NO317301B1 - N-(3-etynylfenylamino)-6,7-bis(2-metoksyetoksy)-4-quinazolinamin mesylat anhydrat og monohydrat - Google Patents

N-(3-etynylfenylamino)-6,7-bis(2-metoksyetoksy)-4-quinazolinamin mesylat anhydrat og monohydrat Download PDF

Info

Publication number: NO317301B1
Authority: NO; Norway
Prior art keywords: compound; polymorph; pharmaceutical composition; bis; methoxyethoxy
Prior art date: 1998-04-29

Application number

NO20005453A

Other languages

English (en)

Norwegian (no)

Other versions

NO20005453D0 (no

NO20005453L (no

Inventor

Jeffrey William Raggon

Ravi Mysore Shanker

Dinos Paul Santafianos

Douglas John Meldrum Allen

Timothy Norris

Original Assignee

Osi Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-29

Filing date

2000-10-27

Publication date

2004-10-04

2000-10-27 Application filed by Osi Pharm Inc filed Critical Osi Pharm Inc

2000-10-27 Publication of NO20005453D0 publication Critical patent/NO20005453D0/no

2000-12-20 Publication of NO20005453L publication Critical patent/NO20005453L/no

2004-10-04 Publication of NO317301B1 publication Critical patent/NO317301B1/no

Links

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Classifications

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- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Physical Education & Sports Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Dermatology (AREA)
Oncology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NO20005453A 1998-04-29 2000-10-27 N-(3-etynylfenylamino)-6,7-bis(2-metoksyetoksy)-4-quinazolinamin mesylat anhydrat og monohydrat NO317301B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US8344198P	1998-04-29	1998-04-29
PCT/IB1999/000612 WO1999055683A1 (en)	1998-04-29	1999-04-08	N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate

Publications (3)

Publication Number	Publication Date
NO20005453D0 NO20005453D0 (no)	2000-10-27
NO20005453L NO20005453L (no)	2000-12-20
NO317301B1 true NO317301B1 (no)	2004-10-04

Family

ID=22178359

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20005453A NO317301B1 (no)	1998-04-29	2000-10-27	N-(3-etynylfenylamino)-6,7-bis(2-metoksyetoksy)-4-quinazolinamin mesylat anhydrat og monohydrat

Country Status (42)

Country	Link
EP (1)	EP1076652B1 (ru)
JP (1)	JP4652569B2 (ru)
KR (1)	KR100668412B1 (ru)
CN (2)	CN1298396A (ru)
AP (1)	AP1252A (ru)
AR (1)	AR018201A1 (ru)
AT (1)	ATE295839T1 (ru)
AU (1)	AU759691C (ru)
BR (1)	BR9910025A (ru)
CA (1)	CA2330447C (ru)
CO (1)	CO5060467A1 (ru)
CZ (1)	CZ298230B6 (ru)
DE (1)	DE69925366T2 (ru)
DZ (1)	DZ2777A1 (ru)
EA (1)	EA002836B1 (ru)
EG (1)	EG24000A (ru)
ES (1)	ES2238825T3 (ru)
GT (1)	GT199900063A (ru)
HK (1)	HK1037180A1 (ru)
HN (1)	HN1999000057A (ru)
HU (1)	HU227569B1 (ru)
ID (1)	ID27198A (ru)
IL (1)	IL139172A0 (ru)
MA (1)	MA26624A1 (ru)
ME (1)	MEP42008A (ru)
MX (1)	MXPA00010610A (ru)
MY (1)	MY136033A (ru)
NO (1)	NO317301B1 (ru)
NZ (1)	NZ508154A (ru)
OA (1)	OA11769A (ru)
PA (1)	PA8471001A1 (ru)
PE (1)	PE20000441A1 (ru)
PL (1)	PL196940B1 (ru)
RS (1)	RS50081B (ru)
SA (1)	SA99200216B1 (ru)
TN (1)	TNSN99079A1 (ru)
TR (1)	TR200003166T2 (ru)
TW (1)	TWI248437B (ru)
UA (1)	UA60363C2 (ru)
UY (1)	UY26099A1 (ru)
WO (1)	WO1999055683A1 (ru)
ZA (1)	ZA992972B (ru)

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YU13200A (sh)	1999-03-31	2002-10-18	Pfizer Products Inc.	Postupci i intermedijeri za dobijanje anti-kancernih jedinjenja
UA74803C2 (ru) *	1999-11-11	2006-02-15	Осі Фармасьютікалз, Інк.	Стойкий полиморф гидрохлорида n-(3-этинилфенил)-6,7-бис(2-метоксиэтокси)-4-хиназолинамина, способ его получения (варианты) и фармацевтическое применение
US7087613B2 (en)	1999-11-11	2006-08-08	Osi Pharmaceuticals, Inc.	Treating abnormal cell growth with a stable polymorph of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
UA73993C2 (ru) *	2000-06-06	2005-10-17	Астразенека Аб	Хиназолиновые производные для лечения опухолей и фармацевтическая композиция
EP1408980A4 (en)	2001-06-21	2004-10-20	Ariad Pharma Inc	NEW QUINAZOLINES AND THEIR USE
US7078409B2 (en)	2002-03-28	2006-07-18	Beta Pharma, Inc.	Fused quinazoline derivatives useful as tyrosine kinase inhibitors
GB0223854D0 (en) *	2002-10-12	2002-11-20	Astrazeneca Ab	Therapeutic treatment
US7148231B2 (en)	2003-02-17	2006-12-12	Hoffmann-La Roche Inc.	[6,7-Bis(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)amine hydrochloride polymorph
JP4724657B2 (ja)	2003-05-30	2011-07-13	アストラゼネカユーケーリミテッド	プロセス
PL1680426T3 (pl)	2003-06-10	2008-02-29	Hoffmann La Roche	Pochodne 1,3,4-triazafenalenu i 1,3,4,6-tetraazafenalenu
GB0403744D0 (en)	2004-02-20	2004-03-24	Astrazeneca Ab	Chemical process
CA2565721C (en)	2004-05-06	2015-10-06	Bioresponse, L.L.C.	Diindolymethane formulations for the treatment of leiomyomas
WO2006083458A2 (en)	2004-12-30	2006-08-10	Bioresponse Llc	Use of diindolylmethane-related indoles for the treatment and prevention of respiratory syncytial virus associates conditions
WO2008012105A1 (en)	2006-07-28	2008-01-31	Synthon B.V.	Crystalline erlotinib
BRPI0717753B1 (pt)	2006-10-27	2022-04-12	Bioresponse, Llc	Uso de uma composição compreendendo 50-250 mg de um ou mais indóis relacionados com dim e um ou mais agentes anti-protozoários, e, composição
NZ579997A (en) *	2007-04-04	2012-08-31	Cipla Ltd	PROCESS FOR PREPARATION OF N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS
WO2009007984A2 (en)	2007-07-11	2009-01-15	Hetero Drugs Limited	An improved process for erlotinib hydrochloride
EP2176241B1 (en)	2007-08-17	2015-12-23	Hetero Drugs Limited	A novel hydrated form of erlotinib free base and a process for preparation of erlotinib hydrochloride polymorph form a substantially free of polymorph form b
KR101132937B1 (ko) *	2008-10-01	2012-04-06	주식회사종근당	Ｎ-(3-에티닐페닐)-6,7-비스(2-메톡시에톡시)-4-퀴나졸린아민 납실레이트 염
US8440823B2 (en)	2009-03-26	2013-05-14	Ranbaxy Laboratories Limited	Process for the preparation of erlotinib or its pharmaceutically acceptable salts thereof
WO2011068404A2 (en)	2009-12-02	2011-06-09	Ultimorphix Technologies B.V.	Administration of n-(3-ethynylphenylamino)-6,7-bis(2- methoxyethoxy)-4-quinazolinamine mesylate salt by inhalation
DE202010006543U1 (de)	2010-05-07	2010-09-09	Ratiopharm Gmbh	Erlotinibresinat
HU230483B1 (hu)	2011-10-10	2016-07-28	Egis Gyógyszergyár Nyrt.	Erlotinib sók
NZ630289A (en)	2012-09-04	2016-08-26	Shilpa Medicare Ltd	Crystalline erlotinib hydrochloride process

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JP2994165B2 (ja) *	1992-06-26	1999-12-27	ゼネカ・リミテッド	キナゾリン誘導体、その製造法および該キナゾリン誘導体を含有する抗癌作用を得るための医薬調剤
GB9323290D0 (en) *	1992-12-10	1994-01-05	Zeneca Ltd	Quinazoline derivatives
PT817775E (pt) *	1995-03-30	2002-01-30	Pfizer	Derivados de quinazolina
US5747498A (en) *	1996-05-28	1998-05-05	Pfizer Inc.	Alkynyl and azido-substituted 4-anilinoquinazolines

1999
- 1999-04-08 CN CN99805497A patent/CN1298396A/zh active Pending
- 1999-04-08 BR BR9910025-8A patent/BR9910025A/pt not_active Application Discontinuation
- 1999-04-08 ME MEP-420/08A patent/MEP42008A/xx unknown
- 1999-04-08 ES ES99909165T patent/ES2238825T3/es not_active Expired - Lifetime
- 1999-04-08 IL IL13917299A patent/IL139172A0/xx not_active IP Right Cessation
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- 1999-04-08 ID IDW20002186A patent/ID27198A/id unknown
- 1999-04-08 AU AU28509/99A patent/AU759691C/en not_active Expired
- 1999-04-08 CN CNA2008100051101A patent/CN101219999A/zh active Pending
- 1999-04-08 HU HU0101818A patent/HU227569B1/hu unknown
- 1999-04-08 CA CA002330447A patent/CA2330447C/en not_active Expired - Lifetime
- 1999-04-08 JP JP2000545843A patent/JP4652569B2/ja not_active Expired - Lifetime
- 1999-04-08 WO PCT/IB1999/000612 patent/WO1999055683A1/en active IP Right Grant
- 1999-04-08 MX MXPA00010610A patent/MXPA00010610A/es active IP Right Grant
- 1999-04-08 AT AT99909165T patent/ATE295839T1/de not_active IP Right Cessation
- 1999-04-08 KR KR1020007011998A patent/KR100668412B1/ko not_active IP Right Cessation
- 1999-04-08 TR TR2000/03166T patent/TR200003166T2/xx unknown
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- 1999-04-08 DE DE69925366T patent/DE69925366T2/de not_active Expired - Lifetime
- 1999-04-08 NZ NZ508154A patent/NZ508154A/en not_active IP Right Cessation
- 1999-04-08 EA EA200001112A patent/EA002836B1/ru not_active IP Right Cessation
- 1999-04-08 OA OA1200000300A patent/OA11769A/en unknown
- 1999-04-08 PL PL343766A patent/PL196940B1/pl not_active IP Right Cessation
- 1999-04-08 RS YUP-661/00A patent/RS50081B/sr unknown
- 1999-04-23 TW TW088106555A patent/TWI248437B/zh not_active IP Right Cessation
- 1999-04-26 HN HN1999000057A patent/HN1999000057A/es unknown
- 1999-04-27 MY MYPI99001636A patent/MY136033A/en unknown
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- 1999-04-28 ZA ZA9902972A patent/ZA992972B/xx unknown
- 1999-04-28 MA MA25557A patent/MA26624A1/fr unknown
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- 1999-04-29 EG EG48299A patent/EG24000A/xx active
- 1999-04-29 PE PE1999000356A patent/PE20000441A1/es not_active Application Discontinuation
- 1999-04-29 AP APAP/P/1999/001523A patent/AP1252A/en active
- 1999-04-29 CO CO99026003A patent/CO5060467A1/es unknown
- 1999-06-02 SA SA99200216A patent/SA99200216B1/ar unknown
- 1999-08-04 UA UA2000116681A patent/UA60363C2/ru unknown
2000
- 2000-04-05 UY UY26099A patent/UY26099A1/es not_active Application Discontinuation
- 2000-10-27 NO NO20005453A patent/NO317301B1/no not_active IP Right Cessation
2001
- 2001-08-17 HK HK01105821A patent/HK1037180A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
HUP0101818A3 (en)	2002-05-28
NO20005453D0 (no)	2000-10-27
HU227569B1 (en)	2011-08-29
JP2002513009A (ja)	2002-05-08
ES2238825T3 (es)	2005-09-01
CO5060467A1 (es)	2001-07-30
BR9910025A (pt)	2000-12-26
CA2330447A1 (en)	1999-11-04
MA26624A1 (fr)	2004-12-20
IL139172A0 (en)	2001-11-25
SA99200216B1 (ar)	2006-06-04
EP1076652A1 (en)	2001-02-21
AP9901523A0 (en)	1999-06-30
KR20010078710A (ko)	2001-08-21
EA200001112A1 (ru)	2001-04-23
TNSN99079A1 (fr)	2005-11-10
CN1298396A (zh)	2001-06-06
AP1252A (en)	2004-02-25
AU2850999A (en)	1999-11-16
AU759691B2 (en)	2003-04-17
ID27198A (id)	2001-03-08
PL196940B1 (pl)	2008-02-29
GT199900063A (es)	2000-10-20
MY136033A (en)	2008-07-31
HUP0101818A1 (hu)	2002-03-28
EA002836B1 (ru)	2002-10-31
HN1999000057A (es)	1999-09-29
EG24000A (en)	2008-03-19
CN101219999A (zh)	2008-07-16
TR200003166T2 (tr)	2001-02-21
KR100668412B1 (ko)	2007-01-12
UY26099A1 (es)	2001-12-28
YU66100A (sh)	2003-07-07
JP4652569B2 (ja)	2011-03-16
UA60363C2 (ru)	2003-10-15
HK1037180A1 (en)	2002-02-01
RS50081B (sr)	2009-01-22
PA8471001A1 (es)	2000-09-29
PL343766A1 (en)	2001-09-10
DE69925366T2 (de)	2006-03-09
DZ2777A1 (fr)	2003-12-01
DE69925366D1 (de)	2005-06-23
NZ508154A (en)	2003-07-25
NO20005453L (no)	2000-12-20
CZ20003974A3 (en)	2001-05-16
CA2330447C (en)	2009-06-30
TWI248437B (en)	2006-02-01
CZ298230B6 (cs)	2007-08-01
MXPA00010610A (es)	2002-07-02
PE20000441A1 (es)	2000-05-23
OA11769A (en)	2005-07-25
MEP42008A (en)	2011-02-10
AR018201A1 (es)	2001-10-31
AU759691C (en)	2004-04-29
ZA992972B (en)	2000-10-30
WO1999055683A1 (en)	1999-11-04
EP1076652B1 (en)	2005-05-18
ATE295839T1 (de)	2005-06-15

Legal Events

Date	Code	Title	Description
2013-12-02	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO317301B1 (no)	2004-10-04	N-(3-etynylfenylamino)-6,7-bis(2-metoksyetoksy)-4-quinazolinamin mesylat anhydrat og monohydrat
AU784243B2 (en)	2006-02-23	Stable polymorph of N-(3-ethynylphenyl)-6,7-bis (2-methoxyethoxy)-4-quinazolinamine hydrochloride, methods of production, and pharmaceutical uses thereof
EP0824526A1 (en)	1998-02-25	Quinazoline derivative
US6706721B1 (en)	2004-03-16	N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate
ZA200203130B (en)	2003-04-22	Stable polymorph of N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride, methods of production, and pharmaceutical uses thereof.