ES2533874T3 - Armazón proteico - Google Patents

Armazón proteico Download PDF

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ES2533874T3
ES2533874T3 ES08845766.8T ES08845766T ES2533874T3 ES 2533874 T3 ES2533874 T3 ES 2533874T3 ES 08845766 T ES08845766 T ES 08845766T ES 2533874 T3 ES2533874 T3 ES 2533874T3
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beta chain
seq
framework comprises
loop
tn3ss3
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Herren Wu
Manuel Baca
Jeffrey Swers
Benoy Chacko
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MedImmune LLC
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MedImmune LLC
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C12N15/09—Recombinant DNA-technology
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    • C07K2319/00—Fusion polypeptide

Abstract

Un armazón polipeptídico recombinante que comprende: I. siete dominios de cadena beta designados A, B, C, D, E, F y G; II. unidos a seis regiones de bucle, en las que una región de bucle conecta cada cadena beta y se designa bucle AB, BC, CD, DE, EF y FG; III. en el que al menos una región de bucle varía por deleción, sustitución o adición de al menos un aminoácido de las regiones de bucle de SEC ID Nº: 1; y IV. en el que dicho armazón comprende al menos un enlace disulfuro para unir dos cualesquiera de dichos sietes dominios de cadena beta, en el que dicho armazón comprende las secuencias de cadena beta del tercer dominio de Fibronectina III de tenascina C, Tn3SS3 (SEC ID Nº: 65), o Tn3SS4 (SEC ID Nº: 66); o en el que dicho armazón comprende al menos dos enlaces disulfuro para unir dos cualesquiera de dichos siete dominios de cadena beta, en el que dicho armazón comprende las secuencias de cadena beta de Tn3SS3+4 (SEC ID Nº: 67).

Description

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Claims (1)

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ES08845766.8T 2007-10-31 2008-10-31 Armazón proteico Active ES2533874T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US98420907P 2007-10-31 2007-10-31
US984209P 2007-10-31
PCT/US2008/012398 WO2009058379A2 (en) 2007-10-31 2008-10-31 Protein scaffolds

Publications (1)

Publication Number Publication Date
ES2533874T3 true ES2533874T3 (es) 2015-04-15

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ES08845766.8T Active ES2533874T3 (es) 2007-10-31 2008-10-31 Armazón proteico

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US (2) US8633297B2 (es)
EP (1) EP2215246B1 (es)
JP (2) JP2011501951A (es)
KR (1) KR101686247B1 (es)
CN (1) CN101932720A (es)
AU (1) AU2008319298B2 (es)
BR (1) BRPI0818810A2 (es)
CA (1) CA2704229C (es)
ES (1) ES2533874T3 (es)
HK (1) HK1147286A1 (es)
MX (1) MX2010004374A (es)
RU (1) RU2010121967A (es)
WO (1) WO2009058379A2 (es)

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