US2779780A
(en)
|
1955-03-01 |
1957-01-29 |
Du Pont |
1, 4-diamino-2, 3-dicyano-1, 4-bis (substituted mercapto) butadienes and their preparation
|
US4458066A
(en)
|
1980-02-29 |
1984-07-03 |
University Patents, Inc. |
Process for preparing polynucleotides
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
US4690915A
(en)
|
1985-08-08 |
1987-09-01 |
The United States Of America As Represented By The Department Of Health And Human Services |
Adoptive immunotherapy as a treatment modality in humans
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
CA1291706C
(en)
|
1986-04-03 |
1991-11-05 |
Alfred Rudolph |
COMBINATION THERAPY USING INTERFERON-.beta. AND INTERLEUKIN-2
|
CA1290249C
(en)
|
1986-04-09 |
1991-10-08 |
Cetus Corporation |
COMBINATION THERAPY USING INTERLEUKIN-2 AND/OR INTERFERON-.beta. AND TUMOR NECROSIS FACTOR
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
AU617295B2
(en)
|
1986-11-13 |
1991-11-28 |
Sloan-Kettering Institute For Cancer Research |
Compositions and method for treatment of cancer using monoclonal antibody against gd3 ganglioside together with il-2
|
DE3883899T3
(de)
|
1987-03-18 |
1999-04-22 |
Sb2 Inc |
Geänderte antikörper.
|
US5677425A
(en)
|
1987-09-04 |
1997-10-14 |
Celltech Therapeutics Limited |
Recombinant antibody
|
DE3856516T2
(de)
|
1987-09-22 |
2002-10-10 |
Chiron Corp |
Verwendung von rekombinantem koloniestimulierendem Faktor-1 zur Herstellung eines Medikaments gegen Cytomegalovirusinfektionen
|
US5336603A
(en)
|
1987-10-02 |
1994-08-09 |
Genentech, Inc. |
CD4 adheson variants
|
US4999339A
(en)
|
1988-03-28 |
1991-03-12 |
Cetus Corporation |
Combination therapy of IL-2 and DTIC for the treatment of melanoma
|
US5061488A
(en)
|
1988-04-15 |
1991-10-29 |
The United States Of America As Represented Department Of Health & Human Services |
Flavone-8-acetic acid and interleukin-2 for cancer therapy
|
US5126129A
(en)
|
1988-05-23 |
1992-06-30 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services |
Cancer therapy using interleukin-2 and flavone compounds
|
KR900005995A
(ko)
|
1988-10-31 |
1990-05-07 |
우메모또 요시마사 |
변형 인터류킨-2 및 그의 제조방법
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
US5112946A
(en)
|
1989-07-06 |
1992-05-12 |
Repligen Corporation |
Modified pf4 compositions and methods of use
|
US5126132A
(en)
|
1989-08-21 |
1992-06-30 |
The United States Of America As Represented By The Department Of Health And Human Services |
Tumor infiltrating lymphocytes as a treatment modality for human cancer
|
WO1991006570A1
(en)
|
1989-10-25 |
1991-05-16 |
The University Of Melbourne |
HYBRID Fc RECEPTOR MOLECULES
|
US5349053A
(en)
|
1990-06-01 |
1994-09-20 |
Protein Design Labs, Inc. |
Chimeric ligand/immunoglobulin molecules and their uses
|
CA2074825C
(en)
|
1990-12-14 |
2005-04-12 |
Daniel J. Capon |
Chimeric chains for receptor-associated signal transduction pathways
|
US5622929A
(en)
|
1992-01-23 |
1997-04-22 |
Bristol-Myers Squibb Company |
Thioether conjugates
|
US5714350A
(en)
|
1992-03-09 |
1998-02-03 |
Protein Design Labs, Inc. |
Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
|
US5447851B1
(en)
|
1992-04-02 |
1999-07-06 |
Univ Texas System Board Of |
Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
|
US5229109A
(en)
*
|
1992-04-14 |
1993-07-20 |
Board Of Regents, The University Of Texas System |
Low toxicity interleukin-2 analogues for use in immunotherapy
|
US5306490A
(en)
|
1992-04-20 |
1994-04-26 |
Medlogic, Inc. |
Methods for retarding blister formation by use of cyanoacrylate adhesives
|
AU4116793A
(en)
|
1992-04-24 |
1993-11-29 |
Board Of Regents, The University Of Texas System |
Recombinant production of immunoglobulin-like domains in prokaryotic cells
|
WO1994004196A1
(en)
|
1992-08-14 |
1994-03-03 |
Imperial Cancer Research Technology Limited |
Tumour therapy
|
CA2163345A1
(en)
|
1993-06-16 |
1994-12-22 |
Susan Adrienne Morgan |
Antibodies
|
US5834441A
(en)
|
1993-09-13 |
1998-11-10 |
Rhone-Poulenc Rorer Pharmaceuticals Inc. |
Adeno-associated viral (AAV) liposomes and methods related thereto
|
US5837458A
(en)
|
1994-02-17 |
1998-11-17 |
Maxygen, Inc. |
Methods and compositions for cellular and metabolic engineering
|
US5605793A
(en)
|
1994-02-17 |
1997-02-25 |
Affymax Technologies N.V. |
Methods for in vitro recombination
|
US5834252A
(en)
|
1995-04-18 |
1998-11-10 |
Glaxo Group Limited |
End-complementary polymerase reaction
|
CA2188432C
(en)
|
1994-04-22 |
2011-02-01 |
Yutaka Kawakami |
Melanoma antigens
|
EP0770135A1
(en)
|
1994-07-29 |
1997-05-02 |
Smithkline Beecham Plc |
Novel compounds
|
EP0793504B1
(en)
|
1994-12-12 |
2005-06-08 |
Beth Israel Deaconess Medical Center, Inc. |
Chimeric cytokines and uses thereof
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
US6121022A
(en)
|
1995-04-14 |
2000-09-19 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
WO1996040176A1
(en)
|
1995-06-07 |
1996-12-19 |
Sloan-Kettering Institute For Cancer Research |
Therapeutic uses of monoclonal antibody ta99 in combination with interleukin-2 and/or lymphokine activated killer cells
|
US5985270A
(en)
|
1995-09-13 |
1999-11-16 |
Fordham University |
Adoptive immunotherapy using macrophages sensitized with heat shock protein-epitope complexes
|
US6406689B1
(en)
|
1995-10-03 |
2002-06-18 |
Frank W. Falkenberg |
Compositions and methods for treatment of tumors and metastatic diseases
|
US6045788A
(en)
|
1996-02-28 |
2000-04-04 |
Cornell Research Foundation, Inc. |
Method of stimulation of immune response with low doses of IL-2
|
WO1997034631A1
(en)
|
1996-03-18 |
1997-09-25 |
Board Of Regents, The University Of Texas System |
Immunoglobin-like domains with increased half lives
|
US6001329A
(en)
|
1996-05-06 |
1999-12-14 |
Uab Research Foundation |
Radiolabeled fusion toxins for cancer therapy
|
WO1998023289A1
(en)
|
1996-11-27 |
1998-06-04 |
The General Hospital Corporation |
MODULATION OF IgG BINDING TO FcRn
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
EP1724282B1
(en)
|
1997-05-21 |
2013-05-15 |
Merck Patent GmbH |
Method for the production of non-immunogenic proteins
|
CA2309766C
(en)
|
1997-11-20 |
2008-09-30 |
Vical Incorporated |
Treatment of cancer using cytokine-expressing polynucleotides and compositions therefor
|
US20030105294A1
(en)
|
1998-02-25 |
2003-06-05 |
Stephen Gillies |
Enhancing the circulating half life of antibody-based fusion proteins
|
HUP0100813A3
(en)
|
1998-02-25 |
2003-08-28 |
Lexigen Pharmaceuticals Corp L |
Enhancing the circulating half-life of antibody-based fusion proteins
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
DK2180007T4
(da)
|
1998-04-20 |
2017-11-27 |
Roche Glycart Ag |
Glycosyleringsteknik for antistoffer til forbedring af antistofafhængig cellecytotoxicitet
|
DZ2788A1
(fr)
|
1998-05-15 |
2003-12-01 |
Bayer Ag |
Agonistes et antagonistes selectifs à IL-2.
|
US6620382B1
(en)
|
1998-05-22 |
2003-09-16 |
Biopheresis Technologies, Llc. |
Method and compositions for treatment of cancers
|
US6168785B1
(en)
|
1998-07-16 |
2001-01-02 |
Institut Pasteur |
Biological applications of new peptides of IL-2 and derivatives and use as therapeutic agents
|
US6013659A
(en)
|
1998-09-04 |
2000-01-11 |
University Of Pittsburgh |
Methods of reducing tumor colony number using novel benzothiazole compounds
|
HUP0104693A3
(en)
|
1998-12-16 |
2003-12-29 |
Warner Lambert Co |
Treatment of arthritis with mek inhibitors
|
KR101077001B1
(ko)
|
1999-01-15 |
2011-10-26 |
제넨테크, 인크. |
효과기 기능이 변화된 폴리펩티드 변이체
|
RU2236251C2
(ru)
|
1999-02-12 |
2004-09-20 |
Дзе Скриппс Рисерч Инститьют |
Способы лечения опухолей и метастазов с использованием комбинации антиангиогенной терапии и иммунотерапии
|
US20020058609A1
(en)
|
1999-02-26 |
2002-05-16 |
Eli Gilboa |
Compositions and methods using complexes of calreticulin and antigenic molecules
|
JP2002541113A
(ja)
|
1999-04-02 |
2002-12-03 |
ザ・ブリガーム・アンド・ウーメンズ・ホスピタル・インコーポレーテッド |
免疫調節ポリマー
|
PT1535623E
(pt)
|
1999-04-08 |
2009-03-19 |
Schering Corp |
Tratamento para carcinoma de células renais
|
PT1176195E
(pt)
|
1999-04-09 |
2013-07-18 |
Kyowa Hakko Kirin Co Ltd |
Processo para controlar a actividade de uma molécula funcional sob o ponto de vista imunológico
|
AU778611B2
(en)
|
1999-08-09 |
2004-12-16 |
Merck Patent Gmbh |
Multiple cytokine-antibody complexes
|
CN1371416B
(zh)
|
1999-08-24 |
2012-10-10 |
梅达里克斯公司 |
人ctla-4抗体及其应用
|
ES2246314T3
(es)
|
2000-01-20 |
2006-02-16 |
Universitat Zurich Institut Fur Medizinische Virologie |
Administracion intratumoral de moleculas desnudas de acido nucleico que codifican il-12.
|
WO2001074847A2
(en)
|
2000-03-30 |
2001-10-11 |
The Government Of The United States Of America Represented By The Secretary, Department Of Health And Human Services |
T-cell epitope of mage-12 and related nucleic acids, vectors, cells, compositions and methods of inducing an immune response to cancer
|
CA2405709A1
(en)
|
2000-04-12 |
2001-10-25 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
AU7013401A
(en)
|
2000-06-22 |
2002-01-02 |
Univ Iowa Res Found |
Methods for enhancing antibody-induced cell lysis and treating cancer
|
CN1219753C
(zh)
|
2000-07-19 |
2005-09-21 |
沃尼尔·朗伯公司 |
4-碘苯氨基苯氧肟酸的氧合酯
|
WO2004007529A2
(en)
|
2002-07-15 |
2004-01-22 |
The Trustees Of Princeton University |
Iap binding compounds
|
WO2002044197A2
(en)
|
2000-12-01 |
2002-06-06 |
Fish Eleanor N |
Cytokine receptor binding peptides
|
US7396917B2
(en)
|
2000-12-05 |
2008-07-08 |
Alexion Pharmaceuticals, Inc. |
Rationally designed antibodies
|
US20040253242A1
(en)
|
2000-12-05 |
2004-12-16 |
Bowdish Katherine S. |
Rationally designed antibodies
|
CA2436671C
(en)
|
2000-12-05 |
2015-02-03 |
Alexion Pharmaceuticals, Inc. |
Rationally designed antibodies
|
IL140796A0
(en)
|
2001-01-08 |
2002-02-10 |
Hadasit Med Res Service |
An autologous anti-cancer vaccine
|
PL362324A1
(en)
|
2001-02-19 |
2004-10-18 |
Merck Patent Gmbh |
Artificial fusion proteins with reduced immunogenicity
|
ES2393733T3
(es)
|
2001-03-07 |
2012-12-27 |
Merck Patent Gmbh |
Tecnología de expresión para proteínas que contienen una fracción de anticuerpo de isotipo híbrido
|
RU2306320C9
(ru)
|
2001-05-03 |
2008-01-27 |
Мерк Патент Гмбх |
Рекомбинантное опухолеспецифичное антитело (варианты) и его применение
|
CA2448109A1
(en)
|
2001-05-25 |
2002-12-05 |
Thomas Jefferson University |
Alternative splice forms of proteins as basis for multiple therapeutic modalities
|
FR2825279B1
(fr)
|
2001-06-01 |
2005-04-08 |
Molecular Engines Lab |
Medicament utile dans le traitement du cancer
|
EP1476180A4
(en)
|
2001-08-13 |
2005-04-20 |
Univ Southern California |
INTERLEUKIN-2 MUTANTS WITH REDUCED TOXICITY
|
KR100988949B1
(ko)
|
2001-10-25 |
2010-10-20 |
제넨테크, 인크. |
당단백질 조성물
|
CN100390282C
(zh)
*
|
2001-12-04 |
2008-05-28 |
默克专利有限公司 |
具有调节的选择性的il-2融合蛋白
|
US20060084123A1
(en)
|
2001-12-13 |
2006-04-20 |
Harris Adrian L |
MN and hypoxia
|
KR101004224B1
(ko)
|
2002-02-01 |
2010-12-27 |
어리어드 파마슈티칼스, 인코포레이티드 |
인 함유 화합물 및 이의 용도
|
CA2478012C
(en)
*
|
2002-03-01 |
2012-06-19 |
Immunomedics, Inc. |
Internalizing anti-cd74 antibodies and methods of use
|
MXPA04008722A
(es)
|
2002-03-08 |
2005-07-13 |
Eisai Co Ltd |
Compuestos macrociclicos utiles como farmaceuticos.
|
AU2003226141A1
(en)
|
2002-03-27 |
2003-10-13 |
The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services |
Method for treating cancer in humans
|
US7939641B2
(en)
|
2002-04-09 |
2011-05-10 |
The Scripps Research Institute |
Motif-grafted hybrid polypeptides and uses thereof
|
TWI275390B
(en)
|
2002-04-30 |
2007-03-11 |
Wyeth Corp |
Process for the preparation of 7-substituted-3- quinolinecarbonitriles
|
NZ572388A
(en)
|
2002-05-17 |
2010-05-28 |
Celgene Corp |
Methods and compositions using immunomodulatory compounds for treatment and management of cancers and other diseases
|
EP1556033A4
(en)
|
2002-05-17 |
2006-05-31 |
Celgene Corp |
METHODS AND COMPOSITIONS USING CYTOKINE INHIBITOR SELECTIVE MEDICAMENTS FOR THE TREATMENT AND MANAGEMENT OF CANCERS AND OTHER DISEASES
|
AU2003280442B2
(en)
|
2002-07-01 |
2009-02-05 |
Wilex Ag |
Co-administration of CG250 and IL-2 or IFN-alpha for treating cancer such as renal cell carcinomas
|
GB0215823D0
(en)
|
2002-07-09 |
2002-08-14 |
Astrazeneca Ab |
Quinazoline derivatives
|
WO2004020468A2
(en)
|
2002-08-28 |
2004-03-11 |
Maxygen Aps |
Interferon beta-like molecules for treatment of cancer
|
WO2004021995A2
(en)
|
2002-09-06 |
2004-03-18 |
The Government Of The United States Of America, Represented By The Secretary, Departement Of Health And Human Services |
Immunotherapy with in vitro-selected antigen-specific lymphocytes after nonmyeloablative lymphodepleting chemotherapy
|
WO2004022747A1
(en)
|
2002-09-09 |
2004-03-18 |
Nautilus Biotech |
Rational directed protein evolution using two-dimensional rational mutagenesis scanning
|
US20040121971A1
(en)
|
2002-12-20 |
2004-06-24 |
Gang Chen |
Therapeutic use of tumor necrosis factor-alpha mutein
|
AU2003294930B2
(en)
|
2002-12-23 |
2008-12-04 |
Innate Pharma |
Pharmaceutical compositions having an effect on the proliferation of NK cells and a method using the same
|
ES2367430T3
(es)
|
2002-12-23 |
2011-11-03 |
Wyeth Llc |
Anticuerpos contra pd-1 y sus usos.
|
US7772188B2
(en)
|
2003-01-28 |
2010-08-10 |
Ironwood Pharmaceuticals, Inc. |
Methods and compositions for the treatment of gastrointestinal disorders
|
US20050008625A1
(en)
|
2003-02-13 |
2005-01-13 |
Kalobios, Inc. |
Antibody affinity engineering by serial epitope-guided complementarity replacement
|
WO2004080445A1
(en)
|
2003-03-12 |
2004-09-23 |
Molecular Engines Laboratories Sa |
Methods and compositions for the treatment of cancer
|
WO2004098529A2
(en)
|
2003-04-30 |
2004-11-18 |
Emory University |
Therapeutic compositions and vaccines by glycosyl-phosphatidylinositol (gpi)-anchored cytokines and immunostimulatory molecules
|
US20060165744A1
(en)
|
2003-05-22 |
2006-07-27 |
Neopharm, Inc |
Combination liposomal formulations
|
WO2004108078A2
(en)
|
2003-06-02 |
2004-12-16 |
Alexion Pharmaceuticals Inc. |
Rationally designed antibodies
|
WO2005007121A2
(en)
|
2003-07-18 |
2005-01-27 |
Massachusetts Institute Of Technology |
Mutant interleukin-2(il-2) polypeptides
|
US8147832B2
(en)
|
2003-08-14 |
2012-04-03 |
Merck Patent Gmbh |
CD20-binding polypeptide compositions and methods
|
US7399865B2
(en)
|
2003-09-15 |
2008-07-15 |
Wyeth |
Protein tyrosine kinase enzyme inhibitors
|
AU2004280623B2
(en)
|
2003-10-08 |
2010-12-02 |
Wilson Wolf Manufacturing, LLC |
Cell culture methods and devices utilizing gas permeable materials
|
ATE474599T1
(de)
|
2003-11-04 |
2010-08-15 |
Novartis Vaccines & Diagnostic |
Verwendung von antagonisten-anti-cd40- monoklonalen antikörpern zur behandlung von multiplem myelom
|
EP2962699A3
(en)
|
2003-12-01 |
2016-04-06 |
Immunomedics Inc. |
Improved method for preparing conjugates of proteins and chelating agents
|
RU2369616C2
(ru)
|
2003-12-30 |
2009-10-10 |
Мерк Патент Гмбх |
Слитые белки il-7
|
JP2007522116A
(ja)
|
2004-01-16 |
2007-08-09 |
ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン |
コンホメーションが制約されたSmac模倣物およびその使用
|
JP2007523061A
(ja)
|
2004-01-16 |
2007-08-16 |
ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン |
Smacペプチドミメティクスおよびその使用法
|
EP1761561B1
(en)
|
2004-01-20 |
2015-08-26 |
KaloBios Pharmaceuticals, Inc. |
Antibody specificity transfer using minimal essential binding determinants
|
KR20060125909A
(ko)
|
2004-02-26 |
2006-12-06 |
이노텍 파마슈티컬스 코포레이션 |
이소퀴놀린 유도체 및 이의 사용 방법
|
US7345081B2
(en)
|
2004-03-23 |
2008-03-18 |
Genentech, Inc. |
Azabicyclo-octane inhibitors of IAP
|
EP2253614B1
(en)
|
2004-04-07 |
2012-09-19 |
Novartis AG |
Inhibitors of IAP
|
US7244851B2
(en)
|
2004-07-02 |
2007-07-17 |
Genentech, Inc. |
Inhibitors of IAP
|
US7674787B2
(en)
|
2004-07-09 |
2010-03-09 |
The Regents Of The University Of Michigan |
Conformationally constrained Smac mimetics and the uses thereof
|
BRPI0513310A
(pt)
|
2004-07-12 |
2008-05-06 |
Idun Pharmaceuticals Inc |
análogos de tetrapeptìdeo
|
JP5230865B2
(ja)
|
2004-07-15 |
2013-07-10 |
テトラロジック ファーマシューティカルズ コーポレーション |
Iap結合性化合物
|
CN1721533A
(zh)
|
2004-07-16 |
2006-01-18 |
中国科学院沈阳应用生态研究所 |
Il2与抗gd2单链抗体融合蛋白及编码基因和应用
|
AU2005330703A1
(en)
|
2004-07-19 |
2006-10-26 |
Baylor College Of Medicine |
Modulation of cytokine signaling regulators and applications for immunotherapy
|
JP2008510829A
(ja)
|
2004-08-25 |
2008-04-10 |
ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン |
デンドリマーに基づく組成物およびそれらの使用法
|
EP1640018A1
(en)
|
2004-09-24 |
2006-03-29 |
Universität Zürich |
Combinational therapy for treating cancer
|
WO2006042237A2
(en)
|
2004-10-06 |
2006-04-20 |
Mayo Foundation For Medical Education And Research |
B7-h1 and methods of diagnosis, prognosis, and treatment of cancer
|
WO2006050166A2
(en)
|
2004-10-29 |
2006-05-11 |
Medimmune, Inc. |
Methods of preventing and treating rsv infections and related conditions
|
CU23297A1
(es)
|
2004-11-16 |
2008-07-24 |
Ct De Inmunologa A Molecular |
Formulaciones inmunoterapã0/00uticas para la inducciã"n de autoanticuerpos bloqueadores de la uniã"n de interleucina-2 a su receptor. su uso en el tratamiento del cã ncer
|
PT3540062T
(pt)
|
2004-11-16 |
2021-07-06 |
Humanigen Inc |
Permuta de cassete de região variável de imunoglobulina
|
KR20070085886A
(ko)
|
2004-12-09 |
2007-08-27 |
메르크 파텐트 게엠베하 |
감소된 면역원성의 il-7 변이체
|
EA019420B1
(ru)
|
2004-12-20 |
2014-03-31 |
Дженентех, Инк. |
Пирролидиновые ингибиторы иап (ингибиторов апоптоза)
|
JP2008528621A
(ja)
|
2005-01-27 |
2008-07-31 |
ノバルティス ヴァクシンズ アンド ダイアグノスティクス インコーポレイテッド |
腎細胞ガンを処置するための方法
|
DE602005001688T2
(de)
|
2005-02-07 |
2008-04-10 |
Novartis Vaccines and Diagnostics, Inc., Emeryville |
Aufbereitung von Aldesleukin zur pharmazeutischen Verwendung
|
WO2006089230A2
(en)
|
2005-02-18 |
2006-08-24 |
Medarex, Inc. |
Human monoclonal antibodies to prostate specific membrane antigen (psma)
|
CN101146549A
(zh)
|
2005-02-18 |
2008-03-19 |
诺华疫苗和诊断公司 |
抗血管新生剂与阿地白介素
|
US20060287311A1
(en)
|
2005-02-25 |
2006-12-21 |
Inotek Pharmaceuticals Corporation |
Tetracyclic Sulfonamide Compounds and methods of use thereof
|
AU2006219022A1
(en)
|
2005-02-25 |
2006-09-08 |
Inotek Pharmaceuticals Corporation |
Isoqunoline Compounds and methods of use thereof
|
ES2427646T5
(es)
|
2005-05-09 |
2017-08-22 |
Ono Pharmaceutical Co., Ltd. |
Anticuerpos monoclonales humanos contra muerte programada 1 (PD1) y métodos para el tratamiento del cáncer mediante el uso de anticuerpos anti-PD-1 solos o combinados con otros agentes inmunoterapéuticos
|
EP1881835A4
(en)
|
2005-05-19 |
2010-04-07 |
Prometic Biosciences Inc |
TRIAZINE COMPOUNDS AND COMPOSITIONS THEREOF FOR THE TREATMENT OF CANCER
|
GB0510390D0
(en)
|
2005-05-20 |
2005-06-29 |
Novartis Ag |
Organic compounds
|
CA2612762C
(en)
|
2005-06-20 |
2013-12-10 |
Psma Development Company, Llc |
Psma antibody-drug conjugates
|
MX2007015942A
(es)
|
2005-07-01 |
2008-03-07 |
Medarex Inc |
Anticuerpos monoclonales humanos para ligandos 1 (pd-l1) de muerte programada.
|
PL1912636T3
(pl)
|
2005-07-21 |
2015-02-27 |
Ardea Biosciences Inc |
N-(aryloamino)sulfonamidowe inhibitory mek
|
KR20090004839A
(ko)
|
2005-09-07 |
2009-01-12 |
제네렉스, 인코포레이티드 |
Gm-csf를 발현하는 폭스바이러스를 사용한 전이성및/또는 전신 파종성 암의 전신 치료법
|
EP1928471A2
(en)
|
2005-09-26 |
2008-06-11 |
Novacea, Inc. |
Prevention and treatment of gastrointestinal and bladder disorders associated with chemotherapy or radiation therapy using active vitamin d compounds
|
WO2007051119A1
(en)
|
2005-10-26 |
2007-05-03 |
Mgi Gp, Inc. |
Methods and compositions of parp inhibitors as potentiators in cancer therapy
|
JO2660B1
(en)
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
Pi-3 inhibitors and methods of use
|
AU2007222080B2
(en)
|
2006-03-01 |
2012-08-16 |
Janssen Pharmaceutica N.V. |
Cancer treatment combining lymphodepleting agent with CTLs and cytokines
|
JP2009542592A
(ja)
|
2006-07-06 |
2009-12-03 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング |
Il−2媒介性免疫応答の有効性を高める組成物および方法
|
US8119772B2
(en)
|
2006-09-29 |
2012-02-21 |
California Institute Of Technology |
MART-1 T cell receptors
|
WO2008051220A1
(en)
|
2006-10-24 |
2008-05-02 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Interaction of il-27 and il-2 for treatment of tumors
|
WO2008112563A1
(en)
|
2007-03-09 |
2008-09-18 |
Flowmedica, Inc. |
Acute kidney injury treatment systems and methods
|
TW200843766A
(en)
|
2007-03-09 |
2008-11-16 |
Novartis Ag |
Treatment of melanoma
|
WO2008109953A1
(en)
|
2007-03-14 |
2008-09-18 |
Sai Ying Ko |
Method for treating cancer via the mucosal administration of interleukin
|
CA2683392A1
(en)
|
2007-04-30 |
2008-11-06 |
Genentech, Inc. |
Inhibitors of iap
|
WO2008146167A2
(en)
|
2007-06-01 |
2008-12-04 |
Innate Pharma S.A. |
Improved methods of using phosphoantigens together with interleukin-2 for the treatment of cancer
|
RS53072B
(en)
|
2007-06-18 |
2014-04-30 |
Merck Sharp & Dohme B.V. |
HUMAN RECEPTOR ANTIBODIES PROGRAMMED DEATH PD-1
|
US8247397B2
(en)
|
2007-09-12 |
2012-08-21 |
Genentech, Inc. |
Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use
|
ES2504690T3
(es)
|
2007-10-03 |
2014-10-08 |
Eisai Inc. |
Compuestos inhibidores de PARP, composiciones y métodos de uso
|
EP2050458A1
(en)
|
2007-10-17 |
2009-04-22 |
Institut National De La Sante Et De La Recherche Medicale (Inserm) |
IL24 for inducing hyperproliferative or autoimmune cell death
|
JP5348725B2
(ja)
|
2007-10-25 |
2013-11-20 |
ジェネンテック, インコーポレイテッド |
チエノピリミジン化合物の製造方法
|
CA2711256C
(en)
|
2008-01-03 |
2019-01-15 |
The Scripps Research Institute |
Antibody targeting through a modular recognition domain
|
US8454960B2
(en)
|
2008-01-03 |
2013-06-04 |
The Scripps Research Institute |
Multispecific antibody targeting and multivalency through modular recognition domains
|
US20140127200A1
(en)
|
2008-01-03 |
2014-05-08 |
The Scripps Research Institute |
Multispecific Antibody Targeting and Multivalency Through Modular Recognition Domains
|
ES2382058T3
(es)
|
2008-01-17 |
2012-06-04 |
Philogen S.P.A. |
Combinación de una proteína de fusión de un anticuerpo dirigido contra el EDB de la fibronectina-IL-2, y una molécula de unión a los linfocitos B, progenitores de los linfocitos B y/o sus homólogos cancerosos
|
PT2242773T
(pt)
|
2008-02-11 |
2017-09-15 |
Cure Tech Ltd |
Anticorpos monoclonais para o tratamento de tumores
|
EP2262837A4
(en)
|
2008-03-12 |
2011-04-06 |
Merck Sharp & Dohme |
PD-1 BINDING PROTEINS
|
WO2009152610A1
(en)
|
2008-06-20 |
2009-12-23 |
The Royal Institution For The Advancement Of Learning/Mcgill University |
Interleukin-2/soluble tgf-beta type ii receptor b conjugates and methods and uses thereof
|
US8168784B2
(en)
|
2008-06-20 |
2012-05-01 |
Abbott Laboratories |
Processes to make apoptosis promoters
|
GB0815216D0
(en)
|
2008-08-21 |
2008-09-24 |
Asterion Ltd |
Interleukin
|
WO2010027423A2
(en)
|
2008-08-25 |
2010-03-11 |
Amplimmune, Inc. |
Compositions of pd-1 antagonists and methods of use
|
WO2010042765A1
(en)
|
2008-10-08 |
2010-04-15 |
The Regents Of The University Of California |
Ca9 gene single nucleotide polymorphisms predict prognosis and treatment response of metastatic renal cell carcinoma
|
WO2010081172A1
(en)
|
2009-01-12 |
2010-07-15 |
Akebia Therapeutics Inc. |
Methods for treating vascular leak syndrome
|
RU2559526C2
(ru)
|
2009-02-24 |
2015-08-10 |
Алексион Фармасьютикалз, Инк. |
Антитела, содержащие терапевтические пептиды-миметики тро/еро
|
DK2429585T3
(en)
|
2009-05-15 |
2018-07-30 |
Irx Therapeutics Inc |
VACCINE IMMUNOTHERAPY
|
WO2011005380A2
(en)
|
2009-06-12 |
2011-01-13 |
Stc. Unm |
Arg-gly-asp-conjugated alpha-melanocyte stimulating hormone hybrid peptide for use in diagnosing and treating melanoma, including metastatic melanoma and methods related to same
|
SG178443A1
(en)
|
2009-08-17 |
2012-04-27 |
Roche Glycart Ag |
Targeted immunoconjugates
|
US8383099B2
(en)
|
2009-08-28 |
2013-02-26 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Adoptive cell therapy with young T cells
|
US20110152512A1
(en)
|
2009-09-09 |
2011-06-23 |
John Ryan |
Cyclodextrin-based polymers for therapeutics delivery
|
WO2011066521A2
(en)
|
2009-11-30 |
2011-06-03 |
Stc. Unm |
Compounds with reduced ring size for use in diagnosing and treating melanoma, including metastatic melanoma and methods related to same
|
US20130115617A1
(en)
|
2009-12-08 |
2013-05-09 |
John R. Wilson |
Methods of cell culture for adoptive cell therapy
|
US8956860B2
(en)
|
2009-12-08 |
2015-02-17 |
Juan F. Vera |
Methods of cell culture for adoptive cell therapy
|
CN102762719A
(zh)
|
2009-12-08 |
2012-10-31 |
威尔森沃尔夫制造公司 |
用于过继细胞疗法的细胞培养的改进方法
|
EP2525820B1
(en)
|
2010-01-19 |
2016-05-11 |
Immunomedics, Inc. |
Novel class of monospecific and bispecific humanized antibodies that target the insulin-like growth factor type i receptor (igf-1r)
|
WO2011139738A2
(en)
|
2010-04-28 |
2011-11-10 |
Tenx Biopharma, Inc. |
Therapies using zanolimumab to enhance the immune response
|
WO2012009705A1
(en)
|
2010-07-15 |
2012-01-19 |
Zyngenia, Inc. |
Ang-2 binding complexes and uses thereof
|
WO2012021609A2
(en)
|
2010-08-12 |
2012-02-16 |
Ulrik Mouritzen |
Neoadjuvant treatment of cancer with proleukin
|
WO2012037551A2
(en)
|
2010-09-17 |
2012-03-22 |
Irx Therapeutics, Inc. |
Primary cell-derived biologic and wt1 synthetic long peptide vaccine
|
US20120201750A1
(en)
|
2010-09-20 |
2012-08-09 |
Bungwoo Ryu |
Serum biomarkers for melanoma metastasis
|
WO2012045334A1
(en)
|
2010-10-05 |
2012-04-12 |
Synthon Bv |
Biologically active il-10 fusion proteins
|
CU23923B1
(es)
|
2010-11-12 |
2013-07-31 |
Ct De Inmunología Molecular |
Polipéptidos derivados de la il-2 con actividad agonista
|
HUE029139T2
(hu)
*
|
2011-02-10 |
2017-02-28 |
Roche Glycart Ag |
Mutáns interleukin-2 polipeptidek
|
JP2014511147A
(ja)
|
2011-02-10 |
2014-05-12 |
ロシュ グリクアート アーゲー |
改善された免疫療法
|
US20120244133A1
(en)
|
2011-03-22 |
2012-09-27 |
The United States of America, as represented by the Secretary, Department of Health and |
Methods of growing tumor infiltrating lymphocytes in gas-permeable containers
|
EA201892619A1
(ru)
|
2011-04-29 |
2019-04-30 |
Роше Гликарт Аг |
Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2
|
WO2012178137A1
(en)
|
2011-06-24 |
2012-12-27 |
Gillies Stephen D |
Light chain immunoglobulin fusion proteins and methods of use thereof
|
WO2013044169A1
(en)
|
2011-09-21 |
2013-03-28 |
Nestec S.A. |
Methods for determining combination therapy with il-2 for the treatment of cancer
|
DK2760886T3
(da)
|
2011-09-26 |
2019-12-09 |
Philogen Spa |
Immunocytokin-kombinationsterapi
|
CN104039351A
(zh)
|
2011-10-13 |
2014-09-10 |
阿尔皮奥治疗学股份有限公司 |
用于治疗血管渗漏综合征和癌症的方法
|
WO2013057500A1
(en)
|
2011-10-21 |
2013-04-25 |
Cell Medica Limited |
Device for the aseptic expansion of cells
|
GB201121308D0
(en)
|
2011-12-12 |
2012-01-25 |
Cell Medica Ltd |
Process
|
EP3663314A1
(en)
*
|
2012-01-09 |
2020-06-10 |
The Scripps Research Institute |
Humanized antibodies with ultralong cdr3s
|
JP6684490B2
(ja)
*
|
2012-01-09 |
2020-04-22 |
ザ・スクリップス・リサーチ・インスティテュート |
超長相補性決定領域及びその使用
|
EP2809335A4
(en)
|
2012-02-02 |
2015-10-28 |
Acceleron Pharma Inc |
ALK1 ANTAGONISTS AND USES THEREOF IN THE TREATMENT OF NEPHROCARCINOMA
|
KR20190134832A
(ko)
|
2012-03-29 |
2019-12-04 |
알토 바이오사이언스 코포레이션 |
종양 형성 치료방법
|
CN104394877B
(zh)
|
2012-05-08 |
2017-11-28 |
约翰·霍普金斯大学 |
用于输注短暂植入的同种异体淋巴细胞的选定群体来治疗癌症的方法和组合物
|
SG10202111564SA
(en)
|
2012-05-18 |
2021-12-30 |
Wilson Wolf Mfg Corporation |
Improved methods of cell culture for adoptive cell therapy
|
WO2013177187A2
(en)
|
2012-05-22 |
2013-11-28 |
Massachusetts Institute Of Technology |
Synergistic tumor treatment with extended-pk il-2 and therapeutic agents
|
IL288241B2
(en)
|
2012-06-11 |
2023-10-01 |
Wilson Wolf Mfg Corporation |
Improved cell culture methods for stress cell therapy
|
MX365382B
(es)
|
2012-08-07 |
2019-05-31 |
Roche Glycart Ag |
Una combinación de inmunoconjugado y anticuerpo para usarse en el tratamiento de cáncer.
|
MA20150232A1
(fr)
|
2012-08-08 |
2015-07-31 |
Roche Glycart Ag |
Protéines de fusion de l'interleukine-10 et leurs utilisations
|
US20140044675A1
(en)
|
2012-08-10 |
2014-02-13 |
Roche Glycart Ag |
Interleukin-2 fusion proteins and uses thereof
|
US9970936B2
(en)
|
2012-11-13 |
2018-05-15 |
Mayo Foundation For Medical Education And Research |
Methods and materials for assessing immune system profiles
|
EP2943512A4
(en)
|
2013-01-11 |
2016-06-01 |
California Inst Biomedical Res |
FUSION BOVINE ANTIBODIES
|
RU2671897C2
(ru)
|
2013-03-01 |
2018-11-07 |
Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез |
Способы получения из опухоли обогащенных популяций реактивных в отношении опухоли т-клеток
|
WO2014133568A1
(en)
|
2013-03-01 |
2014-09-04 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Methods of producing enriched populations of tumor reactive t cells from peripheral blood
|
AU2014225307A1
(en)
|
2013-03-08 |
2015-09-24 |
The Curators Of The University Of Missouri |
Methods and compositions for the treatment and/or prevention of type 1 diabetes
|
US10293023B2
(en)
|
2013-03-15 |
2019-05-21 |
Children's Medical Center Corporation |
Method of altering vascular permeability and uses thereof
|
WO2014201378A1
(en)
|
2013-06-13 |
2014-12-18 |
Massachusetts Institute Of Technology |
Synergistic tumor treatment with extended-pk il -2 and adoptive cell therapy
|
CN110564612A
(zh)
|
2013-06-24 |
2019-12-13 |
威尔逊沃夫制造公司 |
用于透气性细胞培养过程的封闭***装置和方法
|
US10683353B2
(en)
|
2013-07-11 |
2020-06-16 |
The Scripps Research Institute |
Coiled coil immunoglobulin fusion proteins and compositions thereof
|
US20160168231A1
(en)
|
2013-07-18 |
2016-06-16 |
Fabrus, Inc. |
Antibodies with ultralong complementarity determining regions
|
US9572828B2
(en)
|
2013-07-18 |
2017-02-21 |
The Board Of Regents Of The University Of Texas System |
Treatment for melanoma
|
EP3022221B1
(en)
|
2013-07-18 |
2021-09-15 |
Taurus Biosciences, LLC |
Humanized antibodies with ultralong complementarity determining regions
|
US10233425B2
(en)
|
2013-09-16 |
2019-03-19 |
The Trustees Of The University Of Pennsylvania |
CD137 enrichment for efficient tumor infiltrating lymphocyte selection
|
JOP20200096A1
(ar)
|
2014-01-31 |
2017-06-16 |
Children’S Medical Center Corp |
جزيئات جسم مضاد لـ tim-3 واستخداماتها
|
LT3102595T
(lt)
|
2014-02-06 |
2019-01-25 |
F. Hoffmann-La Roche Ag |
Interleukino-2 sulieti baltymai ir jų panaudojimas
|
MX2016010174A
(es)
|
2014-02-06 |
2016-11-15 |
Hoffmann La Roche |
Proteinas de fusion de interleucina-10 y usos de las mismas.
|
US9555088B2
(en)
|
2014-03-06 |
2017-01-31 |
Morphogenesis, Inc. |
DNA vector and transformed tumor cell vaccines
|
WO2015140150A1
(en)
|
2014-03-17 |
2015-09-24 |
Piotr Jachimczak |
Combination for use in a method of treating cancer
|
ES2906598T3
(es)
|
2014-03-17 |
2022-04-19 |
Bundesrepublik Deutschland Letztvertreten Durch Das Robert Koch Inst Vertreten Durch Seinen Praeside |
Un medicamento para el uso en un método para inducir o extender una respuesta inmunitaria citotóxica celular
|
JP2017511375A
(ja)
|
2014-03-20 |
2017-04-20 |
エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド |
養子細胞療法のための腫瘍浸潤リンパ球
|
WO2015157636A1
(en)
|
2014-04-10 |
2015-10-15 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
Enhanced expansion of tumor-infiltrating lymphocytes for adoptive cell therapy
|
KR102441940B1
(ko)
|
2014-06-11 |
2022-09-08 |
폴리바이오셉트 게엠베하 |
시토킨 조성물을 이용한 능동 세포적 면역 치료법을 위한 림프구의 증식
|
WO2016025645A1
(en)
|
2014-08-12 |
2016-02-18 |
Massachusetts Institute Of Technology |
Synergistic tumor treatment with il-2, a therapeutic antibody, and an immune checkpoint blocker
|
CA3133162C
(en)
|
2014-08-12 |
2024-02-13 |
Massachusetts Institute Of Technology |
Synergistic tumor treatment with il-2 and integrin-binding-fc-fusion protein
|
RS59939B1
(sr)
|
2014-08-29 |
2020-03-31 |
Hoffmann La Roche |
Kombinovana terapija il-2 varijantom imunocitokina sa ciljanim delovanjem na tumor i antitelima na humani pd-l1
|
AU2014407539B2
(en)
|
2014-10-02 |
2020-10-22 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Methods of isolating T cell receptors having antigenic specificity for a cancer-specific mutation
|
UY36351A
(es)
|
2014-10-14 |
2016-06-01 |
Novartis Ag |
Moléculas de anticuerpo que se unen a pd-l1 y usos de las mismas
|
AU2015338974B2
(en)
|
2014-10-31 |
2021-08-26 |
Oncomed Pharmaceuticals, Inc. |
Combination therapy for treatment of disease
|
GB201419976D0
(en)
|
2014-11-10 |
2014-12-24 |
Univ Newcastle |
Biomarkers for disease progression in melanoma
|
EP3034092A1
(en)
|
2014-12-17 |
2016-06-22 |
Université de Lausanne |
Adoptive immunotherapy for treating cancer
|
WO2017093947A1
(en)
*
|
2015-12-04 |
2017-06-08 |
Novartis Ag |
Antibody cytokine engrafted compositions and methods of use for immunoregulation
|
JP7308505B2
(ja)
|
2016-01-08 |
2023-07-14 |
マキシオン セラピューティクス リミテッド |
多様性を変化させた足場ドメインを有する結合メンバー
|
EP4180520A1
(en)
|
2016-10-26 |
2023-05-17 |
Iovance Biotherapeutics, Inc. |
Restimulation of cryopreserved tumor infiltrating lymphocytes
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