MX365985B - Antagonistas de il-6 para aumentar la albumina y/o disminuir la crp. - Google Patents

Antagonistas de il-6 para aumentar la albumina y/o disminuir la crp.

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Publication number
MX365985B
MX365985B MX2014004474A MX2014004474A MX365985B MX 365985 B MX365985 B MX 365985B MX 2014004474 A MX2014004474 A MX 2014004474A MX 2014004474 A MX2014004474 A MX 2014004474A MX 365985 B MX365985 B MX 365985B
Authority
MX
Mexico
Prior art keywords
antagonists
antibodies
patient
preferred embodiments
survivability
Prior art date
Application number
MX2014004474A
Other languages
English (en)
Inventor
T L Smith Jeffrey
Original Assignee
Alderbio Holdings Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/366,567 external-priority patent/US8062864B2/en
Priority claimed from US12/391,717 external-priority patent/US8178101B2/en
Priority claimed from US12/399,156 external-priority patent/US20090238825A1/en
Priority claimed from US12/502,581 external-priority patent/US8323649B2/en
Application filed by Alderbio Holdings Llc filed Critical Alderbio Holdings Llc
Publication of MX365985B publication Critical patent/MX365985B/es

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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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Abstract

La presente invención se refiere a el uso de un antagonista de interleucina 6 (IL-6), para preparar un medicamento para preparar un medicamento para mejorar la capacidad de supervivencia o la calidad de vida de un paciente que lo necesita, por el cual; (i) el nivel de proteína C reactiva en suero ("CRP") del paciente se reduce, y/o (ii) el nivel de albúmina sérica del paciente aumenta y, además, en donde el antagonista de IL-6 comprende un anti-IL-6 o fragmento de anticuerpo cuyo anticuerpo anti-IL-6 comprende un polipéptido VL que comprende los polipéptidos CDR de la SEQ ID NO; 103; SEQ ID NO: 104; y la SEQ ID NO: 105 y un polipéptido VH que comprende los polipéptidos en donde la administración de dicho anticuerpo o fragmento de anticuerpo mejora la capacidad de supervivencia o la calidad de vida del paciente que lo necesita reduciendo el nivel de proteína c reactiva en suero ("CRP") del paciente y/o aumentando el nivel de albúmina sérica del paciente.
MX2014004474A 2008-11-25 2009-11-24 Antagonistas de il-6 para aumentar la albumina y/o disminuir la crp. MX365985B (es)

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US11786108P 2008-11-25 2008-11-25
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US12/366,567 US8062864B2 (en) 2007-05-21 2009-02-05 Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
US39161509A 2009-02-24 2009-02-24
US12/391,717 US8178101B2 (en) 2007-05-21 2009-02-24 Use of anti-IL-6 antibodies having specific binding properties to treat cachexia
US12/399,156 US20090238825A1 (en) 2007-05-21 2009-03-06 Novel rabbit antibody humanization methods and humanized rabbit antibodies
US12/502,581 US8323649B2 (en) 2008-11-25 2009-07-14 Antibodies to IL-6 and use thereof
PCT/US2009/006257 WO2010065072A1 (en) 2008-11-25 2009-11-24 Antagonists of il-6 to raise albumin and/or lower crp

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MX2011005396A MX2011005396A (es) 2008-11-25 2009-11-24 Antagonistas de il-6 para aumentar la albumina y/o disminuir la crp.
MX2011005408A MX2011005408A (es) 2008-11-25 2009-11-24 Antagonistas de il-6 para prevenir o tratar la trombosis.
MX2011005411A MX2011005411A (es) 2008-11-25 2009-11-24 Anticuerpos de il-6 y uso de los mismos.
MX2014008792A MX364874B (es) 2008-11-25 2009-11-24 Anticuerpos de il-6 y uso de los mismos.
MX2019005415A MX2019005415A (es) 2008-11-25 2011-05-20 Anticuerpos de il-6 y uso de los mismos.
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MX2011005411A MX2011005411A (es) 2008-11-25 2009-11-24 Anticuerpos de il-6 y uso de los mismos.
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