MX2011011335A - Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamifero de rapamicina. - Google Patents

Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamifero de rapamicina.

Info

Publication number
MX2011011335A
MX2011011335A MX2011011335A MX2011011335A MX2011011335A MX 2011011335 A MX2011011335 A MX 2011011335A MX 2011011335 A MX2011011335 A MX 2011011335A MX 2011011335 A MX2011011335 A MX 2011011335A MX 2011011335 A MX2011011335 A MX 2011011335A
Authority
MX
Mexico
Prior art keywords
mtor
kinase
inhibitors
compounds
variables
Prior art date
Application number
MX2011011335A
Other languages
English (en)
Inventor
Bin Wu
Shon Booker
Mark H Norman
Yunxin Y Bo
Seifu Tadesse
Hongyu Liao
Liping H Pettus
Longbin Liu
Kevin Yang
Nobuko Nishimura
Bradley J Herberich
Victor J Cee
Nuria A Tamayo
Kristin Andrews
Anthony B Reed
Noel D Angelo
Fang-Tsao Hong
Claire L M Jackson
Brian A Lanman
Adrian L Smith
Ryan Wurz
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MX2011011335A publication Critical patent/MX2011011335A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

La presente invención se refiere a compuestos de la Fórmula I, o una sal farmacéuticamente aceptable del mismo; (ver fórmula (I)) métodos para tratar enfermedades o afecciones, tal como cáncer, usando los compuestos; y composiciones farmacéuticas que contienen los compuestos, en donde las variables son como se define en la presente.
MX2011011335A 2009-04-28 2010-04-27 Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamifero de rapamicina. MX2011011335A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17352009P 2009-04-28 2009-04-28
US25853209P 2009-11-05 2009-11-05
PCT/US2010/032593 WO2010126895A1 (en) 2009-04-28 2010-04-27 Inhibitors of pi3 kinase and / or mtor

Publications (1)

Publication Number Publication Date
MX2011011335A true MX2011011335A (es) 2011-11-18

Family

ID=42315845

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011011335A MX2011011335A (es) 2009-04-28 2010-04-27 Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamifero de rapamicina.

Country Status (24)

Country Link
US (2) US8362241B2 (es)
EP (1) EP2424859B1 (es)
JP (1) JP5697662B2 (es)
KR (1) KR20120007540A (es)
CN (1) CN102548984B (es)
AR (1) AR076486A1 (es)
AU (1) AU2010241723B2 (es)
BR (1) BRPI1015262A2 (es)
CA (1) CA2758986C (es)
CL (1) CL2011002691A1 (es)
CO (1) CO6440596A2 (es)
CR (1) CR20110634A (es)
EA (1) EA019700B1 (es)
HK (1) HK1167862A1 (es)
IL (1) IL215731A0 (es)
MA (1) MA34207B1 (es)
MX (1) MX2011011335A (es)
NZ (1) NZ595572A (es)
PE (1) PE20121159A1 (es)
SG (1) SG175364A1 (es)
TW (1) TW201103902A (es)
UY (1) UY32582A (es)
WO (1) WO2010126895A1 (es)
ZA (1) ZA201108101B (es)

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AU2010241723A1 (en) 2011-11-17
US8362241B2 (en) 2013-01-29
EP2424859B1 (en) 2015-04-08
US20130079303A1 (en) 2013-03-28
PE20121159A1 (es) 2012-09-19
NZ595572A (en) 2013-07-26
CN102548984B (zh) 2015-11-25
UY32582A (es) 2010-11-30
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US8772480B2 (en) 2014-07-08
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KR20120007540A (ko) 2012-01-20
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AU2010241723B2 (en) 2012-12-13
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TW201103902A (en) 2011-02-01

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