BR112018073291A2 - métodos para tratar câncer de pele através da administração de inibidor de pd-1 - Google Patents
métodos para tratar câncer de pele através da administração de inibidor de pd-1Info
- Publication number
- BR112018073291A2 BR112018073291A2 BR112018073291-5A BR112018073291A BR112018073291A2 BR 112018073291 A2 BR112018073291 A2 BR 112018073291A2 BR 112018073291 A BR112018073291 A BR 112018073291A BR 112018073291 A2 BR112018073291 A2 BR 112018073291A2
- Authority
- BR
- Brazil
- Prior art keywords
- methods
- skin cancer
- administering
- inhibitor
- treat skin
- Prior art date
Links
- 208000000453 Skin Neoplasms Diseases 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 201000000849 skin cancer Diseases 0.000 title abstract 3
- 239000012270 PD-1 inhibitor Substances 0.000 title 1
- 239000012668 PD-1-inhibitor Substances 0.000 title 1
- 229940121655 pd-1 inhibitor Drugs 0.000 title 1
- 206010004146 Basal cell carcinoma Diseases 0.000 abstract 1
- 208000037845 Cutaneous squamous cell carcinoma Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 238000003782 apoptosis assay Methods 0.000 abstract 1
- 230000005907 cancer growth Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000005522 programmed cell death Effects 0.000 abstract 1
- 201000010106 skin squamous cell carcinoma Diseases 0.000 abstract 1
Classifications
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Abstract
a presente invenção refere-se a métodos para tratamento, redução da gravidade ou inibição do crescimento do câncer (por exemplo, câncer de pele). os métodos da presente invenção compreendem administrar a um indivíduo em necessidade da mesma uma quantidade terapeuticamente eficaz de um antagonista de morte celular programada 1 (pd-1) (por exemplo, um anticorpo anti-pd-1). em certas modalidades, o câncer de pele é carcinoma de células escamosas cutâneas ou carcinoma basocelular.
Applications Claiming Priority (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662335743P | 2016-05-13 | 2016-05-13 | |
US62/335,743 | 2016-05-13 | ||
US201662340142P | 2016-05-23 | 2016-05-23 | |
US62/340,142 | 2016-05-23 | ||
US201662348546P | 2016-06-10 | 2016-06-10 | |
US62/348,546 | 2016-06-10 | ||
US201662350305P | 2016-06-15 | 2016-06-15 | |
US62/350,305 | 2016-06-15 | ||
US201662364920P | 2016-07-21 | 2016-07-21 | |
US62/364,920 | 2016-07-21 | ||
US201662374020P | 2016-08-12 | 2016-08-12 | |
US62/374,020 | 2016-08-12 | ||
US201762451274P | 2017-01-27 | 2017-01-27 | |
US62/451,274 | 2017-01-27 | ||
PCT/US2017/032408 WO2017197263A1 (en) | 2016-05-13 | 2017-05-12 | Methods of treating skin cancer by administering a pd-1 inhibitor |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018073291A2 true BR112018073291A2 (pt) | 2019-03-19 |
Family
ID=58800911
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018073291-5A BR112018073291A2 (pt) | 2016-05-13 | 2017-05-12 | métodos para tratar câncer de pele através da administração de inibidor de pd-1 |
Country Status (31)
Country | Link |
---|---|
US (4) | US10457725B2 (pt) |
EP (4) | EP3455259B1 (pt) |
JP (4) | JP6999577B2 (pt) |
KR (5) | KR102464774B1 (pt) |
CN (4) | CN109153724B (pt) |
AU (2) | AU2017264959A1 (pt) |
BR (1) | BR112018073291A2 (pt) |
CA (2) | CA3023985A1 (pt) |
CL (1) | CL2018003207A1 (pt) |
CY (1) | CY1124901T1 (pt) |
DK (3) | DK3932951T3 (pt) |
ES (3) | ES2938321T3 (pt) |
FI (2) | FI3932951T3 (pt) |
HR (3) | HRP20220014T1 (pt) |
HU (3) | HUE061874T2 (pt) |
IL (3) | IL302924A (pt) |
LT (2) | LT3932951T (pt) |
MD (3) | MD3932951T2 (pt) |
MX (4) | MX2018013848A (pt) |
MY (1) | MY194085A (pt) |
NZ (1) | NZ748192A (pt) |
PH (1) | PH12018502263A1 (pt) |
PL (3) | PL3932951T3 (pt) |
PT (3) | PT3455259T (pt) |
RS (3) | RS62783B1 (pt) |
SG (2) | SG11201809554VA (pt) |
SI (3) | SI3455259T1 (pt) |
TW (3) | TWI755395B (pt) |
UA (1) | UA124151C2 (pt) |
WO (2) | WO2017197263A1 (pt) |
ZA (2) | ZA201807050B (pt) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3322732A2 (en) | 2015-07-13 | 2018-05-23 | Cytomx Therapeutics Inc. | Anti-pd-1 antibodies, activatable anti-pd-1 antibodies, and methods of use thereof |
US20210363242A1 (en) * | 2018-01-16 | 2021-11-25 | Bristol-Myers Squibb Company | Methods of treating cancer with antibodies against tim3 |
EP3788079A4 (en) * | 2018-05-03 | 2022-12-21 | Shanghai Epimab Biotherapeutics Co., Ltd. | HIGH AFFINITY ANTIBODIES AGAINST PD-1 AND LAG-3 AND B-SPECIFIC BINDING PROTEINS PRODUCED FROM THEM |
TW202005985A (zh) * | 2018-06-21 | 2020-02-01 | 美商再生元醫藥公司 | 用雙特異性抗CD3xMUC16抗體及抗PD-1抗體治療癌症的方法 |
CN112752854A (zh) | 2018-07-23 | 2021-05-04 | 夸登特健康公司 | 用于通过肿瘤分数和覆盖率调整肿瘤突变负荷的方法和*** |
KR20210052511A (ko) | 2018-08-31 | 2021-05-10 | 가던트 헬쓰, 인크. | 무세포 dna에서의 미세부수체 불안정성 검출 |
WO2020081971A1 (en) * | 2018-10-19 | 2020-04-23 | Senhwa Biosciences, Inc. | Combinations for immune-modulation in cancer treatment |
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