MX2013005966A - Nuevos compuestos de benzofurano. - Google Patents

Nuevos compuestos de benzofurano.

Info

Publication number
MX2013005966A
MX2013005966A MX2013005966A MX2013005966A MX2013005966A MX 2013005966 A MX2013005966 A MX 2013005966A MX 2013005966 A MX2013005966 A MX 2013005966A MX 2013005966 A MX2013005966 A MX 2013005966A MX 2013005966 A MX2013005966 A MX 2013005966A
Authority
MX
Mexico
Prior art keywords
compounds
novel
concerned
formula
benzofurane compounds
Prior art date
Application number
MX2013005966A
Other languages
English (en)
Inventor
Rosa Maria Rodriguez Sarmiento
Juergen Wichmann
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2013005966A publication Critical patent/MX2013005966A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Abstract

La presente invención se refiere a nuevos moduladores duales de los receptores 5-HT2A y D3 de fórmula (I) en donde n, x, Y, R1, R2, R3, y R4 son como se describen en la presente, así como también sales y ésteres de los mismos farmacéuticamente aceptables. Además la presente invención está relacionada con la manufactura de los compuestos de fórmula (I), composiciones farmacéuticas que los comprenden y su uso como medicamentos.
MX2013005966A 2010-12-15 2011-12-12 Nuevos compuestos de benzofurano. MX2013005966A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10195231 2010-12-15
PCT/EP2011/072403 WO2012080149A1 (en) 2010-12-15 2011-12-12 Novel benzofurane compounds

Publications (1)

Publication Number Publication Date
MX2013005966A true MX2013005966A (es) 2013-07-15

Family

ID=45218739

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013005966A MX2013005966A (es) 2010-12-15 2011-12-12 Nuevos compuestos de benzofurano.

Country Status (10)

Country Link
US (1) US8877778B2 (es)
EP (1) EP2651929A1 (es)
JP (1) JP2014503519A (es)
KR (1) KR20130126958A (es)
CN (1) CN103261190A (es)
BR (1) BR112013014770A2 (es)
CA (1) CA2819970A1 (es)
MX (1) MX2013005966A (es)
RU (1) RU2013132409A (es)
WO (1) WO2012080149A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008280187B2 (en) * 2007-07-26 2013-05-16 F. Hoffmann-La Roche Ag Dual modulators of 5-HT2A and D3 receptors
CN106518841B (zh) * 2015-09-15 2019-03-05 浙江京新药业股份有限公司 环己烷衍生物或其立体异构体或盐及其制备与应用
EP3495363B1 (en) 2016-07-28 2023-08-23 Shionogi & Co., Ltd Nitrogen-containing condensed ring compounds having dopamine d3 receptor antagonistic effect
CN111801330B (zh) 2018-01-26 2024-04-05 盐野义制药株式会社 具有多巴胺d3受体拮抗作用的稠环化合物
WO2019146740A1 (ja) * 2018-01-26 2019-08-01 塩野義製薬株式会社 ドーパミンｄ３受容体拮抗作用を有する環式化合物

Family Cites Families (24)

* Cited by examiner, † Cited by third party
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US5776963A (en) 1989-05-19 1998-07-07 Hoechst Marion Roussel, Inc. 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility
DK60693D0 (da) 1993-05-26 1993-05-26 Novo Nordisk As Kemiske forbindelser, deres fremstilling og anvendelse
DE4333254A1 (de) * 1993-09-30 1995-04-06 Merck Patent Gmbh Piperidine und Piperazine
CN1154105A (zh) * 1994-06-08 1997-07-09 H·隆德贝克有限公司 4-芳基-1-(二氢化茚甲基、二氢苯并呋喃甲基或二氢苯并噻吩甲基)哌啶、-四氢吡啶或哌嗪类化合物
DE69812980T2 (de) 1997-02-07 2003-11-13 Aventis Pharma Inc (4-piperidinyl)-1h-2-benzopyran derivate verwendbar als antipsychotische mittel
TW530054B (en) 1997-09-24 2003-05-01 Duphar Int Res New piperazine and piperidine compounds
WO1999040067A2 (en) 1998-02-09 1999-08-12 Duphar International Research B.V. Benzisoxazole derivatives having d4-antagonistic activity
GB0117577D0 (en) * 2001-02-16 2001-09-12 Aventis Pharm Prod Inc Novel heterocyclic substituted carbonyl derivatives and their use as dopamine D receptor ligands
ATE412638T1 (de) 2001-02-16 2008-11-15 Aventis Pharma Inc Heterocyclische substituierte carbonyl derivate und ihre verwendung als dopamin d3 rezeptor liganden
GB0117950D0 (en) 2001-02-16 2001-09-19 Aventis Pharma Inc Novel heterocyclic urea derivatives andd their use as dopamine D3 receptor ligands
JP4497815B2 (ja) 2001-02-16 2010-07-07 アベンティス・ファーマスーティカルズ・インコーポレイテツド 新規な複素環式アミド誘導体およびドーパミンｄ３受容体リガンドとしてのその使用
JP2006503106A (ja) 2002-09-17 2006-01-26 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー 統合失調症を処置するためのヘテロ環式置換ピペラジン
CA2525866A1 (en) 2003-05-16 2004-11-25 Pfizer Products Inc. Treatment of psychotic and depressive disorders
BRPI0410419A (pt) 2003-05-16 2006-05-30 Pfizer Prod Inc tratamento para a ansiedade com ziprasidona
HUP0500170A3 (en) 2005-02-03 2007-11-28 Richter Gedeon Nyrt Piperazine derivatives, process for producing them and pharmaceutical compositions containing them
BRPI0707960A2 (pt) 2006-02-17 2011-05-10 Hoffmann La Roche derivados de benzoil-piperidina como moduladores de 5ht2/d3, medicamento e uso dos mesmos
EP1870405A1 (en) 2006-06-22 2007-12-26 Bioprojet Carbonylated (Aza)cyclohexanes as dopamine D3 receptor ligands
AU2007316249B2 (en) 2006-10-31 2013-01-24 F. Hoffmann-La Roche Ag Ether derivatives dual modulators of the 5-HT2A and D3 receptors
AU2008280187B2 (en) * 2007-07-26 2013-05-16 F. Hoffmann-La Roche Ag Dual modulators of 5-HT2A and D3 receptors
AU2009294695B2 (en) 2008-09-22 2012-09-13 F. Hoffmann-La Roche Ag Piperazine D3 and 5-HT2a receptor modulators
JP2012502948A (ja) 2008-09-23 2012-02-02 エフ．ホフマン−ラ ロシュ アーゲー ドーパミンｄ３受容体の調節剤として有用なイソオキサゾロ［４，５］ピリジン−３−イル−ピペラジン誘導体
JP2012502947A (ja) 2008-09-23 2012-02-02 エフ．ホフマン−ラ ロシュ アーゲー ドーパミンＤ３受容体の調節剤として有用なベンゾ［ｄ］イソオキサゾール−３−イル−ピペラジン誘導体
WO2010034648A1 (en) 2008-09-23 2010-04-01 F. Hoffmann-La Roche Ag Pyridinylpiperazin derivatives useful as modulators of dopamine d3 receptors
US8586579B2 (en) 2010-06-21 2013-11-19 Hoffmann-La Roche Inc. Anellated pyridine compounds

Also Published As

Publication number Publication date
WO2012080149A1 (en) 2012-06-21
EP2651929A1 (en) 2013-10-23
US20120157449A1 (en) 2012-06-21
BR112013014770A2 (pt) 2016-10-04
CN103261190A (zh) 2013-08-21
JP2014503519A (ja) 2014-02-13
KR20130126958A (ko) 2013-11-21
CA2819970A1 (en) 2012-06-21
US8877778B2 (en) 2014-11-04
RU2013132409A (ru) 2015-01-20

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Legal Events

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