MX2019003934A - Métodos terapéuticos y de diagnóstico para el cáncer. - Google Patents

Métodos terapéuticos y de diagnóstico para el cáncer.

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Publication number
MX2019003934A
MX2019003934A MX2019003934A MX2019003934A MX2019003934A MX 2019003934 A MX2019003934 A MX 2019003934A MX 2019003934 A MX2019003934 A MX 2019003934A MX 2019003934 A MX2019003934 A MX 2019003934A MX 2019003934 A MX2019003934 A MX 2019003934A
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MX
Mexico
Prior art keywords
cancer
tumor
tnbc
rcc
nsclc
Prior art date
Application number
MX2019003934A
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English (en)
Inventor
Yelensky Roman
Fabrizio David
KOWANETZ Marcin
Shames David
M Frampton Garrett
Hegde Priti
J Stephens Philip
Xin Sun James
Zou Wei
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Genentech Inc
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Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX2019003934A publication Critical patent/MX2019003934A/es

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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
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    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70532—B7 molecules, e.g. CD80, CD86
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12Q2600/00—Oligonucleotides characterized by their use
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    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
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    • G01—MEASURING; TESTING
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    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

La presente invención proporciona métodos y composiciones terapéuticos y de diagnóstico para el cáncer por ejemplo, cáncer de pulmón (por ejemplo, NSCLC), cáncer de vejiga (por ejemplo, UC), cáncer de riñón (por ejemplo, RCC), cáncer de mama (por ejemplo, TNBC) o melanoma. La invención proporciona métodos para el tratamiento del cáncer (por ejemplo, cáncer de pulmón (por ejemplo, NSCLC), cáncer de vejiga (por ejemplo, UC), cáncer de riñón (por ejemplo, RCC), cáncer de mama (por ejemplo, TNBC) o melanoma), métodos para determinar si un paciente que padece de cáncer (por ejemplo, cáncer de pulmón (por ejemplo, NSCLC), cáncer de vejiga (por ejemplo, UC), cáncer de riñón (por ejemplo, RCC), cáncer de mama (por ejemplo, TNBC) o melanoma) tiene probabilidades de responder al tratamiento que comprende un antagonista de unión al eje de PD-L1, métodos para predecir la respuesta de un paciente que padece cáncer (por ejemplo, cáncer de pulmón (por ejemplo, NSCLC), cáncer de vejiga (por ejemplo, UC), cáncer de riñón (por ejemplo, RCC), cáncer de mama (por ejemplo, TNBC) o melanoma) al tratamiento que comprende un antagonista de unión al eje de PD-L1 y métodos para seleccionar una terapia para un paciente que padece cáncer (por ejemplo, cáncer de pulmón (por ejemplo, NSCLC), cáncer de vejiga (por ejemplo, UC), cáncer de riñón (por ejemplo, RCC), cáncer de mama (por ejemplo, TNBC) o melanoma), en función del puntaje de carga mutacional tumoral del tejido (tTMB), que refleja niveles de mutación somáticos de genes en una muestra de tejido tumoral obtenida del paciente, solo o en combinación con niveles de expresión de PD-L1 (por ejemplo, niveles de expresión de PD-L1 en células inmunitarias tumorales o infiltrantes de tumor en una muestra tumoral (área tumoral) obtenida del paciente).
MX2019003934A 2016-10-06 2017-10-06 Métodos terapéuticos y de diagnóstico para el cáncer. MX2019003934A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662405209P 2016-10-06 2016-10-06
PCT/US2017/055669 WO2018068028A1 (en) 2016-10-06 2017-10-06 Therapeutic and diagnostic methods for cancer

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MX2019003934A true MX2019003934A (es) 2019-07-10

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US (2) US11300570B2 (es)
EP (1) EP3523451A1 (es)
JP (2) JP2019535237A (es)
KR (1) KR20190072528A (es)
CN (1) CN110418851A (es)
AU (1) AU2017339517B2 (es)
CA (1) CA3038712A1 (es)
IL (1) IL265759A (es)
MX (1) MX2019003934A (es)
TW (1) TWI775781B (es)
WO (1) WO2018068028A1 (es)

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