MX368110B - Procedimiento para la preparacion de n-[(3-aminooxetan-3-il)metil] -2-(1,1-dioxo-3,5-dihidro-1,4-benzotiazepin-4-il)-6-metil-quinazo lin-4-amina. - Google Patents

Procedimiento para la preparacion de n-[(3-aminooxetan-3-il)metil] -2-(1,1-dioxo-3,5-dihidro-1,4-benzotiazepin-4-il)-6-metil-quinazo lin-4-amina.

Info

Publication number
MX368110B
MX368110B MX2016009514A MX2016009514A MX368110B MX 368110 B MX368110 B MX 368110B MX 2016009514 A MX2016009514 A MX 2016009514A MX 2016009514 A MX2016009514 A MX 2016009514A MX 368110 B MX368110 B MX 368110B
Authority
MX
Mexico
Prior art keywords
methyl
preparation
aminooxetan
quinazol
benzothiazepin
Prior art date
Application number
MX2016009514A
Other languages
English (en)
Other versions
MX2016009514A (es
Inventor
She Jin
Wang Lin
Yu Jianhua
Chen Junli
Zhang Guocai
Ren Yi
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2016009514A publication Critical patent/MX2016009514A/es
Publication of MX368110B publication Critical patent/MX368110B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/04—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D305/06—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/04—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D305/08—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

La presente invención se refiere a un nuevo procedimiento para la preparación de un compuesto de fórmula (I): (ver Fórmula) y sales de adición farmacéuticamente aceptables del mismo, que resulta útil para la profilaxis y tratamiento de la infección por virus sincitial respiratorio (VSR) en un mamífero o ser humano.
MX2016009514A 2014-01-24 2015-01-21 Procedimiento para la preparacion de n-[(3-aminooxetan-3-il)metil] -2-(1,1-dioxo-3,5-dihidro-1,4-benzotiazepin-4-il)-6-metil-quinazo lin-4-amina. MX368110B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNPCT/CN2014/071331 2014-01-24
PCT/EP2015/051066 WO2015110446A1 (en) 2014-01-24 2015-01-21 Process for the preparation of n-[(3-aminooxetan-3-yl)methyl]-2-(1,1-dioxo-3,5-dihydro-1,4-benzothiazepin-4-yl)-6-methyl-quinazolin-4-amine

Publications (2)

Publication Number Publication Date
MX2016009514A MX2016009514A (es) 2016-10-26
MX368110B true MX368110B (es) 2019-09-18

Family

ID=52358790

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016009514A MX368110B (es) 2014-01-24 2015-01-21 Procedimiento para la preparacion de n-[(3-aminooxetan-3-il)metil] -2-(1,1-dioxo-3,5-dihidro-1,4-benzotiazepin-4-il)-6-metil-quinazo lin-4-amina.

Country Status (20)

Country Link
US (2) US10005770B2 (es)
EP (2) EP3248969B1 (es)
JP (1) JP6397501B2 (es)
KR (1) KR101841866B1 (es)
CN (2) CN109879837B (es)
AR (2) AR099134A1 (es)
AU (1) AU2015208244B2 (es)
BR (1) BR112016016978B1 (es)
CA (1) CA2934225C (es)
ES (2) ES2788900T3 (es)
HR (2) HRP20200680T1 (es)
IL (1) IL245882B (es)
MX (1) MX368110B (es)
MY (1) MY176210A (es)
NZ (1) NZ721534A (es)
PL (2) PL3097098T3 (es)
RU (1) RU2664643C2 (es)
SG (1) SG11201605916QA (es)
SI (2) SI3248969T1 (es)
WO (1) WO2015110446A1 (es)

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PL3324977T3 (pl) 2015-07-22 2022-11-14 Enanta Pharmaceuticals, Inc. Pochodne benzodiazepiny jako inhibitory rsv
MX2018005890A (es) 2015-11-12 2018-08-15 Hoffmann La Roche Composiciones para tratar atrofia muscular espinal.
ES2879995T3 (es) 2015-12-10 2021-11-23 Ptc Therapeutics Inc Métodos para el tratamiento de la enfermedad de Huntington
CN108137579B (zh) 2015-12-10 2022-01-07 豪夫迈·罗氏有限公司 桥连哌啶衍生物
CN108017599B (zh) * 2016-11-04 2020-03-03 上海爱科百发生物医药技术有限公司 [3-(胺甲基)-氧杂环丁烷-3-基]氨基甲酸对甲氧基苄酯对氯苯甲酸盐合成方法
EA201992878A1 (ru) 2017-06-05 2020-05-08 ПиТиСи ТЕРАПЬЮТИКС, ИНК. Соединения для лечения болезни хантингтона
BR112019027717A2 (pt) 2017-06-28 2020-07-28 Ptc Therapeutics, Inc. métodos para tratar a doença de huntington
MX2019015580A (es) 2017-06-28 2020-07-28 Ptc Therapeutics Inc Metodos para tratar la enfermedad de huntington.
WO2019006295A1 (en) 2017-06-30 2019-01-03 Enanta Pharmaceuticals, Inc. HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS
CN112135815A (zh) 2018-03-27 2020-12-25 Ptc医疗公司 用于治疗亨廷顿氏病的化合物
EP3814360A1 (en) 2018-06-27 2021-05-05 PTC Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
AU2019294478B2 (en) 2018-06-27 2023-03-23 Ptc Therapeutics, Inc. Heterocyclic and heteroaryl compounds for treating Huntington's disease
US11254664B2 (en) 2019-03-18 2022-02-22 Enanta Pharmaceuticals, Inc. Benzodiazepine derivatives as RSV inhibitors
KR20220101083A (ko) 2019-10-04 2022-07-19 이난타 파마슈티칼스, 인코포레이티드 항바이러스 헤테로사이클릭 화합물
US11505558B1 (en) 2019-10-04 2022-11-22 Enanta Pharmaceuticals, Inc. Antiviral heterocyclic compounds
WO2021083290A1 (en) * 2019-10-31 2021-05-06 Shanghai Ark Biopharmaceutical Co. Ltd. Respiratory syncytial virus fusion protein inhibitor compositions and methods for the treatment and prophylaxis of rsv diseases using the same
CN113149977A (zh) * 2020-01-22 2021-07-23 苏州爱科百发生物医药技术有限公司 一类呼吸道合胞病毒抑制剂的合成与用途
UY39032A (es) 2020-01-24 2021-07-30 Enanta Pharm Inc Compuestos heterocíclicos como agentes antivirales
CN111518055A (zh) * 2020-05-16 2020-08-11 西安都创医药科技有限公司 一种苯并硫氮杂卓氧化物的制备方法及其制备的产品及其应用
CN111548325A (zh) * 2020-05-16 2020-08-18 西安都创医药科技有限公司 一种卤代苯并硫氮杂卓化合物的制备方法及其制备的产品及其应用
CN111620838A (zh) * 2020-05-16 2020-09-04 西安都创医药科技有限公司 一种氯代苯并硫氮杂卓化合物的制备方法及其制备的产品及其应用
CN111574475B (zh) * 2020-06-03 2022-09-20 西安都创医药科技有限公司 卤代苯并硫杂卓氧化物的制备方法及其制备的产品及其应用
US11534439B2 (en) 2020-07-07 2022-12-27 Enanta Pharmaceuticals, Inc. Dihydroquinoxaline and dihydropyridopyrazine derivatives as RSV inhibitors
US11945824B2 (en) 2020-10-19 2024-04-02 Enanta Pharmaceuticals, Inc. Heterocyclic compounds as anti-viral agents
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Also Published As

Publication number Publication date
CA2934225A1 (en) 2015-07-30
US10005770B2 (en) 2018-06-26
CN106414436B (zh) 2019-04-23
EP3097098A1 (en) 2016-11-30
CN109879837A (zh) 2019-06-14
EP3248969A1 (en) 2017-11-29
CN109879837B (zh) 2023-06-09
US20180265505A1 (en) 2018-09-20
ES2788900T3 (es) 2020-10-23
RU2664643C2 (ru) 2018-08-21
AU2015208244B2 (en) 2017-11-02
EP3097098B1 (en) 2020-03-04
MX2016009514A (es) 2016-10-26
RU2016133187A (ru) 2018-02-28
MY176210A (en) 2020-07-24
AR118371A2 (es) 2021-09-29
RU2016133187A3 (es) 2018-02-28
HRP20200680T1 (hr) 2020-07-24
AR099134A1 (es) 2016-06-29
KR101841866B1 (ko) 2018-03-23
CN106414436A (zh) 2017-02-15
IL245882B (en) 2019-09-26
HRP20200715T1 (hr) 2020-07-24
SI3097098T1 (sl) 2020-07-31
ES2789798T3 (es) 2020-10-26
WO2015110446A1 (en) 2015-07-30
JP2017503843A (ja) 2017-02-02
NZ721534A (en) 2018-02-23
US10253022B2 (en) 2019-04-09
AU2015208244A1 (en) 2016-06-16
PL3097098T3 (pl) 2020-06-29
US20160326160A1 (en) 2016-11-10
BR112016016978A2 (es) 2017-08-08
SI3248969T1 (sl) 2020-07-31
SG11201605916QA (en) 2016-08-30
PL3248969T3 (pl) 2020-06-29
BR112016016978B1 (pt) 2022-08-16
CA2934225C (en) 2018-09-04
IL245882A0 (en) 2016-08-02
JP6397501B2 (ja) 2018-09-26
EP3248969B1 (en) 2020-03-04
KR20160102055A (ko) 2016-08-26

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