NO319030B1 - Paroxetinmetansulfonat, anvendelse derav samt fremgangsmate for fremstilling og farmasoytisk preparat. - Google Patents

Paroxetinmetansulfonat, anvendelse derav samt fremgangsmate for fremstilling og farmasoytisk preparat. Download PDF

Info

Publication number: NO319030B1
Authority: NO; Norway
Prior art keywords: paroxetine; solution; crystallization; solvent; paroxetine methanesulfonate
Prior art date: 1998-07-02

Application number

NO19991944A

Other languages

English (en)

Norwegian (no)

Other versions

NO991944D0 (no

NO991944L (no

Inventor

Neal Ward

Alan David Jones

Deirdre O'keefe

Andrew Simon Craig

Original Assignee

Smithkline Beecham Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-02

Filing date

1999-04-23

Publication date

2005-06-06

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27269380&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO319030(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1998-07-02 Priority claimed from GBGB9814316.7A external-priority patent/GB9814316D0/en

1998-10-06 Priority claimed from GBGB9821732.6A external-priority patent/GB9821732D0/en

1999-02-10 Priority claimed from GBGB9902935.7A external-priority patent/GB9902935D0/en

1999-04-23 Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc

1999-04-23 Publication of NO991944D0 publication Critical patent/NO991944D0/no

2000-01-03 Publication of NO991944L publication Critical patent/NO991944L/no

2005-06-06 Publication of NO319030B1 publication Critical patent/NO319030B1/no

Links

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KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 description 1
RQBJOWKBGCDPOS-RVXRQPKJSA-N acetic acid;(3s,4r)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine Chemical compound CC(O)=O.C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 RQBJOWKBGCDPOS-RVXRQPKJSA-N 0.000 description 1
125000002339 acetoacetyl group Chemical group O=C([*])C([H])([H])C(=O)C([H])([H])[H] 0.000 description 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
239000013543 active substance Substances 0.000 description 1
150000008044 alkali metal hydroxides Chemical class 0.000 description 1
125000003545 alkoxy group Chemical group 0.000 description 1
125000002877 alkyl aryl group Chemical group 0.000 description 1
AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
150000001412 amines Chemical class 0.000 description 1
230000001430 anti-depressive effect Effects 0.000 description 1
230000000648 anti-parkinson Effects 0.000 description 1
239000000939 antiparkinson agent Substances 0.000 description 1
244000052616 bacterial pathogen Species 0.000 description 1
230000008901 benefit Effects 0.000 description 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 1
PUJDIJCNWFYVJX-UHFFFAOYSA-N benzyl carbamate Chemical compound NC(=O)OCC1=CC=CC=C1 PUJDIJCNWFYVJX-UHFFFAOYSA-N 0.000 description 1
239000008609 bushi Substances 0.000 description 1
150000004657 carbamic acid derivatives Chemical class 0.000 description 1
229910052799 carbon Inorganic materials 0.000 description 1
239000000969 carrier Substances 0.000 description 1
229920001429 chelating resin Polymers 0.000 description 1
238000007385 chemical modification Methods 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
238000007906 compression Methods 0.000 description 1
230000006835 compression Effects 0.000 description 1
238000009833 condensation Methods 0.000 description 1
230000005494 condensation Effects 0.000 description 1
239000006184 cosolvent Substances 0.000 description 1
238000005859 coupling reaction Methods 0.000 description 1
150000004292 cyclic ethers Chemical class 0.000 description 1
238000000354 decomposition reaction Methods 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
238000004821 distillation Methods 0.000 description 1
230000000694 effects Effects 0.000 description 1
238000011049 filling Methods 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 1
239000011521 glass Substances 0.000 description 1
239000003365 glass fiber Substances 0.000 description 1
FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
150000004677 hydrates Chemical class 0.000 description 1
BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
230000006872 improvement Effects 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
239000004179 indigotine Substances 0.000 description 1
235000012738 indigotine Nutrition 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
JMMWKPVZQRWMSS-UHFFFAOYSA-N isopropanol acetate Natural products CC(C)OC(C)=O JMMWKPVZQRWMSS-UHFFFAOYSA-N 0.000 description 1
229940011051 isopropyl acetate Drugs 0.000 description 1
GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 description 1
239000004922 lacquer Substances 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
239000011976 maleic acid Substances 0.000 description 1
239000000155 melt Substances 0.000 description 1
AFVFQIVMOAPDHO-UHFFFAOYSA-M methanesulfonate group Chemical group CS(=O)(=O)[O-] AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 description 1
125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 description 1
229940043265 methyl isobutyl ketone Drugs 0.000 description 1
235000019813 microcrystalline cellulose Nutrition 0.000 description 1
239000008108 microcrystalline cellulose Substances 0.000 description 1
229940016286 microcrystalline cellulose Drugs 0.000 description 1
239000012046 mixed solvent Substances 0.000 description 1
YKYONYBAUNKHLG-UHFFFAOYSA-N n-Propyl acetate Natural products CCCOC(C)=O YKYONYBAUNKHLG-UHFFFAOYSA-N 0.000 description 1
150000002832 nitroso derivatives Chemical class 0.000 description 1
230000006911 nucleation Effects 0.000 description 1
238000010899 nucleation Methods 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
125000001181 organosilyl group Chemical group [SiH3]* 0.000 description 1
238000000643 oven drying Methods 0.000 description 1
229910052763 palladium Inorganic materials 0.000 description 1
239000008177 pharmaceutical agent Substances 0.000 description 1
229940127557 pharmaceutical product Drugs 0.000 description 1
125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 description 1
229910001392 phosphorus oxide Inorganic materials 0.000 description 1
229910052697 platinum Inorganic materials 0.000 description 1
XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
OCAAZRFBJBEVPS-UHFFFAOYSA-N prop-2-enyl carbamate Chemical compound NC(=O)OCC=C OCAAZRFBJBEVPS-UHFFFAOYSA-N 0.000 description 1
XYKIUTSFQGXHOW-UHFFFAOYSA-N propan-2-one;toluene Chemical compound CC(C)=O.CC1=CC=CC=C1 XYKIUTSFQGXHOW-UHFFFAOYSA-N 0.000 description 1
229940090181 propyl acetate Drugs 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
125000001453 quaternary ammonium group Chemical group 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
238000000926 separation method Methods 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
238000007711 solidification Methods 0.000 description 1
230000008023 solidification Effects 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
239000000758 substrate Substances 0.000 description 1
238000001308 synthesis method Methods 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
238000009492 tablet coating Methods 0.000 description 1
239000002700 tablet coating Substances 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
WGHIJTFVCGNFTJ-UHFFFAOYSA-N tert-butyl 2-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine-1-carboxylate Chemical compound C1C(COC=2C=C3OCOC3=CC=2)N(C(=O)OC(C)(C)C)CCC1C1=CC=C(F)C=C1 WGHIJTFVCGNFTJ-UHFFFAOYSA-N 0.000 description 1
125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
VSAISIQCTGDGPU-UHFFFAOYSA-N tetraphosphorus hexaoxide Chemical compound O1P(O2)OP3OP1OP2O3 VSAISIQCTGDGPU-UHFFFAOYSA-N 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
238000001291 vacuum drying Methods 0.000 description 1
238000003828 vacuum filtration Methods 0.000 description 1
NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
LVLANIHJQRZTPY-UHFFFAOYSA-N vinyl carbamate Chemical compound NC(=O)OC=C LVLANIHJQRZTPY-UHFFFAOYSA-N 0.000 description 1
238000005406 washing Methods 0.000 description 1
239000008096 xylene Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Inorganic Chemistry (AREA)
Pain & Pain Management (AREA)
Addiction (AREA)
Hematology (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Psychology (AREA)
Child & Adolescent Psychology (AREA)
Obesity (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Hydrogenated Pyridines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO19991944A 1998-07-02 1999-04-23 Paroxetinmetansulfonat, anvendelse derav samt fremgangsmate for fremstilling og farmasoytisk preparat. NO319030B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9814316.7A GB9814316D0 (en)	1998-07-02	1998-07-02	Novel compounds
GBGB9821732.6A GB9821732D0 (en)	1998-10-06	1998-10-06	Novel compound
GBGB9902935.7A GB9902935D0 (en)	1999-02-10	1999-02-10	Novel compound

Publications (3)

Publication Number	Publication Date
NO991944D0 NO991944D0 (no)	1999-04-23
NO991944L NO991944L (no)	2000-01-03
NO319030B1 true NO319030B1 (no)	2005-06-06

Family

ID=27269380

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19991944A NO319030B1 (no)	1998-07-02	1999-04-23	Paroxetinmetansulfonat, anvendelse derav samt fremgangsmate for fremstilling og farmasoytisk preparat.

Country Status (35)

Country	Link
US (4)	US6063927A (zh)
EP (5)	EP1020464B1 (zh)
JP (1)	JP2002519422A (zh)
KR (1)	KR20010053336A (zh)
CN (1)	CN1127502C (zh)
AR (2)	AR011759A1 (zh)
AT (4)	ATE251155T1 (zh)
AU (4)	AU713131B3 (zh)
BE (3)	BE1011664A6 (zh)
BR (1)	BR9911682A (zh)
CA (1)	CA2269999A1 (zh)
CH (1)	CH689805A8 (zh)
DE (5)	DE29907248U1 (zh)
DK (7)	DK199900554A (zh)
ES (4)	ES2209428T3 (zh)
FI (2)	FI4209U1 (zh)
FR (2)	FR2780728B1 (zh)
GB (5)	GB2377637A (zh)
GR (3)	GR990100140A (zh)
HK (1)	HK1037877A1 (zh)
HU (1)	HUP0102334A3 (zh)
IE (5)	IES81166B2 (zh)
IL (1)	IL140628A (zh)
IT (1)	IT1312540B1 (zh)
LU (1)	LU90388B1 (zh)
NL (4)	NL1011875C2 (zh)
NO (1)	NO319030B1 (zh)
NZ (1)	NZ509180A (zh)
PL (1)	PL345214A1 (zh)
PT (4)	PT102291B (zh)
SE (1)	SE9901462A0 (zh)
SI (3)	SI0970955T1 (zh)
SK (1)	SK20262000A3 (zh)
TR (1)	TR200100054T2 (zh)
WO (1)	WO2000001694A1 (zh)

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GB0015981D0 (en) *	2000-06-29	2000-08-23	Glaxo Group Ltd	Novel process for preparing crystalline particles
WO2002017921A2 (en) *	2000-08-28	2002-03-07	Synthon B.V.	Paroxetine compositions and processes for making the same
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US20100249166A1 (en)	2007-09-19	2010-09-30	Xy, Inc.	Differential evaporation potentiated disinfectant system
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1999
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2000
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2001
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2002
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Also Published As

Publication number	Publication date
SI1089996T1 (en)	2004-04-30
US20020035130A1 (en)	2002-03-21
GB9909505D0 (en)	1999-06-23
EP1020464A1 (en)	2000-07-19
SE9901462A0 (sv)	2000-01-03
GB0119695D0 (en)	2001-10-03
GB0216752D0 (en)	2002-08-28
ES2149044T3 (es)	2000-10-16
CN1127502C (zh)	2003-11-12
CN1315949A (zh)	2001-10-03
NO991944D0 (no)	1999-04-23
SE9901462L (zh)
LU90388B1 (fr)	2001-01-29
NL1011875C2 (nl)	2000-03-24
AR018197A1 (es)	2001-10-31
BE1012403A5 (fr)	2000-10-03
US20020193406A1 (en)	2002-12-19
GB0026487D0 (en)	2000-12-13
TR200100054T2 (tr)	2001-06-21
PT102291B (pt)	2002-07-31
AR011759A1 (es)	2000-09-13
ATE251155T1 (de)	2003-10-15
DK199900234U1 (da)	2000-12-22
AU2392899A (en)	2000-01-20
EP1288214A1 (en)	2003-03-05
FR2802098A1 (fr)	2001-06-15
NL1011875A1 (nl)	2000-01-07
GR1003350B (el)	2000-03-29
HUP0102334A3 (en)	2003-12-29
PL345214A1 (en)	2001-12-03
GB2339428A (en)	2000-01-26
NL1012272C1 (nl)	1999-07-12
DE69900007T2 (de)	2001-06-07
ES2158778B1 (es)	2002-03-16
PT102291A (pt)	2000-05-31
ES2209428T3 (es)	2004-06-16
CA2269999A1 (en)	2000-01-02
KR20010053336A (ko)	2001-06-25
EP0970955A1 (en)	2000-01-12
ES2158778A1 (es)	2001-09-01
DE69911774T2 (de)	2004-08-05
BR9911682A (pt)	2001-12-26
NZ509180A (en)	2001-06-29
FR2780728A1 (fr)	2000-01-07
GB2377637A (en)	2003-01-22
PT970955E (pt)	2000-11-30
FI112077B (fi)	2003-10-31
NL1012271C2 (nl)	1999-09-23
WO2000001694A1 (en)	2000-01-13
IES20000893A2 (en)	2001-05-30
DE69911774D1 (de)	2003-11-06
SK20262000A3 (sk)	2001-07-10
CH689805A8 (fr)	2000-02-29
DE19918588A1 (de)	2000-01-27
AU3619199A (en)	2000-01-24
EP1020464B1 (en)	2001-07-04
JP2002519422A (ja)	2002-07-02
AU732211C (en)	2004-05-06
ES2157881T3 (es)	2001-09-01
AU713131B3 (en)	1999-11-25
DK199900554A (da)	2000-01-03
IES81166B2 (en)	2000-05-31
GB2336364A (en)	1999-10-20
GB2352395A (en)	2001-01-31
US6063927A (en)	2000-05-16
SI1020464T1 (en)	2001-12-31
IE990344A1 (en)	2000-05-03
BE1012420A6 (fr)	2000-10-03
DK1020464T3 (da)	2001-09-24
IT1312540B1 (it)	2002-04-22
US20010023253A1 (en)	2001-09-20
NL1011874C1 (nl)	1999-07-12
EP1089996B1 (en)	2003-10-01
IL140628A (en)	2004-06-20
DK1089996T3 (da)	2004-02-09
NO991944L (no)	2000-01-03
IES990343A2 (en)	2000-01-02
PT1020464E (pt)	2001-10-30
SE9901462D0 (sv)	1999-04-23
ATE195121T1 (de)	2000-08-15
AU713877B3 (en)	1999-12-09
GR3034328T3 (en)	2000-12-29
DE60000003D1 (de)	2001-08-09
GB2367003A (en)	2002-03-27
DE69900007D1 (de)	2000-09-07
FIU990190U0 (fi)	1999-04-23
AU732211B2 (en)	2001-04-12
BE1011664A6 (fr)	1999-11-09
IE20000633A1 (en)	2001-10-17
FR2780728B1 (fr)	2001-02-16
DK200000390U1 (da)	2000-12-27
AT3185U3 (de)	2000-01-25
FI990922A (fi)	2000-01-03
GB9920332D0 (en)	1999-11-03
GR3036208T3 (en)	2001-10-31
SI0970955T1 (en)	2001-02-28
NL1012271A1 (nl)	1999-07-12
PT1089996E (pt)	2004-02-27
CH689805A5 (fr)	1999-11-30
GB2336364B (en)	2000-05-10
EP0970955B1 (en)	2000-08-02
IES20000894A2 (en)	2001-05-30
AT3185U2 (de)	1999-11-25
DK199900176U3 (da)	1999-08-13
DK0970955T3 (da)	2000-10-09
DK199900234U4 (da)	2000-12-22
GB2352395B (en)	2004-02-11
FI990922A0 (fi)	1999-04-23
GR990100140A (el)	2000-03-31
DE29907248U1 (de)	1999-09-09
FI4209U1 (fi)	1999-11-10
HK1037877A1 (en)	2002-02-22
DE60000003T2 (de)	2002-03-21
IL140628A0 (en)	2002-02-10
EP1089996A1 (en)	2001-04-11
ITMI990866A1 (it)	2000-10-23
ATE202777T1 (de)	2001-07-15
EP1020463A1 (en)	2000-07-19
HUP0102334A2 (hu)	2002-05-29

Publication	Publication Date	Title
NO319030B1 (no)	2005-06-06	Paroxetinmetansulfonat, anvendelse derav samt fremgangsmate for fremstilling og farmasoytisk preparat.
AU2002100370A4 (en)	2002-06-06	Novel compound
AU724845B3 (en)	2000-09-28	Novel compound
AU2001100025A4 (en)	2001-06-21	Novel compound
AU732558B3 (en)	2001-04-26	Novel compound
MXPA01000307A (en)	2001-09-07	Paroxetine methanesulfonate
AU5430701A (en)	2001-12-06	Novel compound
CZ20004924A3 (cs)	2001-06-13	Methansulfonat paroxetinu