MXPA02007031A - Proceso para la preparacion de 5-carboxiftaluro y su uso para la produccion de citalopram. - Google Patents

Proceso para la preparacion de 5-carboxiftaluro y su uso para la produccion de citalopram.

Info

Publication number
MXPA02007031A
MXPA02007031A MXPA02007031A MXPA02007031A MXPA02007031A MX PA02007031 A MXPA02007031 A MX PA02007031A MX PA02007031 A MXPA02007031 A MX PA02007031A MX PA02007031 A MXPA02007031 A MX PA02007031A MX PA02007031 A MXPA02007031 A MX PA02007031A
Authority
MX
Mexico
Prior art keywords
preparation
citalopram
production
mixture
isolating
Prior art date
Application number
MXPA02007031A
Other languages
English (en)
Inventor
Giovani Cotticelli
Original Assignee
Norpharma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26332721&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MXPA02007031(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Norpharma Spa filed Critical Norpharma Spa
Publication of MXPA02007031A publication Critical patent/MXPA02007031A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Seasonings (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Se describe un proceso para la preparacion de 5-carboxiftaluro, el cual comprende adicionar acido tereftalico a acido sulfurico fumante conteniendo al menos 20% en peso de SO3, entonces adicionar formaldehido a la mezcla, calentar la mezcla a una temperatura de 120- 145 degree C y aislar 5-carboxiftaluro a partir de la mezcla de reaccion.
MXPA02007031A 2000-01-18 2001-01-17 Proceso para la preparacion de 5-carboxiftaluro y su uso para la produccion de citalopram. MXPA02007031A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT2000MI000050A IT1317729B1 (it) 2000-01-18 2000-01-18 Procedimento per la preparazione della 5-carbossiftalide.
US09/690,301 US6458973B1 (en) 2000-01-18 2000-10-17 Process for the preparation of 5-carboxyphthalide
PCT/EP2001/000617 WO2001053284A1 (en) 2000-01-18 2001-01-17 Process for the preparation of 5-carboxyphthalide and its use for the production of citalopram

Publications (1)

Publication Number Publication Date
MXPA02007031A true MXPA02007031A (es) 2004-09-06

Family

ID=26332721

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02007031A MXPA02007031A (es) 2000-01-18 2001-01-17 Proceso para la preparacion de 5-carboxiftaluro y su uso para la produccion de citalopram.

Country Status (21)

Country Link
US (4) US6458973B1 (es)
EP (2) EP1118614B2 (es)
JP (1) JP4558182B2 (es)
CN (1) CN1184220C (es)
AT (1) ATE219489T1 (es)
AU (1) AU779581B2 (es)
BG (1) BG65763B1 (es)
BR (1) BR0107853A (es)
CA (1) CA2397497C (es)
DE (1) DE60000226T3 (es)
DK (1) DK1118614T4 (es)
ES (1) ES2178626T5 (es)
HK (1) HK1042290B (es)
HU (1) HUP0204187A3 (es)
IT (1) IT1317729B1 (es)
MX (1) MXPA02007031A (es)
PL (1) PL356563A1 (es)
PT (1) PT1118614E (es)
RO (1) RO121737B1 (es)
WO (1) WO2001053284A1 (es)
ZA (1) ZA200205475B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR026063A1 (es) * 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
KR20020080485A (ko) * 2000-03-13 2002-10-23 하. 룬트벡 아크티에 셀스카브 5-치환 1-(4-플루오로페닐)-1,3-디히드로이소벤조푸란의단계적 알킬화
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
CN101362743A (zh) * 2003-03-21 2009-02-11 H.隆德贝克有限公司 用于制备西酞普兰和依他普仑的中间体
AU2003223105A1 (en) * 2003-03-24 2004-10-18 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
WO2006090409A1 (en) * 2005-02-28 2006-08-31 Kekule Pharma Ltd., An improved process for the preparation of 5 - carboxyphthalide

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3607884A (en) * 1969-03-11 1971-09-21 Mobil Oil Corp Preparation of 5-carboxyphthalide in liquid sodium trioxide
US3976751A (en) † 1974-10-21 1976-08-24 Allied Chemical Corporation Stabilization of liquid sulfur trioxide
DE2630927A1 (de) 1976-07-09 1978-01-19 Basf Ag Verfahren zur herstellung von phthalidcarbonsaeure-(5)
DE3605716A1 (de) 1986-02-22 1987-09-03 Henkel Kgaa Verwendung von unloeslichen schmutzsammlern zur regenerierung von wasch- und reinigungsloesungen
DE69801764T2 (de) * 1997-07-08 2002-07-04 Lundbeck & Co As H Verfahren zur herstellung von citalopram
US6365747B1 (en) * 1998-10-20 2002-04-02 H. Lundbeck A/S Method for the preparation of citalopram
AR026063A1 (es) * 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
WO2001032643A1 (en) 1999-11-01 2001-05-10 H. Lundbeck A/S Method for the preparation of 5-carboxyphthalide
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram

Also Published As

Publication number Publication date
US20030009038A1 (en) 2003-01-09
DE60000226T3 (de) 2012-02-16
EP1118614B1 (en) 2002-06-19
DK1118614T3 (da) 2002-10-14
EP1187822A1 (en) 2002-03-20
PT1118614E (pt) 2002-11-29
HUP0204187A2 (hu) 2003-03-28
US20080249319A1 (en) 2008-10-09
BR0107853A (pt) 2002-10-29
ATE219489T1 (de) 2002-07-15
JP2001206881A (ja) 2001-07-31
AU779581B2 (en) 2005-01-27
IT1317729B1 (it) 2003-07-15
ES2178626T5 (es) 2011-06-02
HUP0204187A3 (en) 2005-05-30
EP1118614A2 (en) 2001-07-25
WO2001053284A1 (en) 2001-07-26
CA2397497C (en) 2010-07-06
HK1042290A1 (en) 2002-08-09
ITMI20000050A0 (it) 2000-01-18
AU2679801A (en) 2001-07-31
CN1406236A (zh) 2003-03-26
EP1118614A3 (en) 2001-10-24
PL356563A1 (en) 2004-06-28
EP1118614B2 (en) 2011-03-09
US6703516B2 (en) 2004-03-09
DK1118614T4 (da) 2011-06-27
RO121737B1 (ro) 2008-03-28
US20040171851A1 (en) 2004-09-02
DE60000226D1 (de) 2002-07-25
ITMI20000050A1 (it) 2001-07-18
ZA200205475B (en) 2003-12-31
US6458973B1 (en) 2002-10-01
HK1042290B (zh) 2003-07-18
BG65763B1 (bg) 2009-10-30
ES2178626T3 (es) 2003-01-01
CN1184220C (zh) 2005-01-12
JP4558182B2 (ja) 2010-10-06
DE60000226T2 (de) 2003-03-06
BG106925A (bg) 2004-01-30
CA2397497A1 (en) 2001-07-26

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