MA54547A - Amides d'hétéroaryle utiles en tant qu'inhibiteurs de kif18a - Google Patents

Amides d'hétéroaryle utiles en tant qu'inhibiteurs de kif18a

Info

Publication number
MA54547A
MA54547A MA054547A MA54547A MA54547A MA 54547 A MA54547 A MA 54547A MA 054547 A MA054547 A MA 054547A MA 54547 A MA54547 A MA 54547A MA 54547 A MA54547 A MA 54547A
Authority
MA
Morocco
Prior art keywords
amides useful
heteroaryl amides
kif18a
inhibitors
kif18a inhibitors
Prior art date
Application number
MA054547A
Other languages
English (en)
Inventor
John Gordon Allen
Abhisek Banerjee
Matthew Paul Bourbeau
Jian Jeffrey Chen
Michael J Frohn
Lei Jia
Matthew Richard Kaller
Kexue Li
Thomas T Nguyen
Nobuko Nishimura
Nuria A Tamayo
Qiufen May Xue
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MA54547A publication Critical patent/MA54547A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
MA054547A 2018-12-20 2019-12-20 Amides d'hétéroaryle utiles en tant qu'inhibiteurs de kif18a MA54547A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862783053P 2018-12-20 2018-12-20

Publications (1)

Publication Number Publication Date
MA54547A true MA54547A (fr) 2022-03-30

Family

ID=69374368

Family Applications (1)

Application Number Title Priority Date Filing Date
MA054547A MA54547A (fr) 2018-12-20 2019-12-20 Amides d'hétéroaryle utiles en tant qu'inhibiteurs de kif18a

Country Status (8)

Country Link
US (1) US20220002311A1 (fr)
EP (1) EP3898592A1 (fr)
JP (1) JP2022513971A (fr)
AU (1) AU2019401495A1 (fr)
CA (1) CA3123044A1 (fr)
MA (1) MA54547A (fr)
MX (1) MX2021007157A (fr)
WO (1) WO2020132653A1 (fr)

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PE20211475A1 (es) * 2018-12-20 2021-08-05 Amgen Inc Inhibidores de kif18a
AU2020324963A1 (en) * 2019-08-02 2022-02-24 Amgen Inc. KIF18A inhibitors
WO2021026098A1 (fr) * 2019-08-02 2021-02-11 Amgen Inc. Inhibiteurs de kif18a
CN114401953A (zh) * 2019-08-02 2022-04-26 美国安进公司 Kif18a抑制剂
CA3199082A1 (fr) 2020-10-27 2022-05-05 Amgen Inc. Composes spiro heterocycliques et procedes d'utilisation
EP4329888A1 (fr) 2021-04-29 2024-03-06 Amgen Inc. Composés de 2-aminobenzothiazole et leurs procédés d'utilisation
AU2022298761A1 (en) 2021-06-25 2024-02-15 Hangzhou Innogate Pharma Co., Ltd. Compound as kif18a inhibitor
CA3230123A1 (fr) * 2021-08-26 2023-03-02 Derek A. Cogan Inhibiteurs spiro-indoliniques de la kif18a
WO2023041055A1 (fr) * 2021-09-16 2023-03-23 微境生物医药科技(上海)有限公司 Inhibiteur de kif18a
WO2023088441A1 (fr) * 2021-11-19 2023-05-25 微境生物医药科技(上海)有限公司 Inhibiteur de kif18a
WO2023159087A1 (fr) 2022-02-16 2023-08-24 Amgen Inc. Composés quinazoline et leur utilisation en tant qu'inhibiteurs de protéines kras mutantes
WO2023159086A1 (fr) 2022-02-16 2023-08-24 Amgen Inc. Composés de quinazoline et leur utilisation en tant qu'inhibiteurs de protéines kras mutantes
WO2023174175A1 (fr) * 2022-03-17 2023-09-21 微境生物医药科技(上海)有限公司 Inhibiteur de kif18a
US20230382889A1 (en) * 2022-04-28 2023-11-30 Volastra Therapeutics, Inc. Compounds for inhibiting kif18a
TW202400581A (zh) * 2022-05-13 2024-01-01 大陸商上海湃隆生物科技有限公司 驅動蛋白kif18a抑制劑及其應用
WO2024002328A1 (fr) * 2022-06-30 2024-01-04 勤浩医药（苏州）有限公司 Composé contenant de l'azote et son utilisation
CN117466899A (zh) * 2022-07-29 2024-01-30 武汉人福创新药物研发中心有限公司 Kif18a抑制剂及用途
WO2024035950A1 (fr) * 2022-08-12 2024-02-15 Accent Therapeutics, Inc. Inhibiteurs de kif18a et leurs utilisations
WO2024039829A1 (fr) * 2022-08-18 2024-02-22 Accent Therapeutics, Inc. Inhibiteurs de kif18a et leurs utilisations

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US20220002311A1 (en) 2022-01-06
WO2020132653A1 (fr) 2020-06-25
MX2021007157A (es) 2021-08-16
AU2019401495A1 (en) 2021-06-24
CA3123044A1 (fr) 2020-06-25
JP2022513971A (ja) 2022-02-09

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