MX2011008335A - Novedosos compuestos heterociclicos biciclicos sustituidos como moduladores de la gamma secretasa. - Google Patents
Novedosos compuestos heterociclicos biciclicos sustituidos como moduladores de la gamma secretasa.Info
- Publication number
- MX2011008335A MX2011008335A MX2011008335A MX2011008335A MX2011008335A MX 2011008335 A MX2011008335 A MX 2011008335A MX 2011008335 A MX2011008335 A MX 2011008335A MX 2011008335 A MX2011008335 A MX 2011008335A MX 2011008335 A MX2011008335 A MX 2011008335A
- Authority
- MX
- Mexico
- Prior art keywords
- bicyclic heterocyclic
- compounds
- gamma secretase
- substituted bicyclic
- heterocyclic compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
La presente invención se refiere a compuestos heterocíclicos bicíclicos sustituidos de la Fórmula (I) (ver fórmula (I)) donde Het1, Het2, A1, A2, A3 y A4 tienen el significado que se define en las reivindicaciones; los compuestos de conformidad con la presente invención resultan de utilidad como moduladores de la gamma secretasa; la invención también se refiere a los procedimientos para elaborar tales compuestos novedosos, a composiciones farmacéuticas que comprenden dichos compuestos novedosos a modo de ingrediente activo, así como al uso de dichos compuestos como medicamento.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09152254 | 2009-02-06 | ||
PCT/EP2010/051244 WO2010089292A1 (en) | 2009-02-06 | 2010-02-02 | Novel substituted bicyclic heterocyclic compounds as gamma secretase modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2011008335A true MX2011008335A (es) | 2011-09-06 |
Family
ID=40756688
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2011008335A MX2011008335A (es) | 2009-02-06 | 2010-02-02 | Novedosos compuestos heterociclicos biciclicos sustituidos como moduladores de la gamma secretasa. |
Country Status (20)
Country | Link |
---|---|
US (2) | US8946426B2 (es) |
EP (1) | EP2393804B1 (es) |
JP (1) | JP5576403B2 (es) |
KR (1) | KR20110113197A (es) |
CN (1) | CN102325765B (es) |
AP (1) | AP2011005779A0 (es) |
AR (1) | AR075366A1 (es) |
AU (1) | AU2010211109B2 (es) |
BR (1) | BRPI1008473A2 (es) |
CA (1) | CA2748862A1 (es) |
EA (1) | EA019685B1 (es) |
ES (1) | ES2481715T3 (es) |
IL (1) | IL214425A (es) |
MX (1) | MX2011008335A (es) |
NZ (1) | NZ593951A (es) |
SG (1) | SG173510A1 (es) |
TW (1) | TWI496780B (es) |
UA (1) | UA106360C2 (es) |
WO (1) | WO2010089292A1 (es) |
ZA (1) | ZA201105788B (es) |
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JP2010274429A (ja) | 2009-05-26 | 2010-12-09 | Ihi Corp | アライメントステージ |
EP2454239B1 (en) | 2009-07-15 | 2014-08-13 | Janssen Pharmaceuticals Inc. | Substituted triazole and imidazole derivatives as gamma secretase modulators |
BR112012017310A2 (pt) | 2010-01-15 | 2016-04-19 | Janssen Pharmaceuticals Inc | derivados de triazol substituídos como moduladores de gama secretase |
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2010
- 2010-02-02 AP AP2011005779A patent/AP2011005779A0/xx unknown
- 2010-02-02 JP JP2011548663A patent/JP5576403B2/ja not_active Expired - Fee Related
- 2010-02-02 CA CA2748862A patent/CA2748862A1/en not_active Abandoned
- 2010-02-02 EP EP10701701.4A patent/EP2393804B1/en active Active
- 2010-02-02 US US13/144,554 patent/US8946426B2/en not_active Expired - Fee Related
- 2010-02-02 BR BRPI1008473-8A patent/BRPI1008473A2/pt not_active IP Right Cessation
- 2010-02-02 NZ NZ593951A patent/NZ593951A/xx not_active IP Right Cessation
- 2010-02-02 WO PCT/EP2010/051244 patent/WO2010089292A1/en active Application Filing
- 2010-02-02 CN CN201080007206.7A patent/CN102325765B/zh not_active Expired - Fee Related
- 2010-02-02 SG SG2011055746A patent/SG173510A1/en unknown
- 2010-02-02 EA EA201171008A patent/EA019685B1/ru not_active IP Right Cessation
- 2010-02-02 KR KR1020117020288A patent/KR20110113197A/ko not_active Application Discontinuation
- 2010-02-02 MX MX2011008335A patent/MX2011008335A/es active IP Right Grant
- 2010-02-02 ES ES10701701.4T patent/ES2481715T3/es active Active
- 2010-02-02 UA UAA201108162A patent/UA106360C2/ru unknown
- 2010-02-02 AU AU2010211109A patent/AU2010211109B2/en not_active Ceased
- 2010-02-05 TW TW099103416A patent/TWI496780B/zh not_active IP Right Cessation
- 2010-02-05 AR ARP100100325A patent/AR075366A1/es not_active Application Discontinuation
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2011
- 2011-08-03 IL IL214425A patent/IL214425A/en not_active IP Right Cessation
- 2011-08-05 ZA ZA2011/05788A patent/ZA201105788B/en unknown
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2014
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AU2010211109B2 (en) | 2014-11-27 |
NZ593951A (en) | 2013-01-25 |
WO2010089292A1 (en) | 2010-08-12 |
US20150094311A1 (en) | 2015-04-02 |
IL214425A0 (en) | 2011-09-27 |
JP2012516870A (ja) | 2012-07-26 |
TW201040176A (en) | 2010-11-16 |
ES2481715T3 (es) | 2014-07-31 |
EP2393804B1 (en) | 2014-04-16 |
EA201171008A1 (ru) | 2012-02-28 |
US8946426B2 (en) | 2015-02-03 |
EA019685B1 (ru) | 2014-05-30 |
KR20110113197A (ko) | 2011-10-14 |
AU2010211109A1 (en) | 2011-07-21 |
US20110281881A1 (en) | 2011-11-17 |
BRPI1008473A2 (pt) | 2019-04-02 |
CA2748862A1 (en) | 2010-08-12 |
CN102325765A (zh) | 2012-01-18 |
ZA201105788B (en) | 2015-06-24 |
SG173510A1 (en) | 2011-09-29 |
UA106360C2 (ru) | 2014-08-26 |
JP5576403B2 (ja) | 2014-08-20 |
IL214425A (en) | 2015-07-30 |
TWI496780B (zh) | 2015-08-21 |
CN102325765B (zh) | 2014-12-24 |
AP2011005779A0 (en) | 2011-08-31 |
EP2393804A1 (en) | 2011-12-14 |
AR075366A1 (es) | 2011-03-30 |
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