PA8789601A1 - Proceso para la preparación de trifluoralquil-fenil sulfonamidas y de sulfonamidas heterocíclicas - Google Patents
Proceso para la preparación de trifluoralquil-fenil sulfonamidas y de sulfonamidas heterocíclicasInfo
- Publication number
- PA8789601A1 PA8789601A1 PA20088789601A PA8789601A PA8789601A1 PA 8789601 A1 PA8789601 A1 PA 8789601A1 PA 20088789601 A PA20088789601 A PA 20088789601A PA 8789601 A PA8789601 A PA 8789601A PA 8789601 A1 PA8789601 A1 PA 8789601A1
- Authority
- PA
- Panama
- Prior art keywords
- sulfonamids
- phenyl
- preparation
- heterocyclic
- trifluoralquil
- Prior art date
Links
- -1 SULFONAMIDE COMPOUNDS Chemical class 0.000 abstract 4
- 229940124530 sulfonamide Drugs 0.000 abstract 4
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000003456 sulfonamides Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Abstract
SE DESCRIBE UN NUEVO AGENTE DE TRIFLUORACETILACIÓN, ES DECIR, N-TRIFLUORACETILMORFOLINA. ESTE REACTIVO ES ÚTIL EN LA PREPARACIÓN DE COMPUESTOS DE FENIL SULFONAMIDA Y DE SULFONAMIDA HETEROCÍCLICA. POR CONSIGUIENTE SE DESCRIBEN MÉTODOS PARA PREPARAR COMPUESTOS DE SULFONAMIDA DE LA SIGUIENTE ESTRUCTURA, EN DONDE R1 Y R2 SE DEFINEN EN LA PRESENTE, UTILIZANDO N-TRIFLUORACETILMORFOLINA. LOS COMPUESTOS DE SULFONAMIDA QUE SE PUEDEN PREPARAR SEGÚN SE DESCRIBE EN LA PRESENTE INCLUYEN [(1S,2R)-2-(3,5-DIFLUOR-FENIL)-3,3,3-TRIFLUOR-1-HIDROXIMETIL-PROPIL]-AMIDA DE ÁCIDO 5-CLORO-TIOFEN-2-SULFÓNICO UTILIZANDO N-TRIFLUORACETILMORFOLINA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95965907P | 2007-07-16 | 2007-07-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
PA8789601A1 true PA8789601A1 (es) | 2009-02-09 |
Family
ID=40260327
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PA20088789601A PA8789601A1 (es) | 2007-07-16 | 2008-07-14 | Proceso para la preparación de trifluoralquil-fenil sulfonamidas y de sulfonamidas heterocíclicas |
Country Status (7)
Country | Link |
---|---|
US (1) | US20090023903A1 (es) |
AR (1) | AR067534A1 (es) |
CL (1) | CL2008002058A1 (es) |
PA (1) | PA8789601A1 (es) |
PE (1) | PE20090824A1 (es) |
TW (1) | TW200911778A (es) |
WO (1) | WO2009012201A2 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CL2004000647A1 (es) * | 2003-03-31 | 2005-02-04 | Wyeth Corp | Compuestos derivados de heterociclicos de sulfonamida que contienen fluoro y trifluoro alquilo; composicion farmaceutica; kit farmaceutico; procedimiento de preparacion; y su uso como inhibidores de beta amiloides para tratar alzheimer, angiopatia am |
US9223217B2 (en) * | 2010-02-19 | 2015-12-29 | International Business Machines Corporation | Sulfonamide-containing topcoat and photoresist additive compositions and methods of use |
US9223209B2 (en) * | 2010-02-19 | 2015-12-29 | International Business Machines Corporation | Sulfonamide-containing photoresist compositions and methods of use |
CN102964233A (zh) * | 2012-11-18 | 2013-03-13 | 大连九信生物化工科技有限公司 | 一种3,5-二氟三氟甲基苯酮的合成方法 |
CN103214413B (zh) * | 2013-03-22 | 2015-05-13 | 郑州泰基鸿诺药物科技有限公司 | 一种含杂环的三氟甲基酮化合物及其制备方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2703802A (en) * | 1953-08-20 | 1955-03-08 | Dow Chemical Co | 4-(trifluoroacetyl) morpholine |
US5461162A (en) * | 1994-07-27 | 1995-10-24 | Merck & Co., Inc. | Process of synthesizing n-acyl auxiliaries |
US5594134A (en) * | 1995-03-31 | 1997-01-14 | Merck & Co., Inc. | Process of synthesizing N-acyl auxiliaries |
SI1341779T1 (sl) * | 2000-12-13 | 2006-12-31 | Wyeth Corp | Heterociklicni sulfonamidni inhibitorji produkcije beta amiloida |
IL165265A0 (en) * | 2002-06-11 | 2005-12-18 | Wyeth Corp | Substituted phenylsulfonamide inhibitors of beta amyloid production |
CL2004000647A1 (es) * | 2003-03-31 | 2005-02-04 | Wyeth Corp | Compuestos derivados de heterociclicos de sulfonamida que contienen fluoro y trifluoro alquilo; composicion farmaceutica; kit farmaceutico; procedimiento de preparacion; y su uso como inhibidores de beta amiloides para tratar alzheimer, angiopatia am |
JP2007517905A (ja) * | 2004-01-16 | 2007-07-05 | ワイス | アゾールを含有するベータアミロイド産生のヘテロ環式スルホンアミド阻害剤 |
RU2008129797A (ru) * | 2006-02-17 | 2010-03-27 | Вайет (Us) | Способы получения сульфонамид-замещенных спиртов и их промежуточных соединений |
RU2008131051A (ru) * | 2006-02-17 | 2010-03-27 | Вайет (Us) | Избирательное n-сульфонилирование 2-амино трифторалкильнзамещенных спиртов |
US7476762B2 (en) * | 2006-04-21 | 2009-01-13 | Wyeth | Methods for preparing sulfonamide compounds |
US7550629B2 (en) * | 2006-04-21 | 2009-06-23 | Wyeth | Trifluoromethyl-containing phenylsulfonamide beta amyloid inhibitors |
-
2008
- 2008-07-14 US US12/172,486 patent/US20090023903A1/en not_active Abandoned
- 2008-07-14 TW TW097126639A patent/TW200911778A/zh unknown
- 2008-07-14 WO PCT/US2008/069934 patent/WO2009012201A2/en active Application Filing
- 2008-07-14 PA PA20088789601A patent/PA8789601A1/es unknown
- 2008-07-14 PE PE2008001177A patent/PE20090824A1/es not_active Application Discontinuation
- 2008-07-14 AR ARP080103020A patent/AR067534A1/es unknown
- 2008-07-14 CL CL2008002058A patent/CL2008002058A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
PE20090824A1 (es) | 2009-07-24 |
CL2008002058A1 (es) | 2008-11-14 |
WO2009012201A2 (en) | 2009-01-22 |
TW200911778A (en) | 2009-03-16 |
AR067534A1 (es) | 2009-10-14 |
WO2009012201A3 (en) | 2009-07-02 |
US20090023903A1 (en) | 2009-01-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0911681B8 (pt) | composto, composição farmacêutica, e, método para ativar a via de proteína quinase ativada por 5'-amp em uma célula in vitro | |
HN2010001059A (es) | Nuevo titulo modificado: compuestos derivados de pirimidina, un proceso para la preparacion de los mismos, una composicion farmaceutica que los comprenden y combinaciones de dichos compuestos con otros agentes. | |
CL2012002319A1 (es) | Compuestos derivados de amino-tienopirimidinas que contienen un grupo alquilo sustituido, inhibidores de mnk| o mnk2; composición farmacéutica; y su uso para la profilaxis o la terapia de enfermedades metabólicas, trastornos hematopoyéticos, enfermedades neurodegenerativas, cáncer, entre otras. | |
ECSP109917A (es) | Nuevos derivados de ácido azabifenilaminobenzoico | |
UY30444A1 (es) | Derivados de pirimidina, procesos para su preparacinn, composiciones farmaccuticos y usos de los mismos. | |
BR112015022456A2 (pt) | síntese de líquidos iônicos de compostos derivados de lignina | |
GT200600112A (es) | Composiciiones de tigeciclina y metodos de preparacion | |
UY31806A (es) | Compuestos de tiazole y oxazole de sulfonamida de benceno | |
BR112014009031A2 (pt) | formulações de etanercept estabilizadas com íons de metais | |
SV2010003673A (es) | Compuestos heterociclicos novedosos y usos de los mismos | |
CL2010001348A1 (es) | Compuestos derivados de 1-oxo-2,3-dihidro-1h-isoindolin-5-il)-isoxazol-3-carboxamida, potenciadores de los mglur2; composicion farmaceutica; y su uso para aliviar los sintomas o disminuir la aparicion de los sintomas de ezquizofrenia o ansiedad. | |
CL2008003910A1 (es) | Formulacion liquida, estable, conteniendo anticuerpo que comprende arginina y metionina; procedimiento para inhibir la deamidacion de moleculas de un anticuerpo que comprende agregar arginina a la formulacion liquida. | |
AR047928A1 (es) | Derivados de tetrahidropiridoindol | |
CL2008002076A1 (es) | Compuestos derivados de ariloxazoles sustituidos; procedimiento de preparacion de dichos compuestos; composicion farmaceutica que los comprende; y su uso para tratar diabetes, sindrome metabolico, dislipidemias, entre otras enfermedades. | |
CR20130543A (es) | Derivados de pirrolotriazinona como inhibidores de pi3k | |
BRPI0820171B8 (pt) | compostos de carboxamida, sulfonamida e amina para distúrbios metabólicos, composição farmacêutica, e, uso dos mesmos | |
MX352627B (es) | Agentes estabilizantes de emulsion para fluidos de perforacion y terminacion. | |
CL2007001759A1 (es) | Compuesto metformina r-(+) lipoato; mezcla que comprende metformina y acido r-(+) lipoico; composicion farmaceutica que comprende el compuesto; metodo para preparar el compuesto; kit; y uso para tratar la diabetes. | |
UY32239A (es) | Nuevos derivados de (3-oxo)piridazin-4-ilurea | |
AR068369A1 (es) | Sal de xinafoato de n4-[(2,2-difluor-4h-benzo[1,4]oxazin-3-on)-6-il]-5-fluor-n2-[3-(metilaminocarbonilmetilenoxi)-fenil]2,4-pirimidindiamina" | |
BR112012022775A2 (pt) | composições para a lavagem, do cólon e métodos para a produção e utilização das mesmas | |
CL2008001951A1 (es) | Compuestos derivados de imidazo[1,2-a]pirimidin-2-ilmetil sustituidos; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el trastorno del sueno, depresion, ansiedad, trastorno relacionado con el abuso de sustancias, entre otras. | |
UY31502A1 (es) | Proceso mejorado para sintetizar 5-cyclopentyl-5-11-dihydro-10-oxa-1-aza-dibenzo[a,d]cyclohepten-5-ol usando tmeda | |
ECSP099296A (es) | Inmuno-reguladores, preparaciones y composiciones que incluyen los inmuno-reguladores, pruebas para evaluar la actividad de los inmuno-reguladores y preparaciones y composiciones que incluyen los mismos y métodos | |
BR112012017994A2 (pt) | composição líquida, uso de uma composição líquida, e, métodos para preparar uma composição líquida e para tratamento de um distúrbio |