ES2155540T3 - Adyuvante para vacunas que comprende un polisacarido sulfolipidico hidrofobo. - Google Patents
Adyuvante para vacunas que comprende un polisacarido sulfolipidico hidrofobo.Info
- Publication number
- ES2155540T3 ES2155540T3 ES95942007T ES95942007T ES2155540T3 ES 2155540 T3 ES2155540 T3 ES 2155540T3 ES 95942007 T ES95942007 T ES 95942007T ES 95942007 T ES95942007 T ES 95942007T ES 2155540 T3 ES2155540 T3 ES 2155540T3
- Authority
- ES
- Spain
- Prior art keywords
- sulfolipidic
- polyacaride
- hydrophobo
- vaccines
- adjuster
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55583—Polysaccharides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
AYUDANTES PARA VACUNAS QUE COMPRENDEN UN POLISACARIDO SULFOLIPIDICO COMBINADO CON UN COMPUESTO QUE FORMA UNA INTERFASE. SE PROPONE TAMBIEN UN PROCEDIMIENTO PARA PREPARAR UNA VACUNA EMULSIONANDO UNA SOLUCION ACUOSA DE UN ANTIGENO Y UN POLISACARIDO SULFOLIPIDICO. LOS AYUDANTES PROPUESTOS SON ESTABLES A ALTA TEMPERATURA, SU EFICACIA ES COMPARABLE O INCLUSO SUPERIOR A LA DE LOS AYUDANTES CONVENCIONALES. SU TOXICIDAD ES LOCAL, ES DECIR SU REACTOGENICIDAD ES, EN GENERAL, INFERIOR A LA DE LOS AYUDANTES CONVENCIONALES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BE9401174A BE1008978A5 (fr) | 1994-12-27 | 1994-12-27 | Adjuvants pour vaccins. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2155540T3 true ES2155540T3 (es) | 2001-05-16 |
Family
ID=3888560
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95942008T Expired - Lifetime ES2204969T3 (es) | 1994-12-27 | 1995-12-21 | Derivados de ciclodextrina y metodos de preparacion de los mismos. |
ES95942007T Expired - Lifetime ES2155540T3 (es) | 1994-12-27 | 1995-12-21 | Adyuvante para vacunas que comprende un polisacarido sulfolipidico hidrofobo. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95942008T Expired - Lifetime ES2204969T3 (es) | 1994-12-27 | 1995-12-21 | Derivados de ciclodextrina y metodos de preparacion de los mismos. |
Country Status (17)
Country | Link |
---|---|
US (2) | US6165995A (es) |
EP (2) | EP0814836B1 (es) |
JP (2) | JP3927235B2 (es) |
CN (2) | CN1132630C (es) |
AT (2) | ATE199644T1 (es) |
AU (2) | AU709104B2 (es) |
BE (1) | BE1008978A5 (es) |
BR (2) | BR9510223A (es) |
CA (2) | CA2208790C (es) |
DE (2) | DE69520376T2 (es) |
DK (2) | DK0814836T3 (es) |
ES (2) | ES2204969T3 (es) |
GR (1) | GR3035941T3 (es) |
MX (1) | MX9704822A (es) |
PT (2) | PT814836E (es) |
SI (1) | SI0800539T1 (es) |
WO (2) | WO1996020008A1 (es) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE1008978A5 (fr) * | 1994-12-27 | 1996-10-01 | Solvay | Adjuvants pour vaccins. |
US5916883A (en) | 1996-11-01 | 1999-06-29 | Poly-Med, Inc. | Acylated cyclodextrin derivatives |
ES2500490T3 (es) * | 1997-08-29 | 2014-09-30 | Antigenics Inc. | Composiciones que comprenden el adyuvante QS-21 y polisorbato o ciclodextrina como excipiente |
EP1104767A1 (en) * | 1999-11-30 | 2001-06-06 | Stichting Dienst Landbouwkundig Onderzoek | Mono- and disaccharide derivatives containing both fatty acid ester and sulfate ester groups |
AT408150B (de) * | 2000-04-14 | 2001-09-25 | Oesterr Forsch Seibersdorf | Verfahren zur immobilisierung eines analyten an einer festen oberfläche |
FR2808691B1 (fr) | 2000-05-12 | 2005-06-24 | Coletica | Cyclodextrines substituees preferentiellement sur leur face primaire par des fonctions acide ou amine |
FR2825714B1 (fr) * | 2001-06-08 | 2005-03-25 | Seppic Sa | Nouvelle utilisation de complexes d'inclusion de cyclodestrine |
MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
EP1496916A2 (en) * | 2002-04-09 | 2005-01-19 | Greenville Hospital System | Metastasis modulating activity of highly sulfated oligosaccharides |
EP2591786B1 (en) * | 2003-10-16 | 2017-04-12 | Cancure Limited | Immunomodulating compositions and uses therefor |
CA2631014C (en) | 2005-11-28 | 2015-04-28 | Vernon D. Rowe | Compositions useful for reducing nephrotoxicity and methods of use thereof |
US20090017064A1 (en) * | 2007-07-10 | 2009-01-15 | Wyeth | Methods and Compositions for Immunizing Pigs Against Porcine Circovirus |
AU2008324780A1 (en) | 2007-11-06 | 2009-05-14 | Pah W Llc | Mycoplasma hyopneumoniae avirulent -adjuvanted live vaccine |
EP2062594A1 (en) * | 2007-11-21 | 2009-05-27 | Wyeth Farma, S.A. | Bluetongue virus vaccine and immunogenic compositions, methods of use and methods of producing same |
US8192721B2 (en) * | 2007-12-13 | 2012-06-05 | Verrow Pharmaceuticals, Inc. | Compositions useful for reducing toxicity associated with gadolinium-based contrast agents |
PE20110023A1 (es) | 2009-06-22 | 2011-01-31 | Wyeth Llc | Composiciones inmunogenicas de antigenos de staphylococcus aureus |
EP3461496B1 (en) | 2009-06-22 | 2023-08-23 | Wyeth LLC | Compositions and methods for preparing staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions |
US20110110980A1 (en) * | 2009-09-02 | 2011-05-12 | Wyeth Llc | Heterlogous prime-boost immunization regimen |
EP2397484A1 (en) | 2010-06-11 | 2011-12-21 | Immunovo B.V. | Trisaccharide derivates, and their use as adjuvants |
RU2580620C2 (ru) | 2010-08-23 | 2016-04-10 | ВАЙЕТ ЭлЭлСи | СТАБИЛЬНЫЕ КОМПОЗИЦИИ АНТИГЕНОВ Neisseria meningitidis rLP2086 |
PE20140173A1 (es) | 2010-09-10 | 2014-02-20 | Wyeth Llc | Variantes no lipidadas de antigenos orf2086 de neisseria meningitidis |
CN101972477B (zh) * | 2010-10-21 | 2012-09-26 | 中国医学科学院医学生物学研究所 | 磷酸锌疫苗佐剂 |
KR20130114210A (ko) | 2010-12-22 | 2013-10-16 | 와이어쓰 엘엘씨 | 스타필로코커스 아우레우스 항원의 안정한 면역원성 조성물 |
SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
MY198910A (en) | 2012-03-09 | 2023-10-02 | Pfizer | Neisseria meningitidis compositions and methods thereof |
UA114503C2 (uk) | 2012-04-04 | 2017-06-26 | Зоетіс Сервісіз Ллс | Комбінована вакцина pcv та mycoplasma hyopneumoniae |
US9120859B2 (en) | 2012-04-04 | 2015-09-01 | Zoetis Services Llc | Mycoplasma hyopneumoniae vaccine |
UA114504C2 (uk) | 2012-04-04 | 2017-06-26 | Зоетіс Сервісіз Ллс | Комбінована вакцина pcv, mycoplasma hyopneumoniae та prrs |
PL3363806T3 (pl) | 2012-12-20 | 2022-12-19 | Pfizer Inc. | Sposób glikokoniugacji |
EP2964665B1 (en) | 2013-03-08 | 2018-08-01 | Pfizer Inc | Immunogenic fusion polypeptides |
MX369534B (es) | 2013-09-08 | 2019-11-11 | Pfizer | Composiciones de neisseria meningitidis y sus metodos. |
KR102319843B1 (ko) | 2013-09-25 | 2021-10-29 | 조에티스 서비시즈 엘엘씨 | Pcv2b 분지형 백신 조성물 및 사용 방법 |
CN104013955B (zh) * | 2014-06-18 | 2016-02-24 | 中国科学院过程工程研究所 | 一种不含表面活性剂的水包油乳液及其用途 |
CN104086676B (zh) * | 2014-07-18 | 2017-01-25 | 江苏省农业科学院 | 一种环糊精酯化衍生物、制备方法及其应用 |
ES2759542T3 (es) * | 2014-07-24 | 2020-05-11 | Litevax B V | Adyuvantes |
CN107249626A (zh) | 2015-02-19 | 2017-10-13 | 辉瑞大药厂 | 脑膜炎奈瑟球菌组合物及其方法 |
TWI718144B (zh) | 2015-05-04 | 2021-02-11 | 美商輝瑞股份有限公司 | B型鏈球菌多醣-蛋白質軛合物、製造軛合物之方法、含軛合物之免疫原性組成物、及其用途 |
US10751402B2 (en) | 2016-11-09 | 2020-08-25 | Pfizer Inc. | Immunogenic compositions and uses thereof |
SG11201906519RA (en) | 2017-01-31 | 2019-08-27 | Pfizer | Neisseria meningitidis compositions and methods thereof |
CN106928378A (zh) * | 2017-03-29 | 2017-07-07 | 中国药科大学 | 一种十二酰基‑β‑环糊精的制备方法和用于色氨酸手性拆分的聚砜膜的制备方法 |
US11433139B2 (en) | 2018-03-16 | 2022-09-06 | Zoetis Services Llc | Peptide vaccines against interleukin-31 |
EP4203995A1 (en) | 2020-08-26 | 2023-07-05 | Pfizer Inc. | Group b streptococcus polysaccharide-protein conjugates, methods for producing conjugates, immunogenic compositions comprising conjugates, and uses thereof |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3565887A (en) * | 1968-05-15 | 1971-02-23 | Corn Products Co | Unsaturated and long chain esters of cyclodextrin |
US4247535A (en) * | 1979-11-05 | 1981-01-27 | American Cyanamid Company | Modified cyclodextrin sulfate salts as complement inhibitors |
US5760015A (en) * | 1988-01-19 | 1998-06-02 | The Trustees Of The University Of Pennsylvania | Cyclodextrin compounds and methods of making and use thereof |
US5658894A (en) * | 1989-04-23 | 1997-08-19 | The Trustees Of The University Of Pennsylvania | Compositions for inhibiting restenosis |
KR0166088B1 (ko) * | 1990-01-23 | 1999-01-15 | . | 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도 |
EP0518930A4 (en) * | 1990-03-02 | 1993-09-15 | Australian Commercial Research & Development Limited | Cyclodextrin compositions and methods for pharmaceutical and industrial applications |
FR2672496B3 (fr) * | 1990-07-18 | 1993-05-28 | Vacsyn France Sa | Compositions a base de substances hydrophobes, solubilisables dans un solvant aqueux, leur procede d'obtention, et leurs utilisations notamment dans le domaine pharmaceutique. |
US5180716A (en) * | 1990-08-01 | 1993-01-19 | The Regents Of The University Of California | Cyclodextrin complexes for neuraxial administration of drugs |
IT1242214B (it) * | 1990-11-13 | 1994-03-03 | Emo Chiellini | Derivati polifunzionali delle ciclodestrine |
JP2556236B2 (ja) * | 1991-08-29 | 1996-11-20 | 田辺製薬株式会社 | β−シクロデキストリン誘導体のポリ硫酸エステル及びその製法 |
CA2085827C (en) * | 1991-12-23 | 2003-10-14 | Lucas A. T. Hilgers | Adjuvant composition containing synthetic hydrophobic lipopolysaccharide |
WO1993017711A1 (en) * | 1992-03-11 | 1993-09-16 | Australian Commercial Research & Development Limited | New cyclodextrins and new formulated drugs |
DE4220734A1 (de) * | 1992-06-25 | 1994-01-05 | Puetter Medice Chem Pharm | Lipophile Cyclodextrinpolymere |
US5464827A (en) * | 1994-06-20 | 1995-11-07 | American Home Products Corporation | Esterified polyanionic cyclodextrins as smooth muscle cell proliferation inhibitors |
BE1008978A5 (fr) * | 1994-12-27 | 1996-10-01 | Solvay | Adjuvants pour vaccins. |
-
1994
- 1994-12-27 BE BE9401174A patent/BE1008978A5/fr active
-
1995
- 1995-12-21 DE DE69520376T patent/DE69520376T2/de not_active Expired - Lifetime
- 1995-12-21 EP EP95942007A patent/EP0814836B1/fr not_active Expired - Lifetime
- 1995-12-21 US US08/860,454 patent/US6165995A/en not_active Expired - Lifetime
- 1995-12-21 US US08/860,453 patent/US6328965B1/en not_active Expired - Lifetime
- 1995-12-21 SI SI9530679T patent/SI0800539T1/xx unknown
- 1995-12-21 DK DK95942007T patent/DK0814836T3/da active
- 1995-12-21 PT PT95942007T patent/PT814836E/pt unknown
- 1995-12-21 PT PT95942008T patent/PT800539E/pt unknown
- 1995-12-21 CA CA2208790A patent/CA2208790C/en not_active Expired - Lifetime
- 1995-12-21 JP JP52008196A patent/JP3927235B2/ja not_active Expired - Lifetime
- 1995-12-21 CA CA002208849A patent/CA2208849C/en not_active Expired - Lifetime
- 1995-12-21 CN CN95197099A patent/CN1132630C/zh not_active Expired - Lifetime
- 1995-12-21 AT AT95942007T patent/ATE199644T1/de active
- 1995-12-21 ES ES95942008T patent/ES2204969T3/es not_active Expired - Lifetime
- 1995-12-21 MX MX9704822A patent/MX9704822A/es unknown
- 1995-12-21 BR BR9510223A patent/BR9510223A/pt not_active IP Right Cessation
- 1995-12-21 AU AU43248/96A patent/AU709104B2/en not_active Ceased
- 1995-12-21 WO PCT/BE1995/000119 patent/WO1996020008A1/fr active IP Right Grant
- 1995-12-21 AU AU43249/96A patent/AU713997B2/en not_active Ceased
- 1995-12-21 ES ES95942007T patent/ES2155540T3/es not_active Expired - Lifetime
- 1995-12-21 AT AT95942008T patent/ATE248863T1/de active
- 1995-12-21 WO PCT/BE1995/000120 patent/WO1996020222A1/en active IP Right Grant
- 1995-12-21 EP EP95942008A patent/EP0800539B1/en not_active Expired - Lifetime
- 1995-12-21 JP JP52008296A patent/JP4087900B2/ja not_active Expired - Lifetime
- 1995-12-21 BR BR9510263A patent/BR9510263A/pt not_active IP Right Cessation
- 1995-12-21 CN CN95197557A patent/CN1109049C/zh not_active Expired - Lifetime
- 1995-12-21 DE DE69531699T patent/DE69531699T2/de not_active Expired - Lifetime
- 1995-12-21 DK DK95942008T patent/DK0800539T3/da active
-
2001
- 2001-05-28 GR GR20010400796T patent/GR3035941T3/el unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA2A | Application withdrawn |
Effective date: 19960103 |
|
FG2A | Definitive protection |
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