FI20002259A - Menetelmä steroidisulfataasi-inhibiittoreiden valmistamiseksi - Google Patents

Menetelmä steroidisulfataasi-inhibiittoreiden valmistamiseksi Download PDF

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Publication number
FI20002259A
FI20002259A FI20002259A FI20002259A FI20002259A FI 20002259 A FI20002259 A FI 20002259A FI 20002259 A FI20002259 A FI 20002259A FI 20002259 A FI20002259 A FI 20002259A FI 20002259 A FI20002259 A FI 20002259A
Authority
FI
Finland
Prior art keywords
sub
compound
preparation
steroid sulfatase
sulfatase inhibitors
Prior art date
Application number
FI20002259A
Other languages
English (en)
Swedish (sv)
Inventor
Michael John Reed
Barry Victor Lloyd Potter
Original Assignee
Sterix Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterix Ltd filed Critical Sterix Ltd
Publication of FI20002259A publication Critical patent/FI20002259A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Surgical Instruments (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FI20002259A 1991-08-29 2000-10-13 Menetelmä steroidisulfataasi-inhibiittoreiden valmistamiseksi FI20002259A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919118478A GB9118478D0 (en) 1991-08-29 1991-08-29 Steroid sulphatase inhibitors
PCT/GB1992/001587 WO1993005064A1 (en) 1991-08-29 1992-08-28 Steroid sulphatase inhibitors

Publications (1)

Publication Number Publication Date
FI20002259A true FI20002259A (fi) 2000-10-13

Family

ID=10700604

Family Applications (5)

Application Number Title Priority Date Filing Date
FI940903A FI940903A (fi) 1991-08-29 1994-02-25 Steroidisulfataasi-inhibiittorit
FI20002261A FI20002261A (fi) 1991-08-29 2000-10-13 Menetelmä steroidisulfataasi-inhibiittoreita sisältävien lääkeaineiden valmistamiseksi
FI20002259A FI20002259A (fi) 1991-08-29 2000-10-13 Menetelmä steroidisulfataasi-inhibiittoreiden valmistamiseksi
FI20002260A FI20002260A (fi) 1991-08-29 2000-10-13 Menetelmä steroidisulfataasi-inhibiittoreita sisältävien farmaseuttisten koostumusten valmistamiseksi
FI20050991A FI20050991A (fi) 1991-08-29 2005-10-03 Sulfamaattiryhmän sisältävän yhdisteen käyttö steroidisulfataasi-inhibiittoreiden valmistamiseksi

Family Applications Before (2)

Application Number Title Priority Date Filing Date
FI940903A FI940903A (fi) 1991-08-29 1994-02-25 Steroidisulfataasi-inhibiittorit
FI20002261A FI20002261A (fi) 1991-08-29 2000-10-13 Menetelmä steroidisulfataasi-inhibiittoreita sisältävien lääkeaineiden valmistamiseksi

Family Applications After (2)

Application Number Title Priority Date Filing Date
FI20002260A FI20002260A (fi) 1991-08-29 2000-10-13 Menetelmä steroidisulfataasi-inhibiittoreita sisältävien farmaseuttisten koostumusten valmistamiseksi
FI20050991A FI20050991A (fi) 1991-08-29 2005-10-03 Sulfamaattiryhmän sisältävän yhdisteen käyttö steroidisulfataasi-inhibiittoreiden valmistamiseksi

Country Status (26)

Country Link
US (3) US5616574A (fi)
EP (6) EP0928609B1 (fi)
JP (6) JP3219408B2 (fi)
KR (4) KR100258396B1 (fi)
AT (5) ATE237333T1 (fi)
AU (2) AU689043B2 (fi)
BR (1) BR9206434A (fi)
CA (4) CA2305758A1 (fi)
CY (4) CY2253B1 (fi)
CZ (1) CZ295939B6 (fi)
DE (5) DE69233020T2 (fi)
DK (4) DK0982032T3 (fi)
ES (4) ES2193475T3 (fi)
FI (5) FI940903A (fi)
GB (1) GB9118478D0 (fi)
GE (6) GEP20022637B (fi)
GR (1) GR3034579T3 (fi)
HK (3) HK1020672A1 (fi)
HU (1) HUT66097A (fi)
LV (1) LV12618B (fi)
NO (6) NO307301B1 (fi)
RU (4) RU2207134C2 (fi)
SG (7) SG115508A1 (fi)
SK (4) SK282187B6 (fi)
UA (4) UA41875C2 (fi)
WO (1) WO1993005064A1 (fi)

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US6476011B1 (en) 1991-08-28 2002-11-05 Sterix Limited Methods for introducing an estrogenic compound
US6903084B2 (en) * 1991-08-29 2005-06-07 Sterix Limited Steroid sulphatase inhibitors
US6013642A (en) * 1994-04-05 2000-01-11 Foulkes; Roland Use of estrone derivatives as steroid sulphatase inhibitors
DE4429397C2 (de) * 1994-08-09 2003-11-20 Jenapharm Gmbh Estra-1,3,5(10)-trien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE4447714C2 (de) * 1994-08-09 1998-02-05 Jenapharm Gmbh Verwendung von Estra-1,3,5(10)-trien-Derivaten zur Hormonsubstitutions-Therapie
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US5571933A (en) * 1994-11-17 1996-11-05 Duquesne University Of The Holy Ghost Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use
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US6506792B1 (en) 1997-03-04 2003-01-14 Sterix Limited Compounds that inhibit oestrone sulphatase and/or aromatase and methods for making and using
US6921776B1 (en) 1996-02-16 2005-07-26 Sterix Limited Compound
AU2225597A (en) * 1996-03-05 1997-09-22 Imperial College Of Science, Technology And Medicine Compounds with a sulfamate group
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US6642220B1 (en) * 1996-12-05 2003-11-04 Sterix Limited Compounds that inhibit oestrone sulphatase; compositions thereof; and methods employing the same
US20040127473A1 (en) * 1996-12-05 2004-07-01 Reed Michael John Compound
US5763432A (en) * 1997-01-29 1998-06-09 Sri International Steriod inhibitors of estrone sulfatase and associated pharmaceutical compositions and methods of use
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US5880115A (en) * 1997-07-18 1999-03-09 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
US6376687B1 (en) 1997-07-18 2002-04-23 Duquesne University Of The Holy Ghost Steroid sulfatase inhibitors and methods for making and using the same
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US6248780B1 (en) 1998-10-01 2001-06-19 Duquesne University Of The Holy Ghost Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the same
US6667299B1 (en) 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
WO2000053620A1 (fr) * 1999-03-10 2000-09-14 Nippon Organon K. K. Nouveaux derives d'oestradiol
JP2000309599A (ja) 1999-04-13 2000-11-07 Kyowa Hakko Kogyo Co Ltd エストラ−１，３，５（１０），１６−テトラエン誘導体
EP1173182A2 (en) * 1999-04-30 2002-01-23 Sterix Limited Use of estrone derivatives as antitumour agents
AU2005225148B2 (en) * 1999-04-30 2008-04-03 Sterix Limited Use
US7078395B1 (en) 1999-06-16 2006-07-18 Sterix Limited Methods for treating or preventing cancer by preventing, inhibiting or arresting cell cycling
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DK1237902T3 (da) 1999-12-13 2006-03-06 Sterix Ltd Halogenerede sulphamat-, fosfonat-, thiofosfonat-, sulfonat- og sulfonamidforbindelser som hæmmere af steroid sulfatase
US7335650B2 (en) 2000-01-14 2008-02-26 Sterix Limited Composition
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KR101117061B1 (ko) 2003-05-21 2012-05-16 아스카 세이야쿠 가부시키가이샤 고리형 아미노페닐술파메이트 유도체
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CN103259027A (zh) 2005-04-28 2013-08-21 普罗透斯数字保健公司 药物信息***
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GB0511190D0 (en) * 2005-06-01 2005-07-06 Sterix Ltd Use
EP1945240B1 (en) 2005-09-16 2016-12-28 Raptor Pharmaceutical Inc Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof
GB0624105D0 (en) * 2006-12-01 2007-01-10 Sterix Ltd Use
GB0706072D0 (en) 2007-03-28 2007-05-09 Sterix Ltd Compound
WO2009037539A2 (en) 2007-09-17 2009-03-26 Preglem S.A. Treatment of oestrogen dependant conditions in pre-menopausal women
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PL3395372T3 (pl) 2009-02-20 2022-07-25 EnhanX Biopharm Inc. Układ do dostarczania leków na bazie glutationu
KR20190116576A (ko) 2009-05-06 2019-10-14 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
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Also Published As

Publication number Publication date
HUT66097A (en) 1994-09-28
SG115508A1 (en) 2005-10-28
JP3219408B2 (ja) 2001-10-15
NO995075L (no) 1994-04-29
NO308774B1 (no) 2000-10-30
UA70957C2 (uk) 2004-11-15
KR100322650B1 (ko) 2002-03-20
EP0982032A2 (en) 2000-03-01
JP2000038341A (ja) 2000-02-08
RU2001125673A (ru) 2003-06-27
JP3581802B2 (ja) 2004-10-27
CY2394B1 (en) 2004-09-10
JPH07501515A (ja) 1995-02-16
EP1522543A1 (en) 2005-04-13
JP3581821B2 (ja) 2004-10-27
AU2490592A (en) 1993-04-05
EP1099706B1 (en) 2004-10-06
CY2398B1 (en) 2004-09-10
RU2210574C2 (ru) 2003-08-20
SK24694A3 (en) 1994-11-09
NO20044458L (no) 1994-04-29
SG106116A1 (en) 2004-09-30
DK0921130T3 (da) 2003-07-21
GEP20033094B (en) 2003-10-27
DE69233431D1 (de) 2004-11-11
DK0641355T3 (da) 2000-10-09
ATE278704T1 (de) 2004-10-15
EP1099706A2 (en) 2001-05-16
NO20025725D0 (no) 2002-11-28
EP0928609A3 (en) 2001-11-07
EP0921130A2 (en) 1999-06-09
AU668882B2 (en) 1996-05-23
ES2148178T3 (es) 2000-10-16
ES2204059T3 (es) 2004-04-16
DE69233431T2 (de) 2006-02-23
CA2305749A1 (en) 1993-03-18
DE69231280D1 (de) 2000-08-24
GB9118478D0 (en) 1991-10-16
AU717116B2 (en) 2000-03-16
ATE239753T1 (de) 2003-05-15
DE69233053D1 (de) 2003-06-12
HK1025051A1 (en) 2000-11-03
EP0641355B1 (en) 2000-07-19
CA2305758A1 (en) 1993-03-18
NO318009B1 (no) 2005-01-17
AU689043B2 (en) 1998-03-19
BR9206434A (pt) 1994-09-27
EP0641355A1 (en) 1995-03-08
DK0982032T3 (da) 2003-11-03
CA2114630C (en) 2003-09-30
SK282188B6 (sk) 2001-12-03
SG103374A1 (en) 2004-04-29
FI940903A (fi) 1994-04-20
SG103820A1 (en) 2004-05-26
NO995076L (no) 1994-04-29
SK282189B6 (sk) 2001-12-03
CA2305767A1 (en) 1993-03-18
DE69233020D1 (de) 2003-05-22
ATE246706T1 (de) 2003-08-15
CZ295939B6 (cs) 2005-12-14
SG73391A1 (en) 2006-08-30
CA2114630A1 (en) 1993-03-18
EP1099706A3 (en) 2002-09-04
ATE237333T1 (de) 2003-05-15
GEP20022802B (en) 2002-09-25
DE69233053T2 (de) 2003-11-20
EP0982032A3 (en) 2002-03-20
JP2000355542A (ja) 2000-12-26
FI20050991A (fi) 2005-10-03
HK1020672A1 (en) 2000-05-19
RU2207134C2 (ru) 2003-06-27
NO995076D0 (no) 1999-10-18
GEP20063773B (en) 2006-03-27
NO308903B1 (no) 2000-11-13
NO995075D0 (no) 1999-10-18
ES2196483T3 (es) 2003-12-16
AU1007799A (en) 1999-03-04
HU9400583D0 (en) 1994-05-30
GEP20022803B (en) 2002-09-25
KR100258396B1 (ko) 2000-08-01
EP0928609A2 (en) 1999-07-14
CZ44094A3 (en) 1995-01-18
CY2253B1 (en) 2003-07-04
GEP20022637B (en) 2002-02-25
KR100321019B1 (ko) 2002-03-20
ES2193475T3 (es) 2003-11-01
GR3034579T3 (en) 2001-01-31
JP2002255993A (ja) 2002-09-11
CY2397B1 (en) 2004-09-10
DE69233149D1 (de) 2003-09-11
EP0928609B1 (en) 2003-04-16
US5830886A (en) 1998-11-03
KR100321018B1 (ko) 2002-03-20
EP0921130A3 (en) 2001-09-05
NO307301B1 (no) 2000-03-13
HK1019753A1 (en) 2000-02-25
DE69231280T2 (de) 2000-11-30
AU5837396A (en) 1996-09-05
JP2003176297A (ja) 2003-06-24
FI20002261A (fi) 2000-10-13
NO20002595D0 (no) 2000-05-19
DE69233149T2 (de) 2004-06-24
SG88782A1 (en) 2002-05-21
UA41875C2 (uk) 2001-10-15
UA70956C2 (uk) 2004-11-15
LV12618A (en) 2001-02-20
DE69233020T2 (de) 2003-11-06
EP0982032B1 (en) 2003-08-06
NO314287B1 (no) 2003-03-03
US6159960A (en) 2000-12-12
NO20025725L (no) 1994-04-29
EP0921130B1 (en) 2003-05-07
ATE194843T1 (de) 2000-08-15
NO940635L (fi) 1994-04-29
LV12618B (en) 2001-07-20
SG88783A1 (en) 2002-05-21
GEP20022766B (en) 2002-08-26
FI20002260A (fi) 2000-10-13
WO1993005064A1 (en) 1993-03-18
DK0928609T3 (da) 2003-07-21
NO2595A (no) 1994-04-29
RU94019334A (ru) 1996-10-20
UA70958C2 (uk) 2004-11-15
US5616574A (en) 1997-04-01
NO940635D0 (no) 1994-02-24
JP2000355598A (ja) 2000-12-26
FI940903A0 (fi) 1994-02-25
SK282187B6 (sk) 2001-12-03
SK282186B6 (sk) 2001-12-03
RU2182152C2 (ru) 2002-05-10
JP3581820B2 (ja) 2004-10-27

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