MA27666A1 - Procede de purification - Google Patents
Procede de purificationInfo
- Publication number
- MA27666A1 MA27666A1 MA28487A MA28487A MA27666A1 MA 27666 A1 MA27666 A1 MA 27666A1 MA 28487 A MA28487 A MA 28487A MA 28487 A MA28487 A MA 28487A MA 27666 A1 MA27666 A1 MA 27666A1
- Authority
- MA
- Morocco
- Prior art keywords
- cytolysin
- purification process
- detergent
- binding
- salt
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C07K14/3156—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Otolaryngology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biotechnology (AREA)
- Communicable Diseases (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La présente invention porte sur un procédé de purification de cytolysines bactériennes telles que la pneumolysine pneumococcique. Une étape unique de chromatographie permet d'effectuer une excellente purification de la cytolysine en liant la cytolysine soluble agrégée à un matériau chromatographique à interaction hydrophobe en présence de détergent et d'une forte quantité de sel.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0305791A GB0305791D0 (en) | 2003-03-13 | 2003-03-13 | Detoxification process |
GB0305792A GB0305792D0 (en) | 2003-03-13 | 2003-03-13 | Purification Process |
Publications (1)
Publication Number | Publication Date |
---|---|
MA27666A1 true MA27666A1 (fr) | 2005-12-01 |
Family
ID=32992596
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA28487A MA27666A1 (fr) | 2003-03-13 | 2005-09-09 | Procede de purification |
Country Status (23)
Country | Link |
---|---|
US (3) | US8084235B2 (fr) |
EP (1) | EP1601689B1 (fr) |
JP (2) | JP4597123B2 (fr) |
KR (1) | KR101052996B1 (fr) |
CN (1) | CN101818185B (fr) |
AU (2) | AU2004219910B2 (fr) |
BR (1) | BRPI0408094A (fr) |
CA (2) | CA2812817C (fr) |
CY (1) | CY1107134T1 (fr) |
DE (1) | DE602004010376T2 (fr) |
DK (1) | DK1601689T3 (fr) |
EG (1) | EG24449A (fr) |
ES (1) | ES2295836T3 (fr) |
HK (1) | HK1086013A1 (fr) |
IL (1) | IL210984A0 (fr) |
IS (1) | IS2587B (fr) |
MA (1) | MA27666A1 (fr) |
MX (1) | MXPA05009579A (fr) |
NO (1) | NO336672B1 (fr) |
NZ (1) | NZ541969A (fr) |
PT (1) | PT1601689E (fr) |
RU (1) | RU2340627C2 (fr) |
WO (1) | WO2004081515A2 (fr) |
Families Citing this family (77)
Publication number | Priority date | Publication date | Assignee | Title |
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RU2340627C2 (ru) | 2003-03-13 | 2008-12-10 | ГлаксоСмитКлайн Байолоджикалз с.а. | Способ очистки бактериального цитолизина |
GB0421083D0 (en) * | 2004-09-22 | 2004-10-27 | Glaxosmithkline Biolog Sa | Purification process |
BRPI0609711B8 (pt) | 2005-03-23 | 2021-05-25 | Oculus Innovative Sciences Inc | uso de uma solução aquosa com potencial redutivo oxidativo (orp) |
PT2351578T (pt) | 2005-06-27 | 2017-04-07 | Glaxosmithkline Biologicals Sa | Processo para o fabrico de vacinas |
GB0607088D0 (en) | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
DK3017827T3 (en) | 2005-12-22 | 2019-02-18 | Glaxosmithkline Biologicals Sa | Pneumococcal polysaccharide conjugate VACCINE |
US8147444B2 (en) | 2006-01-20 | 2012-04-03 | Oculus Innovative Sciences, Inc. | Methods of treating or preventing peritonitis with oxidative reductive potential water solution |
ES2387582T3 (es) | 2006-09-07 | 2012-09-26 | Glaxosmithkline Biologicals S.A. | Vacuna de combinación con cantidades reducidas del antígeno del virus de la polio |
EP2144924B1 (fr) * | 2007-04-16 | 2016-05-11 | MinervaX Aps | Vaccin à protéine de fusion |
EP2142211A1 (fr) | 2007-05-02 | 2010-01-13 | GlaxoSmithKline Biologicals S.A. | Vaccin |
PL2167121T3 (pl) | 2007-06-26 | 2016-01-29 | Glaxosmithkline Biologicals Sa | Szczepionka zawierająca koniugaty polisacharydu otoczkowego streptococcus pneumoniae |
ES2678694T3 (es) | 2008-04-16 | 2018-08-16 | Glaxosmithkline Biologicals Sa | Vacuna |
EA201100268A1 (ru) * | 2008-08-28 | 2011-10-31 | Глаксосмитклайн Байолоджикалс С.А. | Вакцина |
DK2424562T3 (en) | 2009-04-30 | 2015-12-07 | Coley Pharm Group Inc | Pneumococcal vaccine and uses thereof |
US8668911B2 (en) | 2009-05-14 | 2014-03-11 | The Regents Of The University Of Michigan | Streptococcus vaccine compositions and methods of using the same |
CN102480972B (zh) | 2009-06-15 | 2014-12-10 | 奥古露丝创新科学公司 | 含有次氯酸的溶液及其使用方法 |
MX2012002639A (es) | 2009-09-03 | 2012-03-14 | Pfizer Vaccines Llc | Vacuna de pcsk9. |
LT2493498T (lt) | 2009-10-30 | 2017-05-25 | Glaxosmithkline Biologicals Sa | Staphylococcus aureus 5 tipo ir 8 tipo kapsulinių sacharidų gryninimas |
GB201003924D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Immunogenic composition |
US20140004142A1 (en) | 2011-03-02 | 2014-01-02 | Pfizer Inc. | Pcsk9 vaccine |
PT3549949T (pt) * | 2011-04-22 | 2024-02-02 | Wyeth Llc | Composições relacionadas com uma toxina de clostridium difficile mutante e métodos da mesma |
MX339058B (es) | 2011-05-17 | 2016-05-09 | Glaxosmithkline Biolog Sa | Vacuna contra streptococcus pneumoniae. |
JP5854537B2 (ja) * | 2012-09-19 | 2016-02-09 | 国立大学法人大阪大学 | 肺炎球菌表面タンパク質aを含む肺炎球菌ワクチン |
RU2615446C2 (ru) * | 2012-11-30 | 2017-04-04 | Байонир Корпорейшн | Прибор для автоматизированного бесклеточного получения белков и способ получения белков с применением данного прибора |
WO2015095868A1 (fr) | 2013-12-20 | 2015-06-25 | Wake Forest University Health Sciences | Méthodes et compositions permettant d'augmenter les taux d'anticorps protecteurs induits par des vaccins antipneumococciques polyosidiques |
BR122023022294A2 (pt) | 2014-01-21 | 2023-12-12 | Pfizer Inc. | Uso de uma composição imunogênica que compreende um conjugado imunogênico compreendendo um polissacarídeo capsular isolado de streptococcus pneumoniae do sorotipo 15b |
MX2016009470A (es) | 2014-01-21 | 2017-01-18 | Pfizer | Composiciones inmunogenicas que comprenden antigenos sacaridos capsulares conjugados y usos de los mismos. |
US10105431B2 (en) | 2014-01-21 | 2018-10-23 | Pfizer Inc. | Streptococcus pneumoniae capsular polysaccharides and conjugates thereof |
US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
JP2017505792A (ja) | 2014-02-14 | 2017-02-23 | ファイザー・インク | 免疫原性糖タンパク質コンジュゲート |
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US9218427B1 (en) * | 2015-01-21 | 2015-12-22 | Maana, Inc. | Dynamic semantic models having multiple indices |
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KR102225282B1 (ko) | 2015-07-21 | 2021-03-10 | 화이자 인코포레이티드 | 접합된 캡슐형 사카라이드 항원을 포함하는 면역원성 조성물, 그를 포함하는 키트 및 그의 용도 |
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US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
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JP7438102B2 (ja) | 2017-09-07 | 2024-02-26 | メルク・シャープ・アンド・ドーム・エルエルシー | 肺炎球菌多糖体および免疫原性多糖体-キャリアタンパク質コンジュゲートでのその使用 |
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KR20200121822A (ko) | 2018-02-05 | 2020-10-26 | 사노피 파스퇴르 인코포레이티드 | 다가 폐렴구균성 다당류-단백질 접합체 조성물 |
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GB8807860D0 (en) * | 1988-04-05 | 1988-05-05 | Connaught Lab | Pertussis vaccine |
ATE205534T1 (de) * | 1988-12-16 | 2001-09-15 | Nederlanden Staat | Pneumolysin-mutanten und pneumokokken-impfstoffe daraus |
DE4133707A1 (de) * | 1991-10-11 | 1993-04-15 | Behringwerke Ag | Verfahren zur reinigung von streptolysin o, intaktes streptolysin o erhaeltlich nach diesem verfahren und seine verwendung |
GB9216351D0 (en) * | 1992-07-31 | 1992-09-16 | Wellcome Found | Vaccine production |
US5565204A (en) * | 1994-08-24 | 1996-10-15 | American Cyanamid Company | Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections |
WO1996023061A2 (fr) * | 1995-01-27 | 1996-08-01 | Genencor International, Inc. | Procede d'extraction au moyen d'un enzyme tensioactif |
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CA2297374A1 (fr) * | 1997-07-21 | 1999-01-28 | North American Vaccine, Inc. | Compositions de pneumolysine immunogene modifiee utiles en tant que vaccins |
WO2000056360A2 (fr) * | 1999-03-19 | 2000-09-28 | Smithkline Beecham Biologicals S.A. | Vaccin |
JP4132694B2 (ja) * | 2000-03-10 | 2008-08-13 | 独立行政法人科学技術振興機構 | 受容体認識部位が保存された生理活性物質の誘導体及びその使用方法 |
GB0022742D0 (en) | 2000-09-15 | 2000-11-01 | Smithkline Beecham Biolog | Vaccine |
RU2340627C2 (ru) * | 2003-03-13 | 2008-12-10 | ГлаксоСмитКлайн Байолоджикалз с.а. | Способ очистки бактериального цитолизина |
GB0421083D0 (en) | 2004-09-22 | 2004-10-27 | Glaxosmithkline Biolog Sa | Purification process |
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2004
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- 2004-03-11 AU AU2004219910A patent/AU2004219910B2/en not_active Ceased
- 2004-03-11 PT PT04719447T patent/PT1601689E/pt unknown
- 2004-03-11 MX MXPA05009579A patent/MXPA05009579A/es active IP Right Grant
- 2004-03-11 DE DE602004010376T patent/DE602004010376T2/de not_active Expired - Lifetime
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- 2004-03-11 CN CN201010157455.6A patent/CN101818185B/zh not_active Expired - Fee Related
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- 2005-09-06 NO NO20054134A patent/NO336672B1/no not_active IP Right Cessation
- 2005-09-09 MA MA28487A patent/MA27666A1/fr unknown
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2006
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