MD3455259T2 - Combinație de anticorpi anti-PD-1 și radiație pentru tratarea cancerului - Google Patents
Combinație de anticorpi anti-PD-1 și radiație pentru tratarea canceruluiInfo
- Publication number
- MD3455259T2 MD3455259T2 MDE20190335T MDE20190335T MD3455259T2 MD 3455259 T2 MD3455259 T2 MD 3455259T2 MD E20190335 T MDE20190335 T MD E20190335T MD E20190335 T MDE20190335 T MD E20190335T MD 3455259 T2 MD3455259 T2 MD 3455259T2
- Authority
- MD
- Moldova
- Prior art keywords
- combination
- methods
- radiation
- antibodies
- treat cancer
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 230000005855 radiation Effects 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- 101100519207 Mus musculus Pdcd1 gene Proteins 0.000 abstract 2
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000005907 cancer growth Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 238000001959 radiotherapy Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- A61N5/103—Treatment planning systems
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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- C—CHEMISTRY; METALLURGY
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Abstract
Prezenta invenţie se referă la metode pentru tratarea, reducerea severităţii sau inhibarea creşterii cancerului (de exemplu, tumorilor solide). Metodele prezentei invenţii cuprind administrarea la un subiect, care are nevoie de aceasta, a unei cantităţi terapeutic eficiente de un antagonist al morţii programate 1 (PD-1) (de exemplu, un anticorp anti-PD-1), opţional, оn combinaţie cu radioterapie. Оn anumite variante de realizare, metodele cuprind administrarea radiaţiei hipo-fracţionate оn combinaţie cu un anticorp anti-PD-1 sau un fragment al acestuia pentru a obţine un efect abscopal prelungit оn inhibarea tumorii.
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662335743P | 2016-05-13 | 2016-05-13 | |
US201662340142P | 2016-05-23 | 2016-05-23 | |
US201662348546P | 2016-06-10 | 2016-06-10 | |
US201662350305P | 2016-06-15 | 2016-06-15 | |
US201662364920P | 2016-07-21 | 2016-07-21 | |
US201662374020P | 2016-08-12 | 2016-08-12 | |
US201762451274P | 2017-01-27 | 2017-01-27 | |
PCT/US2017/032397 WO2017197259A1 (en) | 2016-05-13 | 2017-05-12 | Combination of anti-pd-1 antibodies and radiation to treat cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
MD3455259T2 true MD3455259T2 (ro) | 2023-07-31 |
Family
ID=58800911
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDE20190335T MD3455259T2 (ro) | 2016-05-13 | 2017-05-12 | Combinație de anticorpi anti-PD-1 și radiație pentru tratarea cancerului |
MDE20220619T MD3932951T2 (ro) | 2016-05-13 | 2017-05-12 | Metode de tratament al cancerului de piele prin administrarea inhibitorului PD-1 |
MDE20190333T MD3455258T2 (ro) | 2016-05-13 | 2017-05-12 | Metode de tratament al cancerului de piele prin administrarea unui inhibitor PD-1 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MDE20220619T MD3932951T2 (ro) | 2016-05-13 | 2017-05-12 | Metode de tratament al cancerului de piele prin administrarea inhibitorului PD-1 |
MDE20190333T MD3455258T2 (ro) | 2016-05-13 | 2017-05-12 | Metode de tratament al cancerului de piele prin administrarea unui inhibitor PD-1 |
Country Status (31)
Country | Link |
---|---|
US (4) | US10457725B2 (ro) |
EP (4) | EP3455259B1 (ro) |
JP (4) | JP7054680B2 (ro) |
KR (5) | KR102595561B1 (ro) |
CN (4) | CN109153724B (ro) |
AU (2) | AU2017264959A1 (ro) |
BR (1) | BR112018073291A2 (ro) |
CA (2) | CA3023984A1 (ro) |
CL (1) | CL2018003207A1 (ro) |
CY (1) | CY1124901T1 (ro) |
DK (3) | DK3455258T3 (ro) |
ES (3) | ES2943640T3 (ro) |
FI (2) | FI3932951T3 (ro) |
HR (3) | HRP20230236T1 (ro) |
HU (3) | HUE061874T2 (ro) |
IL (3) | IL302924A (ro) |
LT (2) | LT3932951T (ro) |
MD (3) | MD3455259T2 (ro) |
MX (4) | MX2018013848A (ro) |
MY (1) | MY194085A (ro) |
NZ (1) | NZ748192A (ro) |
PH (1) | PH12018502263A1 (ro) |
PL (3) | PL3455258T3 (ro) |
PT (3) | PT3932951T (ro) |
RS (3) | RS64218B1 (ro) |
SG (2) | SG10202011110PA (ro) |
SI (3) | SI3455259T1 (ro) |
TW (3) | TWI822521B (ro) |
UA (1) | UA124151C2 (ro) |
WO (2) | WO2017197263A1 (ro) |
ZA (2) | ZA201807050B (ro) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114591433A (zh) | 2015-07-13 | 2022-06-07 | 西托姆克斯治疗公司 | 抗pd-1抗体、可活化抗pd-1抗体及其使用方法 |
WO2019143607A1 (en) * | 2018-01-16 | 2019-07-25 | Bristol-Myers Squibb Company | Methods of treating cancer with antibodies against tim3 |
MX2020011588A (es) * | 2018-05-03 | 2020-12-07 | Shanghai Epimab Biotherapeutics Co Ltd | Anticuerpos de alta afinidad a pd-1 y lag-3 y proteinas de union bispecificas preparadas a partir de las mismas. |
TW202005985A (zh) * | 2018-06-21 | 2020-02-01 | 美商再生元醫藥公司 | 用雙特異性抗CD3xMUC16抗體及抗PD-1抗體治療癌症的方法 |
JP7466519B2 (ja) | 2018-07-23 | 2024-04-12 | ガーダント ヘルス, インコーポレイテッド | 腫瘍遺伝子変異量を腫瘍割合およびカバレッジによって調整するための方法およびシステム |
SG11202101400UA (en) | 2018-08-31 | 2021-03-30 | Guardant Health Inc | Microsatellite instability detection in cell-free dna |
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