FR901228A
(fr)
|
1943-01-16 |
1945-07-20 |
Deutsche Edelstahlwerke Ag |
Système d'aimant à entrefer annulaire
|
US2779780A
(en)
|
1955-03-01 |
1957-01-29 |
Du Pont |
1, 4-diamino-2, 3-dicyano-1, 4-bis (substituted mercapto) butadienes and their preparation
|
GB2116183B
(en)
|
1982-03-03 |
1985-06-05 |
Genentech Inc |
Human antithrombin iii dna sequences therefore expression vehicles and cloning vectors containing such sequences and cell cultures transformed thereby a process for expressing human antithrombin iii and pharmaceutical compositions comprising it
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
JPS6147500A
(ja)
|
1984-08-15 |
1986-03-07 |
Res Dev Corp Of Japan |
キメラモノクロ−ナル抗体及びその製造法
|
EP0173494A3
(en)
|
1984-08-27 |
1987-11-25 |
The Board Of Trustees Of The Leland Stanford Junior University |
Chimeric receptors by dna splicing and expression
|
GB8422238D0
(en)
|
1984-09-03 |
1984-10-10 |
Neuberger M S |
Chimeric proteins
|
JPS61134325A
(ja)
|
1984-12-04 |
1986-06-21 |
Teijin Ltd |
ハイブリツド抗体遺伝子の発現方法
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
EP0307434B2
(en)
|
1987-03-18 |
1998-07-29 |
Scotgen Biopharmaceuticals, Inc. |
Altered antibodies
|
AU1807188A
(en)
|
1987-04-10 |
1988-11-04 |
Xoma Corporation |
Human monoclonal antibodies binding determinants of gram negative bacteria
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
DE68927933T2
(de)
|
1988-09-02 |
1997-08-14 |
Dyax Corp |
Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
GB8905669D0
(en)
|
1989-03-13 |
1989-04-26 |
Celltech Ltd |
Modified antibodies
|
WO1991000906A1
(en)
|
1989-07-12 |
1991-01-24 |
Genetics Institute, Inc. |
Chimeric and transgenic animals capable of producing human antibodies
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
US5859205A
(en)
|
1989-12-21 |
1999-01-12 |
Celltech Limited |
Humanised antibodies
|
EP1690935A3
(en)
|
1990-01-12 |
2008-07-30 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
CA2109602C
(en)
|
1990-07-10 |
2002-10-01 |
Gregory P. Winter |
Methods for producing members of specific binding pairs
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
ES2246502T3
(es)
|
1990-08-29 |
2006-02-16 |
Genpharm International, Inc. |
Animales no humanos transgenicos capaces de producir anticuerpos heterologos.
|
AU664976B2
(en)
|
1990-08-29 |
1995-12-14 |
Gene Pharming Europe Bv |
Homologous recombination in mammalian cells
|
EP0564531B1
(en)
|
1990-12-03 |
1998-03-25 |
Genentech, Inc. |
Enrichment method for variant proteins with altered binding properties
|
DK1279731T3
(da)
|
1991-03-01 |
2007-09-24 |
Dyax Corp |
Fremgangsmåde til udvikling af bindende miniproteiner
|
US20030206899A1
(en)
|
1991-03-29 |
2003-11-06 |
Genentech, Inc. |
Vascular endothelial cell growth factor antagonists
|
US6582959B2
(en)
|
1991-03-29 |
2003-06-24 |
Genentech, Inc. |
Antibodies to vascular endothelial cell growth factor
|
DE69233367T2
(de)
|
1991-04-10 |
2005-05-25 |
The Scripps Research Institute, La Jolla |
Bibliotheken heterodimerer rezeptoren mittels phagemiden
|
EP0519596B1
(en)
|
1991-05-17 |
2005-02-23 |
Merck & Co. Inc. |
A method for reducing the immunogenicity of antibody variable domains
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
WO1993000431A1
(en)
|
1991-06-27 |
1993-01-07 |
Bristol-Myers Squibb Company |
Ctl4a receptor, fusion proteins containing it and uses thereof
|
DE4122599C2
(de)
|
1991-07-08 |
1993-11-11 |
Deutsches Krebsforsch |
Phagemid zum Screenen von Antikörpern
|
ES2149768T3
(es)
|
1992-03-25 |
2000-11-16 |
Immunogen Inc |
Conjugados de agentes enlazantes de celulas derivados de cc-1065.
|
US5260074A
(en)
|
1992-06-22 |
1993-11-09 |
Digestive Care Inc. |
Compositions of digestive enzymes and salts of bile acids and process for preparation thereof
|
EP1621554B2
(en)
|
1992-08-21 |
2012-08-29 |
Vrije Universiteit Brussel |
Immunoglobulins devoid of light chains
|
ATE348110T1
(de)
|
1992-10-28 |
2007-01-15 |
Genentech Inc |
Hvegf rezeptor als vegf antagonist
|
IL108501A
(en)
|
1994-01-31 |
1998-10-30 |
Mor Research Applic Ltd |
Antibodies and pharmaceutical compositions containing them
|
JPH07291996A
(ja)
|
1994-03-01 |
1995-11-07 |
Yuu Honshiyo |
ヒトにおけるプログラムされた細胞死に関連したポリペプチド、それをコードするdna、そのdnaからなるベクター、そのベクターで形質転換された宿主細胞、そのポリペプチドの抗体、およびそのポリペプチドまたはその抗体を含有する薬学的組成物
|
US6066322A
(en)
|
1995-03-03 |
2000-05-23 |
Millennium Pharmaceuticals, Inc. |
Methods for the treatment of immune disorders
|
IL117645A
(en)
|
1995-03-30 |
2005-08-31 |
Genentech Inc |
Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration
|
US6051227A
(en)
|
1995-07-25 |
2000-04-18 |
The Regents Of The University Of California, Office Of Technology Transfer |
Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
|
US5811097A
(en)
|
1995-07-25 |
1998-09-22 |
The Regents Of The University Of California |
Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
|
US6632976B1
(en)
|
1995-08-29 |
2003-10-14 |
Kirin Beer Kabushiki Kaisha |
Chimeric mice that are produced by microcell mediated chromosome transfer and that retain a human antibody gene
|
EP0843961B1
(en)
|
1995-08-29 |
2007-01-24 |
Kirin Beer Kabushiki Kaisha |
Chimeric animal and method for constructing the same
|
US5968511A
(en)
|
1996-03-27 |
1999-10-19 |
Genentech, Inc. |
ErbB3 antibodies
|
AU4055697A
(en)
|
1996-08-16 |
1998-03-06 |
Schering Corporation |
Mammalian cell surface antigens; related reagents
|
US6111090A
(en)
|
1996-08-16 |
2000-08-29 |
Schering Corporation |
Mammalian cell surface antigens; related reagents
|
US20020032315A1
(en)
|
1997-08-06 |
2002-03-14 |
Manuel Baca |
Anti-vegf antibodies
|
ES2236634T3
(es)
|
1997-04-07 |
2005-07-16 |
Genentech, Inc. |
Anticuerpos anti-vegf.
|
US6884879B1
(en)
|
1997-04-07 |
2005-04-26 |
Genentech, Inc. |
Anti-VEGF antibodies
|
KR100794454B1
(ko)
|
1997-04-07 |
2008-01-16 |
제넨테크, 인크. |
항-vegf 항체
|
JP2001520039A
(ja)
|
1997-10-21 |
2001-10-30 |
ヒューマン ジノーム サイエンシーズ, インコーポレイテッド |
ヒト腫瘍壊死因子レセプター様タンパク質、tr11,tr11sv1およびtr11sv2
|
US6689607B2
(en)
|
1997-10-21 |
2004-02-10 |
Human Genome Sciences, Inc. |
Human tumor, necrosis factor receptor-like proteins TR11, TR11SV1 and TR11SV2
|
AU2591599A
(en)
|
1998-02-09 |
1999-08-23 |
Genentech Inc. |
Novel tumor necrosis factor receptor homolog and nucleic acids encoding the same
|
ATE298248T1
(de)
|
1998-04-15 |
2005-07-15 |
Brigham & Womens Hospital |
T-zell inhibierende rezeptorzusammensetzungen sowie deren verwendung
|
DE69938871D1
(de)
|
1998-12-03 |
2008-07-17 |
Univ California |
Stimulierung von T-Zellen gegen Selbstantigene unter Verwendung von CTLA-4 inhibierenden Wirkstoffen
|
JP2002532415A
(ja)
|
1998-12-16 |
2002-10-02 |
ワーナー−ランバート・カンパニー |
Mek阻害剤による関節炎の治療
|
US7041474B2
(en)
|
1998-12-30 |
2006-05-09 |
Millennium Pharmaceuticals, Inc. |
Nucleic acid encoding human tango 509
|
IL129299A0
(en)
|
1999-03-31 |
2000-02-17 |
Mor Research Applic Ltd |
Monoclonal antibodies antigens and diagnosis of malignant diseases
|
US6703020B1
(en)
|
1999-04-28 |
2004-03-09 |
Board Of Regents, The University Of Texas System |
Antibody conjugate methods for selectively inhibiting VEGF
|
FR2794025A1
(fr)
|
1999-05-25 |
2000-12-01 |
Transgene Sa |
Composition destinee a la mise en oeuvre d'un traitement antitumoral ou antiviral chez un mammifere
|
WO2000073498A1
(en)
|
1999-06-02 |
2000-12-07 |
Millennium Pharmaceuticals, Inc. |
Compositions and methods for the treatment and diagnosis of immune disorders
|
PT1196186E
(pt)
|
1999-07-12 |
2008-02-14 |
Genentech Inc |
Promoção ou inibição da angiogénese e da cardiovascularização com homólogos de ligandos/receptores do factor de necrose tumoral.
|
IL148021A0
(en)
|
1999-08-23 |
2002-09-12 |
Dana Farber Cancer Inst Inc |
Novel b7-4 molecules and uses therefor
|
PT1210428E
(pt)
|
1999-08-23 |
2015-07-21 |
Genetics Inst Llc |
Pd-1, um recetor para b7-4 e suas utilizações
|
EP1212422B1
(en)
|
1999-08-24 |
2007-02-21 |
Medarex, Inc. |
Human ctla-4 antibodies and their uses
|
US6803192B1
(en)
|
1999-11-30 |
2004-10-12 |
Mayo Foundation For Medical Education And Research |
B7-H1, a novel immunoregulatory molecule
|
CA2392477A1
(en)
|
1999-11-30 |
2001-06-07 |
Mayo Foundation For Medical Education And Research |
B7-h1, a novel immunoregulatory molecule
|
LT2857516T
(lt)
|
2000-04-11 |
2017-09-11 |
Genentech, Inc. |
Multivalentiniai antikūnai ir jų panaudojimas
|
US7030219B2
(en)
|
2000-04-28 |
2006-04-18 |
Johns Hopkins University |
B7-DC, Dendritic cell co-stimulatory molecules
|
AU2001275285A1
(en)
|
2000-06-06 |
2001-12-17 |
Bristol-Myers Squibb Company |
B7-related nucleic acids and polypeptides and their uses for immunomodulation
|
AU7309601A
(en)
|
2000-06-28 |
2002-01-08 |
Genetics Inst |
Pd-l2 molecules: novel pd-1 ligands and uses therefor
|
CZ303815B6
(cs)
|
2000-07-19 |
2013-05-15 |
Warner-Lambert Company |
Derivát O-substituovaného esteru 4-jodfenylaminobenzhydroxamové kyseliny a farmaceutický prípravek s jeho obsahem
|
PE20020354A1
(es)
|
2000-09-01 |
2002-06-12 |
Novartis Ag |
Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
|
CA2422215A1
(en)
|
2000-09-20 |
2002-03-28 |
Amgen Inc. |
B7-like molecules and uses thereof
|
US7132109B1
(en)
|
2000-10-20 |
2006-11-07 |
University Of Connecticut Health Center |
Using heat shock proteins to increase immune response
|
EP1368061B1
(en)
|
2000-10-20 |
2008-12-24 |
Tsuneya Ohno |
Fusion cells and cytokine compositions for treatment of disease
|
EP1334659B1
(en)
|
2000-11-15 |
2012-01-11 |
Ono Pharmaceutical Co., Ltd. |
Pd-1-lacking mouse and use thereof
|
JP2002194491A
(ja)
|
2000-12-27 |
2002-07-10 |
Daido Steel Co Ltd |
ばね用鋼材
|
US6995162B2
(en)
|
2001-01-12 |
2006-02-07 |
Amgen Inc. |
Substituted alkylamine derivatives and methods of use
|
AR036993A1
(es)
|
2001-04-02 |
2004-10-20 |
Wyeth Corp |
Uso de agentes que modulan la interaccion entre pd-1 y sus ligandos en la submodulacion de respuestas inmunologicas
|
CA2442066C
(en)
|
2001-04-02 |
2005-11-01 |
Wyeth |
Pd-1, a receptor for b7-4, and uses therefor
|
US7794710B2
(en)
|
2001-04-20 |
2010-09-14 |
Mayo Foundation For Medical Education And Research |
Methods of enhancing T cell responsiveness
|
US6727072B2
(en)
|
2001-05-01 |
2004-04-27 |
Dako Corporation |
EGF-r detection kit
|
US6592849B2
(en)
|
2001-06-21 |
2003-07-15 |
Colgate Palmolive Company |
Chewing gum to control malodorous breath
|
US8709412B2
(en)
|
2001-06-29 |
2014-04-29 |
The Board Of Trustees Of The Leland Stanford Junior University |
Modulation of TIM receptor activity in combination with cytoreductive therapy
|
US7838220B2
(en)
|
2001-06-29 |
2010-11-23 |
The Board Of Trustees Of The Leland Stanford Junior University |
T cell regulatory genes associated with immune disease
|
IL159627A0
(en)
|
2001-06-29 |
2004-06-01 |
Univ Leland Stanford Junior |
T-cell regulatory genes and diagnostic methods utilizing the same
|
JP2003029846A
(ja)
|
2001-07-11 |
2003-01-31 |
Sanyo Electric Co Ltd |
流量調整器および流量調整器を備えた飲料供給装置
|
US20040241745A1
(en)
|
2001-07-31 |
2004-12-02 |
Tasuku Honjo |
Substance specific to pd-1
|
IL145926A0
(en)
|
2001-10-15 |
2002-07-25 |
Mor Research Applic Ltd |
Peptide epitopes of mimotopes useful in immunomodulation
|
EP1456652A4
(en)
|
2001-11-13 |
2005-11-02 |
Dana Farber Cancer Inst Inc |
IMMUNOCELL ACTIVATION MODULATING SUBSTANCES AND USE METHOD THEREFOR
|
WO2003063792A2
(en)
|
2002-01-30 |
2003-08-07 |
The Brigham And Women's Hospital, Inc. |
Compositions and methods related to tim-3, a th1-specific cell surface molecule
|
EP1478648B1
(en)
|
2002-02-01 |
2014-04-30 |
ARIAD Pharmaceuticals, Inc. |
Phosphorus-containing compounds and uses thereof
|
ES2555307T3
(es)
|
2002-03-08 |
2015-12-30 |
Eisai R&D Management Co., Ltd. |
Compuestos macrocíclicos útiles como agentes farmacéuticos
|
DOP2003000613A
(es)
|
2002-03-13 |
2003-09-30 |
Array Biopharma Inc |
Derivados de bencimidazol n3 alquilado como inhibidores de mek (n3 alkylated benzimidazole derivatives as mek inhibitors)
|
TWI275390B
(en)
|
2002-04-30 |
2007-03-11 |
Wyeth Corp |
Process for the preparation of 7-substituted-3- quinolinecarbonitriles
|
IL149820A0
(en)
|
2002-05-23 |
2002-11-10 |
Curetech Ltd |
Humanized immunomodulatory monoclonal antibodies for the treatment of neoplastic disease or immunodeficiency
|
JP4409430B2
(ja)
|
2002-07-03 |
2010-02-03 |
小野薬品工業株式会社 |
免疫賦活組成物
|
GB0215676D0
(en)
|
2002-07-05 |
2002-08-14 |
Novartis Ag |
Organic compounds
|
US7052694B2
(en)
|
2002-07-16 |
2006-05-30 |
Mayo Foundation For Medical Education And Research |
Dendritic cell potentiation
|
US20040047858A1
(en)
|
2002-09-11 |
2004-03-11 |
Blumberg Richard S. |
Therapeutic anti-BGP(C-CAM1) antibodies and uses thereof
|
US7449300B2
(en)
|
2002-11-21 |
2008-11-11 |
Mayo Foundation For Medical Education And Research |
Detection of antibodies specific for B7-H1 in subjects with diseases or pathological conditions mediated by activated T cells
|
CN1753912B
(zh)
|
2002-12-23 |
2011-11-02 |
惠氏公司 |
抗pd-1抗体及其用途
|
EP2572715A1
(en)
|
2002-12-30 |
2013-03-27 |
3M Innovative Properties Company |
Immunostimulatory Combinations
|
JP4532409B2
(ja)
|
2003-01-23 |
2010-08-25 |
小野薬品工業株式会社 |
ヒトpd−1に対し特異性を有する物質
|
EP1897548B1
(en)
|
2003-02-28 |
2013-08-14 |
The Johns Hopkins University |
T cell regulation
|
KR20060052681A
(ko)
|
2003-05-23 |
2006-05-19 |
와이어쓰 |
Gitr 리간드, gitr 리간드-연관 분자, 항체 및그의 용도
|
UA101945C2
(uk)
|
2003-05-30 |
2013-05-27 |
Дженентек, Инк. |
Лікування злоякісного новоутворення за допомогою бевацизумабу
|
EP1660126A1
(en)
|
2003-07-11 |
2006-05-31 |
Schering Corporation |
Agonists or antagonists of the clucocorticoid-induced tumour necrosis factor receptor (gitr) or its ligand for the treatment of immune disorders, infections and cancer
|
US20050106667A1
(en)
|
2003-08-01 |
2005-05-19 |
Genentech, Inc |
Binding polypeptides with restricted diversity sequences
|
WO2005044853A2
(en)
|
2003-11-01 |
2005-05-19 |
Genentech, Inc. |
Anti-vegf antibodies
|
WO2005033144A2
(en)
|
2003-10-03 |
2005-04-14 |
Brigham And Women's Hospital |
Tim-3 polypeptides
|
KR101128777B1
(ko)
*
|
2003-11-04 |
2012-04-13 |
조마 테크놀로지 리미티드 |
다발성 골수종을 치료하기 위한 길항제 항-cd40단클론성 항체의 용도
|
WO2005055808A2
(en)
|
2003-12-02 |
2005-06-23 |
Genzyme Corporation |
Compositions and methods to diagnose and treat lung cancer
|
AU2005231685A1
(en)
|
2004-03-24 |
2005-10-20 |
Telos Pharmaceuticals Llc |
Compositions as adjuvants to improve immune responses to vaccines and methods of use
|
GB0409799D0
(en)
|
2004-04-30 |
2004-06-09 |
Isis Innovation |
Method of generating improved immune response
|
EP3943494A1
(en)
|
2004-05-13 |
2022-01-26 |
Icos Corporation |
Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta
|
WO2006083289A2
(en)
|
2004-06-04 |
2006-08-10 |
Duke University |
Methods and compositions for enhancement of immunity by in vivo depletion of immunosuppressive cell activity
|
RS52670B
(en)
|
2004-06-11 |
2013-06-28 |
Japan Tobacco Inc. |
5-AMINO-2,4,7-TRIOXO-3,4,7,8-TETRAHYDRO-2H-PIRIDO (2,3-D) PYRIMIDINE DERIVATIVES AND SIMILAR COMPOUNDS FOR CANCER TREATMENT
|
GB0512324D0
(en)
|
2005-06-16 |
2005-07-27 |
Novartis Ag |
Organic compounds
|
US20060009360A1
(en)
|
2004-06-25 |
2006-01-12 |
Robert Pifer |
New adjuvant composition
|
EP1768999B1
(en)
|
2004-06-30 |
2013-06-19 |
Mayo Foundation For Medical Education And Research |
sHIgM12 antibody useful to treat multiple sclerosis
|
WO2006021955A2
(en)
|
2004-08-23 |
2006-03-02 |
Mor Research Applications Ltd. |
Use of bat monoclonal antibody for immunotherapy
|
EA201890903A9
(ru)
|
2004-09-02 |
2021-11-10 |
Дженентек, Инк. |
Соединения пиридиловых ингибиторов передачи сигналов белком hedgehog, способ их получения, композиция и способы лечения рака и ингибирований ангиогенеза и сигнального пути hedgehog в клетках на их основе
|
MX2007004176A
(es)
|
2004-10-06 |
2007-06-15 |
Mayo Foundation |
B7-h1 y metodos de diagnosis, prognosis, y tratamiento de cancer.
|
US7423128B2
(en)
|
2004-11-03 |
2008-09-09 |
Amgen Fremont Inc. |
Anti-properdin antibodies, and methods for making and using same
|
DK1866339T3
(da)
|
2005-03-25 |
2013-09-02 |
Gitr Inc |
GTR-bindende molekyler og anvendelser heraf
|
CN109485727A
(zh)
|
2005-05-09 |
2019-03-19 |
小野药品工业株式会社 |
程序性死亡-1(pd-1)的人单克隆抗体及使用抗pd-1抗体来治疗癌症的方法
|
WO2006124269A2
(en)
|
2005-05-16 |
2006-11-23 |
Amgen Fremont Inc. |
Human monoclonal antibodies that bind to very late antigen-1 for the treatment of inflammation and other disorders
|
GB0510390D0
(en)
|
2005-05-20 |
2005-06-29 |
Novartis Ag |
Organic compounds
|
BRPI0611766A2
(pt)
|
2005-06-08 |
2011-12-20 |
Dana Farber Cancer Inst Inc |
métodos e composições para o tratamento de infecções persistentes e cáncer por inibição da rota de morte celular programada
|
US8901281B2
(en)
|
2005-06-17 |
2014-12-02 |
Merck Sharp & Dohme Corp. |
ILT3 binding molecules and uses therefor
|
JP4557003B2
(ja)
|
2005-07-01 |
2010-10-06 |
株式会社村田製作所 |
多層セラミック基板およびその製造方法ならびに多層セラミック基板作製用複合グリーンシート
|
DK1907424T3
(en)
|
2005-07-01 |
2015-11-09 |
Squibb & Sons Llc |
HUMAN MONOCLONAL ANTIBODIES TO PROGRAMMED death ligand 1 (PD-L1)
|
HUE035853T2
(en)
|
2005-07-18 |
2018-05-28 |
Seattle Genetics Inc |
Beta-glucuronide-linker-drug conjugates
|
AU2006272837B2
(en)
|
2005-07-21 |
2012-08-23 |
Ardea Biosciences, Inc. |
N-(arylamino)-sulfonamide inhibitors of MEK
|
WO2007024715A2
(en)
|
2005-08-19 |
2007-03-01 |
Abbott Laboratories |
Dual variable domain immunoglobin and uses thereof
|
US7612181B2
(en)
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
US20070041905A1
(en)
|
2005-08-19 |
2007-02-22 |
Hoffman Rebecca S |
Method of treating depression using a TNF-alpha antibody
|
ES2700433T3
(es)
|
2005-12-13 |
2019-02-15 |
Incyte Holdings Corp |
Derivados de pirrolo[2,3-d]pirimidina como inhibidores de quinasas Janus
|
US20090215084A1
(en)
|
2006-01-05 |
2009-08-27 |
Mayo Foundation For Medical Education And Research |
B7-h1 and b7-h4 in cancer
|
US20110212086A1
(en)
|
2006-01-19 |
2011-09-01 |
Genzyme Corporation |
GITR Antibodies For The Treatment of Cancer
|
JO2660B1
(en)
|
2006-01-20 |
2012-06-17 |
نوفارتيس ايه جي |
Pi-3 inhibitors and methods of use
|
WO2007113648A2
(en)
|
2006-04-05 |
2007-10-11 |
Pfizer Products Inc. |
Ctla4 antibody combination therapy
|
CA2654317A1
(en)
|
2006-06-12 |
2007-12-21 |
Trubion Pharmaceuticals, Inc. |
Single-chain multivalent binding proteins with effector function
|
PE20110220A1
(es)
|
2006-08-02 |
2011-04-11 |
Novartis Ag |
DERIVADOS DE 2-OXO-ETIL-AMINO-PROPIONAMIDA-PIRROLIDIN-2-IL-SUSTITUIDOS COMO INHIBIDORES DEL ENLACE DE LA PROTEINA Smac AL INHIBIDOR DE LA PROTEINA DE APOPTOSIS
|
EP2069354B1
(en)
|
2006-08-21 |
2011-11-02 |
Genentech, Inc. |
Aza-benzofuranyl compounds and methods of use
|
WO2008085562A2
(en)
|
2006-09-20 |
2008-07-17 |
The Johns Hopkins University |
Combinatorieal therapy of cancer and infectious diseases with anti-b7-h1 antibodies
|
JP2010510223A
(ja)
|
2006-11-15 |
2010-04-02 |
サ ブリガム アンド ウィメンズ ホスピタル インコーポレーティッド |
Tim−3調節物質の治療的使用
|
WO2008064157A1
(en)
|
2006-11-22 |
2008-05-29 |
Incyte Corporation |
Imidazotriazines and imidazopyrimidines as kinase inhibitors
|
WO2008067283A2
(en)
|
2006-11-27 |
2008-06-05 |
Diadexus, Inc. |
Ovr110 antibody compositions and methods of use
|
CN101616895A
(zh)
|
2006-12-08 |
2009-12-30 |
Irm责任有限公司 |
作为蛋白激酶抑制剂的化合物和组合物
|
KR101149295B1
(ko)
|
2006-12-08 |
2012-07-05 |
아이알엠 엘엘씨 |
단백질 키나제 억제제로서의 화합물
|
US8907065B2
(en)
|
2006-12-15 |
2014-12-09 |
Ablynx N.V. |
Polypeptides that modulate the interaction between cells of the immune system
|
CA3045637A1
(en)
|
2006-12-27 |
2008-07-10 |
Emory University |
Compositions and methods for the treatment of infections and tumors
|
EP1987839A1
(en)
|
2007-04-30 |
2008-11-05 |
I.N.S.E.R.M. Institut National de la Sante et de la Recherche Medicale |
Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
|
ES2437327T3
(es)
|
2007-06-18 |
2014-01-10 |
Merck Sharp & Dohme B.V. |
Anticuerpos para el receptor PD-1 humano de muerte programada
|
ES2591281T3
(es)
|
2007-07-12 |
2016-11-25 |
Gitr, Inc. |
Terapias de combinación que emplean moléculas de enlazamiento a GITR
|
EP2514762B1
(en)
|
2007-07-13 |
2015-04-08 |
The Johns Hopkins University |
B7-DC variants
|
WO2009014708A2
(en)
|
2007-07-23 |
2009-01-29 |
Cell Genesys, Inc. |
Pd-1 antibodies in combination with a cytokine-secreting cell and methods of use thereof
|
JP2010535032A
(ja)
|
2007-07-31 |
2010-11-18 |
メディミューン,エルエルシー |
多重特異性エピトープ結合性タンパク質およびその用途
|
US9243052B2
(en)
|
2007-08-17 |
2016-01-26 |
Daniel Olive |
Method for treating and diagnosing hematologic malignancies
|
WO2009030285A1
(en)
|
2007-09-07 |
2009-03-12 |
Ablynx N.V. |
Binding molecules with multiple binding sites, compositions comprising the same and uses thereof
|
MX338504B
(es)
|
2007-09-12 |
2016-04-20 |
Genentech Inc |
Combinaciones de compuestos inhibidores de fosfoinosituro 3-cinasa y agentes quimioterapeuticos, y metodos de uso.
|
US8354528B2
(en)
|
2007-10-25 |
2013-01-15 |
Genentech, Inc. |
Process for making thienopyrimidine compounds
|
AR069803A1
(es)
|
2007-12-19 |
2010-02-17 |
Genentech Inc |
5- anilinoimiazopiridinas y metodos de uso
|
ES2796085T3
(es)
|
2008-01-15 |
2020-11-25 |
Univ Leland Stanford Junior |
Marcadores de células madre de leucemia mieloide aguda
|
EP2252319A2
(en)
|
2008-01-29 |
2010-11-24 |
The Brigham and Women's Hospital, Inc. |
Methods for modulating a population of myeloid-derived suppressor cells and uses thereof
|
US8747847B2
(en)
|
2008-02-11 |
2014-06-10 |
Curetech Ltd. |
Monoclonal antibodies for tumor treatment
|
EP2262837A4
(en)
|
2008-03-12 |
2011-04-06 |
Merck Sharp & Dohme |
PD-1 BINDING PROTEINS
|
WO2009114870A2
(en)
|
2008-03-14 |
2009-09-17 |
Intellikine, Inc. |
Kinase inhibitors and methods of use
|
EP2271673B1
(en)
|
2008-03-26 |
2016-02-24 |
Cellerant Therapeutics, Inc. |
Cytokine receptors associated with myelogenous haematological proliferative disorders and uses thereof
|
NZ588554A
(en)
|
2008-04-29 |
2013-03-28 |
Abbott Lab |
Dual variable domain immunoglobulins and uses thereof
|
US20100260668A1
(en)
|
2008-04-29 |
2010-10-14 |
Abbott Laboratories |
Dual Variable Domain Immunoglobulins and Uses Thereof
|
KR101257158B1
(ko)
|
2008-05-23 |
2013-04-23 |
노파르티스 아게 |
단백질 티로신 키나제 억제제로서의 퀴놀린 및 퀴녹살린의 유도체
|
CN102112494A
(zh)
|
2008-06-03 |
2011-06-29 |
雅培制药有限公司 |
双重可变结构域免疫球蛋白及其用途
|
AR072001A1
(es)
|
2008-06-03 |
2010-07-28 |
Abbott Lab |
Inmunoglobulina con dominio variable dual y usos de la misma
|
US20110177070A1
(en)
|
2008-07-02 |
2011-07-21 |
Emergent Product Development Seatlle, LLC |
TGF-Beta Antagonist Multi-Target Binding Proteins
|
JP5945096B2
(ja)
|
2008-07-04 |
2016-07-05 |
小野薬品工業株式会社 |
抗ヒトpd−1抗体の癌に対する治療効果を最適化するための判定マーカーの使用
|
CA2730106A1
(en)
|
2008-07-08 |
2010-01-14 |
Intellikine, Inc. |
Kinase inhibitors and methods of use
|
WO2010006060A2
(en)
|
2008-07-08 |
2010-01-14 |
Abbott Laboratories |
Prostaglandin e2 dual variable domain immunoglobulins and uses thereof
|
AR072999A1
(es)
|
2008-08-11 |
2010-10-06 |
Medarex Inc |
Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
|
EP2331547B1
(en)
|
2008-08-22 |
2014-07-30 |
Novartis AG |
Pyrrolopyrimidine compounds as cdk inhibitors
|
US20110223188A1
(en)
|
2008-08-25 |
2011-09-15 |
Solomon Langermann |
Targeted costimulatory polypeptides and methods of use to treat cancer
|
PE20110435A1
(es)
|
2008-08-25 |
2011-07-20 |
Amplimmune Inc |
Composiciones antagonistas del pd-1
|
PT2344474E
(pt)
|
2008-09-02 |
2015-12-28 |
Novartis Ag |
Derivados de picolinamida como inibidores de cinase
|
UA104147C2
(uk)
|
2008-09-10 |
2014-01-10 |
Новартис Аг |
Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань
|
WO2010030002A1
(ja)
|
2008-09-12 |
2010-03-18 |
国立大学法人三重大学 |
外来性gitrリガンド発現細胞
|
JP2012501670A
(ja)
|
2008-09-12 |
2012-01-26 |
アイシス・イノベーション・リミテッド |
Pd−1特異抗体およびその使用
|
CA2736816C
(en)
|
2008-09-12 |
2018-05-22 |
Isis Innovation Limited |
Pd-1 specific antibodies and uses thereof
|
JP5731978B2
(ja)
|
2008-09-26 |
2015-06-10 |
インテリカイン, エルエルシー |
複素環キナーゼ阻害剤
|
KR102097887B1
(ko)
|
2008-09-26 |
2020-04-06 |
다나-파버 캔서 인스티튜트 인크. |
인간 항-pd-1, pd-l1, 및 pd-l2 항체 및 그의 용도
|
KR101050829B1
(ko)
|
2008-10-02 |
2011-07-20 |
서울대학교산학협력단 |
항 pd-1 항체 또는 항 pd-l1 항체를 포함하는 항암제
|
WO2010051502A2
(en)
|
2008-10-31 |
2010-05-06 |
Biogen Idec Ma Inc. |
Light targeting molecules and uses thereof
|
WO2010056735A1
(en)
|
2008-11-11 |
2010-05-20 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for inhibiting an oncogenic protein to enhance immunogenicity
|
WO2010063011A2
(en)
|
2008-11-28 |
2010-06-03 |
Emory University |
Methods for the treatment of infections and tumors
|
RU2011127198A
(ru)
|
2008-12-04 |
2013-01-10 |
Эбботт Лэборетриз |
Иммуноглобулины с двойными вариабельными доменами и их применение
|
BRPI0917592B1
(pt)
|
2008-12-09 |
2021-08-17 |
Genentech, Inc |
Anticorpo anti-pd-l1, composição, artigos manufaturados e usos de uma composição
|
JP5569946B2
(ja)
|
2009-01-26 |
2014-08-13 |
国立大学法人 岡山大学 |
免疫抑制剤および自己免疫疾患の予防および治療剤
|
EP3192811A1
(en)
|
2009-02-09 |
2017-07-19 |
Université d'Aix-Marseille |
Pd-1 antibodies and pd-l1 antibodies and uses thereof
|
UA103918C2
(en)
|
2009-03-02 |
2013-12-10 |
Айерем Элелси |
N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators
|
JP5836807B2
(ja)
|
2009-03-05 |
2015-12-24 |
アッヴィ・インコーポレイテッド |
Il−17結合タンパク質
|
WO2010102278A1
(en)
|
2009-03-06 |
2010-09-10 |
President And Fellows Of Harvard College |
Methods and compositions for the generation and maintenance of regulatory t cells
|
WO2010110346A1
(ja)
|
2009-03-24 |
2010-09-30 |
独立行政法人理化学研究所 |
白血病幹細胞マーカー
|
EP2417984B1
(en)
|
2009-04-10 |
2016-03-30 |
Kyowa Hakko Kirin Co., Ltd. |
Method for treatment of blood tumor using anti-tim-3 antibody
|
KR20180077322A
(ko)
|
2009-04-30 |
2018-07-06 |
텔 하쇼머 메디컬 리서치 인프라스트럭쳐 앤드 서비시스 리미티드. |
항-ceacam1 항체들과 이를 이용하는 방법들
|
MX2011011669A
(es)
|
2009-05-01 |
2011-11-18 |
Abbott Lab |
Inmunoglobulinas de dominio variable dual y usos de las misma.
|
EP2424566A4
(en)
|
2009-05-01 |
2013-07-31 |
Abbvie Inc |
IMMUNOGLOBULINE WITH DOUBLE VARIABLE DOMAIN AND ITS USE
|
EP2436397B1
(en)
|
2009-05-29 |
2017-05-10 |
Chugai Seiyaku Kabushiki Kaisha |
Pharmaceutical composition containing antagonist of egf family ligand as component
|
CN102802661B
(zh)
|
2009-06-22 |
2016-01-13 |
米迪缪尼有限公司 |
用于位点特异性偶联的工程改造的Fc区
|
EP2947098B1
(en)
|
2009-07-20 |
2019-11-20 |
Bristol-Myers Squibb Company |
Combination of anti-ctla4 antibody with gemcitabine for the synergistic treatment of proliferative diseases
|
UY32808A
(es)
|
2009-07-29 |
2011-02-28 |
Abbott Lab |
Inmunoglobulinas como dominio variable dual y usos de las mismas
|
AR077975A1
(es)
|
2009-08-28 |
2011-10-05 |
Irm Llc |
Derivados de pirazol pirimidina y composiciones como inhibidores de cinasa de proteina
|
EP2473524A4
(en)
|
2009-09-01 |
2013-05-22 |
Abbott Lab |
IMMUNOGLOBULINE WITH DOUBLE VARIABLE DOMAIN AND ITS USE
|
WO2011028952A1
(en)
|
2009-09-02 |
2011-03-10 |
Xencor, Inc. |
Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens
|
KR20170119746A
(ko)
|
2009-09-03 |
2017-10-27 |
머크 샤프 앤드 돔 코포레이션 |
항-gitr 항체
|
IT1395574B1
(it)
|
2009-09-14 |
2012-10-16 |
Guala Dispensing Spa |
Dispositivo di erogazione
|
EP3375791A1
(en)
|
2009-09-30 |
2018-09-19 |
Memorial Sloan Kettering Cancer Center |
Combination immunotherapy for the treatment of cancer
|
EP2488658A4
(en)
|
2009-10-15 |
2013-06-19 |
Abbvie Inc |
IMMUNOGLOBULINE WITH DOUBLE VARIABLE DOMAIN AND ITS USE
|
UY32979A
(es)
|
2009-10-28 |
2011-02-28 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
GB0919054D0
(en)
|
2009-10-30 |
2009-12-16 |
Isis Innovation |
Treatment of obesity
|
RS56469B1
(sr)
|
2009-11-24 |
2018-01-31 |
Medimmune Ltd |
Ciljano vezujući agensi usmereni na b7-h1
|
WO2011066342A2
(en)
|
2009-11-24 |
2011-06-03 |
Amplimmune, Inc. |
Simultaneous inhibition of pd-l1/pd-l2
|
CA2781682A1
(en)
|
2009-12-04 |
2011-06-09 |
Genentech, Inc. |
Multispecific antibodies, antibody analogs, compositions, and methods
|
US8440693B2
(en)
|
2009-12-22 |
2013-05-14 |
Novartis Ag |
Substituted isoquinolinones and quinazolinones
|
JP5856073B2
(ja)
|
2009-12-29 |
2016-02-09 |
エマージェント プロダクト デベロップメント シアトル, エルエルシー |
Ron結合構築体およびその使用方法
|
WO2011091078A2
(en)
|
2010-01-19 |
2011-07-28 |
Xencor, Inc. |
Antibody fc variants with enhanced complement activity
|
US20130202623A1
(en)
|
2010-02-16 |
2013-08-08 |
Nicolas Chomont |
Pd-1 modulation and uses thereof for modulating hiv replication
|
TW201134488A
(en)
|
2010-03-11 |
2011-10-16 |
Ucb Pharma Sa |
PD-1 antibodies
|
CA2791930A1
(en)
|
2010-03-11 |
2011-09-15 |
Kerry Louise Tyson |
Pd-1 antibody
|
US8828944B2
(en)
|
2010-04-22 |
2014-09-09 |
Institut Gustave Roussy |
Compounds and uses thereof to induce an immunogenic cancer cell death in a subject
|
CA2796633C
(en)
|
2010-04-23 |
2020-10-27 |
Genentech, Inc. |
Production of heteromultimeric proteins
|
US20110280877A1
(en)
|
2010-05-11 |
2011-11-17 |
Koji Tamada |
Inhibition of B7-H1/CD80 interaction and uses thereof
|
PE20130205A1
(es)
|
2010-05-14 |
2013-03-24 |
Abbvie Inc |
Proteinas de union a il-1
|
PL2581113T3
(pl)
|
2010-06-11 |
2018-11-30 |
Kyowa Hakko Kirin Co., Ltd. |
Przeciwciało anty-tim-3
|
JP2013532153A
(ja)
|
2010-06-18 |
2013-08-15 |
ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド |
慢性免疫病に対する免疫治療のためのtim−3およびpd−1に対する二重特異性抗体
|
UY33492A
(es)
|
2010-07-09 |
2012-01-31 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
WO2012018538A2
(en)
|
2010-07-26 |
2012-02-09 |
Schering Corporation |
Bioassays for determining pd-1 modulation
|
EP3252072A3
(en)
|
2010-08-03 |
2018-03-14 |
AbbVie Inc. |
Dual variable domain immunoglobulins and uses thereof
|
BR112013004012B1
(pt)
|
2010-08-20 |
2021-03-23 |
Novartis Ag |
Anticorpo monoclonal isolado ou fragmento de ligação ao antígeno do mesmo ao receptor her3, seu uso e composição farmacêutica
|
KR20130139884A
(ko)
|
2010-08-26 |
2013-12-23 |
애브비 인코포레이티드 |
이원 가변 도메인 면역글로불린 및 이의 용도
|
US9155802B2
(en)
|
2010-11-01 |
2015-10-13 |
Symphogen A/S |
Pan-HER antibody composition
|
EP2635694A4
(en)
|
2010-11-02 |
2015-11-11 |
Abbott Lab |
VARIABLE DOUBLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF
|
AR083705A1
(es)
|
2010-11-04 |
2013-03-13 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
EP2638066A4
(en)
|
2010-11-09 |
2015-06-03 |
Medimmune Llc |
ANTIBODY EQUIPMENT FOR HOMOGENEOUS CONJUGATION
|
BR122021026173B1
(pt)
|
2010-12-09 |
2023-12-05 |
The Trustees Of The University Of Pennsylvania |
Composição farmacêutica
|
US20120195900A1
(en)
|
2010-12-22 |
2012-08-02 |
Abbott Laboratories |
Tri-variable domain binding proteins and uses thereof
|
WO2012088302A2
(en)
|
2010-12-22 |
2012-06-28 |
Abbott Laboratories |
Half immunoglobulin binding proteins and uses thereof
|
US8814630B2
(en)
|
2011-01-04 |
2014-08-26 |
Carl T. Rittberger |
PVC beehive
|
KR101913448B1
(ko)
|
2011-02-04 |
2018-10-30 |
제넨테크, 인크. |
Fc 변이체 및 그의 생산 방법
|
MX341076B
(es)
|
2011-03-31 |
2016-08-04 |
Merck Sharp & Dohme |
Formulaciones estables de anticuerpos para el receptor humano pd-1 de meurte programada y tratamientos relacionados.
|
KR101970025B1
(ko)
|
2011-04-20 |
2019-04-17 |
메디뮨 엘엘씨 |
B7-h1 및 pd-1과 결합하는 항체 및 다른 분자들
|
WO2012162561A2
(en)
|
2011-05-24 |
2012-11-29 |
Zyngenia, Inc. |
Multivalent and monovalent multispecific complexes and their uses
|
US20140234320A1
(en)
|
2011-06-20 |
2014-08-21 |
La Jolla Institute For Allergy And Immunology |
Modulators of 4-1bb and immune responses
|
CN103796680A
(zh)
|
2011-06-21 |
2014-05-14 |
约翰霍普金斯大学 |
用于增强针对赘生物的基于免疫的治疗的聚焦放射
|
WO2013006490A2
(en)
|
2011-07-01 |
2013-01-10 |
Cellerant Therapeutics, Inc. |
Antibodies that specifically bind to tim3
|
CN103842030B
(zh)
|
2011-08-01 |
2018-07-31 |
霍夫曼-拉罗奇有限公司 |
使用pd-1轴结合拮抗剂和mek抑制剂治疗癌症的方法
|
US20130108641A1
(en)
|
2011-09-14 |
2013-05-02 |
Sanofi |
Anti-gitr antibodies
|
CA2849259A1
(en)
|
2011-09-19 |
2013-03-28 |
The Johns Hopkins University |
Cancer immunotherapy
|
WO2013054320A1
(en)
|
2011-10-11 |
2013-04-18 |
Tel Hashomer Medical Research Infrastructure And Services Ltd. |
Antibodies to carcinoembryonic antigen-related cell adhesion molecule (ceacam)
|
WO2013059740A1
(en)
*
|
2011-10-21 |
2013-04-25 |
Foundation Medicine, Inc. |
Novel alk and ntrk1 fusion molecules and uses thereof
|
CN104011076A
(zh)
|
2011-10-31 |
2014-08-27 |
默沙东公司 |
用于制备具有改善性能的抗体的方法
|
DK2785375T3
(da)
|
2011-11-28 |
2020-10-12 |
Merck Patent Gmbh |
Anti-pd-l1-antistoffer og anvendelser deraf
|
GB201120527D0
(en)
|
2011-11-29 |
2012-01-11 |
Ucl Business Plc |
Method
|
JP6385277B2
(ja)
|
2011-12-01 |
2018-09-05 |
ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドThe Brigham and Women’s Hospital, Inc. |
癌治療のための抗ceacam1組換え型抗体
|
CN102492038B
(zh)
|
2011-12-09 |
2014-05-28 |
中国人民解放军军事医学科学院基础医学研究所 |
抗人Tim-3的中和性单克隆抗体L3D及其用途
|
WO2013169693A1
(en)
|
2012-05-09 |
2013-11-14 |
Bristol-Myers Squibb Company |
Methods of treating cancer using an il-21 polypeptide and an anti-pd-1 antibody
|
ES2905448T3
(es)
*
|
2012-05-10 |
2022-04-08 |
Massachusetts Gen Hospital |
Métodos para determinar una secuencia nucleotídica
|
WO2013173223A1
(en)
|
2012-05-15 |
2013-11-21 |
Bristol-Myers Squibb Company |
Cancer immunotherapy by disrupting pd-1/pd-l1 signaling
|
WO2013179174A1
(en)
|
2012-05-29 |
2013-12-05 |
Koninklijke Philips N.V. |
Lighting arrangement
|
SG10201603055WA
(en)
|
2012-05-31 |
2016-05-30 |
Genentech Inc |
Methods Of Treating Cancer Using PD-L1 Axis Binding Antagonists And VEGF Antagonists
|
EP3553086A1
(en)
|
2012-05-31 |
2019-10-16 |
Sorrento Therapeutics Inc. |
Antigen binding proteins that bind pd-l1
|
JO3300B1
(ar)
*
|
2012-06-06 |
2018-09-16 |
Novartis Ag |
مركبات وتركيبات لتعديل نشاط egfr
|
KR101566538B1
(ko)
|
2012-06-08 |
2015-11-05 |
국립암센터 |
신규한 Th17 세포 전환용 에피토프 및 이의 용도
|
UY34887A
(es)
|
2012-07-02 |
2013-12-31 |
Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware |
Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos
|
CN112587658A
(zh)
|
2012-07-18 |
2021-04-02 |
博笛生物科技有限公司 |
癌症的靶向免疫治疗
|
WO2014018632A1
(en)
|
2012-07-27 |
2014-01-30 |
Novartis Ag |
Prediction of treatment response to jak/stat inhibitor
|
CA2877414A1
(en)
|
2012-07-30 |
2014-02-06 |
Alex Wah Hin Yeung |
Live and in-vivo tumor specified cancer vaccine system
|
JP2015525781A
(ja)
|
2012-07-31 |
2015-09-07 |
ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドThe Brigham and Women’s Hospital, Inc. |
免疫応答の調節
|
ES2848052T3
(es)
|
2012-08-03 |
2021-08-05 |
Dana Farber Cancer Inst Inc |
Anticuerpos de unión dual anti-PD-L1 y PD-L2 de agente individual y métodos de uso
|
US9682143B2
(en)
*
|
2012-08-14 |
2017-06-20 |
Ibc Pharmaceuticals, Inc. |
Combination therapy for inducing immune response to disease
|
WO2014047350A1
(en)
|
2012-09-20 |
2014-03-27 |
Morningside Technology Ventures Ltd. |
Oncolytic virus encoding pd-1 binding agents and uses of the same
|
RS56624B1
(sr)
*
|
2012-10-02 |
2018-03-30 |
Bristol Myers Squibb Co |
Kombinacija anti-kir antitela i anti-pd-1 antitela u lečenju kancera
|
AU2013326901B2
(en)
|
2012-10-04 |
2018-05-31 |
Dana-Farber Cancer Institute, Inc. |
Human monoclonal anti-PD-L1 antibodies and methods of use
|
KR102229873B1
(ko)
|
2012-10-12 |
2021-03-19 |
더 브리검 앤드 우먼즈 하스피털, 인크. |
면역 반응의 향상
|
WO2014071832A1
(en)
*
|
2012-11-06 |
2014-05-15 |
Shanghai Fochon Pharmaceutical Co Ltd |
Alk kinase inhibitors
|
BR112015010477A2
(pt)
|
2012-11-08 |
2017-07-11 |
Novartis Ag |
combinação farmacêutica que compreende um inibidor b-raf e um inibidor de histona desacetilase e o uso dos mesmos no tratamento de doenças proliferativas
|
WO2014085318A1
(en)
|
2012-11-28 |
2014-06-05 |
Novartis Ag |
Combination therapy
|
AR093984A1
(es)
|
2012-12-21 |
2015-07-01 |
Merck Sharp & Dohme |
Anticuerpos que se unen a ligando 1 de muerte programada (pd-l1) humano
|
WO2014165082A2
(en)
|
2013-03-13 |
2014-10-09 |
Medimmune, Llc |
Antibodies and methods of detection
|
US20160084839A1
(en)
|
2013-04-02 |
2016-03-24 |
Marisa Dolled-Filhart |
Immunohistochemical assay for detecting expression of programmed death ligand 1 (pd-l1) in tumor tissue
|
BR112015026823A2
(pt)
|
2013-05-02 |
2017-09-05 |
Anaptysbio Inc |
Polipeptídeo de cadeia pesada de imunoglobulina isolada, polipeptídeo de cadeia leve de imunoglobulina isolada, sequência de ácido nucleico isolada ou purificada, vetor, agente de ligação de proteína de morte-1 programada (pd-1) isolada, célula isolada, composição, e uso do agente de ligação da pd-1 isolada
|
JP6453855B2
(ja)
|
2013-05-18 |
2019-01-16 |
アドゥロ バイオテック,インク. |
「インターフェロン遺伝子の刺激因子」依存性シグナル伝達を活性化するための組成物及び方法
|
CN103242448B
(zh)
|
2013-05-27 |
2015-01-14 |
郑州大学 |
一种全人源化抗pd-1单克隆抗体及其制备方法和应用
|
SG11201509742QA
(en)
|
2013-06-03 |
2015-12-30 |
Novartis Ag |
Combinations of an anti-pd-l1 antibody and a mek inhibitor and/or a braf inhibitor
|
US20140378401A1
(en)
*
|
2013-06-21 |
2014-12-25 |
Gnt, Llc |
Ophthalmic Lipophilic and Hydrophilic Drug Delivery Vehicle Formulations
|
ES2819209T3
(es)
|
2013-07-16 |
2021-04-15 |
Hoffmann La Roche |
Procedimientos de tratamiento del cáncer usando antagonistas de unión al eje de PD-1 e inhibidores de TIGIT
|
WO2015026634A1
(en)
|
2013-08-20 |
2015-02-26 |
Merck Sharp & Dohme Corp. |
Treating cancer with a combination of a pd-1 antagonist and dinaciclib
|
AR097306A1
(es)
|
2013-08-20 |
2016-03-02 |
Merck Sharp & Dohme |
Modulación de la inmunidad tumoral
|
US10077305B2
(en)
|
2013-09-10 |
2018-09-18 |
Medimmune Limited |
Antibodies against PD-1 and uses thereof
|
DK3043816T3
(da)
|
2013-09-11 |
2019-10-14 |
Medimmune Ltd |
Anti-b7-h1-antistoffer til behandling af tumorer
|
AR097584A1
(es)
|
2013-09-12 |
2016-03-23 |
Hoffmann La Roche |
Terapia de combinación de anticuerpos contra el csf-1r humano y anticuerpos contra el pd-l1 humano
|
PL3702373T3
(pl)
|
2013-09-13 |
2022-12-05 |
Beigene Switzerland Gmbh |
Przeciwciała anty-PD1 i ich zastosowanie jako środki terapeutyczne i diagnostyczne
|
EP3178849B1
(en)
|
2013-09-20 |
2019-03-20 |
Bristol-Myers Squibb Company |
Combination of anti-lag-3 antibodies and anti-pd-1 antibodies to treat tumors
|
EP3757130A1
(en)
|
2013-09-26 |
2020-12-30 |
Costim Pharmaceuticals Inc. |
Methods for treating hematologic cancers
|
MA38960A1
(fr)
|
2013-09-27 |
2017-10-31 |
Genentech Inc |
Formulations d'anticorps anti-pdl1
|
AU2014339900B2
(en)
|
2013-10-25 |
2019-10-24 |
Dana-Farber Cancer Institute, Inc. |
Anti-PD-L1 monoclonal antibodies and fragments thereof
|
EP3066470A4
(en)
|
2013-11-05 |
2017-05-31 |
Immunomedics, Inc. |
Humanized anti-ceacam5 antibody and uses thereof
|
RU2016122957A
(ru)
|
2013-11-11 |
2017-12-19 |
Армо Байосайенсиз, Инк. |
Способы применения интерлейкина-10 для лечения заболеваний и расстройств
|
JP6879739B2
(ja)
|
2013-11-25 |
2021-06-02 |
フェイムウェイヴ リミテッド |
癌治療のための抗ceacam1および抗pd抗体を含む組成物
|
WO2015081158A1
(en)
|
2013-11-26 |
2015-06-04 |
Bristol-Myers Squibb Company |
Method of treating hiv by disrupting pd-1/pd-l1 signaling
|
WO2015088847A1
(en)
|
2013-12-11 |
2015-06-18 |
Glaxosmithkline Llc |
Treating cancer with a combination of a pd-1 antagonist and a vegfr inhibitor
|
DK3081576T3
(da)
|
2013-12-12 |
2019-10-21 |
Shanghai hengrui pharmaceutical co ltd |
Pd-1-antistof, antigenbindende fragment deraf og medicinsk anvendelse deraf
|
US9045545B1
(en)
|
2014-07-15 |
2015-06-02 |
Kymab Limited |
Precision medicine by targeting PD-L1 variants for treatment of cancer
|
CA2934028A1
(en)
|
2013-12-17 |
2015-06-25 |
Genentech, Inc. |
Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists
|
KR20160101073A
(ko)
|
2013-12-20 |
2016-08-24 |
더 브로드 인스티튜트, 인코퍼레이티드 |
신생항원 백신과의 병용 요법
|
EP3092004A4
(en)
|
2014-01-06 |
2017-02-22 |
The Trustees Of The University Of Pennsylvania |
Pd1 and pdl1 antibodies and vaccine combinations and use of same for immunotherapy
|
HUE057917T2
(hu)
|
2014-01-15 |
2022-06-28 |
Kadmon Corp Llc |
Immunmodulátor szerek
|
TWI681969B
(zh)
|
2014-01-23 |
2020-01-11 |
美商再生元醫藥公司 |
針對pd-1的人類抗體
|
TWI680138B
(zh)
|
2014-01-23 |
2019-12-21 |
美商再生元醫藥公司 |
抗pd-l1之人類抗體
|
JOP20200094A1
(ar)
|
2014-01-24 |
2017-06-16 |
Dana Farber Cancer Inst Inc |
جزيئات جسم مضاد لـ pd-1 واستخداماتها
|
CA2974651A1
(en)
|
2014-01-24 |
2015-07-30 |
Children's Hospital Of Eastern Ontario Research Institute Inc. |
Smc combination therapy for the treatment of cancer
|
JOP20200096A1
(ar)
|
2014-01-31 |
2017-06-16 |
Children’S Medical Center Corp |
جزيئات جسم مضاد لـ tim-3 واستخداماتها
|
JP2017508785A
(ja)
|
2014-02-04 |
2017-03-30 |
インサイト・コーポレイションIncyte Corporation |
癌を治療するためのpd−1アンタゴニストおよびido1阻害剤の組み合わせ
|
JP2017507931A
(ja)
|
2014-02-05 |
2017-03-23 |
シーダーズ−サイナイ メディカル センター |
がん及び感染症の治療方法並びに治療用組成物
|
CN106103488B
(zh)
|
2014-02-10 |
2021-07-30 |
默克专利有限公司 |
靶向TGFβ抑制
|
CN106255510A
(zh)
|
2014-03-05 |
2016-12-21 |
百时美施贵宝公司 |
使用抗pd‑1抗体与另一抗癌剂的组合治疗肾癌
|
PT3116909T
(pt)
|
2014-03-14 |
2020-01-30 |
Novartis Ag |
Moléculas de anticorpos para lag-3 e suas utilizações
|
CA2949121A1
(en)
|
2014-05-15 |
2015-11-19 |
Bristol-Myers Squibb Company |
Treatment of lung cancer using a combination of an anti-pd-1 antibody and another anti-cancer agent
|
WO2015181342A1
(en)
|
2014-05-29 |
2015-12-03 |
Spring Bioscience Corporation |
Pd-l1 antibodies and uses thereof
|
WO2015195163A1
(en)
|
2014-06-20 |
2015-12-23 |
R-Pharm Overseas, Inc. |
Pd-l1 antagonist fully human antibody
|
KR102003754B1
(ko)
|
2014-07-03 |
2019-07-25 |
베이진 엘티디 |
Pd-l1 항체와 이를 이용한 치료 및 진단
|
JO3663B1
(ar)
|
2014-08-19 |
2020-08-27 |
Merck Sharp & Dohme |
الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين
|
PT3183268T
(pt)
|
2014-08-19 |
2020-05-15 |
Novartis Ag |
Recetor de antigénio quimérico (car) anti-cd123 para uso no tratamento de cancro
|
EP3191097B1
(en)
|
2014-09-13 |
2019-10-23 |
Novartis AG |
Combination therapies
|
KR20170066546A
(ko)
|
2014-10-03 |
2017-06-14 |
노파르티스 아게 |
조합 요법
|
MX2017004810A
(es)
|
2014-10-14 |
2017-10-16 |
Novartis Ag |
Moleculas de anticuerpo que se unen a pd-l1 y usos de las mismas.
|
AU2015339306B2
(en)
|
2014-10-29 |
2021-07-22 |
Bristol-Myers Squibb Company |
Combination therapy for cancer
|
US20170320954A1
(en)
|
2014-11-17 |
2017-11-09 |
Medimmune Limited |
Therapeutic combinations and methods for treating neoplasia
|
TWI595006B
(zh)
|
2014-12-09 |
2017-08-11 |
禮納特神經系統科學公司 |
抗pd-1抗體類和使用彼等之方法
|
WO2016100882A1
(en)
|
2014-12-19 |
2016-06-23 |
Novartis Ag |
Combination therapies
|
MA41867A
(fr)
|
2015-04-01 |
2018-02-06 |
Anaptysbio Inc |
Anticorps dirigés contre l'immunoglobuline de cellule t et protéine 3 de mucine (tim-3)
|
US10478494B2
(en)
|
2015-04-03 |
2019-11-19 |
Astex Therapeutics Ltd |
FGFR/PD-1 combination therapy for the treatment of cancer
|
SG10201912035YA
(en)
|
2015-04-17 |
2020-02-27 |
Bristol Myers Squibb Co |
Compositions comprising a combination of an anti-pd-1 antibody and another antibody
|
KR20180040138A
(ko)
|
2015-07-13 |
2018-04-19 |
싸이톰스 테라퓨틱스, 인크. |
항pd-1 항체, 활성화 가능한 항pd-1 항체, 및 이들의 사용 방법
|
US20180207273A1
(en)
|
2015-07-29 |
2018-07-26 |
Novartis Ag |
Combination therapies comprising antibody molecules to tim-3
|
JP2018523652A
(ja)
|
2015-07-29 |
2018-08-23 |
ノバルティス アーゲー |
Pd−1アンタゴニストとegfr阻害剤の組み合わせ物
|
DK3317301T3
(da)
|
2015-07-29 |
2021-06-28 |
Immutep Sas |
Kombinationsterapier omfattende antistofmolekyler mod lag-3
|
WO2017019896A1
(en)
|
2015-07-29 |
2017-02-02 |
Novartis Ag |
Combination therapies comprising antibody molecules to pd-1
|
CN108136003A
(zh)
|
2015-07-29 |
2018-06-08 |
诺华股份有限公司 |
抗pd-1和抗m-csf抗体在癌症治疗中的联合应用
|
RS59688B1
(sr)
|
2015-08-11 |
2020-01-31 |
Novartis Ag |
5-bromo-2,6-di-(1h-pirazol-1-il)pirimidin-4-amin za upotrebu pri lečenju raka
|
AR105654A1
(es)
|
2015-08-24 |
2017-10-25 |
Lilly Co Eli |
Anticuerpos pd-l1 (ligando 1 de muerte celular programada)
|
US11058769B2
(en)
|
2015-12-07 |
2021-07-13 |
Merck Patent Gmbh |
Aqueous pharmaceutical formulation comprising anti-PD-L1 antibody Avelumab
|
EP3389712B1
(en)
|
2015-12-17 |
2024-04-10 |
Novartis AG |
Antibody molecules to pd-1 and uses thereof
|
RU2018140960A
(ru)
|
2016-04-25 |
2020-05-26 |
МЕДИММЬЮН, ЭлЭлСи |
Композиции, содержащие комбинированный состав на основе антител к pd-l1 и ctla-4
|
CN117752784A
(zh)
|
2017-02-14 |
2024-03-26 |
诺华股份有限公司 |
Wnt抑制剂和抗PD-1抗体分子组合的给药方案
|
JP2020525483A
(ja)
|
2017-06-27 |
2020-08-27 |
ノバルティス アーゲー |
抗tim−3抗体のための投与レジメンおよびその使用
|
AU2018302283A1
(en)
|
2017-07-20 |
2020-02-06 |
Novartis Ag |
Dosage regimens of anti-LAG-3 antibodies and uses thereof
|
WO2019018640A1
(en)
|
2017-07-21 |
2019-01-24 |
Novartis Ag |
POSOLOGICAL REGIMES FOR ANTI-GITREN ANTIBODIES AND USES THEREOF
|
MX2020004756A
(es)
|
2017-11-16 |
2020-08-20 |
Novartis Ag |
Terapias de combinacion.
|
TWI791794B
(zh)
|
2018-03-20 |
2023-02-11 |
瑞士商諾華公司 |
藥物組合
|
US20210147547A1
(en)
|
2018-04-13 |
2021-05-20 |
Novartis Ag |
Dosage Regimens For Anti-Pd-L1 Antibodies And Uses Thereof
|
CN114786679A
(zh)
|
2019-10-21 |
2022-07-22 |
诺华股份有限公司 |
具有维奈托克和tim-3抑制剂的组合疗法
|
TW202128191A
(zh)
|
2019-10-21 |
2021-08-01 |
瑞士商諾華公司 |
Tim-3抑制劑及其用途
|
WO2021123902A1
(en)
|
2019-12-20 |
2021-06-24 |
Novartis Ag |
Combination of anti tim-3 antibody mbg453 and anti tgf-beta antibody nis793, with or without decitabine or the anti pd-1 antibody spartalizumab, for treating myelofibrosis and myelodysplastic syndrome
|
IL293752A
(en)
|
2020-01-17 |
2022-08-01 |
Novartis Ag |
A combination containing a tim-3 inhibitor and a substance that causes hypomethylation for use in the treatment of myeloplastic syndrome or chronic myelomonocytic leukemia
|