MX9704822A - Nuevos derivados de ciclodextrina y metodos para la preparacion de los mismos. - Google Patents

Nuevos derivados de ciclodextrina y metodos para la preparacion de los mismos.

Info

Publication number
MX9704822A
MX9704822A MX9704822A MX9704822A MX9704822A MX 9704822 A MX9704822 A MX 9704822A MX 9704822 A MX9704822 A MX 9704822A MX 9704822 A MX9704822 A MX 9704822A MX 9704822 A MX9704822 A MX 9704822A
Authority
MX
Mexico
Prior art keywords
derivatives
cyclodextrin
groups
preparation
methods
Prior art date
Application number
MX9704822A
Other languages
English (en)
Inventor
Luuk Hilgers
Original Assignee
Dimminaco Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=3888560&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX9704822(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dimminaco Ag filed Critical Dimminaco Ag
Publication of MX9704822A publication Critical patent/MX9704822A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55583—Polysaccharides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invencion se relaciona con derivados de ciclodextrina y métodos para la preparacion de los mismos, derivados de ciclodextrina los cuales tienen al menos un pero no más de N-1 grupos alquilo "superiores" y al menos pero no más de N-1 grupos sulfato, en donde el numero combinado total de grupos alquilo "superiores" y grupos sulfato no excede de N, y además en donde N es el numero de grupos hidroxilo de la ciclodextrina de la cual el derivado se derivo. Los grupos alquilo "superiores" son lípidos y, de manera más particular, cadenas de carbono alifáticas o aromáticas, especialmente cadenas de carbono lineales que tienen una estructura general de -O-C(=O=)-(CH2)n-CH3, en donde n es de entre 6 y 24 y/o -OC(=O)-(CH2)m-CH=CH-(CH2)m-CH3, en donde m es al menos 6. Los grupos sulfato descritos aquí son grupos sulfato que tiene la formula -OSO3R, en la cual R puede ser H, Na, K, Li, NH4 y/o otros átomos/moléculas que forman cationes monovalentes. Los derivados de CD se obtienen en una reaccion de dos pasos en donde una ciclodextrina se pone en contacto con cloruro de acoilo seguido por la sulfonacion del complejo de SO3.
MX9704822A 1994-12-27 1995-12-21 Nuevos derivados de ciclodextrina y metodos para la preparacion de los mismos. MX9704822A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BE9401174A BE1008978A5 (fr) 1994-12-27 1994-12-27 Adjuvants pour vaccins.
PCT/BE1995/000120 WO1996020222A1 (en) 1994-12-27 1995-12-21 Novel cyclodextrin-derivatives and methods for the preparation thereof

Publications (1)

Publication Number Publication Date
MX9704822A true MX9704822A (es) 1998-05-31

Family

ID=3888560

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9704822A MX9704822A (es) 1994-12-27 1995-12-21 Nuevos derivados de ciclodextrina y metodos para la preparacion de los mismos.

Country Status (17)

Country Link
US (2) US6165995A (es)
EP (2) EP0814836B1 (es)
JP (2) JP3927235B2 (es)
CN (2) CN1132630C (es)
AT (2) ATE199644T1 (es)
AU (2) AU709104B2 (es)
BE (1) BE1008978A5 (es)
BR (2) BR9510223A (es)
CA (2) CA2208790C (es)
DE (2) DE69520376T2 (es)
DK (2) DK0814836T3 (es)
ES (2) ES2204969T3 (es)
GR (1) GR3035941T3 (es)
MX (1) MX9704822A (es)
PT (2) PT814836E (es)
SI (1) SI0800539T1 (es)
WO (2) WO1996020008A1 (es)

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BE1008978A5 (fr) * 1994-12-27 1996-10-01 Solvay Adjuvants pour vaccins.
US5916883A (en) 1996-11-01 1999-06-29 Poly-Med, Inc. Acylated cyclodextrin derivatives
ES2500490T3 (es) * 1997-08-29 2014-09-30 Antigenics Inc. Composiciones que comprenden el adyuvante QS-21 y polisorbato o ciclodextrina como excipiente
EP1104767A1 (en) * 1999-11-30 2001-06-06 Stichting Dienst Landbouwkundig Onderzoek Mono- and disaccharide derivatives containing both fatty acid ester and sulfate ester groups
AT408150B (de) * 2000-04-14 2001-09-25 Oesterr Forsch Seibersdorf Verfahren zur immobilisierung eines analyten an einer festen oberfläche
FR2808691B1 (fr) 2000-05-12 2005-06-24 Coletica Cyclodextrines substituees preferentiellement sur leur face primaire par des fonctions acide ou amine
FR2825714B1 (fr) * 2001-06-08 2005-03-25 Seppic Sa Nouvelle utilisation de complexes d'inclusion de cyclodestrine
MX339524B (es) 2001-10-11 2016-05-30 Wyeth Corp Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
EP1496916A2 (en) * 2002-04-09 2005-01-19 Greenville Hospital System Metastasis modulating activity of highly sulfated oligosaccharides
EP2591786B1 (en) * 2003-10-16 2017-04-12 Cancure Limited Immunomodulating compositions and uses therefor
CA2631014C (en) 2005-11-28 2015-04-28 Vernon D. Rowe Compositions useful for reducing nephrotoxicity and methods of use thereof
US20090017064A1 (en) * 2007-07-10 2009-01-15 Wyeth Methods and Compositions for Immunizing Pigs Against Porcine Circovirus
AU2008324780A1 (en) 2007-11-06 2009-05-14 Pah W Llc Mycoplasma hyopneumoniae avirulent -adjuvanted live vaccine
EP2062594A1 (en) * 2007-11-21 2009-05-27 Wyeth Farma, S.A. Bluetongue virus vaccine and immunogenic compositions, methods of use and methods of producing same
US8192721B2 (en) * 2007-12-13 2012-06-05 Verrow Pharmaceuticals, Inc. Compositions useful for reducing toxicity associated with gadolinium-based contrast agents
PE20110023A1 (es) 2009-06-22 2011-01-31 Wyeth Llc Composiciones inmunogenicas de antigenos de staphylococcus aureus
EP3461496B1 (en) 2009-06-22 2023-08-23 Wyeth LLC Compositions and methods for preparing staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions
US20110110980A1 (en) * 2009-09-02 2011-05-12 Wyeth Llc Heterlogous prime-boost immunization regimen
EP2397484A1 (en) 2010-06-11 2011-12-21 Immunovo B.V. Trisaccharide derivates, and their use as adjuvants
RU2580620C2 (ru) 2010-08-23 2016-04-10 ВАЙЕТ ЭлЭлСи СТАБИЛЬНЫЕ КОМПОЗИЦИИ АНТИГЕНОВ Neisseria meningitidis rLP2086
PE20140173A1 (es) 2010-09-10 2014-02-20 Wyeth Llc Variantes no lipidadas de antigenos orf2086 de neisseria meningitidis
CN101972477B (zh) * 2010-10-21 2012-09-26 中国医学科学院医学生物学研究所 磷酸锌疫苗佐剂
KR20130114210A (ko) 2010-12-22 2013-10-16 와이어쓰 엘엘씨 스타필로코커스 아우레우스 항원의 안정한 면역원성 조성물
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
MY198910A (en) 2012-03-09 2023-10-02 Pfizer Neisseria meningitidis compositions and methods thereof
UA114503C2 (uk) 2012-04-04 2017-06-26 Зоетіс Сервісіз Ллс Комбінована вакцина pcv та mycoplasma hyopneumoniae
US9120859B2 (en) 2012-04-04 2015-09-01 Zoetis Services Llc Mycoplasma hyopneumoniae vaccine
UA114504C2 (uk) 2012-04-04 2017-06-26 Зоетіс Сервісіз Ллс Комбінована вакцина pcv, mycoplasma hyopneumoniae та prrs
PL3363806T3 (pl) 2012-12-20 2022-12-19 Pfizer Inc. Sposób glikokoniugacji
EP2964665B1 (en) 2013-03-08 2018-08-01 Pfizer Inc Immunogenic fusion polypeptides
MX369534B (es) 2013-09-08 2019-11-11 Pfizer Composiciones de neisseria meningitidis y sus metodos.
KR102319843B1 (ko) 2013-09-25 2021-10-29 조에티스 서비시즈 엘엘씨 Pcv2b 분지형 백신 조성물 및 사용 방법
CN104013955B (zh) * 2014-06-18 2016-02-24 中国科学院过程工程研究所 一种不含表面活性剂的水包油乳液及其用途
CN104086676B (zh) * 2014-07-18 2017-01-25 江苏省农业科学院 一种环糊精酯化衍生物、制备方法及其应用
ES2759542T3 (es) * 2014-07-24 2020-05-11 Litevax B V Adyuvantes
CN107249626A (zh) 2015-02-19 2017-10-13 辉瑞大药厂 脑膜炎奈瑟球菌组合物及其方法
TWI718144B (zh) 2015-05-04 2021-02-11 美商輝瑞股份有限公司 Ｂ型鏈球菌多醣－蛋白質軛合物、製造軛合物之方法、含軛合物之免疫原性組成物、及其用途
US10751402B2 (en) 2016-11-09 2020-08-25 Pfizer Inc. Immunogenic compositions and uses thereof
SG11201906519RA (en) 2017-01-31 2019-08-27 Pfizer Neisseria meningitidis compositions and methods thereof
CN106928378A (zh) * 2017-03-29 2017-07-07 中国药科大学 一种十二酰基‑β‑环糊精的制备方法和用于色氨酸手性拆分的聚砜膜的制备方法
US11433139B2 (en) 2018-03-16 2022-09-06 Zoetis Services Llc Peptide vaccines against interleukin-31
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Also Published As

Publication number Publication date
WO1996020008A1 (fr) 1996-07-04
BR9510263A (pt) 1997-11-04
DK0814836T3 (da) 2001-04-17
JPH10511997A (ja) 1998-11-17
CA2208790A1 (en) 1996-07-04
MX9704824A (es) 1998-06-30
EP0800539A1 (en) 1997-10-15
PT814836E (pt) 2001-07-31
ATE248863T1 (de) 2003-09-15
EP0814836A1 (fr) 1998-01-07
CA2208849C (en) 2006-10-10
EP0800539B1 (en) 2003-09-03
BE1008978A5 (fr) 1996-10-01
JPH11502192A (ja) 1999-02-23
AU4324896A (en) 1996-07-19
JP4087900B2 (ja) 2008-05-21
DE69531699T2 (de) 2004-07-08
AU709104B2 (en) 1999-08-19
GR3035941T3 (en) 2001-08-31
EP0814836B1 (fr) 2001-03-14
BR9510223A (pt) 1997-12-30
CN1175264A (zh) 1998-03-04
CN1132630C (zh) 2003-12-31
DK0800539T3 (da) 2003-12-08
CA2208849A1 (en) 1996-07-04
WO1996020222A1 (en) 1996-07-04
CN1171052A (zh) 1998-01-21
ES2204969T3 (es) 2004-05-01
JP3927235B2 (ja) 2007-06-06
DE69520376T2 (de) 2001-08-09
AU4324996A (en) 1996-07-19
PT800539E (pt) 2004-01-30
SI0800539T1 (en) 2003-12-31
ES2155540T3 (es) 2001-05-16
CA2208790C (en) 2012-01-31
DE69520376D1 (de) 2001-04-19
ATE199644T1 (de) 2001-03-15
US6165995A (en) 2000-12-26
DE69531699D1 (de) 2003-10-09
US6328965B1 (en) 2001-12-11
AU713997B2 (en) 1999-12-16
CN1109049C (zh) 2003-05-21

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