AR071392A1 - Derivados de iminopiridina y su uso - Google Patents
Derivados de iminopiridina y su usoInfo
- Publication number
- AR071392A1 AR071392A1 ARP090101416A ARP090101416A AR071392A1 AR 071392 A1 AR071392 A1 AR 071392A1 AR P090101416 A ARP090101416 A AR P090101416A AR P090101416 A ARP090101416 A AR P090101416A AR 071392 A1 AR071392 A1 AR 071392A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- substituent
- optionally
- chloro
- imino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
La presente pretende proporcionar un derivado de compuesto de iminopiridina que tiene una accion antagonista del receptor adrenérgico alfa1D, que es util como un agente para la profilaxis o el tratamiento de una enfermedad del tracto urinario inferior y similares. Profármacos, agentes farmacéuticos que los comprenden. Reivindicacion 1: Un compuesto caracterizado por la formula (1) en el cual el anillo A- es un grupo anular aromático que tiene por lo menos un sustituyente R1 y que tiene en forma adicional y opcional sustituyente (s); R1 es un grupo seleccionado de (i) un grupo representado por la formula -S(O)nR3 en el cual R3 es un átomo de hidrogeno, un grupo hidrocarbonado que tiene, en forma opcional, sustituyente(s) o un grupo amino que tiene, en forma opcional, sustituyente(s), y n es un numero entero de 0 hasta 2; (ii) un grupo heterocíclico no aromático que contiene nitrogeno que tiene, en forma opcional, sustituyente(s); (iii) un grupo carbamoilo que tiene, en forma opcional, sustituyente (s); (iv) un grupo amino sustituido por carbamoilo que tiene, en forma opcional, sustituyente(s); (v) un grupo alcoxicarbonilo; y (vi) un grupo alquilo sustituido por hidroxi; y R2 es un átomo de hidrogeno, un átomo de halogeno, un grupo ciano, un grupo hidrocarbonado que tiene, en forma opcional, sustituyente(s), un grupo acilo, un grupo heterocíclico que tiene, en forma opcional, sustituyente(s), un grupo amino que tiene, en forma opcional, sustituyente(s), un grupo hidroxi que tiene, en forma opcional, un sustituyente, o un grupo mercapto que tiene, en forma opcional, un sustituyente; siempre que 5-cloro-1-{4-[(dimetilamino)sulfonil]bencil}-2-imino-1,2-dihidropiridin-3-carboxamida, 5-cloro-1-[3-(1-hidroxi-1-metiletil)bencil]-2-imino-1,2-dihidropiridin-3-carboxamida, metil 3-{[3-(aminocarbonil)-5-cloro-2-iminopiridin-1(2H)-il]metil}benzoato, 1-[3-(aminocarbonil)bencil]-5-cloro-2-imino-1,2-dihidropiridin-3-carboxamida, 5-cloro-1-[4-cloro-2-(metilsulfonil)bencil]-2-imino-1,2-dihidropiridin-3-carboxamida, 5-cloro-2-imino-1-[4-(metilsulfonil)bencil]-1,2-dihidropiridin-3-carboxamida, 5-cloro-2-imino-1-[2-metoxi-5-(metilsulfonil)bencil)-1,2-dihidropiridin-3-carboxamida, 5-cloro-1-[2-cloro-4-(metilsulfonil)bencil]-2-imino-1,2-dihidropiridin-3-carboxamida, 5-cloro-1-{3-cloro-5-[(metilamino)carbonil]bencil}-2-imino-1,2-dihidropiridin-3-carboxamida, 5-cloro-1-[2-cloro-5-(metilsulfonil)bencil]-2-imino-1,2-dihidropiridin-3-carboxamida, 1-[3-(aminocarbonil)-5-clorobencil]-5-cloro-2-imino-1,2-dihidropiridin-3-carboxamida, 5-cloro-2-imino-1-[3-(metilsulfonil)bencil]-1,2-dihidropiridin-3-carboxamida, y 5-cloro-2-imino-1-(3-morfolin-4-ilbencil)-1,2-dihidropiridin-3-carboxamida están excluidos; o una de sus sales. Reivindicacion 6: Un compuesto caracterizado por la formula (2) en el cual el anillo A0- es un grupo anular aromático que tiene por lo menos un sustituyente R10 y que tiene en forma adicional y opcional sustituyente(s); R10 es un grupo seleccionado de (i) un grupo representado por la formula -S(O)nR30 en el cual R30 es un grupo heterocíclico no aromático que contiene nitrogeno que tiene, en forma opcional, sustituyente(s), y n es un numero entero de 0 hasta 4; (ii) un grupo alcoxicarbonilamino; (iii) un grupo alquilsulfonilamino; y (iv) un grupo alquilcarbonilamino; y R20 es un átomo de hidrogeno, un átomo de halogeno, un grupo ciano, un grupo hidrocarbonado que tiene, en forma opcional, sustituyente(s), un grupo acilo, un grupo heterocíclico que tiene, en forma opcional, sustituyente(s), un grupo amino que tiene, en forma opcional, sustituyente(s), un grupo hidroxi que tiene, en forma opcional, un sustituyente, o un grupo mercapto que tiene, en forma opcional, un sustituyente; o una de sus sales.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008113135 | 2008-04-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR071392A1 true AR071392A1 (es) | 2010-06-16 |
Family
ID=40821652
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090101416A AR071392A1 (es) | 2008-04-23 | 2009-04-22 | Derivados de iminopiridina y su uso |
Country Status (24)
Country | Link |
---|---|
US (2) | US20110039846A1 (es) |
EP (1) | EP2271624B9 (es) |
JP (1) | JP5462803B2 (es) |
KR (1) | KR20100130235A (es) |
CN (1) | CN102066327B (es) |
AR (1) | AR071392A1 (es) |
AU (1) | AU2009238938A1 (es) |
BR (1) | BRPI0910737A2 (es) |
CA (1) | CA2723216C (es) |
CL (1) | CL2009000964A1 (es) |
CO (1) | CO6260091A2 (es) |
CR (1) | CR11765A (es) |
DO (1) | DOP2010000321A (es) |
EA (1) | EA019641B1 (es) |
EC (1) | ECSP10010626A (es) |
ES (1) | ES2478823T3 (es) |
GE (1) | GEP20135883B (es) |
IL (1) | IL208771A0 (es) |
MX (1) | MX2010011652A (es) |
NZ (1) | NZ588909A (es) |
PE (1) | PE20091784A1 (es) |
TW (1) | TW200948784A (es) |
UY (1) | UY31781A (es) |
WO (1) | WO2009131245A1 (es) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7982044B2 (en) | 2008-04-23 | 2011-07-19 | Takeda Pharmaceutical Company Limited | Iminopyridine derivatives and use thereof |
US8470859B2 (en) | 2006-10-23 | 2013-06-25 | Takeda Pharmaceutical Company Limited | Iminopyridine derivative and use thereof |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ588909A (en) * | 2008-04-23 | 2012-08-31 | Takeda Pharmaceutical | Iminopyridine derivatives and use thereof |
US20110039892A1 (en) * | 2008-04-23 | 2011-02-17 | Takeda Pharmaceutical Company Limited | Iminopyridine derivative and use thereof |
RU2014147017A (ru) | 2012-04-24 | 2016-06-10 | Чугаи Сейяку Кабусики Кайся | Производное бензамида |
KR20150003849A (ko) | 2012-04-24 | 2015-01-09 | 추가이 세이야쿠 가부시키가이샤 | 퀴나졸린디온 유도체 |
CN103058913B (zh) * | 2012-12-13 | 2015-09-30 | 江苏弘和药物研发有限公司 | 5-氯异吲哚酮的合成方法 |
AU2014338070A1 (en) | 2013-10-23 | 2016-05-05 | Chugai Seiyaku Kabushiki Kaisha | Quinazolinone and isoquinolinone derivative |
CA2950259C (en) * | 2014-05-28 | 2022-08-23 | Astellas Pharma Inc. | Pyridine derivative for the treatment of nocturia |
CN111217731B (zh) * | 2020-02-19 | 2022-06-03 | 广东工业大学 | 一种邻位亚胺酯或氰基取代的芳基硫醚衍生物及制备与应用 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2540109B1 (fr) * | 1983-01-28 | 1985-08-30 | Logeais Labor Jacques | Imino-2 pyrrolidines, leur procede de preparation et leurs applications en therapeutique |
DE4021439A1 (de) * | 1989-12-14 | 1991-06-20 | Bayer Ag | 2-iminopyridin-derivate |
US5688795A (en) * | 1994-11-08 | 1997-11-18 | Syntex (U.S.A.) Inc. | 3-(4-phenylpiperazin-1-yl)propyl-amino, thio and oxy!-pyridine, pyrimidine and benzene derivatives as α1 -adrenoceptor antagonists |
UA52681C2 (uk) * | 1997-04-08 | 2003-01-15 | Янссен Фармацевтика Н.В. | Похідні 1,2,3,4-тетрагідро-бензофуро[3,2,-c]піридину, спосіб їх одержання та фармацевтична композиція на їх основі |
ZA991315B (en) * | 1998-02-20 | 2000-11-20 | Ortho Mcneil Pharm Inc | Novel substituted pyridino arylpiperazines useful in the treatment of benign prostatic hyperplasia. |
US6153614A (en) * | 1998-07-16 | 2000-11-28 | Abbott Laboratories | Piperazinyl pyrimidine dione compounds selective for adrenoceptors |
DE19845202A1 (de) * | 1998-10-01 | 2000-04-06 | Wella Ag | Haarwuchsmittel |
ES2318649T3 (es) * | 2000-10-20 | 2009-05-01 | EISAI R&D MANAGEMENT CO., LTD. | Procedimiento de preparacion de derivados de 4-fenoxi quinolinas. |
FR2825705B1 (fr) * | 2001-06-08 | 2005-05-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens |
US7375100B2 (en) * | 2003-06-04 | 2008-05-20 | Pfizer Inc | 2-amino-pyridine derivatives useful for the treatment of diseases |
WO2005092840A1 (en) * | 2004-03-23 | 2005-10-06 | Pfizer Limited | Formamide derivatives useful as adrenoceptor |
ES2241496B1 (es) * | 2004-04-15 | 2006-12-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridina. |
US20050288270A1 (en) * | 2004-05-27 | 2005-12-29 | Pfizer Inc | New aminopyridine derivatives and their use as pharmaceuticals |
TW200700392A (en) * | 2005-03-16 | 2007-01-01 | Astrazeneca Ab | Novel compounds |
ES2303758B1 (es) * | 2006-02-20 | 2009-08-13 | Laboratorios Almirall S.A. | Nuevos derivados de piridin-3-amina. |
EP2077262A4 (en) * | 2006-10-23 | 2011-12-28 | Takeda Pharmaceutical | IMINOPYRIDINE DERIVATIVES AND THEIR USE |
EP2178861B1 (en) * | 2007-07-19 | 2014-08-20 | Merck Sharp & Dohme Corp. | Heterocyclic amide compounds as protein kinase inhibitors |
US8129394B2 (en) * | 2008-03-21 | 2012-03-06 | Novartis Ag | Heteroaryl-substituted imidazole compounds and uses thereof |
NZ588909A (en) * | 2008-04-23 | 2012-08-31 | Takeda Pharmaceutical | Iminopyridine derivatives and use thereof |
US8290250B2 (en) * | 2008-12-26 | 2012-10-16 | Five Apes, Inc. | Method and apparatus for creating a pattern recognizer |
-
2009
- 2009-04-22 NZ NZ588909A patent/NZ588909A/xx not_active IP Right Cessation
- 2009-04-22 BR BRPI0910737A patent/BRPI0910737A2/pt not_active IP Right Cessation
- 2009-04-22 EA EA201071229A patent/EA019641B1/ru not_active IP Right Cessation
- 2009-04-22 CN CN2009801238758A patent/CN102066327B/zh not_active Expired - Fee Related
- 2009-04-22 PE PE2009000559A patent/PE20091784A1/es not_active Application Discontinuation
- 2009-04-22 MX MX2010011652A patent/MX2010011652A/es active IP Right Grant
- 2009-04-22 AR ARP090101416A patent/AR071392A1/es not_active Application Discontinuation
- 2009-04-22 JP JP2010541619A patent/JP5462803B2/ja not_active Expired - Fee Related
- 2009-04-22 GE GEAP200912013A patent/GEP20135883B/en unknown
- 2009-04-22 KR KR1020107025893A patent/KR20100130235A/ko not_active Application Discontinuation
- 2009-04-22 TW TW098113294A patent/TW200948784A/zh unknown
- 2009-04-22 ES ES09734608.4T patent/ES2478823T3/es active Active
- 2009-04-22 CL CL2009000964A patent/CL2009000964A1/es unknown
- 2009-04-22 US US12/989,054 patent/US20110039846A1/en not_active Abandoned
- 2009-04-22 UY UY0001031781A patent/UY31781A/es not_active Application Discontinuation
- 2009-04-22 EP EP09734608.4A patent/EP2271624B9/en active Active
- 2009-04-22 US US12/428,368 patent/US20090270393A1/en not_active Abandoned
- 2009-04-22 AU AU2009238938A patent/AU2009238938A1/en not_active Abandoned
- 2009-04-22 WO PCT/JP2009/058434 patent/WO2009131245A1/en active Application Filing
- 2009-04-22 CA CA2723216A patent/CA2723216C/en not_active Expired - Fee Related
-
2010
- 2010-10-17 IL IL208771A patent/IL208771A0/en unknown
- 2010-10-22 DO DO2010000321A patent/DOP2010000321A/es unknown
- 2010-10-27 CR CR11765A patent/CR11765A/es not_active Application Discontinuation
- 2010-11-19 CO CO10145079A patent/CO6260091A2/es active IP Right Grant
- 2010-11-23 EC EC2010010626A patent/ECSP10010626A/es unknown
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8470859B2 (en) | 2006-10-23 | 2013-06-25 | Takeda Pharmaceutical Company Limited | Iminopyridine derivative and use thereof |
US7982044B2 (en) | 2008-04-23 | 2011-07-19 | Takeda Pharmaceutical Company Limited | Iminopyridine derivatives and use thereof |
US7985862B2 (en) | 2008-04-23 | 2011-07-26 | Takeda Pharmaceutical Company Limited | Iminopyridine derivatives and use thereof |
US7985863B2 (en) | 2008-04-23 | 2011-07-26 | Takeda Pharmaceutical Company Limited | Iminopyridine derivatives and uses thereof |
US8481569B2 (en) | 2008-04-23 | 2013-07-09 | Takeda Pharmaceutical Company Limited | Iminopyridine derivatives and use thereof |
Also Published As
Publication number | Publication date |
---|---|
GEP20135883B (en) | 2013-07-25 |
EP2271624B9 (en) | 2014-11-12 |
US20110039846A1 (en) | 2011-02-17 |
CO6260091A2 (es) | 2011-03-22 |
EA019641B1 (ru) | 2014-05-30 |
MX2010011652A (es) | 2010-12-06 |
WO2009131245A1 (en) | 2009-10-29 |
JP5462803B2 (ja) | 2014-04-02 |
TW200948784A (en) | 2009-12-01 |
EP2271624A1 (en) | 2011-01-12 |
JP2011518766A (ja) | 2011-06-30 |
CA2723216C (en) | 2017-01-24 |
BRPI0910737A2 (pt) | 2019-09-24 |
EA201071229A1 (ru) | 2011-06-30 |
CA2723216A1 (en) | 2009-10-29 |
NZ588909A (en) | 2012-08-31 |
DOP2010000321A (es) | 2010-11-15 |
EP2271624B1 (en) | 2014-05-21 |
AU2009238938A1 (en) | 2009-10-29 |
UY31781A (es) | 2009-12-14 |
US20090270393A1 (en) | 2009-10-29 |
CN102066327A (zh) | 2011-05-18 |
CL2009000964A1 (es) | 2010-03-26 |
CN102066327B (zh) | 2013-05-29 |
IL208771A0 (en) | 2010-12-30 |
ECSP10010626A (es) | 2011-03-31 |
KR20100130235A (ko) | 2010-12-10 |
ES2478823T3 (es) | 2014-07-23 |
CR11765A (es) | 2010-12-15 |
PE20091784A1 (es) | 2009-12-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |