G09G—ARRANGEMENTS OR CIRCUITS FOR CONTROL OF INDICATING DEVICES USING STATIC MEANS TO PRESENT VARIABLE INFORMATION
- G09G2320/00—Control of display operating conditions
- G09G2320/06—Adjustment of display parameters
- G09G2320/0606—Manual adjustment
-
- G—PHYSICS
- G09—EDUCATION; CRYPTOGRAPHY; DISPLAY; ADVERTISING; SEALS
- G09G—ARRANGEMENTS OR CIRCUITS FOR CONTROL OF INDICATING DEVICES USING STATIC MEANS TO PRESENT VARIABLE INFORMATION
- G09G2354/00—Aspects of interface with display user
Abstract
LA INVENCIÓN SE REFIERE A NUEVAS MOLÉCULAS DE UNIÓN A ANTÍGENO BIESPECÍFICAS, QUE COMPRENDEN AL MENOS UN DOMINIO DE UNIÓN A ANTÍGENO CAPAZ DE UNIRSE DE MANERA ESPECÍFICA A 4-1BB, AL MENOS UN RESTO CAPAZ DE UNIRSE DE MANERA ESPECÍFICA A UN ANTÍGENO DE CÉLULA DIANA Y UN DOMINIO FC FORMADO POR UNA PRIMERA Y UN SEGUNDA SUBUNIDAD CAPACES DE ASOCIARSE DE MANERA ESTABLE Y A MÉTODOS PARA PRODUCIR ESTAS MOLÉCULAS Y A MÉTODOS PARA USAR LAS MISMAS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17150150 | 2017-01-03 | ||
EP17164224 | 2017-03-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2019001828A1 true CL2019001828A1 (es) | 2019-10-18 |
Family
ID=61024728
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2019001828A CL2019001828A1 (es) | 2017-01-03 | 2019-07-01 | Moléculas de unión a antígeno biespecíficas que comprenden el clon 20h4.9 anti-4-1bb. |
Country Status (19)
Country | Link |
---|---|
US (2) | US11447558B2 (es) |
EP (1) | EP3565843A1 (es) |
JP (1) | JP7122311B2 (es) |
KR (1) | KR20190099527A (es) |
CN (1) | CN110461873B (es) |
AU (1) | AU2018206138A1 (es) |
BR (1) | BR112019013189A2 (es) |
CA (1) | CA3047070A1 (es) |
CL (1) | CL2019001828A1 (es) |
CO (1) | CO2019007046A2 (es) |
CR (1) | CR20190309A (es) |
IL (1) | IL267607A (es) |
MA (1) | MA47200A (es) |
MX (1) | MX2019007795A (es) |
PE (1) | PE20191546A1 (es) |
PH (1) | PH12019501440A1 (es) |
RU (1) | RU2019123613A (es) |
TW (1) | TW201829469A (es) |
WO (1) | WO2018127473A1 (es) |
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BR112019007267A2 (pt) | 2016-12-20 | 2019-07-09 | Hoffmann La Roche | anticorpo biespecífico anti-cd20/anti-cd3, produto farmacêutico, composição farmacêutica que compreende um anticorpo biespecífico anti-cd20/anti-cd3, uso de combinação de anticorpo biespecífico anti-cd20/anti-cd3 e um agonista de 4-1bb e método de tratamento ou retardamento da progressão de câncer em pacientes |
WO2018178055A1 (en) | 2017-03-29 | 2018-10-04 | F. Hoffmann-La Roche Ag | Bispecific antigen binding molecule for a costimulatory tnf receptor |
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-
2018
- 2018-01-02 MA MA047200A patent/MA47200A/fr unknown
- 2018-01-02 CA CA3047070A patent/CA3047070A1/en not_active Abandoned
- 2018-01-02 CN CN201880011647.0A patent/CN110461873B/zh active Active
- 2018-01-02 BR BR112019013189A patent/BR112019013189A2/pt not_active Application Discontinuation
- 2018-01-02 AU AU2018206138A patent/AU2018206138A1/en not_active Abandoned
- 2018-01-02 EP EP18701244.8A patent/EP3565843A1/en active Pending
- 2018-01-02 CR CR20190309A patent/CR20190309A/es unknown
- 2018-01-02 MX MX2019007795A patent/MX2019007795A/es unknown
- 2018-01-02 KR KR1020197022782A patent/KR20190099527A/ko unknown
- 2018-01-02 RU RU2019123613A patent/RU2019123613A/ru not_active Application Discontinuation
- 2018-01-02 PE PE2019001290A patent/PE20191546A1/es unknown
- 2018-01-02 JP JP2019536046A patent/JP7122311B2/ja active Active
- 2018-01-02 WO PCT/EP2018/050024 patent/WO2018127473A1/en unknown
- 2018-01-02 TW TW107100076A patent/TW201829469A/zh unknown
-
2019
- 2019-06-19 US US16/446,486 patent/US11447558B2/en active Active
- 2019-06-21 PH PH12019501440A patent/PH12019501440A1/en unknown
- 2019-06-24 IL IL267607A patent/IL267607A/en unknown
- 2019-06-28 CO CONC2019/0007046A patent/CO2019007046A2/es unknown
- 2019-07-01 CL CL2019001828A patent/CL2019001828A1/es unknown
-
2022
- 2022-08-15 US US17/819,867 patent/US20230045262A1/en active Pending
Also Published As
Publication number | Publication date |
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PE20191546A1 (es) | 2019-10-24 |
AU2018206138A1 (en) | 2019-07-11 |
CN110461873B (zh) | 2023-05-12 |
CO2019007046A2 (es) | 2019-07-10 |
TW201829469A (zh) | 2018-08-16 |
CR20190309A (es) | 2019-08-21 |
JP2020504622A (ja) | 2020-02-13 |
MX2019007795A (es) | 2019-08-16 |
CA3047070A1 (en) | 2018-07-12 |
RU2019123613A (ru) | 2021-02-05 |
US20230045262A1 (en) | 2023-02-09 |
JP7122311B2 (ja) | 2022-08-19 |
CN110461873A (zh) | 2019-11-15 |
EP3565843A1 (en) | 2019-11-13 |
BR112019013189A2 (pt) | 2019-12-10 |
US11447558B2 (en) | 2022-09-20 |
IL267607A (en) | 2019-08-29 |
MA47200A (fr) | 2019-11-13 |
WO2018127473A1 (en) | 2018-07-12 |
KR20190099527A (ko) | 2019-08-27 |
US20200190206A1 (en) | 2020-06-18 |
PH12019501440A1 (en) | 2020-02-10 |
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