MX2020011449A - Oxiesteroles y metodos de uso de los mismos. - Google Patents

Oxiesteroles y metodos de uso de los mismos.

Info

Publication number
MX2020011449A
MX2020011449A MX2020011449A MX2020011449A MX2020011449A MX 2020011449 A MX2020011449 A MX 2020011449A MX 2020011449 A MX2020011449 A MX 2020011449A MX 2020011449 A MX2020011449 A MX 2020011449A MX 2020011449 A MX2020011449 A MX 2020011449A
Authority
MX
Mexico
Prior art keywords
sup
oxysterols
methods
compounds
formula
Prior art date
Application number
MX2020011449A
Other languages
English (en)
Inventor
Francesco G Salituro
Albert Jean Robichaud
Botella Gabriel Martinez
Original Assignee
Sage Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sage Therapeutics Inc filed Critical Sage Therapeutics Inc
Publication of MX2020011449A publication Critical patent/MX2020011449A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Abstract

Se proporcionan compuestos de acuerdo con la Fórmula (I): (ver Fórmula) y sales farmacéuticamente aceptables de la misma, y composiciones farmacéuticas de la misma; en donde R1, R2, R3, R6, R7, R8, y n son como se definen en la presente. Los compuestos de la presente invención se contemplan útiles para la prevención y tratamiento de una variedad de afecciones.
MX2020011449A 2015-07-06 2016-07-06 Oxiesteroles y metodos de uso de los mismos. MX2020011449A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562189048P 2015-07-06 2015-07-06
US201662280394P 2016-01-19 2016-01-19
PCT/US2016/041168 WO2017007836A1 (en) 2015-07-06 2016-07-06 Oxysterols and methods of use thereof

Publications (1)

Publication Number Publication Date
MX2020011449A true MX2020011449A (es) 2022-02-28

Family

ID=57686105

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2020011449A MX2020011449A (es) 2015-07-06 2016-07-06 Oxiesteroles y metodos de uso de los mismos.
MX2018000282A MX2018000282A (es) 2015-07-06 2016-07-06 Oxiesteroles y metodos de uso de los mismos.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2018000282A MX2018000282A (es) 2015-07-06 2016-07-06 Oxiesteroles y metodos de uso de los mismos.

Country Status (28)

Country Link
US (3) US10201550B2 (es)
EP (2) EP3828194A1 (es)
JP (3) JP2018519351A (es)
KR (1) KR20180026743A (es)
CN (2) CN113292623A (es)
AU (3) AU2016289967B2 (es)
BR (3) BR122023021450A2 (es)
CA (1) CA2991214A1 (es)
CO (1) CO2018000660A2 (es)
CY (1) CY1124496T1 (es)
DK (1) DK3319611T3 (es)
ES (1) ES2865258T3 (es)
HR (1) HRP20210526T8 (es)
HU (1) HUE053778T2 (es)
IL (2) IL256710B2 (es)
LT (1) LT3319611T (es)
MA (2) MA55097A (es)
MD (1) MD3319611T2 (es)
MX (2) MX2020011449A (es)
PE (1) PE20180483A1 (es)
PH (1) PH12018500065A1 (es)
PL (1) PL3319611T3 (es)
PT (1) PT3319611T (es)
RS (1) RS61718B1 (es)
RU (2) RU2744267C2 (es)
SG (1) SG10202010553XA (es)
SI (1) SI3319611T1 (es)
WO (1) WO2017007836A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2951664T3 (es) 2011-09-08 2023-10-24 Sage Therapeutics Inc Esteroides neuroactivos, composiciones y usos de los mismos
EP3461834B1 (en) 2013-03-13 2021-05-19 Sage Therapeutics, Inc. Neuroactive steroids
EP3157528B1 (en) 2014-06-18 2023-09-13 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
US10238664B2 (en) 2014-07-09 2019-03-26 Duke University Compositions and methods for the repair of myelin
CA2991311A1 (en) 2015-07-06 2017-01-12 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
KR20180026743A (ko) 2015-07-06 2018-03-13 세이지 테라퓨틱스, 인크. 옥시스테롤 및 그의 사용 방법
HUE055199T2 (hu) 2015-07-06 2021-11-29 Sage Therapeutics Inc Oxiszterolok és alkalmazási eljárásaik
CN109195604B (zh) * 2016-04-01 2023-11-14 萨奇治疗股份有限公司 氧甾醇及其使用方法
WO2017193046A1 (en) 2016-05-06 2017-11-09 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
CA3029900A1 (en) 2016-07-07 2018-01-11 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
CN110023323A (zh) * 2016-09-30 2019-07-16 萨奇治疗股份有限公司 C7取代的氧固醇及其作为nmda调节剂的方法
CN114891056A (zh) 2016-10-18 2022-08-12 萨奇治疗股份有限公司 氧甾醇及其使用方法
IL297804A (en) 2016-10-18 2022-12-01 Sage Therapeutics Inc Oxysterols and methods of using them
EP3568138A4 (en) * 2017-01-13 2020-09-02 Duke University COMPOSITIONS AND METHODS FOR THE TREATMENT OF ILLNESSES OR DISORDERS ASSOCIATED WITH MYELIN AND INFLAMMATION
US10857163B1 (en) 2019-09-30 2020-12-08 Athenen Therapeutics, Inc. Compositions that preferentially potentiate subtypes of GABAA receptors and methods of use thereof
CA3223179A1 (en) 2021-06-11 2022-12-15 Sage Therapeutics, Inc. Neuroactive steroid for the treatment of alzheimer's disease
CN113667734B (zh) * 2021-07-16 2022-05-24 四川大学华西医院 Shank3片段序列甲基化检测试剂在制备精神***症诊断试剂盒中的用途
WO2023028278A2 (en) * 2021-08-25 2023-03-02 Sage Therapeutics, Inc. Positive nmda-modulating compounds and methods of use thereof
WO2023083979A1 (en) * 2021-11-10 2023-05-19 Umecrine Ab 3.beta.-hydroxy, 3.alpha.-ethyl steroids for modulation of the alpha-3 subtype of the gaba-a receptor
WO2023114224A1 (en) 2021-12-13 2023-06-22 Sage Therapeutics, Inc. Combination of muscarinic receptor positive modulators and nmda positive allosteric modulators

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2594323A (en) 1948-07-22 1952-04-29 Upjohn Co 24-substituted delta 5-cholene-3, 24-diols
US3079385A (en) 1961-01-24 1963-02-26 Roussel Uclaf Novel process of preparation of polyhydroxylated pregnanes
US3206459A (en) 1962-10-19 1965-09-14 Syntex Corp 10alpha-pregnan-19-ol derivatives
US4071625A (en) 1974-05-13 1978-01-31 Richardson-Merrell Inc. 19-Oxygenated-5α-androstanes for the enhancement of libido
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
EP0701444B1 (en) 1993-05-24 2010-04-07 Purdue Pharma Ltd. Methods and compositions for inducing sleep
IL110309A0 (en) 1993-07-15 1994-10-21 Univ Kentucky Res Found A method of protecting against neuron loss
ATE375993T1 (de) 1994-02-14 2007-11-15 Euro Celtique Sa Androstane und pregane zur allosterischen modulation des gaba rezeptors
US5595996A (en) 1994-10-25 1997-01-21 Merck & Co., Inc. 7-substituted 4-aza cholanic acid derivatives and their use
JPH08268917A (ja) 1995-03-31 1996-10-15 D D S Kenkyusho:Kk 癌組織への移行性の高い制癌剤
NZ310850A (en) 1995-06-06 1999-07-29 Cocensys Inc 3 alpha hydroxy(17)-unsubstituted derivatives of androstane and 21 substituted derivatives of the pregnane series and medicaments
US6645953B2 (en) 1995-06-23 2003-11-11 Novo Nordisk A/S Meiosis regulating compounds
US5888996A (en) 1995-07-26 1999-03-30 Trustees Of Boston University Inhibition of NMDA receptor activity and modulation of glutamate-mediated synaptic activity
US5841272A (en) 1995-12-20 1998-11-24 Sundstrand Corporation Frequency-insensitive current sensor
US6122371A (en) 1997-07-22 2000-09-19 Atwell; Ronald C. Apparatus for protecting coin-operated telephones from vandalism and larceny
KR20010043558A (ko) 1998-05-13 2001-05-25 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 감수분열 조절 화합물
US8541600B2 (en) 1998-11-24 2013-09-24 Harbor Therapeutics, Inc. 11-aza, 11-thia and 11-oxa sterol compounds and compositions
US6376530B1 (en) * 1999-05-10 2002-04-23 Merck & Co., Inc. Cyclic amidines useful as NMDA NR2B antagonists
GB9910934D0 (en) 1999-05-11 1999-07-14 Res Inst Medicine Chem Chemical compounds
GB0000228D0 (en) 2000-01-06 2000-03-01 Phytopharm Plc Fluoro substituted sapogenins and their use
GB0019290D0 (en) 2000-08-04 2000-09-27 Symphar Sa Methods for inducing apolipoprotein E secretion
GR1003861B (el) 2000-12-29 2002-04-11 Νεα νευροστεροειδη που αλληλεπιδρουν με τον υποδοχεα gabaa.
GB0107822D0 (en) 2001-03-28 2001-05-23 Phytopharm Plc Sapogenin derivatives their synthesis and use methods based upon their use
US20070197484A1 (en) 2001-05-03 2007-08-23 Ching Song Method of treating disorder related to high cholesterol concentration
EP1450816A4 (en) 2001-11-08 2008-02-13 Univ Chicago METHOD FOR TREATING DISORDER IN CONNECTION WITH INCREASED CHOLESTERITE CONCENTRATION
CA2468989A1 (en) 2001-12-07 2003-06-19 Daniel M. Schwartz Treatment for age-related macular degeneration
KR101130212B1 (ko) 2002-03-27 2012-04-13 파이토팜 피엘씨 사포게닌 및 그 유도체의 치료 방법 및 사용법
CN1642558B (zh) 2002-03-27 2012-05-30 菲特法姆股份有限公司 皂角苷配基及其衍生物的用途
GB0216621D0 (en) * 2002-07-17 2002-08-28 Imaging Res Solutions Ltd Imaging compounds
US20060160853A1 (en) * 2002-11-22 2006-07-20 Mccauley John A 2-[(4-Benzyl)-1-piperidinyl)methyl]benzimidazole-5-ol derivatives as nr2b receptor antagonists
WO2004055201A2 (en) 2002-12-13 2004-07-01 Bayer Healthcare Ag Cholesterol 24-hydroxylase (cyp46) as therapeutic target for the treatment of alzheimer's disease
FR2850023B1 (fr) 2003-01-17 2007-04-06 Mapreg Medicaments pour le systeme nerveux
GB0403889D0 (en) 2004-02-21 2004-03-24 Univ Edinburgh Uses of er-beta modulators
US8604011B2 (en) 2004-09-27 2013-12-10 The Regents Of The University Of California Therapy for treatment of chronic degenerative brain diseases and nervous system injury
WO2007098281A2 (en) 2006-02-27 2007-08-30 Regents Of The University Of California Oxysterol compounds and the hedgehog pathway
WO2008057468A1 (en) 2006-11-02 2008-05-15 Curis, Inc. Small organic molecule regulators of cell proliferation
AU2008265595B2 (en) 2007-06-20 2014-12-04 PureTech LYT 100 Inc. Substituted N-Aryl pyridinones as fibrotic inhibitors
GB0712494D0 (en) 2007-06-27 2007-08-08 Isis Innovation Substrate reduction therapy
EP2207542A2 (en) 2007-11-06 2010-07-21 N.V. Organon A method of hormone suppression in humans
WO2009090063A1 (en) 2008-01-16 2009-07-23 Jado Technologies Gmbh Steroid sapogenin, androstane and triterpenoid sapogenin derivatives for the treatment and prevention of infectious diseases
NZ589764A (en) 2008-05-09 2012-10-26 Univ Emory NMDA receptor antagonists for the treatment of neuropsychiatric disorders
WO2010065709A2 (en) 2008-12-03 2010-06-10 Amin Khan Hydroxamic acid derivatives, preparation and therapeutic uses thereof
WO2010075282A1 (en) 2008-12-22 2010-07-01 University Of Washington Molecular inhibitors of the wnt/beta-catenin pathway
WO2010088414A2 (en) 2009-01-28 2010-08-05 Emory University Subunit selective nmda receptor potentiators for the treatment of neurological conditions
WO2011014661A2 (en) 2009-07-29 2011-02-03 The University Of Chicago Liver x receptor agonists
WO2011028794A2 (en) 2009-09-01 2011-03-10 Lazarus Therapeutics, Inc. Treatment of huntington's disease with cycloserine and an nmda receptor antagonist
FR2953138B1 (fr) 2009-12-02 2015-10-16 Assist Publ Hopitaux Marseille Composes aminosteroidiens pour une application topique locale pour la decolonisation cutaneo-muqueuse de staphylococcus aureus
KR101692275B1 (ko) 2010-02-11 2017-01-04 노오쓰웨스턴 유니버시티 ２차 구조 안정화된 ｎｍｄａ 수용체 조절제 및 그의 용도
US8247436B2 (en) 2010-03-19 2012-08-21 Novartis Ag Pyridine and pyrazine derivative for the treatment of CF
GB201008047D0 (en) * 2010-05-14 2010-06-30 Ge Healthcare Ltd Method of synthesis
US20120035156A1 (en) 2010-08-09 2012-02-09 Daniela Alberati Combination of glyt1 compound with antipsychotics
US8969525B2 (en) 2010-11-09 2015-03-03 Enzo Life Sciences, Inc. Hydroxycholesterol immunoassay
WO2012142039A1 (en) 2011-04-15 2012-10-18 University Of North Dakota Combination of liver x receptor modulator and estrogen receptor modulator for the treatment of age-related diseases
US20140335050A1 (en) 2011-05-27 2014-11-13 The General Hospital Corporation Methods, compositions, and kits for the treatment of cancer
EP2736919A4 (en) 2011-07-29 2015-01-14 Univ California NEW 17-BETA-HETEROARYL-SUBSTITUTED STEROIDS AS MODULATORS OF GABAA RECEPTORS
ES2951664T3 (es) 2011-09-08 2023-10-24 Sage Therapeutics Inc Esteroides neuroactivos, composiciones y usos de los mismos
CA2852057C (en) 2011-10-14 2022-06-07 Sage Therapeutics, Inc. 3,3-disubstituted 19-nor pregnane compounds, compositions, and uses thereof for the treatment of cns related disorders
US20150119327A1 (en) 2012-04-25 2015-04-30 The Regents Of The University Of California Drug screening platform for rett syndrome
WO2014028942A2 (en) 2012-08-17 2014-02-20 Trueex Group Llc Interoffice bank offered rate financial product and implementation
EP3392260B1 (en) 2012-12-18 2022-09-21 Washington University Neuroactive 19-alkoxy-17-substituted steroids, useful in methods of treatment
EP3309166A3 (en) 2013-01-23 2018-08-22 Sphaera Pharma Pvt. Ltd. 11beta-hydroxy-steroids for use in mitochondria biogenesis and diseases associated with mitochondrial dysfunction or depletion
EP2951184A1 (en) 2013-01-29 2015-12-09 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
EP3461834B1 (en) 2013-03-13 2021-05-19 Sage Therapeutics, Inc. Neuroactive steroids
JP2016514967A (ja) 2013-03-13 2016-05-26 セージ セラピューティクス， インコーポレイテッド 神経刺激性ステロイド、組成物およびそれらの使用
EP3157528B1 (en) 2014-06-18 2023-09-13 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
US10238664B2 (en) 2014-07-09 2019-03-26 Duke University Compositions and methods for the repair of myelin
US10016095B2 (en) * 2014-10-03 2018-07-10 Progressive International Corporation Salad spinner
PE20170907A1 (es) 2014-10-07 2017-07-12 Sage Therapeutics Inc Compuestos neuroactivos y metodos de uso de los mismos
HUE055199T2 (hu) 2015-07-06 2021-11-29 Sage Therapeutics Inc Oxiszterolok és alkalmazási eljárásaik
CA2991311A1 (en) 2015-07-06 2017-01-12 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
KR20180026743A (ko) 2015-07-06 2018-03-13 세이지 테라퓨틱스, 인크. 옥시스테롤 및 그의 사용 방법
GB2557875A (en) 2015-09-02 2018-07-04 Univ Swansea Diagnostic methods and kits
AU2018234828A1 (en) 2017-03-15 2019-09-19 Modernatx, Inc. Lipid nanoparticle formulation
JP7224307B2 (ja) 2017-06-23 2023-02-17 インターセプト ファーマシューティカルズ， インコーポレイテッド 胆汁酸誘導体の調製のための方法及び中間体
CA3079259A1 (en) 2017-11-10 2019-05-16 Marinus Pharmaceuticals, Inc. Ganaxolone for use in treating genetic epileptic disorders

Also Published As

Publication number Publication date
PH12018500065A1 (en) 2018-07-09
MA42410A (fr) 2018-05-16
US20210145848A1 (en) 2021-05-20
RU2021100620A (ru) 2021-01-29
RU2018104278A (ru) 2019-08-06
EP3319611B1 (en) 2021-01-20
JP2018519351A (ja) 2018-07-19
IL305404A (en) 2023-10-01
BR112018000129A2 (pt) 2018-09-04
MA42410B1 (fr) 2021-04-30
WO2017007836A1 (en) 2017-01-12
CA2991214A1 (en) 2017-01-12
AU2016289967B2 (en) 2021-09-09
BR122021005552B1 (pt) 2024-01-02
KR20180026743A (ko) 2018-03-13
CO2018000660A2 (es) 2018-07-10
RU2018104278A3 (es) 2019-10-31
LT3319611T (lt) 2021-05-10
EP3319611A1 (en) 2018-05-16
HRP20210526T1 (hr) 2021-05-28
RU2744267C2 (ru) 2021-03-04
CY1124496T1 (el) 2022-07-22
ES2865258T3 (es) 2021-10-15
BR122023021450A2 (pt) 2023-12-26
HRP20210526T8 (hr) 2021-08-20
EP3319611A4 (en) 2019-03-06
PE20180483A1 (es) 2018-03-07
IL256710B2 (en) 2024-01-01
IL256710B1 (en) 2023-09-01
EP3828194A1 (en) 2021-06-02
US20180200267A1 (en) 2018-07-19
US10765685B2 (en) 2020-09-08
CN108135912B (zh) 2021-07-02
AU2016289967A1 (en) 2018-02-01
AU2024200268A1 (en) 2024-02-01
BR112018000129B1 (pt) 2024-01-09
HUE053778T2 (hu) 2021-07-28
PL3319611T3 (pl) 2021-07-12
IL256710A (en) 2018-03-29
US20190125764A1 (en) 2019-05-02
SG10202010553XA (en) 2020-12-30
RS61718B1 (sr) 2021-05-31
SI3319611T1 (sl) 2021-08-31
JP2022120062A (ja) 2022-08-17
CN108135912A (zh) 2018-06-08
AU2021218228A1 (en) 2021-09-09
MA55097A (fr) 2022-01-05
DK3319611T3 (da) 2021-04-12
US10201550B2 (en) 2019-02-12
MX2018000282A (es) 2018-03-08
PT3319611T (pt) 2021-04-22
CN113292623A (zh) 2021-08-24
AU2021218228B2 (en) 2023-11-16
JP2021054864A (ja) 2021-04-08
MD3319611T2 (ro) 2021-06-30

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