PE20140917A1 - Sintesis de derivados de 2-carboxamida-cicloamino-urea - Google Patents
Sintesis de derivados de 2-carboxamida-cicloamino-ureaInfo
- Publication number
- PE20140917A1 PE20140917A1 PE2013002003A PE2013002003A PE20140917A1 PE 20140917 A1 PE20140917 A1 PE 20140917A1 PE 2013002003 A PE2013002003 A PE 2013002003A PE 2013002003 A PE2013002003 A PE 2013002003A PE 20140917 A1 PE20140917 A1 PE 20140917A1
- Authority
- PE
- Peru
- Prior art keywords
- formula
- compound
- solvent
- producing
- contact
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/26—Radicals substituted by halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
SE REFIERE A UN PROCESO PARA LA ELABORACION DE UN COMPUESTO DE FORMULA (X) QUE COPRENDE: A) PONER EN CONTACTO EL COMPUESTO DE FORMULA (I) CON UN SOLVENTE TAL COMO UN SOLVENTE AROMATICO, ALIFATICO, HALOGENADO, ENTRE OTROS Y UNA BASE TAL COMO DI-ISOPROPIL-AMIDA DE LITIO, LUEGO PONER EN CONTACTO LA MEZCLA RESULTANTE CON EL COMPUESTO DE FORMULA (II) PRODUCIENDOSE EL COMPUESTO DE FORMULA (III); B) PONER EN CONTACTO EL COMPUESTO DE FORMULA (III) CON TIOUREA, EN UNA MEZCLA DE REACCION QUE COMPRENDE UN SOLVENTE Y UN AGENTE OXIDANTE TAL COMO REACTIVO DE HALOGENO ELECTROFILICO, PRODUCIENDOSE EL COMPUESTO DE FORMULA (V); C) PONER EN CONTACTO LOS COMPUESTOS DE FORMULA (V) Y (VII), EN UNA MEZCLA DE REACCION QUE COMPRENDE UN SOLVENTE Y UNA BASE TAL COMO PIRIDINA, PRODUCIENDOSE EL COMPUESTO DE FORMULA (VIII); Y D) PONER EN CONTACTO LOS COMPUESTOS DE FORMULA (VIII) Y (IX) EN UNA MEZCLA DE REACCION QUE COMPRENDE UN SOLVENTE, PRODUCIENDOSE EL COMPUESTO DE FORMULA (X). R1 ES UN ALQUILO C1-C7 CICLICO O ACICLICO, RAMIFICADO O LINEAL OPCIONALMENTE SUSTITUIDO; R2 ES H, FLUOR, Cl, METILO OPCIONALMENTE SUSTITUIDO
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161448774P | 2011-03-03 | 2011-03-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20140917A1 true PE20140917A1 (es) | 2014-08-14 |
Family
ID=45787206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2013002003A PE20140917A1 (es) | 2011-03-03 | 2012-03-01 | Sintesis de derivados de 2-carboxamida-cicloamino-urea |
Country Status (32)
| Country | Link |
|---|---|
| US (3) | US9650373B2 (es) |
| EP (1) | EP2681192B1 (es) |
| JP (1) | JP6022485B2 (es) |
| KR (1) | KR101851421B1 (es) |
| CN (2) | CN103402982B (es) |
| AR (2) | AR088714A1 (es) |
| AU (1) | AU2012222346B2 (es) |
| BR (1) | BR112013021882A2 (es) |
| CA (1) | CA2828509C (es) |
| CL (1) | CL2013002521A1 (es) |
| CO (1) | CO6751286A2 (es) |
| DK (1) | DK2681192T3 (es) |
| EA (4) | EA201892052A1 (es) |
| EC (1) | ECSP13012914A (es) |
| ES (1) | ES2663717T3 (es) |
| GT (1) | GT201300211A (es) |
| HU (1) | HUE036319T2 (es) |
| IL (1) | IL228023A (es) |
| MA (1) | MA34982B1 (es) |
| MX (2) | MX347348B (es) |
| MY (1) | MY163214A (es) |
| NO (1) | NO2681192T3 (es) |
| PE (1) | PE20140917A1 (es) |
| PL (1) | PL2681192T3 (es) |
| PT (1) | PT2681192T (es) |
| SG (1) | SG192793A1 (es) |
| SI (1) | SI2681192T1 (es) |
| TN (1) | TN2013000354A1 (es) |
| TW (2) | TWI607994B (es) |
| UA (1) | UA112539C2 (es) |
| WO (1) | WO2012117071A1 (es) |
| ZA (1) | ZA201306174B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA112539C2 (uk) * | 2011-03-03 | 2016-09-26 | Новартіс Аг | Спосіб одержання похідних 2-карбоксамідциклоаміносечовини |
| CN111704543A (zh) * | 2014-11-14 | 2020-09-25 | 燿石治疗公司 | 用于制备α,ω-二羧酸封端的二烷醚的方法和中间体 |
| JP7014737B2 (ja) | 2017-01-20 | 2022-02-01 | 株式会社ペーターズ | スケートボード用ハンドル及びハンドル付きスケートボード |
| CN112961090A (zh) * | 2019-12-13 | 2021-06-15 | 武汉九州钰民医药科技有限公司 | 合成Alpelisib的关键中间体及其制备方法 |
| CN111057051A (zh) * | 2019-12-16 | 2020-04-24 | 武汉九州钰民医药科技有限公司 | PI3K抑制剂Alpelisib的新合成方法 |
| CN110964005A (zh) * | 2019-12-16 | 2020-04-07 | 武汉九州钰民医药科技有限公司 | 一种Alpelisib的制备工艺 |
| KR20220125753A (ko) | 2021-03-05 | 2022-09-14 | 배성륭 | 기능성 풍력 발전시스템 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3534056A (en) * | 1967-03-02 | 1970-10-13 | Pennwalt Corp | Fluoro-alkyl pyridines and their preparation |
| UA60365C2 (uk) | 1998-06-04 | 2003-10-15 | Пфайзер Продактс Інк. | Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця |
| PL355639A1 (en) | 1999-09-10 | 2004-05-04 | Merck & Co, Inc. | Tyrosine kinase inhibitors |
| AR044519A1 (es) * | 2003-05-02 | 2005-09-14 | Novartis Ag | Derivados de piridin-tiazol amina y de pirimidin-tiazol amina |
| US8455658B2 (en) | 2006-01-25 | 2013-06-04 | Synta Pharmaceuticals Corp. | Thiazole and thiadiazole compounds for inflammation and immune-related uses |
| TWI428091B (zh) | 2007-10-23 | 2014-03-01 | Du Pont | 殺真菌劑混合物 |
| PE20091523A1 (es) | 2007-12-20 | 2009-10-29 | Novartis Ag | Derivados de tiazol como inhibidores de la enzima fosfatidilinositol 3-cinasa (pi3k) |
| EP2235983B1 (en) * | 2007-12-21 | 2011-07-20 | Telefonaktiebolaget LM Ericsson (publ) | Method, apparatus and computer program for handover from a first access point to a second access point |
| UA104147C2 (uk) * | 2008-09-10 | 2014-01-10 | Новартис Аг | Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань |
| UA112539C2 (uk) * | 2011-03-03 | 2016-09-26 | Новартіс Аг | Спосіб одержання похідних 2-карбоксамідциклоаміносечовини |
-
2012
- 2012-01-03 UA UAA201310018A patent/UA112539C2/uk unknown
- 2012-03-01 EA EA201892052A patent/EA201892052A1/ru unknown
- 2012-03-01 SI SI201231240T patent/SI2681192T1/en unknown
- 2012-03-01 EA EA201792068A patent/EA032802B1/ru not_active IP Right Cessation
- 2012-03-01 MA MA36278A patent/MA34982B1/fr unknown
- 2012-03-01 EA EA201691331A patent/EA201691331A1/ru unknown
- 2012-03-01 DK DK12706843.5T patent/DK2681192T3/en active
- 2012-03-01 EP EP12706843.5A patent/EP2681192B1/en active Active
- 2012-03-01 PT PT127068435T patent/PT2681192T/pt unknown
- 2012-03-01 PE PE2013002003A patent/PE20140917A1/es not_active Application Discontinuation
- 2012-03-01 MX MX2013010132A patent/MX347348B/es active IP Right Grant
- 2012-03-01 US US13/985,069 patent/US9650373B2/en active Active
- 2012-03-01 MY MYPI2013002966A patent/MY163214A/en unknown
- 2012-03-01 BR BR112013021882A patent/BR112013021882A2/pt not_active Application Discontinuation
- 2012-03-01 JP JP2013555878A patent/JP6022485B2/ja active Active
- 2012-03-01 WO PCT/EP2012/053559 patent/WO2012117071A1/en active Application Filing
- 2012-03-01 AR ARP120100665A patent/AR088714A1/es active IP Right Grant
- 2012-03-01 CN CN201280011348.XA patent/CN103402982B/zh active Active
- 2012-03-01 NO NO12706843A patent/NO2681192T3/no unknown
- 2012-03-01 ES ES12706843.5T patent/ES2663717T3/es active Active
- 2012-03-01 EA EA201391267A patent/EA025381B1/ru not_active IP Right Cessation
- 2012-03-01 SG SG2013062153A patent/SG192793A1/en unknown
- 2012-03-01 KR KR1020137025764A patent/KR101851421B1/ko active IP Right Grant
- 2012-03-01 CN CN201610412757.0A patent/CN106083840B/zh active Active
- 2012-03-01 CA CA2828509A patent/CA2828509C/en active Active
- 2012-03-01 AU AU2012222346A patent/AU2012222346B2/en active Active
- 2012-03-01 PL PL12706843T patent/PL2681192T3/pl unknown
- 2012-03-01 MX MX2017005292A patent/MX351740B/es unknown
- 2012-03-01 HU HUE12706843A patent/HUE036319T2/hu unknown
- 2012-03-02 TW TW106106845A patent/TWI607994B/zh not_active IP Right Cessation
- 2012-03-02 TW TW101107070A patent/TWI597279B/zh not_active IP Right Cessation
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2013
- 2013-08-16 ZA ZA2013/06174A patent/ZA201306174B/en unknown
- 2013-08-19 IL IL228023A patent/IL228023A/en active IP Right Grant
- 2013-08-28 TN TNP2013000354A patent/TN2013000354A1/fr unknown
- 2013-08-28 GT GT201300211A patent/GT201300211A/es unknown
- 2013-08-30 CO CO13206319A patent/CO6751286A2/es unknown
- 2013-09-02 CL CL2013002521A patent/CL2013002521A1/es unknown
- 2013-10-02 EC ECSP13012914 patent/ECSP13012914A/es unknown
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2017
- 2017-04-06 US US15/480,835 patent/US9776966B2/en active Active
- 2017-08-23 US US15/684,419 patent/US10059670B2/en active Active
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2021
- 2021-09-23 AR ARP210102644A patent/AR123584A2/es unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |