MX2013001361A - 4-(1h-indol-3-il) - pirimidina como inhibidores de alk. - Google Patents
4-(1h-indol-3-il) - pirimidina como inhibidores de alk.Info
- Publication number
- MX2013001361A MX2013001361A MX2013001361A MX2013001361A MX2013001361A MX 2013001361 A MX2013001361 A MX 2013001361A MX 2013001361 A MX2013001361 A MX 2013001361A MX 2013001361 A MX2013001361 A MX 2013001361A MX 2013001361 A MX2013001361 A MX 2013001361A
- Authority
- MX
- Mexico
- Prior art keywords
- pyrimidines
- indol
- alk inhibitors
- formula
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6568—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms
- C07F9/65685—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus atoms as the only ring hetero atoms the ring phosphorus atom being part of a phosphine oxide or thioxide
Abstract
La presente invención se refiere a compuestos de Fórmula (I) y/o Fórmula (la): (Ver Formulas) y a sus sales, composiciones farmacéuticas, métodos de empleo y métodos para su preparación. Estos compuestos inhiben la actividad cinasa de ALK y, por lo tanto, se pueden utilizar para tratar el cáncer.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36991710P | 2010-08-02 | 2010-08-02 | |
US37205510P | 2010-08-09 | 2010-08-09 | |
US39094410P | 2010-10-07 | 2010-10-07 | |
PCT/GB2011/051465 WO2012017239A2 (en) | 2010-08-02 | 2011-08-02 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2013001361A true MX2013001361A (es) | 2013-05-17 |
Family
ID=45527326
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013001361A MX2013001361A (es) | 2010-08-02 | 2011-08-02 | 4-(1h-indol-3-il) - pirimidina como inhibidores de alk. |
Country Status (14)
Country | Link |
---|---|
US (1) | US8461170B2 (es) |
EP (1) | EP2601186A2 (es) |
JP (1) | JP2013534221A (es) |
KR (1) | KR20130096241A (es) |
CN (1) | CN103153982A (es) |
AR (1) | AR089550A1 (es) |
AU (1) | AU2011287386A1 (es) |
BR (1) | BR112013002587A2 (es) |
CA (1) | CA2805827A1 (es) |
MX (1) | MX2013001361A (es) |
RU (1) | RU2013109132A (es) |
TW (1) | TW201219383A (es) |
UY (1) | UY33539A (es) |
WO (1) | WO2012017239A2 (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI3333161T1 (sl) | 2011-07-27 | 2020-07-31 | Astrazeneca Ab | Derivati 2-(2,4,5-substituiranega-anilino) pirimidina, kot modulatorji EGFR uporabni za zdravljenje raka |
CN102899882B (zh) * | 2012-11-07 | 2014-08-06 | 西南大学 | 超亲水涤纶织物的磷酸制备方法 |
CN104876914B (zh) * | 2014-02-28 | 2017-04-19 | 山东轩竹医药科技有限公司 | 嘧啶衍生物类间变性淋巴瘤激酶抑制剂 |
CN105085550B (zh) * | 2014-05-21 | 2017-05-24 | 海门慧聚药业有限公司 | 一类alk激酶抑制剂及其制备方法 |
BR112016029662B1 (pt) * | 2014-06-19 | 2023-10-24 | Takeda Pharmaceutical Company Limited | COMPOSTO DE FÓRMULA Bf OU UMA FORMA FARMACEUTICAMENTE ACEITÁVEL DO MESMO, COMPOSIÇÃO FARMACÊUTICA COMPREENDENDO O MESMO E SEU USO |
AU2015407300B2 (en) * | 2015-08-31 | 2019-06-20 | Wuxi Shuangliang Biotechnology Co., Ltd. | 2-Arylamino pyridine, pyridine or triazine derivative, preparation method and use thereof |
CN106810553B (zh) * | 2015-11-30 | 2020-03-17 | 江苏正大丰海制药有限公司 | 3-(4,5-取代氨基嘧啶)苯基衍生物及其应用 |
WO2017205459A1 (en) | 2016-05-26 | 2017-11-30 | Kalyra Pharmaceuticals, Inc. | Egfr inhibitor compounds |
DK3514153T3 (da) * | 2017-01-26 | 2021-09-27 | Hanmi Pharm Ind Co Ltd | Pyrimidinforbindelse og farmaceutisk anvendelse deraf |
US11931536B2 (en) * | 2017-07-26 | 2024-03-19 | Dk Medical Technology Co., Ltd. | Surface liquefied drug-coated balloon |
CA3096790C (en) * | 2018-04-09 | 2024-03-19 | Shanghaitech University | Target protein degradation compounds, their anti-tumor use, their intermediates and use of intermediates |
KR101954370B1 (ko) * | 2018-07-25 | 2019-03-05 | 한미약품 주식회사 | 피리미딘 화합물 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물 |
CN114364798A (zh) | 2019-03-21 | 2022-04-15 | 欧恩科斯欧公司 | 用于治疗癌症的Dbait分子与激酶抑制剂的组合 |
CN114761006A (zh) | 2019-11-08 | 2022-07-15 | Inserm(法国国家健康医学研究院) | 对激酶抑制剂产生耐药性的癌症的治疗方法 |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
CN113387935B (zh) * | 2021-07-23 | 2022-06-10 | 苏州雅深智慧科技有限公司 | 抑制三突变表皮生长因子受体酪氨酸激酶的化合物及用途 |
CN116763792B (zh) * | 2023-06-19 | 2024-03-12 | 西安国际医学中心医院 | Hg-14-10-04在制备治疗食管鳞癌的药物中的应用 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
CA2242425C (en) | 1996-02-13 | 2006-07-18 | Zeneca Limited | Quinazoline derivatives as vegf inhibitors |
IL125954A (en) | 1996-03-05 | 2003-06-24 | Zeneca Ltd | Quinazoline derivatives, processes for their preparation, pharmaceutical compositions containing them and use thereof in the manufacture of medicaments having an antiangiogenic and/or vascular permeability reducing effect |
GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
JP2003535078A (ja) | 2000-05-31 | 2003-11-25 | アストラゼネカ アクチボラグ | 血管損傷活性のあるインドール誘導体 |
WO2002008213A1 (en) | 2000-07-07 | 2002-01-31 | Angiogene Pharmaceuticals Limited | Colchinol derivatives as angiogenesis inhibitors |
US20050277627A1 (en) | 2000-07-07 | 2005-12-15 | Arnould Jean C | Colchinol derivatives as vascular damaging agents |
BRPI0620196A2 (pt) | 2005-12-23 | 2013-01-15 | Astrazeneca Ab | composto, processo para a preparaÇço do mesmo, composiÇço farmacÊutica, uso de um composto, e, mÉtodos para a produÇço de um efeito antibacteriano em um animal de sangue quente, para a inibiÇço de dna girase e/ou topoisomerase iv bacteriana em um animal de sangue quente e para o tratamento de uma infecÇço bacteriana em um animal de sangue quente |
US20100267707A1 (en) * | 2006-06-22 | 2010-10-21 | Merck Sharp & Dohme Corp. | Tyrosine Kinase Inhibitors |
ES2400619T3 (es) * | 2007-06-01 | 2013-04-11 | Glaxosmithkline Llc | Inhibidores de imidazopiridina quinasa |
CN103298814A (zh) * | 2007-08-23 | 2013-09-11 | 阿斯利康(瑞典)有限公司 | 作为治疗增殖性疾病的ttk/mps1抑制剂的2-苯胺基嘌呤-8-酮 |
UY32203A (es) * | 2008-10-29 | 2010-05-31 | Astrazeneca Ab | Amino pirimidinas y su uso en terapia |
-
2011
- 2011-08-01 UY UY0001033539A patent/UY33539A/es not_active Application Discontinuation
- 2011-08-01 TW TW100127241A patent/TW201219383A/zh unknown
- 2011-08-02 KR KR1020137003860A patent/KR20130096241A/ko not_active Application Discontinuation
- 2011-08-02 BR BR112013002587A patent/BR112013002587A2/pt not_active IP Right Cessation
- 2011-08-02 MX MX2013001361A patent/MX2013001361A/es not_active Application Discontinuation
- 2011-08-02 EP EP11746007.1A patent/EP2601186A2/en not_active Withdrawn
- 2011-08-02 RU RU2013109132/04A patent/RU2013109132A/ru not_active Application Discontinuation
- 2011-08-02 AU AU2011287386A patent/AU2011287386A1/en not_active Abandoned
- 2011-08-02 CA CA2805827A patent/CA2805827A1/en not_active Abandoned
- 2011-08-02 US US13/196,189 patent/US8461170B2/en not_active Expired - Fee Related
- 2011-08-02 JP JP2013522307A patent/JP2013534221A/ja not_active Withdrawn
- 2011-08-02 AR ARP110102793A patent/AR089550A1/es not_active Application Discontinuation
- 2011-08-02 CN CN201180047702XA patent/CN103153982A/zh active Pending
- 2011-08-02 WO PCT/GB2011/051465 patent/WO2012017239A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
US20120028924A1 (en) | 2012-02-02 |
BR112013002587A2 (pt) | 2019-09-24 |
KR20130096241A (ko) | 2013-08-29 |
AU2011287386A1 (en) | 2013-03-07 |
CA2805827A1 (en) | 2012-02-09 |
UY33539A (es) | 2012-02-29 |
AR089550A1 (es) | 2014-09-03 |
JP2013534221A (ja) | 2013-09-02 |
WO2012017239A2 (en) | 2012-02-09 |
RU2013109132A (ru) | 2014-09-10 |
TW201219383A (en) | 2012-05-16 |
CN103153982A (zh) | 2013-06-12 |
US8461170B2 (en) | 2013-06-11 |
EP2601186A2 (en) | 2013-06-12 |
WO2012017239A3 (en) | 2012-04-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |