MX2019012252A - Composiciones y metodos para inhibir la expresion del gen alas1. - Google Patents

Composiciones y metodos para inhibir la expresion del gen alas1.

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Publication number
MX2019012252A
MX2019012252A MX2019012252A MX2019012252A MX2019012252A MX 2019012252 A MX2019012252 A MX 2019012252A MX 2019012252 A MX2019012252 A MX 2019012252A MX 2019012252 A MX2019012252 A MX 2019012252A MX 2019012252 A MX2019012252 A MX 2019012252A
Authority
MX
Mexico
Prior art keywords
compositions
methods
inhibiting expression
alas1 gene
alas1
Prior art date
Application number
MX2019012252A
Other languages
English (en)
Inventor
Fitzgerald Kevin
Bettencourt Brian
Querbes William
Yasuda Makiko
J Desnick Robert
Original Assignee
Alnylam Pharmaceuticals Inc
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48326393&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2019012252(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alnylam Pharmaceuticals Inc filed Critical Alnylam Pharmaceuticals Inc
Publication of MX2019012252A publication Critical patent/MX2019012252A/es

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Abstract

La invención se refiere a composiciones de ácido ribonucleico bicatenario (ARNbc) que tienen como diana el gen ALAS1 y a métodos para utilizar tales composiciones de ARNbc con el fin de alterar (p. ej., inhibir) la expresión de ALAS1.
MX2019012252A 2012-04-10 2014-10-09 Composiciones y metodos para inhibir la expresion del gen alas1. MX2019012252A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261622288P 2012-04-10 2012-04-10
US13/835,613 US9133461B2 (en) 2012-04-10 2013-03-15 Compositions and methods for inhibiting expression of the ALAS1 gene

Publications (1)

Publication Number Publication Date
MX2019012252A true MX2019012252A (es) 2020-01-23

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ID=48326393

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2014012215A MX368723B (es) 2012-04-10 2013-04-10 Composiciones y metodos para inhibir la expresion del gen alas1.
MX2019012252A MX2019012252A (es) 2012-04-10 2014-10-09 Composiciones y metodos para inhibir la expresion del gen alas1.
MX2021009118A MX2021009118A (es) 2012-04-10 2014-10-09 Composiciones y metodos para inhibir la expresion del gen alas1.

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MX2014012215A MX368723B (es) 2012-04-10 2013-04-10 Composiciones y metodos para inhibir la expresion del gen alas1.

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US (8) US9133461B2 (es)
EP (3) EP3868883A1 (es)
JP (4) JP6422854B2 (es)
KR (3) KR102139451B1 (es)
CN (2) CN104540948B (es)
AR (1) AR090641A1 (es)
AU (4) AU2013245949A1 (es)
BR (1) BR112014025020A2 (es)
CA (2) CA3169218A1 (es)
CL (2) CL2014002725A1 (es)
CO (1) CO7121351A2 (es)
CY (1) CY1119491T1 (es)
DK (1) DK2836595T3 (es)
ES (1) ES2640260T3 (es)
HK (2) HK1201876A1 (es)
HR (1) HRP20171369T1 (es)
HU (1) HUE034311T2 (es)
IL (5) IL281295B (es)
LT (1) LT2836595T (es)
ME (1) ME02850B (es)
MX (3) MX368723B (es)
PL (1) PL2836595T3 (es)
PT (1) PT2836595T (es)
RS (1) RS56428B1 (es)
RU (2) RU2687223C2 (es)
SI (1) SI2836595T1 (es)
WO (1) WO2013155204A2 (es)
ZA (1) ZA201408111B (es)

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US9133461B2 (en) 2012-04-10 2015-09-15 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of the ALAS1 gene
SI2992009T1 (sl) * 2013-05-01 2020-10-30 Ionis Pharmaceuticals, Inc. Sestavki in postopki za moduliranje izražanja apolipoproteina (A)
ES2790574T3 (es) 2013-08-28 2020-10-28 Ionis Pharmaceuticals Inc Modulación de expresión de prekallikrein (PKK)
NZ757749A (en) 2013-10-04 2022-07-01 Icahn School Med Mount Sinai Compositions and methods for inhibiting expression of the alas1 gene
WO2015061536A1 (en) * 2013-10-25 2015-04-30 Regulus Therapeutics Inc. Microrna compounds and methods for modulating mir-21 activity
EP3892727A1 (en) * 2013-12-27 2021-10-13 Dicerna Pharmaceuticals, Inc. Methods and compositions for the specific inhibition of glycolate oxidase (hao1) by double-stranded rna
AU2015217301A1 (en) 2014-02-11 2016-08-25 Alnylam Pharmaceuticals, Inc. Ketohexokinase (KHK) iRNA compositions and methods of use thereof
MX2016014102A (es) 2014-05-01 2017-05-03 Ionis Pharmaceuticals Inc Composiciones y metodos para modular la expresion de similar a la angiopoyetina tipo 3.
MX2016014013A (es) 2014-05-01 2016-11-15 Ionis Pharmaceuticals Inc Composiciones y metodos para modular la expresion del receptor de la hormona del crecimiento.
DK3137091T3 (da) * 2014-05-01 2021-01-25 Ionis Pharmaceuticals Inc Konjugater af modificerede antisense-oligonukleotider og anvendelse deraf til modulation af pkk-ekspression
SG10201913791QA (en) * 2014-08-20 2020-03-30 Alnylam Pharmaceuticals Inc Modified double-stranded rna agents
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