MA29609B1 - Procedes de purification d'anticorps anti a beta - Google Patents
Procedes de purification d'anticorps anti a betaInfo
- Publication number
- MA29609B1 MA29609B1 MA30537A MA30537A MA29609B1 MA 29609 B1 MA29609 B1 MA 29609B1 MA 30537 A MA30537 A MA 30537A MA 30537 A MA30537 A MA 30537A MA 29609 B1 MA29609 B1 MA 29609B1
- Authority
- MA
- Morocco
- Prior art keywords
- methods
- protein
- relates
- binding
- beta antibodies
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La présente invention concerne des procédés de purification de protéines de liaison Aß possédant une région Fc, par exemple, des anticorps anti Aß ou des fusions d'anticorps, par adsorption des protéines de liaison Aß vers un agent de liaison Fc, tel que par exemple, une protéine A ou une protéine G, suivi par un lavage avec un tampon de sel cationique divalent afin de retirer des impuretés et de récupérer ensuite la protéine de liaison Aß adsorbée. Cette invention concerne aussi des procédés d'élution de la protéine de liaison Aß purifiée ainsi que l'incorporation de ces procédés dans un ensemble d'étapes de purification. Cette invention concerne aussi des kits comprenant des composants permettant de réaliser ces procédés et des instructions d'utilisation de ceux-ci.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69182105P | 2005-06-17 | 2005-06-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA29609B1 true MA29609B1 (fr) | 2008-07-01 |
Family
ID=37433887
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA30537A MA29609B1 (fr) | 2005-06-17 | 2008-01-02 | Procedes de purification d'anticorps anti a beta |
Country Status (26)
Country | Link |
---|---|
US (3) | US7820799B2 (fr) |
EP (3) | EP1896504B1 (fr) |
JP (2) | JP5270337B2 (fr) |
KR (2) | KR101247836B1 (fr) |
CN (3) | CN101365722A (fr) |
AR (2) | AR053632A1 (fr) |
AU (2) | AU2006259298B2 (fr) |
BR (2) | BRPI0611600B8 (fr) |
CA (2) | CA2611815A1 (fr) |
CR (2) | CR9582A (fr) |
EA (2) | EA015148B1 (fr) |
EC (1) | ECSP088086A (fr) |
ES (2) | ES2405079T3 (fr) |
HK (1) | HK1117174A1 (fr) |
IL (2) | IL187642A (fr) |
MA (1) | MA29609B1 (fr) |
MX (2) | MX2007015952A (fr) |
MY (1) | MY144484A (fr) |
NI (1) | NI200700329A (fr) |
NO (2) | NO20076082L (fr) |
NZ (1) | NZ565044A (fr) |
RU (1) | RU2415865C2 (fr) |
SG (1) | SG162806A1 (fr) |
TW (2) | TW200740839A (fr) |
WO (2) | WO2006138737A2 (fr) |
ZA (2) | ZA200710330B (fr) |
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US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
MY139983A (en) * | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
PL378571A1 (pl) * | 2003-02-01 | 2006-05-02 | Neuralab Limited | Czynna immunizacja dla wytworzenia przeciwciał przeciw rozpuszczalnemu A-ß |
PE20050627A1 (es) * | 2003-05-30 | 2005-08-10 | Wyeth Corp | Anticuerpos humanizados que reconocen el peptido beta amiloideo |
EA200700751A1 (ru) * | 2004-10-05 | 2008-06-30 | Элан Фарма Интернэшнл Лимитед | Способы и композиции для улучшения продуцирования рекомбинантного белка |
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EP1896504B1 (fr) * | 2005-06-17 | 2012-11-21 | Wyeth LLC | Procedes de purification des anticorps contenant la region fc |
PL2289909T3 (pl) | 2005-11-30 | 2015-04-30 | Abbvie Inc | Sposób przeszukiwania, proces oczyszczania niedyfundujących oligomerów Abeta, selektywne przeciwciała przeciw niedyfundującym oligomerom Abeta i sposób wytwarzania tych przeciwciał |
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WO2010044803A1 (fr) * | 2008-10-17 | 2010-04-22 | Elan Pharma International Limited | Traitement de maladies amyloïdogènes |
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