LV12618B - Sulfamātu atvasinājumu pielietojums par steroidu sulfatāzes inhibītoriem - Google Patents
Sulfamātu atvasinājumu pielietojums par steroidu sulfatāzes inhibītoriem Download PDFInfo
- Publication number
- LV12618B LV12618B LVP-00-131A LV000131A LV12618B LV 12618 B LV12618 B LV 12618B LV 000131 A LV000131 A LV 000131A LV 12618 B LV12618 B LV 12618B
- Authority
- LV
- Latvia
- Prior art keywords
- oestrone
- compound
- sulphamate
- group
- use according
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/36—Antigestagens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Surgical Instruments (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
- Medicinal Preparation (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Claims (12)
- LV 12618 IZGUDROJUMA FORMULA 1. Savienojuma pielietojums zāļu ražošanā, lai nomāktu steroīdu sulfatāzes aktivitāti, kurā savienojums ir gredzena sistēmas savienojums, kas satur gredzenu, kuram ir pievienota sulfamāta grupa ar formulu O II s -o II 0 Ri \ /N r2 kurā katrs Ri un R2 ir neatkarīgi izvēlēts no H, alkila, alkenila, cikloalkila un arila grupas, vai kopā pārstāv alkilēngrupu, kura neobligāti var saturēt vienu vai vairākus heteroatomus vai grupas alkilēnķēdē; un kurā savienojums ir enzīma, kam piemīt steroīdu sulfatāzes aktivitāte (E.C.3.1.6.2), inhibltors; un kurā, ja sulfamāta grupa savienojumā būtu aizvietota ar sulfāta grupu, izveidojot sulfāta savienojumu, un inkubēta ar steroīdu sulfatāzes enzīmu (E.C.3.1.6.2) pie pH 7.4 un 37°C, tas varētu nodrošināt Km lielumu mazāku par 50 μΜ.
- 2. Pielietojums saskaņā ar 1. punktu, kurā savienojums ir savienojums ar formuluO- Policikliska grupa kurā R! un R2 ir tādi, kā ir noteikts 1. punktā.
- 3. Pielietojums saskaņā ar 2. punktu, kurā policikliska grupa ir policikliska alkohola palieka.
- 4. Pielietojums saskaņā ar 2. punktu vai ar 3. punktu, kurā policikliska grupa ir pārstāvēta ar sterola palieku.
- 5. Pielietojums saskaņā ar 4. punktu, kurā sterols ir 3-sterols.
- 6. Pielietojums saskaņā ar 4. punktu vai ar 5. punktu, kurā sterols ir izvēlēts no grupas, kas sastāv no estrona, dehidroepiandrosterona, aizvietotiem estroniem un aizvietotiem dehidroepiandrosteroniem.
- 7. Pielietojums saskaņā ar jebkuru no iepriekšējiem punktiem, kurā Ri un R2 ir neatkarīgi izvēlēti no H vai Ci-Cio alkilgrupām.
- 8. Pielietojums saskaņā ar jebkuru no iepriekšējiem punktiem, kurā Ri un R2 ir neatkarīgi izvēlēti no H vai Ci-C5 alkilgrupām.
- 9. Pielietojums saskaņā ar jebkuru no iepriekšējiem punktiem, kurā Rļ un R2 ir neatkarīgi izvēlēti no H vai metilgrupas.
- 10. Pielietojums saskaņā ar jebkuru no iepriekšējiem punktiem, kurā savienojums ir jebkurš no estrona 3-sulfamāta, estrona 3-N,N-dimetilsulfamāta, estrona 3-N-monometilsulfamāta.
- 11. Pielietojums saskaņā ar jebkuru no iepriekšējiem punktiem, kurā vismaz viens no R! un R2 ir H.
- 12. Savienojuma pielietojums zāļu ražošanā, lai nomāktu steroīdu sulfatāzes aktivitāti, kurā savienojums ir policikliska alkohola sulfamīda skābes esteris, vai N-alkila, N-alkenila, N-cikloalkila vai N-arila grupas šāda estera derivāts, vai farmaceitiski pieņemama sāls jebkura no šādiem estera vai N-aizvietota estera, estera alkohola puse būdama policiklisks alkohols, kura sulfāts ir hidrolizējams ar enzīmiem, kam piemīt steroīdu sulfatāzes (E.C.3.1.6.2) aktivitāte.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919118478A GB9118478D0 (en) | 1991-08-29 | 1991-08-29 | Steroid sulphatase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
LV12618A LV12618A (en) | 2001-02-20 |
LV12618B true LV12618B (lv) | 2001-07-20 |
Family
ID=10700604
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LVP-00-131A LV12618B (lv) | 1991-08-29 | 2000-10-03 | Sulfamātu atvasinājumu pielietojums par steroidu sulfatāzes inhibītoriem |
Country Status (26)
Country | Link |
---|---|
US (3) | US5616574A (lv) |
EP (6) | EP0982032B1 (lv) |
JP (6) | JP3219408B2 (lv) |
KR (4) | KR100258396B1 (lv) |
AT (5) | ATE194843T1 (lv) |
AU (2) | AU689043B2 (lv) |
BR (1) | BR9206434A (lv) |
CA (4) | CA2305758A1 (lv) |
CY (4) | CY2253B1 (lv) |
CZ (1) | CZ295939B6 (lv) |
DE (5) | DE69233020T2 (lv) |
DK (4) | DK0928609T3 (lv) |
ES (4) | ES2148178T3 (lv) |
FI (5) | FI940903A (lv) |
GB (1) | GB9118478D0 (lv) |
GE (6) | GEP20022637B (lv) |
GR (1) | GR3034579T3 (lv) |
HK (3) | HK1019753A1 (lv) |
HU (1) | HUT66097A (lv) |
LV (1) | LV12618B (lv) |
NO (6) | NO307301B1 (lv) |
RU (4) | RU2182152C2 (lv) |
SG (7) | SG103374A1 (lv) |
SK (4) | SK282189B6 (lv) |
UA (4) | UA41875C2 (lv) |
WO (1) | WO1993005064A1 (lv) |
Families Citing this family (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9625334D0 (en) * | 1996-12-05 | 1997-01-22 | Imperial College | Compound |
US6011024A (en) | 1991-08-28 | 2000-01-04 | Imperial College Of Science Technology & Medicine | Steroid sulphatase inhibitors |
US6476011B1 (en) | 1991-08-28 | 2002-11-05 | Sterix Limited | Methods for introducing an estrogenic compound |
GB9603325D0 (en) * | 1996-02-16 | 1996-04-17 | Imperial College | A compound |
GB9604709D0 (en) * | 1996-03-05 | 1996-05-01 | Imperial College | A compound |
GB9118478D0 (en) * | 1991-08-29 | 1991-10-16 | Imperial College | Steroid sulphatase inhibitors |
US6903084B2 (en) | 1991-08-29 | 2005-06-07 | Sterix Limited | Steroid sulphatase inhibitors |
DE69531048T2 (de) * | 1994-04-05 | 2004-05-06 | Celltech Therapeutics Ltd., Slough | Verwendung von steroidsulphatase-hemmern |
DE4447715C2 (de) * | 1994-08-09 | 1998-02-05 | Jenapharm Gmbh | Verwendung von Estra-1,3,5(10)-trien-Derivaten zur hormonalen Behandlung von Prostatakarzinomen |
DE4429397C2 (de) * | 1994-08-09 | 2003-11-20 | Jenapharm Gmbh | Estra-1,3,5(10)-trien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen |
GB9422777D0 (en) * | 1994-11-11 | 1995-01-04 | Imperial College | Assay |
US5571933A (en) * | 1994-11-17 | 1996-11-05 | Duquesne University Of The Holy Ghost | Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use |
US5705495A (en) * | 1995-10-19 | 1998-01-06 | Jenapharm Gmbh & Co. Kg. | Sulfamate derivatives of 1,3,5(10)-estratriene derivatives, methods for their production and pharmaceuticals containing these compounds |
US6506792B1 (en) | 1997-03-04 | 2003-01-14 | Sterix Limited | Compounds that inhibit oestrone sulphatase and/or aromatase and methods for making and using |
US6921776B1 (en) | 1996-02-16 | 2005-07-26 | Sterix Limited | Compound |
JP2000506161A (ja) * | 1996-03-05 | 2000-05-23 | インペリアル カレッジ オブ サイエンス テクノロジー アンド メディシン | スルファメート基を有する化合物 |
KR20000035979A (ko) * | 1996-09-12 | 2000-06-26 | 야마구찌 다까시 | 3-치환-d-호모-1,3,5(10)-에스트라트리엔 유도체 |
WO1999064013A1 (en) | 1998-06-10 | 1999-12-16 | Sterix Limited | Pharmaceutical composition with tumor necrosis factor a and 2-methoxyestrone-3-o-sulphamate for inhibition of estrone sulphatase |
US6642220B1 (en) | 1996-12-05 | 2003-11-04 | Sterix Limited | Compounds that inhibit oestrone sulphatase; compositions thereof; and methods employing the same |
US20040127473A1 (en) * | 1996-12-05 | 2004-07-01 | Reed Michael John | Compound |
US5763432A (en) * | 1997-01-29 | 1998-06-09 | Sri International | Steriod inhibitors of estrone sulfatase and associated pharmaceutical compositions and methods of use |
DE19712488A1 (de) | 1997-03-25 | 1998-10-01 | Knoell Hans Forschung Ev | Steroidsulfamate, Verfahren zu ihrer Herstellung und Anwendung derselben |
GB9708716D0 (en) * | 1997-04-29 | 1997-06-18 | Imperial College | Chronic heart failure |
US5880115A (en) * | 1997-07-18 | 1999-03-09 | Duquesne University Of The Holy Ghost | Steroid sulfatase inhibitors and methods for making and using the same |
US6288050B1 (en) * | 1997-07-18 | 2001-09-11 | Duquesne University Of The Holy Ghost | Steroid sulfatase inhibitors and methods for making and using the same |
US6376687B1 (en) | 1997-07-18 | 2002-04-23 | Duquesne University Of The Holy Ghost | Steroid sulfatase inhibitors and methods for making and using the same |
GB2331987B (en) | 1997-12-04 | 2002-11-27 | Imperial College | Polycyclic sulphamate inhibitors of oestrone sulphatase |
GB2331988B (en) | 1997-12-04 | 2003-04-16 | Imperial College | Polycyclic sulphamate inhibitors or oestrone sulphatase |
US6046186A (en) * | 1997-12-24 | 2000-04-04 | Sri International | Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use |
GB9807779D0 (en) | 1998-04-09 | 1998-06-10 | Ciba Geigy Ag | Organic compounds |
CA2330611A1 (en) | 1998-05-22 | 1999-12-02 | The Board Of Trustees Of The Leland Stanford Junior University | Bifunctional molecules and therapies based thereon |
US6248780B1 (en) | 1998-10-01 | 2001-06-19 | Duquesne University Of The Holy Ghost | Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the same |
US6667299B1 (en) | 2000-03-16 | 2003-12-23 | Hollis-Eden Pharmaceuticals, Inc. | Pharmaceutical compositions and treatment methods |
WO2000053620A1 (fr) * | 1999-03-10 | 2000-09-14 | Nippon Organon K. K. | Nouveaux derives d'oestradiol |
JP2000309599A (ja) | 1999-04-13 | 2000-11-07 | Kyowa Hakko Kogyo Co Ltd | エストラ−1,3,5(10),16−テトラエン誘導体 |
AU2005225148B2 (en) * | 1999-04-30 | 2008-04-03 | Sterix Limited | Use |
US7078395B1 (en) | 1999-06-16 | 2006-07-18 | Sterix Limited | Methods for treating or preventing cancer by preventing, inhibiting or arresting cell cycling |
IL145995A0 (en) | 1999-04-30 | 2002-07-25 | Sterix Ltd | Use |
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US6583130B1 (en) | 1999-09-13 | 2003-06-24 | Schering Ag | C13-substituted estra-1,3,5,(10)-trien-3-yl sulfamates, methods of preparing same, and pharmaceutical compositions containing these compounds |
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US7335650B2 (en) | 2000-01-14 | 2008-02-26 | Sterix Limited | Composition |
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GB0020498D0 (en) | 2000-08-18 | 2000-10-11 | Sterix Ltd | Compound |
EP1406634A1 (en) | 2001-07-13 | 2004-04-14 | Schering Aktiengesellschaft | Combination of drospirenone and an estrogen sulphamate for hrt |
DE60234057D1 (de) | 2001-07-25 | 2009-11-26 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
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DE10139494A1 (de) * | 2001-08-13 | 2003-03-06 | Jenapharm Gmbh | Antitumor wirksame 2-Alkoxyestradiolsulfamate |
ATE408615T1 (de) | 2001-10-18 | 2008-10-15 | Sterix Ltd | Steroidale verbindungen zur hemmung von steroid sulfotase |
EP1448592B1 (en) * | 2001-10-18 | 2006-03-08 | Sterix Limited | Steroidal compounds for inhibiting steroid sulphatase |
US20040254241A1 (en) * | 2002-08-28 | 2004-12-16 | Yoji Ino | Aryl sulfamate derivatives |
WO2004035089A1 (ja) * | 2002-10-09 | 2004-04-29 | Kyowa Hakko Kogyo Co., Ltd. | ホルモン依存性癌の治療剤 |
DE10307104A1 (de) | 2003-02-19 | 2004-09-23 | Schering Ag | Antitumor wirksame 2-substituierte Estra-1,3,5(10)-trien-3-yl sulfamate |
DE10307103A1 (de) * | 2003-02-19 | 2004-09-09 | Schering Ag | Antitumor wirksame 2-substituierte D-Homostra-1,3,5(10)-trien-3-yl sulfamate |
DE10307105A1 (de) * | 2003-02-19 | 2004-09-09 | Schering Ag | Antitumor wirksame 2-substituierte 18a-Homoestra-1,3,5(10)-trien-3-yl sulfamate |
DK1644350T3 (da) * | 2003-05-16 | 2009-11-23 | Theramex | Sullfamatbenzothiophenderivater som steroidsulfataseinhibitorer |
ATE464293T1 (de) | 2003-05-21 | 2010-04-15 | Aska Pharm Co Ltd | Cyclisches aminophenylsulfamatderivativ |
US7534780B2 (en) | 2004-05-21 | 2009-05-19 | Bayer Schering Pharma Aktiengesellschaft | Estradiol prodrugs |
GB0412492D0 (en) | 2004-06-04 | 2004-07-07 | Sterix Ltd | Compound |
CA2789262C (en) | 2005-04-28 | 2016-10-04 | Proteus Digital Health, Inc. | Pharma-informatics system |
US8030298B2 (en) | 2005-05-26 | 2011-10-04 | Abbott Products Gmbh | 17β-HSD1 and STS inhibitors |
GB0511190D0 (en) * | 2005-06-01 | 2005-07-06 | Sterix Ltd | Use |
WO2007035716A2 (en) | 2005-09-16 | 2007-03-29 | Raptor Pharmaceutical Inc. | Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof |
GB0624105D0 (en) * | 2006-12-01 | 2007-01-10 | Sterix Ltd | Use |
GB0706072D0 (en) | 2007-03-28 | 2007-05-09 | Sterix Ltd | Compound |
KR20100068287A (ko) | 2007-09-17 | 2010-06-22 | 쁘레글렘 에스.아. | 폐경기 전 여성의 에스트로겐 의존성 질환의 치료 |
EP2149371A1 (en) * | 2008-07-28 | 2010-02-03 | PregLem S.A. | Use of steroid sulfatase inhibitors for the treatment of preterm labor |
PL2398500T3 (pl) | 2009-02-20 | 2019-09-30 | 2-Bbb Medicines B.V. | System dostarczania leków na bazie glutationu |
KR101741629B1 (ko) | 2009-05-06 | 2017-05-31 | 라보라토리 스킨 케어, 인크. | 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법 |
GB0914767D0 (en) | 2009-08-24 | 2009-09-30 | Sterix Ltd | Compound |
CN110974840A (zh) * | 2019-12-27 | 2020-04-10 | 天津市肿瘤医院 | 一种类固醇硫酸酯酶抑制剂及其药物用途 |
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GB9603325D0 (en) * | 1996-02-16 | 1996-04-17 | Imperial College | A compound |
GB9625334D0 (en) * | 1996-12-05 | 1997-01-22 | Imperial College | Compound |
GB9118478D0 (en) * | 1991-08-29 | 1991-10-16 | Imperial College | Steroid sulphatase inhibitors |
GB9118465D0 (en) * | 1991-08-29 | 1991-10-16 | Imperial College | Steroid sulphatase inhibitors |
US5571933A (en) * | 1994-11-17 | 1996-11-05 | Duquesne University Of The Holy Ghost | Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use |
JP2000506161A (ja) * | 1996-03-05 | 2000-05-23 | インペリアル カレッジ オブ サイエンス テクノロジー アンド メディシン | スルファメート基を有する化合物 |
US5880115A (en) * | 1997-07-18 | 1999-03-09 | Duquesne University Of The Holy Ghost | Steroid sulfatase inhibitors and methods for making and using the same |
-
1991
- 1991-08-29 GB GB919118478A patent/GB9118478D0/en active Pending
-
1992
- 1992-08-28 SK SK1254-2000A patent/SK282189B6/sk unknown
- 1992-08-28 DE DE69233020T patent/DE69233020T2/de not_active Expired - Fee Related
- 1992-08-28 DE DE69233149T patent/DE69233149T2/de not_active Expired - Fee Related
- 1992-08-28 ES ES92918285T patent/ES2148178T3/es not_active Expired - Lifetime
- 1992-08-28 EP EP99203449A patent/EP0982032B1/en not_active Expired - Lifetime
- 1992-08-28 EP EP04077164A patent/EP1522543A1/en not_active Withdrawn
- 1992-08-28 EP EP00204525A patent/EP1099706B1/en not_active Expired - Lifetime
- 1992-08-28 ES ES99203449T patent/ES2204059T3/es not_active Expired - Lifetime
- 1992-08-28 DK DK98204337T patent/DK0928609T3/da active
- 1992-08-28 HU HU9400583A patent/HUT66097A/hu unknown
- 1992-08-28 CA CA002305758A patent/CA2305758A1/en not_active Abandoned
- 1992-08-28 GE GEAP19922403A patent/GEP20022637B/en unknown
- 1992-08-28 SG SG200207242A patent/SG103374A1/en unknown
- 1992-08-28 AT AT92918285T patent/ATE194843T1/de not_active IP Right Cessation
- 1992-08-28 EP EP98204340A patent/EP0921130B1/en not_active Expired - Lifetime
- 1992-08-28 DK DK99203449T patent/DK0982032T3/da active
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- 1992-08-28 DE DE69233053T patent/DE69233053T2/de not_active Expired - Fee Related
- 1992-08-28 WO PCT/GB1992/001587 patent/WO1993005064A1/en not_active Application Discontinuation
- 1992-08-28 SG SG200003815A patent/SG88782A1/en unknown
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- 1992-08-28 UA UA94005380A patent/UA41875C2/uk unknown
- 1992-08-28 CA CA002305749A patent/CA2305749A1/en not_active Abandoned
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- 1992-08-28 ES ES98204337T patent/ES2193475T3/es not_active Expired - Lifetime
- 1992-08-28 DK DK98204340T patent/DK0921130T3/da active
- 1992-08-28 KR KR1019940700671A patent/KR100258396B1/ko not_active IP Right Cessation
- 1992-08-28 SG SG200003817A patent/SG88783A1/en unknown
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- 1992-08-28 EP EP98204337A patent/EP0928609B1/en not_active Expired - Lifetime
- 1992-08-28 SG SG200207232A patent/SG106116A1/en unknown
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- 1992-08-28 CA CA002114630A patent/CA2114630C/en not_active Expired - Fee Related
- 1992-08-28 AT AT99203449T patent/ATE246706T1/de not_active IP Right Cessation
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- 1992-08-28 AT AT00204525T patent/ATE278704T1/de not_active IP Right Cessation
- 1992-08-28 DE DE69233431T patent/DE69233431T2/de not_active Expired - Lifetime
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- 1992-08-28 DK DK92918285T patent/DK0641355T3/da active
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1994
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1995
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1996
- 1996-07-05 AU AU58373/96A patent/AU689043B2/en not_active Ceased
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1998
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1999
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2000
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2001
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2002
- 2002-01-25 JP JP2002017765A patent/JP2002255993A/ja not_active Withdrawn
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2003
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2004
- 2004-10-20 NO NO20044458A patent/NO20044458L/no not_active Application Discontinuation
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2005
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