PE20091784A1 - Derivados de iminopiridina con actividad sobre el receptor adrenergico alfa 1d - Google Patents

Derivados de iminopiridina con actividad sobre el receptor adrenergico alfa 1d

Info

Publication number
PE20091784A1
PE20091784A1 PE2009000559A PE2009000559A PE20091784A1 PE 20091784 A1 PE20091784 A1 PE 20091784A1 PE 2009000559 A PE2009000559 A PE 2009000559A PE 2009000559 A PE2009000559 A PE 2009000559A PE 20091784 A1 PE20091784 A1 PE 20091784A1
Authority
PE
Peru
Prior art keywords
chloro
alpha
dihydropyridin
imino
carboxamide
Prior art date
Application number
PE2009000559A
Other languages
English (en)
Inventor
Masato Yoshida
Nobuki Sakauchi
Ayumu Sato
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of PE20091784A1 publication Critical patent/PE20091784A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

REFERIDA A UN DERIVADO DE IMINOPIRIDINA DE FORMULA (I), DONDE EL ANILLO A ES UN GRUPO AROMATICO DE 6 A 14 CARBONOS QUE TIENE POR LO MENOS UN SUSTITUYENTE R1; R1 ES -S(O)nR3, CARBAMOILO, ALCOXICARBONILO, ENTRE OTROS; R3 ES H, UN GRUPO HIDROCARBONADO TAL COMO ALQUILO C1-C6, ALQUENILO C2-C6, ENTRE OTROS, UN GRUPO AMINO, ENTRE OTROS; n ES UN NUMERO ENTERO DE 0 A 2; R2 ES H, HALOGENO, CN, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 5-CLORO-1-[5-CLORO-2-(METILSULFONIL)BENCIL]-2-IMINO-1,2-DIHIDROPIRIDIN-3-CARBOXAMIDA, 5-CLORO-1-[5-CLORO-2-(METILSULFINIL)BENCIL]-2-IMINO-1,2-DIHIDROPIRIDIN-3-CARBOXAMIDA, 5-CLORO-1-[5-CLORO-2-(2-OXOPIRROLIDIN-1-IL)BENCIL]-2-IMINO-1,2-DIHIDROPIRIDIN-3-CARBOXAMIDA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS TIENEN ACTIVIDAD SELECTIVA SOBRE LOS RECEPTORES ADRENERGICOS ALFA 1D Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES DEL TRACTO URINARIO INFERIOR Y SIMILARES
PE2009000559A 2008-04-23 2009-04-22 Derivados de iminopiridina con actividad sobre el receptor adrenergico alfa 1d PE20091784A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2008113135 2008-04-23

Publications (1)

Publication Number Publication Date
PE20091784A1 true PE20091784A1 (es) 2009-12-05

Family

ID=40821652

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2009000559A PE20091784A1 (es) 2008-04-23 2009-04-22 Derivados de iminopiridina con actividad sobre el receptor adrenergico alfa 1d

Country Status (24)

Country Link
US (2) US20110039846A1 (es)
EP (1) EP2271624B9 (es)
JP (1) JP5462803B2 (es)
KR (1) KR20100130235A (es)
CN (1) CN102066327B (es)
AR (1) AR071392A1 (es)
AU (1) AU2009238938A1 (es)
BR (1) BRPI0910737A2 (es)
CA (1) CA2723216C (es)
CL (1) CL2009000964A1 (es)
CO (1) CO6260091A2 (es)
CR (1) CR11765A (es)
DO (1) DOP2010000321A (es)
EA (1) EA019641B1 (es)
EC (1) ECSP10010626A (es)
ES (1) ES2478823T3 (es)
GE (1) GEP20135883B (es)
IL (1) IL208771A0 (es)
MX (1) MX2010011652A (es)
NZ (1) NZ588909A (es)
PE (1) PE20091784A1 (es)
TW (1) TW200948784A (es)
UY (1) UY31781A (es)
WO (1) WO2009131245A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2077262A4 (en) 2006-10-23 2011-12-28 Takeda Pharmaceutical IMINOPYRIDINE DERIVATIVES AND THEIR USE
NZ588909A (en) * 2008-04-23 2012-08-31 Takeda Pharmaceutical Iminopyridine derivatives and use thereof
US20110039892A1 (en) * 2008-04-23 2011-02-17 Takeda Pharmaceutical Company Limited Iminopyridine derivative and use thereof
US8481569B2 (en) 2008-04-23 2013-07-09 Takeda Pharmaceutical Company Limited Iminopyridine derivatives and use thereof
RU2014147017A (ru) 2012-04-24 2016-06-10 Чугаи Сейяку Кабусики Кайся Производное бензамида
KR20150003849A (ko) 2012-04-24 2015-01-09 추가이 세이야쿠 가부시키가이샤 퀴나졸린디온 유도체
CN103058913B (zh) * 2012-12-13 2015-09-30 江苏弘和药物研发有限公司 5-氯异吲哚酮的合成方法
AU2014338070A1 (en) 2013-10-23 2016-05-05 Chugai Seiyaku Kabushiki Kaisha Quinazolinone and isoquinolinone derivative
CA2950259C (en) * 2014-05-28 2022-08-23 Astellas Pharma Inc. Pyridine derivative for the treatment of nocturia
CN111217731B (zh) * 2020-02-19 2022-06-03 广东工业大学 一种邻位亚胺酯或氰基取代的芳基硫醚衍生物及制备与应用

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FR2540109B1 (fr) * 1983-01-28 1985-08-30 Logeais Labor Jacques Imino-2 pyrrolidines, leur procede de preparation et leurs applications en therapeutique
DE4021439A1 (de) * 1989-12-14 1991-06-20 Bayer Ag 2-iminopyridin-derivate
US5688795A (en) * 1994-11-08 1997-11-18 Syntex (U.S.A.) Inc. 3-(4-phenylpiperazin-1-yl)propyl-amino, thio and oxy!-pyridine, pyrimidine and benzene derivatives as α1 -adrenoceptor antagonists
UA52681C2 (uk) * 1997-04-08 2003-01-15 Янссен Фармацевтика Н.В. Похідні 1,2,3,4-тетрагідро-бензофуро[3,2,-c]піридину, спосіб їх одержання та фармацевтична композиція на їх основі
ZA991315B (en) * 1998-02-20 2000-11-20 Ortho Mcneil Pharm Inc Novel substituted pyridino arylpiperazines useful in the treatment of benign prostatic hyperplasia.
US6153614A (en) * 1998-07-16 2000-11-28 Abbott Laboratories Piperazinyl pyrimidine dione compounds selective for adrenoceptors
DE19845202A1 (de) * 1998-10-01 2000-04-06 Wella Ag Haarwuchsmittel
ES2318649T3 (es) * 2000-10-20 2009-05-01 EISAI R&D MANAGEMENT CO., LTD. Procedimiento de preparacion de derivados de 4-fenoxi quinolinas.
FR2825705B1 (fr) * 2001-06-08 2005-05-20 Aventis Pharma Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens
US7375100B2 (en) * 2003-06-04 2008-05-20 Pfizer Inc 2-amino-pyridine derivatives useful for the treatment of diseases
WO2005092840A1 (en) * 2004-03-23 2005-10-06 Pfizer Limited Formamide derivatives useful as adrenoceptor
ES2241496B1 (es) * 2004-04-15 2006-12-01 Almirall Prodesfarma, S.A. Nuevos derivados de piridina.
US20050288270A1 (en) * 2004-05-27 2005-12-29 Pfizer Inc New aminopyridine derivatives and their use as pharmaceuticals
TW200700392A (en) * 2005-03-16 2007-01-01 Astrazeneca Ab Novel compounds
ES2303758B1 (es) * 2006-02-20 2009-08-13 Laboratorios Almirall S.A. Nuevos derivados de piridin-3-amina.
EP2077262A4 (en) * 2006-10-23 2011-12-28 Takeda Pharmaceutical IMINOPYRIDINE DERIVATIVES AND THEIR USE
EP2178861B1 (en) * 2007-07-19 2014-08-20 Merck Sharp & Dohme Corp. Heterocyclic amide compounds as protein kinase inhibitors
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US8290250B2 (en) * 2008-12-26 2012-10-16 Five Apes, Inc. Method and apparatus for creating a pattern recognizer

Also Published As

Publication number Publication date
GEP20135883B (en) 2013-07-25
EP2271624B9 (en) 2014-11-12
US20110039846A1 (en) 2011-02-17
CO6260091A2 (es) 2011-03-22
EA019641B1 (ru) 2014-05-30
MX2010011652A (es) 2010-12-06
WO2009131245A1 (en) 2009-10-29
JP5462803B2 (ja) 2014-04-02
TW200948784A (en) 2009-12-01
EP2271624A1 (en) 2011-01-12
JP2011518766A (ja) 2011-06-30
CA2723216C (en) 2017-01-24
AR071392A1 (es) 2010-06-16
BRPI0910737A2 (pt) 2019-09-24
EA201071229A1 (ru) 2011-06-30
CA2723216A1 (en) 2009-10-29
NZ588909A (en) 2012-08-31
DOP2010000321A (es) 2010-11-15
EP2271624B1 (en) 2014-05-21
AU2009238938A1 (en) 2009-10-29
UY31781A (es) 2009-12-14
US20090270393A1 (en) 2009-10-29
CN102066327A (zh) 2011-05-18
CL2009000964A1 (es) 2010-03-26
CN102066327B (zh) 2013-05-29
IL208771A0 (en) 2010-12-30
ECSP10010626A (es) 2011-03-31
KR20100130235A (ko) 2010-12-10
ES2478823T3 (es) 2014-07-23
CR11765A (es) 2010-12-15

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