CU23297A1 - Formulaciones inmunoterapã0/00uticas para la inducciã"n de autoanticuerpos bloqueadores de la uniã"n de interleucina-2 a su receptor. su uso en el tratamiento del cã ncer - Google Patents

Formulaciones inmunoterapã0/00uticas para la inducciã"n de autoanticuerpos bloqueadores de la uniã"n de interleucina-2 a su receptor. su uso en el tratamiento del cã ncer

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Publication number
CU23297A1
CU23297A1 CU20040261A CU20040261A CU23297A1 CU 23297 A1 CU23297 A1 CU 23297A1 CU 20040261 A CU20040261 A CU 20040261A CU 20040261 A CU20040261 A CU 20040261A CU 23297 A1 CU23297 A1 CU 23297A1
Authority
CU
Cuba
Prior art keywords
blocking
induction
treatment
formulations
relates
Prior art date
Application number
CU20040261A
Other languages
English (en)
Inventor
Sarduy Liva N Bladimir Alonso
Da Vila Agusta N Bienveni Lage
Casimiro Josa Enrique Montero
Rez Rodra Guez Rolando Pa
Original Assignee
Ct De Inmunologa A Molecular
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct De Inmunologa A Molecular filed Critical Ct De Inmunologa A Molecular
Priority to CU20040261A priority Critical patent/CU23297A1/es
Priority to ARP050104787A priority patent/AR051494A1/es
Priority to PE2005001336A priority patent/PE20061172A1/es
Priority to CN2005800391860A priority patent/CN101061136B/zh
Priority to US11/719,326 priority patent/US20090274647A1/en
Priority to KR1020077010317A priority patent/KR101240457B1/ko
Priority to CA2588573A priority patent/CA2588573C/en
Priority to AU2005306186A priority patent/AU2005306186B2/en
Priority to TR2007/04213T priority patent/TR200704213T2/xx
Priority to EP09164216.5A priority patent/EP2112160B1/en
Priority to BRPI0518007-4A priority patent/BRPI0518007A/pt
Priority to MYPI20055353A priority patent/MY162106A/en
Priority to EA200701071A priority patent/EA012072B1/ru
Priority to TW094140326A priority patent/TWI433853B/zh
Priority to AT05811052T priority patent/ATE525393T1/de
Priority to SG200507053A priority patent/SG122897A1/en
Priority to JP2007541654A priority patent/JP5227028B2/ja
Priority to GEAP200510066A priority patent/GEP20105039B/en
Priority to MX2007005808A priority patent/MX2007005808A/es
Priority to PCT/CU2005/000009 priority patent/WO2006053508A1/es
Priority to EP05811052A priority patent/EP1829893B1/en
Priority to ZA200703528A priority patent/ZA200703528B/en
Priority to CR9097A priority patent/CR9097A/es
Priority to TNP2007000187A priority patent/TNSN07187A1/fr
Priority to MA29960A priority patent/MA29044B1/fr
Priority to HK08102535.0A priority patent/HK1113374A1/xx
Publication of CU23297A1 publication Critical patent/CU23297A1/es

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • C07K14/55IL-2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • A61K2039/6068Other bacterial proteins, e.g. OMP
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se relaciona con formulaciones farmacéuticas útiles en el cáncer mediante el bloqueo de la unión de la Interleucina 2 (IL-2) a su receptor. Más particularmente la presente invención se relaciona con formulaciones terapéuticas capaces de incrementar la inmunogenicidad de la IL-2 por su acoplamiento a la proteína transportadora P64K de la Neisseria Meningitidis en adyuvante Montanide ISA 51 para la inducción de autoanticuerpos bloqueadores de la IL-2 a su receptor y métodos efectivos para el tratamiento de tumores, incluyendo el cáncer de mama. En otro aspecto la presente invención se refiere a la combinación terapéutica de la vacuna basada en IL-2 con otras vacunas de cáncer basadas en antígenos específicos de tumores o factores de crecimiento tumoral, asi como medicamentos quimioterapéuticos o radioterapia de uso convencional en la práctica oncológica.</P>
CU20040261A 2004-11-16 2004-11-16 Formulaciones inmunoterapã0/00uticas para la inducciã"n de autoanticuerpos bloqueadores de la uniã"n de interleucina-2 a su receptor. su uso en el tratamiento del cã ncer CU23297A1 (es)

Priority Applications (26)

Application Number Priority Date Filing Date Title
CU20040261A CU23297A1 (es) 2004-11-16 2004-11-16 Formulaciones inmunoterapã0/00uticas para la inducciã"n de autoanticuerpos bloqueadores de la uniã"n de interleucina-2 a su receptor. su uso en el tratamiento del cã ncer
ARP050104787A AR051494A1 (es) 2004-11-16 2005-11-15 Formulaciones inmunoterapeuticas para la induccion de autoanticuerpos bloqueadores de la union de interleucina -2 a su receptor , su uso en el tratamiento del cancer
PE2005001336A PE20061172A1 (es) 2004-11-16 2005-11-15 Formulaciones inmunoterapeuticas para la induccion de autoanticuerpos bloqueadores de la union de interleucina-2 a su receptor
CN2005800391860A CN101061136B (zh) 2004-11-16 2005-11-16 具有白介素-2中和能力的免疫治疗制剂
US11/719,326 US20090274647A1 (en) 2004-11-16 2005-11-16 Immunotherapeutic Formulations with Interleukin-2-Neutralizing Capacity
KR1020077010317A KR101240457B1 (ko) 2004-11-16 2005-11-16 인터루킨-2 중화 활성을 갖는 면역치료용 제제
CA2588573A CA2588573C (en) 2004-11-16 2005-11-16 Immunotherapeutic formulations to generate autoantibodies capable to avoid the binding of interleukin-2 to its receptor their use in the treatment of cancer
AU2005306186A AU2005306186B2 (en) 2004-11-16 2005-11-16 Immunotherapeutic formulations with Interleukin-2-neutralising capacity
TR2007/04213T TR200704213T2 (tr) 2004-11-16 2005-11-16 İnterleukin-2'nin reseptörüne bağlanmasını önleyebilen otoantikorlar üretmek için immünoterapötik formülasyonlar, bunların kanser tedavisinde kullanımı.
EP09164216.5A EP2112160B1 (en) 2004-11-16 2005-11-16 Immunotherapeutic formulations to generate autoantibodies capable to avoid the binding of interleukin-2 to its receptor. Their use in the treatment of cancer
BRPI0518007-4A BRPI0518007A (pt) 2004-11-16 2005-11-16 formulação terapêutica capaz de produzir uma resposta imune contra a interleucina-2 e uso da mesma
MYPI20055353A MY162106A (en) 2004-11-16 2005-11-16 Immunotherapeutic formulations to generate autoantibodies capable to avoid the binding of interleukin-2 to its receptor.their use in the treatment of cancer.
EA200701071A EA012072B1 (ru) 2004-11-16 2005-11-16 Иммунотерапевтические композиции для получения аутоантител, способных предотвращать связывание интерлейкина-2 со своим рецептором, и их использование в лечении рака
TW094140326A TWI433853B (zh) 2004-11-16 2005-11-16 產生能避免介白素2與其受體結合之自體抗體的免疫治療調製劑及彼於治療癌症上之用途
AT05811052T ATE525393T1 (de) 2004-11-16 2005-11-16 Immuntherapeutische formulierungen mit der fähigkeit, interleukin-2 zu neutralisieren
SG200507053A SG122897A1 (en) 2004-11-16 2005-11-16 Immunotherapeutic formulations to generate autoantibodies capable to avoid the binding of interleukin-2 to its receptor their use in the treatment of cancer
JP2007541654A JP5227028B2 (ja) 2004-11-16 2005-11-16 インターロイキン−2の中和能を有する免疫治療用製剤
GEAP200510066A GEP20105039B (en) 2004-11-16 2005-11-16 Immunotherapeutic formulations for production of the autoantibodies that block the binding of interleukin-2 to the receptor thereof and use thereof for treatment of cancer
MX2007005808A MX2007005808A (es) 2004-11-16 2005-11-16 Formulaciones inmunoterapeuticas para la induccion de autoanticuerpos bloqueadores de la union de interleucina-2 a su receptor, su uso en el tratamiento del cancer.
PCT/CU2005/000009 WO2006053508A1 (es) 2004-11-16 2005-11-16 Formulaciones inmunoterapeuticas con capacidad neutralizante de la interleucina-2.
EP05811052A EP1829893B1 (en) 2004-11-16 2005-11-16 Immunotherapeutic formulations with interleukin-2-neutralising capacity
ZA200703528A ZA200703528B (en) 2004-11-16 2007-05-02 Immunotherapeutic formulations with Interleukin-2-neutralising capacity
CR9097A CR9097A (es) 2004-11-16 2007-05-04 Formulaciones inmunoterapeuticas para la induccion de autoanticuerpos bloqueadores de la union de interleucina-2 a su receptor. su uso en tratamiento del cancer
TNP2007000187A TNSN07187A1 (en) 2004-11-16 2007-05-15 Immunotherapeutic formulations to generate autoantibodies capable to avoid the binding of interleukin-2 to its receptor. their use in the treatment of cancer
MA29960A MA29044B1 (fr) 2004-11-16 2007-05-30 Formulations inmunotherapeutiques a capacite de neutralisation de l'interleukine-2
HK08102535.0A HK1113374A1 (en) 2004-11-16 2008-03-05 Immunotherapeutic formulations with interleukin-2-neutralising capacity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU20040261A CU23297A1 (es) 2004-11-16 2004-11-16 Formulaciones inmunoterapã0/00uticas para la inducciã"n de autoanticuerpos bloqueadores de la uniã"n de interleucina-2 a su receptor. su uso en el tratamiento del cã ncer

Publications (1)

Publication Number Publication Date
CU23297A1 true CU23297A1 (es) 2008-07-24

Family

ID=40122436

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20040261A CU23297A1 (es) 2004-11-16 2004-11-16 Formulaciones inmunoterapã0/00uticas para la inducciã"n de autoanticuerpos bloqueadores de la uniã"n de interleucina-2 a su receptor. su uso en el tratamiento del cã ncer

Country Status (25)

Country Link
US (1) US20090274647A1 (es)
EP (2) EP1829893B1 (es)
JP (1) JP5227028B2 (es)
KR (1) KR101240457B1 (es)
CN (1) CN101061136B (es)
AR (1) AR051494A1 (es)
AT (1) ATE525393T1 (es)
AU (1) AU2005306186B2 (es)
BR (1) BRPI0518007A (es)
CA (1) CA2588573C (es)
CR (1) CR9097A (es)
CU (1) CU23297A1 (es)
EA (1) EA012072B1 (es)
GE (1) GEP20105039B (es)
HK (1) HK1113374A1 (es)
MA (1) MA29044B1 (es)
MX (1) MX2007005808A (es)
MY (1) MY162106A (es)
PE (1) PE20061172A1 (es)
SG (1) SG122897A1 (es)
TN (1) TNSN07187A1 (es)
TR (1) TR200704213T2 (es)
TW (1) TWI433853B (es)
WO (1) WO2006053508A1 (es)
ZA (1) ZA200703528B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007271398B2 (en) * 2006-07-06 2013-06-20 Merck Patent Gmbh Compositions and methods for enhancing the efficacy of IL-2 mediated immune responses
WO2015162124A1 (en) * 2014-04-22 2015-10-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the diagnostic of an autoimmune disease
US10138298B2 (en) 2015-10-23 2018-11-27 The Regents Of The University Of California Anti-IL-2 antibodies and compositions and uses thereof
CU20210021A7 (es) * 2021-03-30 2022-11-07 Ct Inmunologia Molecular Composicones vacunales depletantes de factores de crecimiento hematopoyéticos para el tratamiento de enfermedades inflamatorias

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Also Published As

Publication number Publication date
AU2005306186A1 (en) 2006-05-26
ZA200703528B (en) 2008-06-25
TNSN07187A1 (en) 2008-11-21
EP2112160A3 (en) 2010-01-13
CR9097A (es) 2007-08-28
JP5227028B2 (ja) 2013-07-03
EA012072B1 (ru) 2009-08-28
MY162106A (en) 2017-05-31
CN101061136B (zh) 2012-12-05
HK1113374A1 (en) 2008-10-03
CA2588573A1 (en) 2006-05-26
PE20061172A1 (es) 2006-12-16
EP2112160A2 (en) 2009-10-28
KR101240457B1 (ko) 2013-03-08
EP2112160B1 (en) 2015-07-08
JP2008526686A (ja) 2008-07-24
TWI433853B (zh) 2014-04-11
CA2588573C (en) 2013-12-31
EA200701071A1 (ru) 2007-12-28
AU2005306186B2 (en) 2012-05-31
KR20070084025A (ko) 2007-08-24
TW200631591A (en) 2006-09-16
MX2007005808A (es) 2007-07-20
EP1829893A1 (en) 2007-09-05
MA29044B1 (fr) 2007-11-01
TR200704213T2 (tr) 2007-08-21
ATE525393T1 (de) 2011-10-15
BRPI0518007A (pt) 2008-10-21
US20090274647A1 (en) 2009-11-05
AR051494A1 (es) 2007-01-17
EP1829893B1 (en) 2011-09-21
CN101061136A (zh) 2007-10-24
SG122897A1 (en) 2006-06-29
WO2006053508A1 (es) 2006-05-26
GEP20105039B (en) 2010-07-12

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